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药物代谢研究与药物设计及结构修饰

阿基业,　王广基

(中国药科大学药代中心,南京210009)

摘　要:药物代谢研究可以为药物设计及结构修饰提供帮助和指导。阐述药物代谢研究与药物设计及结构修饰的密切联系,介绍药物代谢和活性代谢产物研究在前体药物设计、化合物结构改造或引入合适基团及硬药和软药开发等方面的作用。

关键词:药物代谢;前体药物;代谢产物;药物设计;结构修饰

中图分类号:R969.1;R914.2 文献标识码:A 文章编号:1001-5094(2002)02-080-07

Drug Metabolism Research for the Design and Structural Modification of Drugs

A J i-ye,　W AN G Guang-ji

(Center of Metabolism and Pharmacokinetics,China Pharmaceutical University,N anjing210009,China)接受日期:2002-02-02