首都医科大学眼科学2015年考博真题考博试卷
首都医科大学眼科学2018年考博真题考博试卷
医学考博真题试卷
首都医科大学
2018 年攻读博士学位研究生入学考试试题
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考试科目：眼科学 注意：所有答案一律写在答题纸上，写在试题纸上或其他地方一律不给分。
一、单选题 1.视功能检查主要是 A.光视觉 B.形视觉 C.D 2.视觉发育的关键期是 3.结膜的血供 4.Honor 综合征的表现 5.抗青光眼药物的作用说法错误的是
二、名词解释 1.假性翼状胬肉 2.Mechasiny 综合征 3.VKH 4.acomdation 5. RAPD 马切山尼综合症（英文）
三、简答题 1.角膜的组织结构 2.动态视野和静态视野 3.铁质沉着症的临床特点 4.后发性白内障的发生机制 5.类固醇的副作用 6.病理性瞳孔阻滞 7.RPE 功能
四、论述题 1.前房角的结构 2 急性闭角型青光眼的分期及诊断标准
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3.视网膜出血的类型和表现 4.ICE 的临床表现和鉴别诊断 5.六条第1页 共1页
首都医科大学博士入学考试试题汇总
目录目录 (1)首都医科大学神经解剖博士入学考试试题 (2)2001年 (2)2002年 (3)2003年 (4)首都医科大学大外科解剖博士入学考试试题 (5)2003年 (5)首都医科大学大外科眼科（记忆版）博士入学考试试题 (5)2004年 (5)首都医科大学神经解剖博士入学考试试题2001年一、名词解释（1-7题，5×7=35；2-12题，3×5=15）1、边缘系统2、脊髓灰质板层3、后屈束4、内侧纵束1、攀缘纤维2、下橄榄核3、桥小脑三角4、 phrenic n.5、 celiac plexus10、obturator n.11、locus reculeus12、carvernous sinus二、问答题（10×5=50）1、纹状体① 位置及组成② 纤维联系③ 化学递质环路④ 动脉供应2、网状结构① 定义② 主要核团③ 机能组合3、神经支配① 肾上腺髓质② 斜方肌③ 二腹肌④ 蚓状肌4、解剖基础① 交叉性瘫痪② 屈曲反射③ 翼状肩④ 猿手5、“听新闻记纪录”的解剖学基础2002年简答：被盖中央束阴捕神经黑质蓝斑论述：1脑干的非脑神经节脑干的运动型交叉纤维Wallenberg的解剖基础2副交感神经系统的二级神经元交通支颌部区的立毛肌支配（不知道该题是否准确）３小脑皮质神经元环路海马结构的分层和分区脑室的边界和CSF的循环2003年名词解释1. 肋间壁神经2. 鼻睫神经3. Ⅶ颅神经4. great petrosol N5. confluence of sinuse6. central tegmentrol decussation简答1. 底丘脑的神经纤维联系2. 下肢非意识感觉到大脑的纤维联系3. 如何理解cerebelar glomorulus论述1. 边缘系统组成；PAPEZ环路；Hippocampal分层。
2. 白质通路和灰质通路；牵涉痛；Otic Ganglion。
2006-2015年首都医科大学考博生理原题及答案(自整理)
2006-2015年首都医科大学考博生理原题及答案(自整理)名词解释：1、all-or-none (2012)细胞产生动作电位的特点是，当刺激强度小于阈刺激时，细胞不产生动作电位，当刺激强度等于或大于阈强度时，细胞即产生动作电位，且幅度不再加大，此种现象称为“全或无”。
即动作电位的大小不随刺激强度的改变而改变。
2、recurrent inhibition (2012)是指某一中枢的神经元兴奋时，其传出冲动沿轴突外传，同时又经轴突侧支去兴奋另一抑制性中间神经元，该抑制性神经元兴奋后，其活动经轴突反过来作用于同一中枢的神经元，抑制原先发动兴奋的神经元及同一中枢的其他神经元。
3、overdrive suppression (2012)当自律细胞在受到高于其固有频率的刺激时，就按外加刺激的频率发生兴奋，称为超速驱动。
在外来的超速驱动停止后，自律细胞不能呈现其固有的自律性活动，需经一段静止期后才逐渐恢复其自律性，这种现象称为超速驱动压抑。
4、renal threshold for glucose (2012)尿中不出现葡萄糖的最高血糖浓度。
OR：近端小管对葡萄糖的吸收有一定限度。
当血糖浓度达180mg/100ml 时，有一部分肾小管对葡萄糖的吸收已达极限，尿中开始出现葡萄糖，此时的血浆葡萄糖浓度称为肾糖阈。
5、transducer function of receptor (2012)各种感受器在功能上的一个共同特点，是能把作用于它们的各种形式的刺激能量转换为传入神经的动作电位，这种能量转换称为感受器的换能作用。
6、basic electrical rhythm (2011，2010，2006)指胃肠平滑肌细胞在静息电位基础上产生缓慢的节律性的自动去极化波，又称慢波。
7、local potential (2011，2009，2007，2006)阈下刺激作用于细胞，引起膜原有的得到电位发生轻微的改变，称为局部电位。
2015年全国医学博士入学统一考试英语真题及答案解析
2015年全国医学博士入学统一考试英语真题及答案解析Part I: Listening comprehension(略)Part II: Vocabulary(10%)Section ADirection: In this section, all the sentences are incomplete. Four word or phrases marked A,B,C and D are given beneath each of them. You are to choose the word the word or phrase that best completes the sentence, then mark your answer on the ANSWER SHEET.31. Despite his doctor’s note of caution, he never____from dring and smorking.A. retainedB. dissuadedC. alleviatedD. abstained32. people with a history of recurrent infections are warned that the use of personal stereos with headsets is likely to____their hearing.A. rehabilitateB. jeopardizeC. tranquilizeD. supplement33. impartial observers had to acknowledge that lack of formal education did not seem to____larry in any way in his success.A. refuteB. ratifyC. facilitateD. impede34. when the supporting finds were reduced, they should have revised their plan______.A. accordinglyB. alternativelyC. considerablyD. relatively35. it is increasingly believed among the expectant parents that prenatal education of classical music can_____ future adults with appreciation of music.A. acquaintB. familiarizedC. endowD. amuse36. if the gain of profit is solely due to rising energy prices, then inflation should be subsided when energy prices_____A. level outB. stand outC. come offD. wear off37. heat stroke is a medical emergency that demands immediate_____ from qualified medical personnel.A. prescriptionB. palpationC. interventionD. interposition38. asbestos exposure results in Mesothelioma, asbestosis and internal organ cancers, and_____ of these diseases is often decades after the initial exposure.A. offsetB. intakeC. outletD. onset39. ebola, which spreads through body fluid or secretions such as urine,______ and semen, can kill up to 90% of those infected.A. salineB. salivaC. scabiesD. scrabs40. the newly designed system is ____ to genetic transfections, and enables an incubation period for studying various genes.A. comparableB. transmissibleC. translatableD. amenable Section BDirections: each of the following sentences has a word or phrase underlined. There are four words or phrases beneath each sentence. Choose the word or phase which can best keep the meaning of the original sentence if it issubstituted for the underlined part. Mark your answer on the ANSWER SHEET.41. every year more than 1000 patients in Britain die on transplant waiting lists, prompting scientists to consider other ways to produce organs.A. propellingB. prolongingC. puzzlingD. promising42. improved treatment has changed the outlook of HIV patients, but there is still a serious stigma attached to AIDS.A. disgraceB. discriminationC. harassmentD. segregation43. surviviors of the shipwreck were finally rescued after their courage of persistence lowered to zero by their physical lassitude.A. depletionB. dehydrationC. exhaustionD. handicap44. scientists have invented a 3D scan technology to read the otherwise illegible wood-carved stone, a method that may apply to other areas such as medicine.A. negativeB. confusingC. eloquentD. indistinct45. top athletes scrutinize both success and failure with their coach to extract lessons from them, but they are never distracted from long-term goals.A. anticipateB. clarifyC. examineD. verify46. his imperative tone of voice reveals his arrogance and arbitrariness.A. challengingB. solemnC. hostileD. demanding47. the discussion on the economic collaboration between the United States and the European Union may be eclipsed by the recent growing trade friction.A. erasedB. triggeredC. shadowedD. suspended48. faster increases in prices foster the belief that the future increases will be also stronger, so that higher prices fuel demand rather than quench it.A. nurtureB. eliminateC. assimilateD. puncture49. some recent developments in photography allow animals to be studied in previously inaccessible places and in unprecedented detail.A. unpredictableB. unconventionalC. unparalleledD. unexpected50. a veteran negotiation specialist should be skillful at manipulating touchy situation.A. estimatingB. handlingC. rectifyingD. anticipatingPart III Cloze(10%)Direction: in this section there is a passage with ten numbered blanks. For each blank, there are four choices marked A, B, C, and D on the right side. Choose the best answer and mark the letter of your choice on the ANSWER SHEET.A mother who is suffering from cancer can pass on the disease to her unborn child in extremely rare cases 