医学微生物-疱疹病毒PPT优选课件

也有性接触传播 HSV-2:性接触传播为主
HSV-infection
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HSV-infection 大多无明显症状或出现局部疱疹
• Primary infection (HSV-1, HSV-2) • Latent and recurrent infection
primary
latent (site of latency)
(transmitted by a variety of route)
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•Vertical transmission
congenital infection perinatal infection
经产道感染(围生期感染)
*隐性感染 *巨细胞包涵体病(CID) *流产、早产或死胎 *先天性畸形/出生后异常
proliferative latent
infection
infection
activate
• common infectious types
*subclinical infection 人普遍易感,感染后大多无明显症状
*primary infection and latent infection
*congenital infection
infection infection
(reactivation of latent virus)
(anew)
HSV-1---三叉神经节 HSV-2---骶神经节
recurrent infection
复发性局部疱疹
• Congenital and newborn infection
• Associated with cancer HSV1---唇癌
孕妇患水痘易致胎儿畸形、流产或死产
• pneumonia (adults)
Recurrent infection
--- zoster(adults)
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单侧成簇性水疱群沿神 经支配的皮肤排列呈带 状，伴有神经痛
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(CMV)
1.Species-specific HCMV只能感染人,只能
2.Cultivation
在人成纤维细胞中增殖
(slow growth, typical CPE)
3.Pathogenicity
细胞肿胀、核变大, 形成巨大细胞,核内有
Primary infection （usually asymptomatic
“猫头鹰眼” 的嗜酸性
in包f涵e体ction）
→latent infection (site of latent) Route of transmission
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HSV2---宫颈癌 9
Coldsore or fever blisters
(唇疱疹或热性疱疹)
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第一课件网网站
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(VZV)
Single serotype
Route of transmission
通过飞沫和直接接触传播
Primary infection
• varicella (chidren)
(耳聋和智力障碍)
• Horizontal transmission
*by transfusion → post-transfusion mono-
nucleosis and hepatitis
*by close contact and sexual contact
*patients with impaired immune function → activation of latent virus 肺炎/视网膜炎/食管炎等
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1.Classification
(P310 Table 24-1)
α-herpesviruses
-herpesviruses
HHV-1(HSV-1) HHV-2(HSV-2) HHV-3(VZV) HHV-5(CMV) HHV-6 HHV-7
-herpesviruses HHV-4(EBV)
HHV-8
*integrative infection
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3.Quick diagnosis
Finding inclusion body (CMV) Detection of viral Ag and specific Ab (HSV,CMV,EBV) Detection of viral DNA
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2.Characteristics
Shape and structure
Glycoprotein spike
Envelope
162 capsomeres
tegument
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Cubic nucleocapsid
Linear ds-DNA
120-130nm in diameter
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1.Serotype :HSV-1 and HSV-2
2.Pathogenicity
Source of infection 病人和健康带毒者
Route of transmission
• by direct contact HSV-1:主要是直接密切接触,
• by sexual contact
body
核内嗜酸性包涵体
• cell fusion form multinuclear giant
cells
细胞融合形成多核巨细胞
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Pathogenicity
• transmission (by many different routes) • infectious mode of virus on host cells
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Cultivation
---- replicate in intranuclear of human diploid cells and produce cytopathic effect (except EBV)
typical CPE:
• intranuclear acidophilic inclusion
Chapter 24
(HHV)
第一课件网网站
2020/10/18
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Oቤተ መጻሕፍቲ ባይዱtline
➢Classification of herpesviruses ➢Characteristics of herpesviruses ➢Quick diagnosis of herpesviruses
2020/10/18