51 a new case report published in PNAS this week.According to researchers in Japan and at the Institute for Cancer Research in Sutton, UK, a Japanese mother had been diagnosed with leukemia a few weeks after giving birth 52 tumors were discovered in her daughter’s cheek and lung when she was 11 months old. Genetic analysis showed that the baby’s cancer cells had the same mutation as the cancer cellsof the mother. But the cancer cells contained no DNA whatsoever from the father 53 would be expected if she had inherited the cancer from conception. That suggests the cancer cell made it into the unborn child’s body across the placental barrier.The Guardian claimed this to be the fires 54 case of cells crossing the placental barrier. But this is not the case----microchimerism 55 cells are exchanged between a mother and her unborn child, is thought to be quite common, with some cells thought to pass from fetus to mother in about 50 to 70 percent of cases and to go the other way about half,56.As the BBC pointed out, the greater 57 in cancer transmission from mother to fetus had been how cancer cells that have slipped through the placental barrier could survive in the fetus without being killed by its immune system. The answer, in this case at least, lies in a second mutation of the cancer cells, which led to the 58 of the specific features that would have allowed the fetal immune system to detect the cells as foreign. As a result, no attack against the invaders was launched.59, according to the researchers there is little reason for concern of “cancer danger”. Only 17 probable cases have been reported worldwide and the combined 60 of cancer cells both passing the placental barrier and having the right mutation to evade the baby’s immune system is extremely low.51. A. suggests B. suggesting C. having suggested D. suggested52. A. since B. although C. whereas D. when53. A. what B. whom C. who D. as54. A. predicted B. notorious C. proven D. detailed55. A. where B. when C. if D. whatever56. A. as many B. as much C. as well D. as often57. A. threat B. puzzle C. obstacle D. dilemma58. A. detection B. deletion C. amplification D. addition59. A. therefore B. furthermore C. nevertheless D. conclusively60. A. likelihood B. function C. influence D. flexibilityPart IV Reading Comprehension(30%)Directions: in this part there are six passages, each of which is followed by five questions. For each question there are four possible answers marked A, B, C, and D. choose the best answer and mark the letter of your choice on the ANSWER SHEET.Passage OneThe American Society of Clinical Oncology wrapped its annual conference this week, going through the usual motions of presenting a lot of drugs that offer some added quality or extension of life to those suffering from a variety of as-yet incurable diseases. But buried deep in an AP story are a couple of promising headlines that seems worthy of more thorough review, including one treatment study where 100 percent of patients saw their cancer diminish byhalf.First of all, it seems pharmaceutical companies are moving away from the main cost-effective one-size-first-all approach to drug development and embracing the long cancer treatments, engineering drugs that only work for a small percentage of patients but work very effectively within that group.Pfizer announced that one such drug it’s pushing into late-stage testing is target for 4% of lung cancer patients. But more than 90% of that tiny cohort responded to the drug initial tests, and 9 out of ten is getting pretty close to the ideal ten out of ten. By gearing toward more boutique treatments rather than broad umbrella pharmaceuticals that try to fit for everyone it seems cancer researchers are making some headway. But how can we close the gap on that remaining ten percent?Ask Takeda Pharmaceutical and Celgene, two drug makers who put aside competitive interests to test a novel combination of their treatments. In a test of 66 patients with the blood disease multiple myeloma, a full 100 percent response to a cancer drug(or in this case a drug cocktail) is more or less unheard of. Moreover, this combination never would’ve been two competing companies hadn’t sat down and put their heads together.Are there more potentially effective drug combos out there separated by competitive interest and proprietary information? Who’s to say, but it seems like with the amount of money and research being pumped into cancer drug development, the outcome pretty good. And if researchers can start pushing more of their response numbers toward 100 percent, we can more easily start talking about oncology’s favorite four-letter word: cure.61. which of the following can be the best title for the passage?A. Competition and CooperationB.Two Competing Pharmaceutical CompaniesC. The promising Future of PharmaceuticalsD. Encouraging News: a 100% Response to a Cancer Drug62. in cancer drug development, according to the passage, the pharmaceuticals now ____A. are adopting the cost-effective one-size-fits-all approachB. are moving towards individualized and targeted treatmentsC. are investing the lion’s shares of their moneyD. care only about their profits63. from the encouraging advance by the two companies, we can infer that____A. the development can be ascribed to their joint efforts and collaborationB. it was their competition that resulted in the accomplishmentC. other pharmaceuticals will join them in the researchD. the future cancer treatment can be nothing but cocktail therapy64. from the last paragraph it can be inferred that the answer to the question___A. is nowhere to be foundB. can drive one crazyC. can be multipleD. is conditional65. the tone of the author of this passage seems to be_____A. neutralB. criticalC. negativeD. potimistPassage TwoLiver disease is the 12th leading cause of death in the US, chiefly because once it’s determined that a patient needs a new liver it’s difficult to get one. Even in case where a suitable donor match is found, there’s guarantee a transplant will be successful. But researchers Massachusetts General Hospital have taken a huge step toward building functioning livers in the lab, successfully transplanting culture-grown livers into rats.The livers aren’t grown from scratch, but rather within the infrastructure of a donor liver. The liver cells in the donor organ are washed out with a detergent that gently strips away the liver cells, leaving behind a biological scaffold of proteins and extracellular architecture that is very hard to duplicate synthetically.With all of that complicated infrastructure already in place, the researchers then seeded the scaffold(支架) with liver cells isolated from health livers, as well as some special endothelial cells to line the bold vessels. Once repopulated with healthy cells, these livers lived in culture for 10 days.The team also translated some two-day-old recellularized livers back into rats, where they continued to thrive for eight hours while connected into the rat’s vascular systems. However, the current method isn’t perfect and can not seem to repopulate the blood vessels quite densely enough and the transplanted livers can’t keep functioning for more than about 24 hours(hence the eight-hour maximum for the rat thansplant).But the initial successes are promising, and the team thinks they can overcome the blood vessel problem and get fully functioning livers into rats within two years. It still might be a decade before the tech hits the clinic, but if nothing goes horribly wrong—and especially if stem-cell research established a reliable way to create health liver cells from the every patients who need transplants-lab-generated livers that are perfect matches for their recipients could become a reality.66. it can be inferred from the passage that the animal model was mainly intended to____A. investigate the possibility of growing blood vessels in the labB. explore the unknown functions of the human liverC. reduce the incidence of liver disease in the US.D. address the source of liver transplants67. what does the author mean when he says that the livers aren’t grown from scratch?A. the making of a biological scaffold of proteins and extracellular architectureB. a huge step toward building functioning livers in the labC. the building of the infrastructure of a donor liverD. growing liver cells in the donor organ68. the biological scaffold was not put into the culture in the lab until____A. duplicated syntheticallyB. isolated from the healthy liverC. repopulated with the healthy cellsD. the addition of some man-made blood vessels69. what seems to be the problem in the planted liver?A. the rats as wrong recipientsB. the time point of the transplantationC. the short period of the recellularizationD. the insufficient repopulation of the blood vessels70. the research team holds high hopes of_____A. creating lab-generated livers for patients within two yearsB. the timetable for generating human livers in the labC. stem-cell research as the future of medicineD. building a fully functioning liver into ratsPassage ThreePatients whose eyes have suffered heat or chemical bums typically experience severe damage to the cornea—the thin, transparent front of the eye that refracts light and contributes most of the eye’s focusing ability. In a long-term study, Italian researchers use stem cells taken from the limbus, the border between the cornea and the white of the eye, to cultivate a graft of healthy cells in a lab to help restore vision in eyes. During the 10-years study, the researchers implanted the healthy stem cells into the damaged cornea in 113 eyes of 112 patients. The treatment was fully successful in more than 75 percent of the patients, and partially successful in 13 percent. Moreover, the restored vision remained stable over 10 years. Success was defined as an absence of all symptoms and permanent restoration of the cornea.Treatment outcome was initially assessed at one year, with up to 10 years of follow-up evaluations. The procedure was even successful on several patients whose bum injuries had occurred years earlier and who had already undergone surgery.Current treatment for burned eyes involves taking stem cells from a patient’s healthy eye, or from the eyes of another person, and transferring them to the burned eye. The new procedure, however, stimulates the limbal stem cells from the patient’s own eye to reproduce in a lab culture. Several types of treatments using stem cells have proven successful in restoring blindness, but the long-term effectiveness shown here is significant. The treatment is only for blindness caused by damage to the cornea; it is not effective for repairing damaged retinas or optic nerves.Chemical eye burns often occur in the workplace, but can also happen due to mishaps involving household cleaning products and automobile batteries.The result of the study, based at Italy’s University of Modena and Reggio Emilia, were published in the June 23 online issue of the New England Journalof Medicine.71. what is the main idea of this passage?A. stem cells can help restore vision in the eyes blinded by bums.B. the vision in the eyes blinded by bums for 10 years can be restoredC. the restored vision of the burned eyes treated with stem cells can last for10 yearsD. the burned eyes can only be treated with stem cells from other healthy persons72. the Italian technique reported in this passage_____A. can repair damaged retinasB. is able to treat damaged optic nervesC. is especially effective for burn injuries in the eyes already treated surgicallyD. shows a long-term effectiveness for blindness in vision caused by damage to cornea73. which of the following is NOT mentioned about eye bums?A. the places in which people workB. the accidents that involve using household cleaning productsC. the mishaps that involved vehicles batteriesD. the disasters caused by battery explosion at home74. what is one of the requirements for the current approach?A. the stem cells taken from a healthy eyeB. the patient physically healthyC. the damaged eye with partial visionD. the blindness due to damaged optic nerves75. which of the following words can best describe the author’s attitude towards the new method?A. sarcasticB. indifferentC. criticalD. positivePassage FourHere is a charming statistic: divide the us by race, sex and county of residence, and differences in average life expectancy across the various groups can exceed 30 years. The most disadvantaged look like denizens of a poor African country: a boy born on a Native American reservation in Jackson County, South Dakota, for example, will be lucky to reach his 60th birthday, a typical child in Senegal can expect to live longer than that.America is not alone in this respect. While the picture is extreme in other rich nations, health inequalities based on race, sex and class exist in most societies—and are only party explained by access to healthcare.But fresh insights and solutions may soon be at hand. An innovative project in Chicago to unite sociology and biology is blazing the trail(开创), after discovering that social isolation and fear of crime can help to explain the alarmingly high death rate from breast cancer among the city’s black women. Living in these conditions seems to make tumors more aggressive by changing gene activity, so that cancer cells can use nutrients more effectively.We are already familiar with the lethal effect of stress on people clinging to the bottom rungs of the societal ladder, thanks to pioneering studies of British civil servants conducted by Michael Marmot of University College London. What’s exciting about the Chicago project is that it both probes the mechanisms involved in a specific disease and suggests precise remedies that it both probes the mechanisms invlilved in a specific disease and suggests precise remedies. There are drugs that may stave tumors of nutrients and community coordinators could be employed to help reduce social isolation. Encouraged by the US National Institutes of Health , similar projects are springing up to study other pockets of poor health, in populations ranging from urban black men to while poor women in rural Appalachia.To realize the full potential of such projects, biologists and sociologists will have to start treating one other with a new respect and learn how to collaborate outside their comfort zones. Too many biomedical researchers still take the arrogant view that sociology is a “soft science” with little that’s serious to say about health. And too many sociologists reject any biological angle—fearing that their expertise will be swept aside and that this approach will be used to bolster discredited theories of eugenics, or crude race-based medicine.It’s time to drop these outdated attitudes and work together for the good of society’s most deprived members. More important, it’s time to use this fusion of biology and sociology to inform public policy. This endeavor has huge implications, not least in cutting the wide health gaps between blacks and whites, rich and poor.76. as shown in the 1st paragraph, the shaming statistic reflects______.A. injustice everywhereB. racial discriminationC. a growing life spanD. health inequalities77. which of the following can have a negative impact on health according to the Chicago-based project?A. where to liveB. which race to belong toC. how to adjust environmentallyD. what medical problem to suffer78. the Chicago-based project focuses its management on_____A. a particular medical problem and its related social issueB. racial discrimination and its related social problemsC. the social ladder and its related medical conditionsD. a specific disease and its medical treatment79. which of the following can most probably neglected by sociologists?A. the racial perspectiveB. the environmental aspectC. the biological dimensionD. the psychological angel80. the author is a big fan of______A. the combination of a traditional and new way of thinking in promoting healthB. the integration of biologists and sociologists to reduce health inequalitiesC. the mutual understanding and respect between racesD. public education and health promotionPassage FiveAmerican researchers are working on three antibodies that many mark a new step on the path toward an HIV vaccine, according to a report published online Thursday, July 8,2010, in the journal Science.One of the antibodies suppresses 91 percent of HIV strains, more than any AIDS antibody ever discovered, according to a report on the findings published in the Wall Street Journal. The antibodies were discovered in the cells of a 60-year-old African-American gay man whose body produced them naturally. One antibody in particular is substantially different from its precursors, the Science study says.The antibodies could be tried as a treatment for people already infected with HIV, the WSJ reports. At the very least, they might boost the efficacy of current antiretroviral drugs.It is welcome news for the 33 million people the United Nations estimated were living with AIDS at the end of 2008.The WSJ outlines the painstaking method the team used to find the antibody amid the cells of the African—American man, known as Donor 45. First they designed a probe that looks just like a spot on a particular molecule on the cells that HIV infects. They used the probe to attract only the antibodies that efficiently attack that spot. They screened 25 million of Donor 45’s cell to find just 12 cells that produced the antibodies.Scientists have already discovered plenty of antibodies that either don’t work at all or only work on a couple of HIV strains. Last year marked the first time that researchers found ”broadly neutralizing antibodies”, which knock out many HIV strains. But none of those antibodies neutralized more than about 40 percent of them, the WSJ says. The newest antibody, at 91 percent neutralization , is a marked improvement.Still, more work needs to be done to ensure the antibodies would activate the immune system to produce natural defenses against AIDS, the study authors say. They suggest there test methods that blend the three new antibodies together—in raw form to prevent transmission of the virus, such as from mother to child; in a microbicide gel that women or gay men could use before sex to prevent infection; or as a treatment for HIV/AIDS, combined with antiretroviral drug.If the scientists can find the right way to stimulate production of the antibodies, they think most people could produce then, the WSJ says.81. we can learn from the beginning of the passage that_______A. a newly discovered antibody defeats 91% of the HIV strainsB. a new antiretroviral drug has just come on the marketC. American researchers have developed a new vaccine for HIVD. the African—American gay man was cured of this HIV infection82. what is the implication of the antibodies discovered in the cells of the African—American gay man?A. they can cure the 33 million AIDS patients in the worldB. they may strengthen the effects of the existing antiretroviral drugsC. they will kill all the HIV virusesD. they will help make a quick diagnosis of an HIV infection83. the newest antibody found in Donor 45 reflects a dramatic advance in terms of_____.A. pathologyB. pharmacologyC. HIV neutralizationD. HIV epidemiology84. according to the study authors, the three test methods are intended to____.A. advance the technology in condom production to prevent HIV infectionB. facilitate the natural immune defense against AIDSC. develop more effective antiretroviral drugs85. the passage is most likely_____.A. a news reportB. a paper in ScienceC. an excerpt from an Immunology TextbookD. an episode in a science fiction novel.Passage SixWhitening the world's roofs would offset the emissions of the world's cars for 20 years, according to a new study from Lawrence Berkeley National Laboratory.Overall, installing lighter-colored roofs and pavement can cancel the heat effect of two years of global carbon dioxide emissions, Berkeley Lab says. It's the first roof-cooling study to use a global model to examine the issue.Lightening-up roofs and pavement can offset 57 billion metric tons of carbon dioxide, about double the amount the world emitted in 2006, the study found. It was published in the journalEnvironmental Research Letters.Researchers used a conservative estimate of increased albedo, or solar reflection, suggesting that purely white roofs would be even better. They increased the albedo of all roofs by 0.25 and pavement by 0.15. That means a black roof, which has an albedo of zero, would only need to be replaced by a roof of a cooler color -- which might be more feasible to implement than a snowy white roof, Berkeley Lab says.The researchers extrapolated a roof's CO2 offset over its average lifespan. If all roofs were converted to white or cool colors, they would offset about 24 gigatons (24 billion metric tons) of CO2, but only once. But assuming roofs last about 20 years, the researchers came up with 1.2 gigatons per year. That equates to offsetting the emissions of roughly 300 million cars, all the cars in the world, for 20 years.Pavement and roofs cover 50 to 65 percent of urban areas, and cause a heat-island effect because they absorb so much heat. That's why cities aresignificantly warmer than their surrounding rural areas. This effect makes it harder -- and therefore more expensive -- to keep buildings cool in the summer. Winds also move the heat into the atmosphere, causing a regional warming effect.Energy Secretary Steven Chu, a Nobel laureate in physics (and former Berkeley Lab director), has advocated white roofs for years. He put his words into action Monday by directing all Energy Department offices to install white roofs. All newly installed roofs will be white, and black roofs might be replaced when it is cost-effective over the lifetime of the roof."Cool roofs are one of the quickest and lowest-cost ways we can reduce our global carbon emissions and begin the hard work of slowing climate change," he said in a statement.86. which of the following can be the best title for the passage?A. a Decline in Car EmissionsB. white Roofs or Black PavementsC. the Effect of Linghting-up RoofsD. climate Change and Extreme Weathers87. a indicated by the passage, black roofs______A. are better than snowy white onesB. reflect not heat from the sunC. are more expensive to build in the urban areasD. are supposed to be placed by snowy white ones88. if they are converted to white or cooler colors, all roofs in the world in their lifetime_____A. can absorb 1.2 gigattons of CO2 a yearB. could serve as 300 million cars in terms of emissionC. would offset the emissions from 300 million carsD. would offset about 24 gigatons of CO2 as emitted from the cars89. according to the passage, it is hard and expensive to keep the urban buildings cool because of______A. the heat-island effectB. the lack of seasonal windsC. the local unique weatherD. the fast urban shrinkage90. energy Secretary Steven Chu implies that_____A. nothing could be more effective in cooling global warming than method he has advocatedB. the method in question still needs to be justified in the futureC. our global carbon emissions can be reduced by half if cool roofs are installedD. weather change and global warming can be addressed in no timePart V Writing(20%)Directions: in this part there is an essay in Chinese. Read it carefully and then write a summary of 200 words in English on the ANSWER SHEET. Make sure that your summary covers the major points of the passage.什么是健康？人的健康包括身体健康和心理健康两个方面。
眼科考博问答题
首都医科大学北京同仁医院眼科09年博士入学考试试题一. 简答30分1.视网膜中央动脉阻塞的急诊处理。
2.高度近视眼的眼科并发症。
3.单纯疱疹病毒角膜炎的致病机制，临床分类和治疗。
4.睫状神经节的组成和部位。
5.来源中胚层的眼组织二. 论述（任选三道做）30分1.青光眼药物的分类，作用机制和副作用2.糖网的国际和国内分期3.常见造成突眼的炎症性眼病分类和临床特征4.糖网新生血管的形成过程、机制、促进和抑制其生长的因子、可能的治疗方法。
32首医考博2008三、简答（5分x5=25分）1、中胚叶发育的眼球组织2、睫状神经节位置和组成3、瞳孔对光反射传导通路4、白瞳症概念可见于哪些疾病5、急性视力下降，不伴有眼前节病变，有哪些疾病四、论述（5选3，10分x3=30分）1、急闭临床表现及治疗原则2、糖网国际分期及国内分期3、角膜内皮细胞功能、特点4、不同部位视网膜出血的特点5、眼科常用分子生物学技术和实验方法首都医科大学2004年博士入学考试眼科试题2、简答题泪膜的组成及功能真菌性角膜炎的感染菌属及临床表现外伤性青光眼性低眼压第机制视觉的种类及简查3、问答题青光眼的分类、详细列举继发青光眼的类型和现代青光眼的治疗Coats病的机制、临床表现糖尿病视网膜病变的分期及治疗首都医科大学2003年眼科学（博士）三、问答题（每题10分，共30分）1 .请解释交感性眼炎的定义；简介其成因和发病机理；描述其临床表现及并发症；并简介其治疗。
2.请分别说明YAG激光、氩离子激光、氦氖激光以及二氧化碳激光适合治疗哪些眼病？3.请描述甲状腺相关眼眶病的临床体征和检查所见，并简述鉴别诊断要点？不同部位视网膜出血的特点干眼的个体化治疗、治疗进展黄斑水肿发病机制，临床表现及治疗北京大学医学部研究生考试试题（眼科学）三. 问答题（共50分，每题10分）1.试述恶性青光眼的发病机理及临床处理原则。
2.简述糖尿病可能引起致盲的眼部并发症3.急性虹膜睫状体炎是致盲疾患之一，试述其致盲的临床病理过程4.简述急性球后视神经炎，前部缺血性视乳头病变及视乳头水肿的鉴别诊断5.简述眼球的血液供应北京大学医学部（第一附属医院眼科）四. 问答题（50分）1.目前应用于眼科的视觉电生理检查主要有那几种，介绍它们的基本原理和临床应用。
首都医科大学眼科学2004年考博真题试卷
Байду номын сангаас
首都医科大学
医学考博真题试卷
攻读博士学位研究生入学考试试卷
首都医科大学
2004年攻读博士学位研究生入学考试试题
考试科目：眼科学
注意：所有答案一律写在答题纸上，写在试题纸上或其他地方一律不给分。
一、名词解释 1． 视网膜前膜
第1页 共1页
2． 迷离瘤 3． 牵牛花综合征 4． leber氏病 5． 眼球痨 6． 波前相差 7． ICE 8． Berlin水肿 二、简答题 1. 泪膜的组成及功能 2. 真菌性角膜炎的感染菌属及临床表现 3. 外伤性青光眼低眼压的机制 4. 视觉的种类及检查 三、问答题 1. 青光眼的分类、详细列举继发性青光眼的类型和现代青光眼的治疗 2. Coats病的机制、临床表现 3. 糖尿病视网膜病变的分期及治疗
历年考博专业课真题
中科院 2003 生化考博题 1.详述原核与真核生物基因在转录水平表达调控? 2.近年真核生物基因表达调控新进展? 3.四种分析蛋白质纯度方法原理? 4.七种重组体筛选方法,原理? 5.包含体? 6.一支痢疾杆菌和一支小鼠细胞株.如何分离出他们的二氢叶酸还原酶基因. 7.蛋白质一,二,三,四结构?用什么方法测定. 8.从 cDNA 文库中用特定一对引物利用 PCR 扩增一个酶蛋白基因.将该基因重组到一个通 用表达载体上进行表达. 对经过纯化的酶蛋白进行活性测定表明, 重组蛋白具有相应酶活性. 是否可以认为有关蛋白质基因表达纯化工作是否完成?为什么?复旦大学 2002 年试题(金融学) 1,分析发达国家设立政策性金融机构的原因和效果. (20 分) 2,试从投资成本效应和资产结构调整效应,评述我国最近几年降低利率的效果. (30 分) 3,什么叫可维持的国际收支结构,结合它来分析资本账户下货币自由兑换的条件. (20 分) 4, 全面阐述第一代和第二代货币危机模型, 并结合某国实际来比较分析这二代模型的优劣. (30 分)2004 年人大民法考博试题 民法: 1,论请求权 2,人格与人格权的区别以及人格权的民事权利的性质 3,相邻权与地役权的区别 4,论商业秘密权 民事诉讼: 1,论不要证事实 2,论当事人更换 3,论上诉审程序 4,破产申请要件 中国人民大学民商法专业考博试题 民法 93. 1.论合同自由 2.新闻监督与侵害名誉权 3.证券市场的现状与对策 94. 1.试论我国物权制度的建立与完善(40) 2.我国公司法中有限责任公司与股份有限 公司的异同(30) 3.侵权行为责任与不当得利返还责任之间的联系和区别(30)95. 1.论物权分类 2.企业法人与社团法人的关系 3.侵权行为与违约行为的异同 96. 1.评析民法通则 2.物上请求权与侵权行为请求权之间的联系与区别 3.缔约过失责 任与合同责任的联系与区别 4.评析人身保险合同(3,4 选一) 97. 1.论我国社会主义市场经济与我国民商立法 2.行使同时履行抗辩权和行使合同解除 权的区别 3.论典权的性质,典权与抵押,质押,买卖和租赁的法律关系 4.论保险合同中 当事人的基本权利义务 98. 1.国有企业改革中的民法适用问题 2.效力待定行为与可撤销行为之间的区别 3.试 析最高人民法院关于《民法通则》的解释 200 条 4.侵权民事责任与不当得利民事责任之间 的比较 99. 1.我国《民法通则》和其他有关于我国民事权利主体的分类及法律地位 2.用益物权 的种类及逐一评述 3.知识产权及其他财产权的异同,著作权与工业产权的异同 4.有限责 任公司与股份有限公司的异同 2000. 1, WTO 规则对我国民商事立法的影响 2, 论经营权 3, 论合同自愿原则 4, 网 络环境下的知识产权保护 2001. 1.法人有限责任 2.善意取得 3.表见代理 4.代位权行使的要件 2002. 1. 论民事法律行为的发展和完善 2. 论物权请求权 3. 合同成立和效力的关系 4. 知 识产权在民法中的地位 2003 1.论民法典制定中的法人制度的完善 2.评析物权行为理论 3.论信托法律关系中的受托 人的权利性质 4.辨析效力待定合同与无效合同 5.论知识产权的私权本质 2004 1,论民法请求权 2,从人格权和人格的关系论述人格权的民事法律性质 3,论相邻权 和地役权的关系 4,论商业秘密权 民诉 93. 1.论市场经济条件下民事诉讼法的完善. 2.论公示催告程序. 3.诉讼保全与债的 保全的关系 4.民事诉讼法中当事人制度的新的发展. 5.其他组织问题 94. 1. 试析我国民事诉讼法中保护当事人行使诉讼权利的优先及其在民事诉讼法条文中的 体现 2.财产保全与先予执行的异同 3.试述督促程序在适用中的问题及处理方法 4.试论 法院对涉外仲裁裁决执行的审查 95.1. 试析民事审判中重实体轻程序的现象 2. 申请代位执行的根据 3. 公示催告程序 4. 诉 权与起诉权的关系 96. 1.评严格执行民事诉讼法,确保案件公正审理 2.代位申请执行与代位权 3.当事人 查证与法院取证的根据 4.涉外民事诉讼中管辖权冲突的解决途径 97. 1.关于建立我国民事审判模式的理论思考 2.评析新民事诉讼法 3.论举证责任倒置 4.论民事诉讼法与仲裁法的关系 98. 1.建立我国诉讼标的理论 2.调解与审判分离理论 3.启动再审的三种方式间的关系 99. 1.试述程序公正与程序效益价值之间的关系 2.重塑我国再审程序制度的理论思考 3.论执行难及其解决途径 2000. 1.诉权在司法实践中的保护 2,诉讼程序与非讼程序的交叉适用 3,论执行的性质 4,论缺席判决 2001. 1.调解制度的完善 2.执行权性质及与裁判权的区别 3.诚信原则是否适用于民诉 举证责任的分配 2002. 1.评析民诉法关于审前准备的规定 2.法律推定与事实推定的效力 3.判决的形式 确定力与实质确定力 4.执行竞合及其解决 2003 1.论书证的分类及其法律意义 2.论检察机关在民事诉讼中的作用(地位) 3.论当事人能力与民事权利能力的一致与分离 4.辨析代位申请执行和代位权 2004 1,论民事诉讼法中的免予证明事实 2,论当事人变更 3,论二审对一审的裁判 4,论 破产申请提出的条件武汉大学 2004 年医学考博试题 消化内科试题 1 慢性腹泻的发病机制和病因 2 IBD 遗传易感性表现在那些方面 3 肝性胸水的发病机制 4 GERD 的诊断与治疗 5 肝性脑病与亚临床肝性脑病的诊断与治疗 6 NSAID 诱发溃疡的机制病生 试题一,简答题 1 简述凋亡的基本过程 2 水中毒的病因和对机体的影响 3 低钾血症对机体的影响 4 心肌肥大的基本特点 5 简述钙超载引起心肌损伤的机制 6 何为缺血预处理?它有哪些保护作用? 二,论述题 1 一例严重感染并发急性肾小管坏死的病人会出现哪些酸碱平衡紊乱,为什么? 2 何为自由基?试述它在体内的作用. 2004 年华中科技大学同济医学院骨科考博专业试题 一名解(原题为英文) 1.休克抑制期 2.骨不连 3.骨筋膜室综合征 4.非少尿型肾功衰 5.预存自体回输血二.问答题 1.创伤的检查与诊断方法 2.脑复苏的现代概念及主要治疗方法 3.腰椎间盘的分型 进展及治疗方法 4.周围神经损伤的分类及修复方法 5.股骨头缺血坏死的 FICAT 分期 6.你对骨肉瘤的最新看法 7.骨肿瘤保肢手术的适应征.协和 2003 年分子生物学专业试题(博士) 1, 近年来人们对真核基因调控理论有了深入的认识, 现在大家普遍接受"unified theory" 的理论,请你谈一谈对该理论的理解及其你的观点. 2,用微球菌核酸酶酶解染色质,然后进行电泳,发现 200bp,400bp,600bp,800bp... 的条带,试问从该现象可以得出什么结论?图 1 所示的条带不是非常狭窄,试解释其原因武汉大学 2001 比较文学与世界文学专题试题 一.20 分.AB 任选 A.莎士比亚的《麦克白》是怎样将主人公的内在心理感受和精神状态"外化"为舞台形象 的?表现主义文学(如奥尼尔的《琼斯皇》)又是如何系统的运用这类"外化"手法的? B. 以你熟悉的世界文学作品为例, 谈谈你对用喜剧性情节表达悲剧性内涵这一艺术手法的 见解.(说明:不限于戏剧,也可以举小说等为例.) 二.30 分.在你所涉猎的世界文学作品中,你对哪一部印象最深?描述你阅读它事的初始 感受,然后从理论上对你的这些感受进行反思,剖析和评价. 三.20 分.CD 任选 C.结合具体的作家和作品,论述中西诗歌的区别性基本特征. D.从 T.S.艾略特在《批评的功能》中所阐述的文学"总体论"出发,结合其他西方学 者的相关理论,论述民族文学,总体文学与比较文学的相互关系. 四.30 分.古希腊的柏拉图在《伊安篇》中提出了"迷狂说".中国宋代诗学家严羽在《沧 浪诗话.诗辨》中提出了"妙悟说".结合他们的具体论述,以"迷狂说与妙悟说"为题 ,从学说产生的时代与社会环境, 诗任的创作过程, 艺术心理的运动规律等层面进行比较和辨 析第四军医大学一九九二年攻读博士学位研究生入学试题 学科专业: 传染病学 考试科目: 免疫学 一. 名词解释(每题 4 分,共 32 分) 1. ICAM-1 2. interleukin 12(IL-12) 3. tumor infiltrating lymphocyte 4. TCR/CD3 complex 5. hematopoietin receptor family 6. individual idiotype(IdI) 7. integrin 8. colony-stimulatory factor (CSF) 二. 简答题(每题 8 分,共 32 分) 1. 免疫球蛋白重链的基因如何进行类别转换(class switching )? 2. 简述杀伤性 T 细胞(Tc)杀伤病毒感染靶细胞的机理. 3. 生物应答调节剂( biological response modifier,BRM)主要有哪几类?简要介绍在传染 性疾病防治中的作用. 4. 简述抗原提呈细胞(APC)与辅助性 T 细胞(Th)相互作用的关系. 三. 问答题(每题 18 分,共 36 分) 1. 试述干扰素的分类及其生物学作用特点. 主要可以治疗哪些传染性疾病?简述干扰素检测 的方法和原理. 2. 何为基因工程抗体?目前国内外在基因工程抗体研究中有哪些主要进展? 第四军医大学 一九九三年攻读博士学位入学考试试题 学科专业: 传染病学, 消化内科 考试科目: 免疫 学 一. 名词解释(每题 4 分,共 40 分) 1. CD4 2. T cell receptor(TCR) 3. immunoglobulin superfamily (IgSF) 4. selectin 5. anti-idiotypic antibody (αId)6. major histocompatibility complex(MHC) 7. immunotolerance 8. biological reponse modifier(BRM) 9. immune reponse gene (Ir gene) 10. reshaped antibody (or reconstituted antibody) 二. 简答题(每题 8 分,共 32 分) 1. 简述白细胞介素 6(IL-6)主要的生物学活性. 2. 细胞毒性 T 淋巴细胞(Tc 或 CTL)与抗体依赖的细胞介导的细胞毒(ADCC)杀伤机理有何不 同? 3. 简述第Ⅳ型(迟发型)变态反应的发生机理. 4. NK 细胞有哪些主要的表面标记?NK 细胞有哪些主要的生物学活性? 三. 问答题(每题 14 分,共 28 分) 供传染病学专业试题: 1. 机体有哪些免疫细胞和免疫分子参与抗病毒感染?它们是如何发挥病毒免疫作用的? 2. 目前单克隆抗体在病毒学中有哪些主要用途?今后可能有哪些主要的发展方向? 供消化内科专业试题: 1. 目前体内和体外检测肿瘤患者免疫功能的方法主要有哪些?分别叙述每种方法的原理和 结果测定? 2. 目前单克隆抗体在肿瘤学中有哪些主要的用途?今后可能有哪些主要的发展方向? 第四军医大学一九九四年攻读博士学位入学考试试题 学科专业: 传染病学, 消化内科 考试科目: 免疫学 一. 名词解释(每题 4 分,共 40 分) 1. CD8 2. T cell receptor α and β chain (TCRαβ ) 3. immunoglobulin fold(Ig fold) 4. cadherin (Ca-dependent cell adhesion moleculers) 5. idiotype-anti-idiotypic antibody immune network theory 6. HLA class II antigen 7. complementarity-determining region (CDR)8. perforin(or pore-forming protein ,PFP) 9. high affinity IL-2 receptor 10. artificial active immunization 二. 简答题(每题 8 分,共 32 分) 1. 简述白细胞介素 2(IL-2)主要的生物学活性及其在临床治疗中的应用. 2. 请比较第Ⅰ型(速发型)超敏反应与第Ⅳ型(迟发型)超敏反应的发病特点. 3. 试述分泌型 IgA(secretory IgA)的结构特点和合成分泌过程. 4. 试比较 T,B 淋巴细胞细胞膜表面分子(如表面抗原,表面受体等)的异同点. 三. 问答题(每题 14 分,共 28 分.请注意:每位考生只能从 1,2 题中选一题,3,4 题中选 一题,共答两题,多答者不计分.) 1. 目前检测细胞因子主要有生物学活性检测法和免疫学 检测法,请举例分别叙述两种方法的实验原理. 2. 为了避免 IgG 抗体 Fc 段非特异性作用,常应用胃蛋白酶水解的 F(ab')2 段,试问如何应 用 SDS-PAGE 方法对 F(ab')2 进行鉴定? 3. 试述抗肿瘤基因工程抗体的研究进展. 4. 试述抗病毒基因工程抗体的研究进展. 第四军医大学一九九五年攻读博士学位入学考试试题 学科专业:免疫学,传染病学,消化内科 考试科目:免疫学 一. 名词解释(每题 4 分,共 40 分) 1. immunoglobulin gene rearrangement 2. the common chain of cytokine receptor (or a cytokine receptor subunit shared by some cytokine receptors) 3. flow cytometry(FCM) 4. carrier effect 5. positive selection of T lymphocytes in thymus 6. mouse TH1(Th1) and TH2(Th2) subsets 7. perforin (pore-forming protein ,PFP) 8. ADCC(antibody-dependent cell-mediated cytotoxicity) 9. SH-2(src-homology region 2) 10. Ab2β (internal image) 二. 简答题(每题 8 分,共 32 分)1. 近年来在人类白细胞分化抗原(CD)研究领域中有哪些主要进展? 2. 参与活化 T 细胞与活化 B 细胞相互作用的分子主要有哪些?简述其结构和功能? 3. 试述 HLA 在临床上的主要应用. 4. 例举三种从人外周血单个核细胞(PBMC)中纯化 T 细胞的方法,分别叙述其实验原理和主 要操作步骤. 5. 评价红细胞生成素(EPO),干扰素(IFN)和集落刺激因子(CSF)在临床某些疾病的应用. 三. 选择问答题(每题 10 分,共 20 分.请按报考专业答题,如答非本专业题或多答题均视为 无效.) 免疫学专业: 1. 试述细胞因子受体中,Ig 超家族,造血因子受体超家族,神经生长因子受体超家族以及 趋化因子受体超家族的主要结构特点,每个超家族例举出 2 个成员. 2. 试比较人 T,B 淋巴细胞细胞膜表面分子(表面标记)的异同点,它们分别参与哪些主要的 免疫功能? 传染病学专业: 1. 人类免疫缺陷病毒(HIV)感染人体后,免疫功能可发生哪些主要的变化?机理是什么?如 何进行相应的免疫学功能检测? 2. 请评述肾综合征出血热病毒(HFRSV)感染后机体免疫学变化的与病理损伤的关系. 消化专业: 1.试述与消化系统有关的肿瘤相关抗原研究的进展. 2.简述粘膜相关淋巴样组织(mucosal assiociated lymphoid tissue,MALT)的组成和功能特 点.分泌型 IgA 是如何进行合成和分泌的? 第四军医大学一九九六年攻读博士学位入学考试试题 免疫学试题 一. 名词解释(每题 4 分,共 40 分) 1. Fas(CD95)/FasL 2. common chain of cytokine receptor 3 . TCR/CD3 complex 4. negaive selection of thymocytes 5. artificial active immune 6. anti-idiotypic 7. IgSF 8. Integrin9. chemokine 10. B7/CD28 二. 问答题(每题 12 分,共 60 分) 1. 比较 MHCⅠ和 MHCⅡ类抗原参与的加工提呈抗原的过程. 2. 比较 CTL 和 NK 杀伤靶细胞时识别和杀伤机制的特点. 3. 比较免疫学检测法和生物学活性检测法检测细胞因子的优缺点. 4. 发现一种新的白细胞分化抗原或肿瘤相关抗原,并制备了单克隆抗体,试设计实验方案 克隆此基因. 5. 选择下述中一个专题,叙述我国在这一研究领域的现状及面临的挑战 src="./images/smilies/sad.gif" border=0 smilieid="2">1)肿瘤免疫;(2)基因治疗; (3)CD 抗原. 第四军医大学一九九七年博士研究生入学考试免疫学试题 一. 名词解释(每题 4 分,共 40 分) 1. B7/CD28 2. Th1 subset 3. seven predicated transmembrane domain receptor superfamily(STR superfamily) 4. antibody affinity maturation 5. AP-1 6. single chain variable fragment(ScFv) 7. NK cell receptor 8. Zinkernagel-Doherty phenomenon 9. Ig fold 10. CD40/CD40L 二. 问答题(每题 12 分,共 36 分) 1. 试述胸腺微环境对胸腺细胞的选择作用及其与 T 细胞功能性亚群形成的关系. 2. 试述体液免疫应答的规律,回忆反应和抗体类别转换的机制是什么? 3. 试从结构和功能等角度,阐述白细胞分化抗原(CD),粘附分子(integrin)和免疫球 蛋白超家族(IgSF)三类分子的相互关系.目前在这一领域中主要研究热点是什么? 三. 问答题(24 分,第 1 题为免疫学专业考生试题,第 2 题为血液病学科考生试题,第 3 题为消化内科考生试题,只允许答本专业试题)1. 试比较 TCR 和 BCR 结构及其识别抗原,淋巴细胞活化信号的分子机理. (免疫学专业). 2. 试述白血病免疫学分型理论和方法的研究进展.(血液病学专业). 3. 试述肿瘤疫苗的研究进展.(消化内科专业). 一九九八年博士研究生入学考试试题 (免疫学专业和专业基础) 一.名词解释(每题 3 分,共 45 分) 1.Co-stimulators (or co-stimulating molecules) 2.NK-kB 3.Immunoglobulin superfamily 4.antigen-presenting cell (APC) 5.death domain R and CXCR 7.Lectin (or mitogen) 8.Clusters of differentiation, CD) 9.B7 family 10.Cytotoxic T lymphocyte, CTL) 11.IL-15 and IL-15 receptor (IL-15R) 12.MHC restriction 13.Affinity-chromatography 14.Cyctosprin A, CsA 15.Antibody-dependent cell-mediated cytotoxicity, ADCC) 二.问答题(每题 10 分,共 30 分) 1.何为 Th1 和 Th2 亚群?如何检测?在临床上有何意义? 2.试述免疫球蛋白(Ig)的结构与功能的关系. 3.试比较 T 细胞受体(TCR/CD3)与 B 细胞受体(BCR)的组成,结构及其识别 抗原的特点. 三.选择问答题(各专业考生只答一道本专业试题,25 分) 免疫学专业: 1.试述 B7/CD28, CTLA-4,CD40/CD40L,LFA-1/ICAM-1,CD2/LFA-3 的结构,分布以及相互 作用后介导的主要生物学功能.消化内科: 2.肿瘤抗原分为哪几类?机体抗肿瘤免疫主要有哪些因素(机制)?简述提高 抗肿瘤免疫研究的略策. 血液病学专业: 3.何为白血病的免疫学分型?何为移植物抗宿主反应(GVHR)?GVHR 发 生的主要原因(条件)是什么? 一九九年九博士生入学考试试题 (专业基础: 免疫学) 一.名词解释(每题 5 分,共 45 分) 1. ADCC(antibody dependent cell-mediated cytotoxicity) 2. 环孢菌素(cyclosporin) 3. KIR(killer cell inhibitory receptor) 4. HLDA(human leucocyte differentiation antigen) 5. Interleukin 18(IL-18) 6. 整合素(integrin) 7. Fas/FasL 8. FcR(免疫球蛋白 Fc 段受体) 9. 细胞间粘附分子(ICAM) 10. Th1/Th2 11. 基因疫苗(DNA 疫苗) 12. chemokines and chemokine receptor 13. 免疫耐受 14. 共刺激分子 15. 死亡结构域(death domain) 二.问答题(第 1,2 题各 18 分,第 3 题 19 分) 1. 试比较杀伤性 T 细胞(CTL)与自然杀伤细胞(NK)在杀伤靶细胞过程中,识别细胞毒及介导 免疫功能有何不同? 2. 70 年代以来,有关 Ig 和体液免疫研究存在以下几项重大发现和突破而获得医学和生物学 诺贝尔奖,请分别阐述它们的理论意义及在医学实践中的应用. (1)1972 年:胃蛋白酶和木瓜蛋白酶水解 Ig,获得 Fab,Fc,F(ab')2 等片段 (2)1977 年:放射免疫法 (3)1984 年:淋巴细胞杂交瘤和单克隆抗体(4)1987 年: Ig 基因的结构 3. 近年来在肿瘤免疫研究领域中有哪些重要进展?试述当前 提高机体抗肿瘤免疫的主要策略. 一九九九年博士生入学考试试题(免疫学专业) 问答题(每题 25 分) 1. 试比较 T 细胞受体(TCR),B 细胞受体(BCR)和 NK 细胞受体(NKCR)的组成,识别配 体以及信号转导的异同点. 2. 以胸腺依赖抗原刺激机体产生抗体的免疫应答为例,T 细胞和 B 细胞是如何相互作用? 有哪些粘附分子和共刺激分子参与 T,B 细胞的相互作用? 3. 肾综合征出血热(HFRS)病毒的结构基因已经搞清楚,为了证实 HFRS 病毒感染机体(以 Balb/C 小鼠为例)可产生 HFRS 病毒核衣壳蛋白(NP)特异性 CTL,并在免疫防护中起重要作用, 请应用免疫学理论和方法,设计一系统实验,加以证实. 4. 例举二个近年来细胞和分子免疫 学研究中出现的新的热点,请分别评述其研究意义,发展趋势以及应用前景.中科院动物所博士生入学试题生物化学和高级生物化学 中国科学院动物研究所生物化学 1996 年博士研究生入学试题 1.蛋白质和蛋白质相互分离时主要根据它们之间的种有差别的 特征,这些差别特征有哪些方面?并举例说明. 2 试述三种粘多糖的名称,在动物体内的 主要分布, 主要构成单糖及其它糖类. 3 试举例说明蛋白质和它的前体的一级结构关系. 4 J. D. Watson 因其证明 DNA 的双螺旋结构,曾与 Crick 共获诺贝尔奖.这位科学泰头在他后 来一体名著中解释 DNA 形状时写过这样一段话:"Does DNAchain fold up into a regular configulation dominated by its regular backbone? If so, the configulation would most likely be a helical one in which all the sugar-phosphate groupl would have identical chemincal environments". 你认为他在这里用 configulation 一词描述 DNA 的三维结构确切吗?为什么? (此段英原文不必译出, 但须回答为什么, 否则无分) 中国科学院动物研究所生物化学 1998 年博士研究生入学试题一, 填充题 1 DNA 具有的两个重要功能是 , 核糖体的功能是 2 逆 转录酶是一种多功能酶,它兼有 指导的 DNA 聚合酶, 指导的 DNA 聚合酶. 3 能够用来 将外源的 DNA 片段转移到活细胞内部的 , 或 统称为克隆载体. 4 绝大多数真核生物信 使 RNA3'端有 . 5 证明 DNA 是遗传信息携带者的科学家是 . 6 蛋白质可与碱共热而水 解,碱水解引起 , , 和 的破坏. 7 蛋白质的三维构象也称 或 . 8 生物膜主要是由 和 两大类物质组成, 生物膜的基因结构形式是 . 膜两侧的物质和离子转运主要是通过 ,和 等 方式进行. 9 1997 年诺贝尔化学奖授予 , 主要是基于他们阐明了 反应机制分子结构及 酶 的作用机制. 10 脂肪和磷脂的合成主要是来自 和 . 11 糖蛋白的糖链,是由专一性很低 强的 ,从糖核苷酸上把单糖一个一个转移上去而形成的.二,解释名词和英文符号的科学 含义 1 △Gp 2 Q cycle 3ABC 4 Kcat 5 protomnotive force 6 Synonycodon 7 RT-PCR 8 genomic library 9 DNAfinger printing 10 DNAfoot printing 三,问答题 1 热力学第二定律证明任何体 系的它的外围环境必须不断增加它的熵, 然而活的生物体却从比较无序状态的物质不断建立 起高度有序的结构,这是否说明活的生物体不遵守热力学第二定律?为什么? 2 回答下述 问题是对或是错,假若是错请解释为什么? 1) 在底物饱和的条件下,酶的催化反应速率 与酶浓度成比例. 2) 在底物浓度成为反应限速因子是,酶的催化反应速率随反应时间而 下降. 3 举例简述生物体系中的氧化还原反应的重要意义. 4 在静息态的神经细胞中,胞内外的 K 与 Na 浓度的不同分布导致胞膜内侧表现为负电荷较大, 此种浓度梯差和电荷梯差 的总称是什么?假若以△G'代表在这种离子浓度梯差存在时的离子跨膜转运的能量变化, 其 反应表示为请解释上述充应式中的符号参量表示什么?其意义何在? 5 举例简述对细胞中 多种膜系统结构与功能的研究对神经系统疾病的重要性. 6 什么是回文结构(palindrome)? 请举例说明. 7 试述氨基酸顺序与三维结构构象的关系. 8 什么是核蛋白体(nucleoprotein) 比较重要的核蛋白体有那些? 9 举例说明三种糖蛋白的名称, 化学组成及其生理意义. 10 什么是终止密码子,已知的终止密码了有那些? 11 分子杂交是分子生物学重要的研究手 段,在核酸分子杂交中哪些参数是研究人员设计实验时必须考虑的基本参数? 中国科学院 动物研究所高级生物化学 1999 年博士研究生入学试题 一, 填充题 1 主动运输的主要特点 是 , , , , . 2 辅酶中 A 分子中含有 , , , . 3 线粒体 DNA 的复制方式是 , 其复制特点是 . 4 高能磷酸化物可分为 , , , . 5 糖类物质是含 和 化合物;常见 的糖有 和 ,它们分解后可分为 , , , . 6 蛋白质按其分子外型的对称程度可分为 和 蛋白质,按生物功能可分为 , , , , . 7 酶作为生物催化剂的特点是 , , , , . 二,解释基本概念 1 呼吸控制 2 DDRT-PCR 3 装配型质粒 4 翻译阻遏 5 离子载体 6 Seliwanoff 反应 7 茚三酮反应 8 萜类 9 蜡 10 同工酶 三,问答题(任选 7 题) 1 试述 逆转录酶的生物学意义. 2 简要介绍免疫系统中程序化细胞死亡. 3 简述生物膜运送的分 子机理. 4 写出 20 种常见氨基酸的中文名称和三字母符号. 5 分光光度计测定蛋白质含 量的基本原理是什么? 6 简述测定一种酶活力的基本原则. 7 说明磺胺药治病的基本原 理. 8 举例说明激素作用原理的四种不同方式. 9 根据你的生理学,细胞生物学和分子生 物学的知识, 构思一实验方案, 差异筛选和考虑克隆某器官或组织与发育或病理改变相关的 特异功能基因. 中国科学院动物研究所高级生物化学 2000 年博士研究生入学试题 一, 解 释基本概念 1 关向异构体 2 甘油三酯 3 花生四烯酸 4 溶菌酶 5 多酶体系 6 别构酶 7 辅酶 I 和辅酶 II 8 叶酸 9 激素 10 G-蛋白 11 叶绿素 12 前列腺素 13 脱氨基作用 14 转 氨酶 15 卟啉 16 密码子 17 质粒 18 基因文库 19 钙调蛋白 20 线粒体 二, 回答问题 (其 中 7,8 两题任选一题) 1 阐述糖蛋白及其生物功能. 2 阐述生物界蛋白质的多样性及其 在生物进化和生物功能中的意义. 3 RNA 在那些类型?比较它们的结构与功能. 4 阐述 生物大分子跨膜运送的方法及其作用机制. 5 试述脂蛋白的种类, 化学组成和生物功能. 6 说明真核生物的 DNA 聚合酶的种类及其生理功能. 7 根据你所掌握的知识阐述细胞质和 细胞核的相互关系.中国科学院发育生物学所博士研究生入学试题 中国科学院发育生物学所分子生物学 2000 年博士研究生入学试题 (一,二,三题为必答题,五和六可任选一题) 一, 请解释下列 名词,并写出它们的英文术词: 1 基因家族 2 持家基因 3 同形异位盒 4 基因沉默 5 功 能基因组学 6 信号肽 7 信号传递 8 细胞编程性死亡 二, 限制性内切酶是如何发现的? 限制性内切酶可分成几类?如何使用限制内切酶进行分子生物学的研究? 三, 请分别列出 用于蛋白质和核酸的电泳分析和分离的技术,并说明这些技术与蛋白质和核酸的性质的关 系. 四, 请比较植物和动物基因工程的异同,并在你所熟悉的生物(植物或动物)的范围 内探讨基因工程的前沿和瓶颈问题. 五, 获得一个功能未知的基因克隆后,怎样才能阐明 该基因的功能?请你根据自己熟悉的某种真核生物提出具体的研究方案. 六, 在真核生物 基因的 DNA 序列中,哪些部分的核苷酸序列的变异会影响其编码的蛋白质的结构和功能?。
首都医科大学病理学2015年考博真题考博试卷
医学考博真题试卷
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首都医科大学
2015 年攻读博士学位一律写在答题纸上，写在试题纸上或其他地方一律不给分。 一、名词解释 1、borderline tumor 2、primary complexion 3、lewy body 4、蜂窝织炎 5、心室壁瘤 二、选择题 1 到 9 是单选，10 到 12 是多选 三、多选题 哪些疾病可以表现出大叶性肺炎，选项有支肺、军团肺、肺鳞癌等 哪些疾病是由两种以上细胞组成，选项有畸胎瘤、精原细胞瘤、绒癌、乳腺纤 维腺瘤等 哪些疾病是感染性肉芽肿，选项有矽肺、瘤型麻风、类风湿结节等 四、简答题 1、三种导致右心肥大的疾病。 2、肿瘤的转移途径。 3、三种肝细胞病理改变。 4、什么是纤维素性炎并举例说明其病理变化。 5、六种癌前病变及导致的肿瘤。 五、论述题 1、三种人类生发系突变所致的疾病及突变的基因。 2、动脉粥样硬化的表现。 3、慢性宫颈炎伴宫颈糜烂发展为宫颈癌的过程。 4、病理学主要研究方法及研究进展，临床应用。
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2015考博真题
一、单选1×50
上下尖牙区别
monson球面的半径
下颌神经前支中的感觉神经
前牙切割运动的杠杆运动形式
单囊性成釉细胞瘤处理方式
腺淋巴瘤病理特点
舌下腺结构
放射性骨髓炎病理表现
翼下颌间隙内容
下颌运动特点
下颌体骨化中心
颞下颌关节手术时切口方式
牙受垂直向力时牙龈主纤维中不受力的是
（以后想起来再补充）
二、名解2×10
近唇线角
pterygoid process
Terra dentition index
mento-cervical angle
taste threshold
alveolar bone proper
candidiasis
chronic gingivitis
branchial cleft cyst
lymphoepithelial carcinoma
三、简答5×6
解剖
1.根管系统在根部侧面开口的系统名称，并从解剖角度解释牙周病和牙髓病的相互影响。
2.口颌系统肌链的组成与功能？
3.临床上面神经的解剖方法，面神经主干的解剖标志点？
病理
1.口腔黏膜鳞癌有很多亚型，请举3例口腔黏膜鳞癌亚型，并叙述其镜下特点及生物学行为？
2.根据牙骨质组织结构学特性，叙述牙骨质龋特点？
3.肌上皮细胞来源的唾液腺良恶性肿瘤各举两例，及其镜下鉴别要点。
2015年医学博士外语真题试卷
2015年医学博士外语真题试卷(总分：206.00，做题时间：90分钟)1.Section A（分数：10.00）__________________________________________________________________________________________ （分数：10.00）A.How to deal with his sleeping problem.B.The cause of his sleeping problem.C.What follows his insomnia.D.The severity of his medical problem.A.To take the medicine for a longer time.B.To discontinue the medication.C.To come to see her again.D.To switch to other medications.A.To take it easy and continue to work.B.To take a sick leave.C.To keep away from work.D.To have a follow-up.A.Fullness in the stomach.B.Occasional stomachache.C.Stomach distention.D.Frequent belches.A.Extremely severe.B.Not very severe.C.More severe than expected.D.It's hard to say.（分数：10.00）A.He has lost some weight.B.He has gained a lot.C.He needs to exercise more.D.He is still overweight.A.She is giving the man an injection.B.She is listening to the man's heart.C.She is feeling the man's pulse.D.She is helping the man stop shivering.A.In the gym.B.In the office.C.In the clinic.D.In the boat.A.Diarrhea.B.Vomiting.C.Nausea.D.A cold.A.She has developed allergies.B.She doesn't know what allergies are.C.She doesn't have any allergies.D.She has allergies treated already.（分数：10.00）A.Listen to music.B.Read magazines.C.Go play tennis.D.Stay in the house.A.She isn't feeling well.B.She is under pressure.C.She doesn't like the weather.D.She is feeling relieved.A.Michael's wife was ill.B.Michael's daughter was ill.C.Michael's daughter gave birth to twins.D.Michael was hospitalized for a check-up.A.She is absent-minded.B.She is in high spirits.C.She is indifferent.D.She is compassionate.A.Ten years ago.B.Five years ago.C.Fifteen years ago.D.Several weeks ago.2.Section B（分数：10.00）__________________________________________________________________________________________ （分数：10.00）A.A blood test.B.A gastroscopy.C.A chest X-ray exam.D.A barium X-ray test.A.To lose some weight.B.To take a few more tests.C.To sleep on three pillows.D.To eat smaller, lighter meals.A.Potato chips.B.Chicken.C.Cereal.D.Fish.A.Ulcer.B.Cancer.C.Depression.D.Hernia.A.He will try the diet the doctor recommended.B.He will ask for a sick leave and relax at home.C.He will take the medicine the doctor prescribed.D.He will take a few more tests to rule out cancer.（分数：10.00）A.A new concept of diabetes.B.The definition of Type 1 and Type 2 diabetes.C.The new management of diabetics in the hospital.D.The new development of non-perishable insulin pills.A.Because it vaporizes easily.B.Because it becomes overactive easily.C.Because it is usually in injection form.D.Because it is not stable above 40 degrees Fahrenheit.A.The diabetics can be cured without taking synthetic insulin any longer.B.The findings provide insight into how insulin works.C.Insulin can be more stable than it is now.D.Insulin can be produced naturally.A.It is stable at room temperature for several years.B.It is administered directly into the bloodstream.C.It delivers glucose from blood to the cells.D.It is more chemically complex.A.Why insulin is not stable at room temperature.B.How important it is to understand the chemical bonds of insulin.C.Why people with Type 1 and Type 2 diabetes don't produce enough insulin.D.What shape insulin takes when it unlocks the cells to take sugar from blood.（分数：10.00）A.Vegetative patients are more aware.B.Vegetative patients retain some control of their eye movements.C.EEG scans may help us communicate with the vegetative patients.D.We usually communicate with the brain-dead people by brain-wave.A.The left-hand side of the brain.B.The right-hand side of the brain.C.The central part of the brain.D.The front part of the brain.A.31.B.6.C.4.D.1A.The patient was brain-dead.B.The patient wasn't brain-dead.C.The patient had some control over his eye movements.D.The patient knew the movement he or she was making.A.The patient is no technically vegetative.B.The patient can communicate in some way.C.We can train the patient to speak.D.The family members and doctors can provide better care.3.Section A（分数：2.00）__________________________________________________________________________________________4.Despite his doctor's note of caution, he never______from drinking and smoking.（分数：2.00）A.retainedB.dissuadedC.alleviatedD.abstained5.People with a history of recurrent infections are warned that the use of personal stereos with headsets is likelyto______their hearing.（分数：2.00）A.rehabilitateB.jeopardizeC.tranquilizeD.supplement6.Impartial observers had to acknowledge that lack of formal education did not seem to______Larry in any way in his success.（分数：2.00）A.refuteB.ratifyC.facilitateD.impede7.When the supporting finds were reduced, they should have revised their plan______.（分数：2.00）A.accordinglyB.alternativelyC.considerablyD.relatively8.It is increasingly believed among the expectant parents that prenatal education of classical music can______future adults with appreciation of music.（分数：2.00）A.acquaintB.familiarizeC.endowD.amuse9.If the gain of profit is solely due to rising energy prices, then inflation should be subsided when energy prices______. （分数：2.00）A.level outB.stand oute offD.wear off10.Heat stroke is a medical emergency that demands immediate______from qualified medical personnel.（分数：2.00）A.prescriptionB.palpationC.interventionD.interposition11.Asbestos exposure results in Mesothelioma, asbestosis and internal organ cancers, and______of these diseases is often decades after the initial exposure.（分数：2.00）A.offsetB.intakeC.outletD.onset12.Ebola, which spreads through body fluid or secretions such as urine, ______and semen, can kill up to 90% of those infected.（分数：2.00）A.salineB.salivaC.scabiesD.scrabs13.The newly designed system is______to genetic transfections, and enables an incubation period for studying various genes.（分数：2.00）parableB.transmissibleC.translatableD.amenable14.Section B（分数：2.00）__________________________________________________________________________________________15.Every year more than 1, 000 patients in Britain die on transplant waiting lists, prompting scientists to consider other ways to produce organs.（分数：2.00）A.propellingB.prolongingC.puzzlingD.promising16.Improved treatment has changed the outlook of HIV patients, but there is still a serious stigma attached to AIDS. （分数：2.00）A.disgraceB.discriminationC.harassmentD.segregation17.Surviviors of the shipwreck were finally rescued after their courage of persistence lowered to zero by their physical lassitude .（分数：2.00）A.depletionB.dehydrationC.exhaustionD.handicap18.Scientists have invented a 3D scan technology to read the otherwise illegible wood-carved stone, a method that may apply to other areas such as medicine.（分数：2.00）A.negativeB.confusingC.eloquentD.indistinct19.Top athletes scrutinize both success and failure with their coach to extract lessons from them, but they are never distracted from long-term goals.（分数：2.00）A.anticipateB.clarifyC.examineD.verify20.His imperative tone of voice reveals his arrogance and arbitrariness.（分数：2.00）A.challengingB.solemnC.hostileD.demanding21.The discussion on the economic collaboration between the United States and the European Union may be eclipsed by the recent growing trade friction.（分数：2.00）A.erasedB.triggeredC.shadowedD.suspended22.Faster increases in prices foster the belief that the future increases will be also stronger, so that higher prices fuel demand rather than quench it.（分数：2.00）B.eliminateC.assimilateD.puncture23.Some recent developments in photography allow animals to be studied in previously inaccessible places and in unprecedented detail.（分数：2.00）A.unpredictableB.unconventionalC.unparalleledD.unexpected24.A veteran negotiation specialist should be skillful at manipulating touchy situation.（分数：2.00）A.estimatingB.handlingC.rectifyingD.anticipating五、PartⅢ Cloze(总题数：1，分数：20.00)A mother who is suffering from cancer can pass on the disease to her unborn child in extremely rare cases,【C1】______a new case report published in PNAS this week. According to researchers in Japan and at the Institute for Cancer Research in Sutton, UK, a Japanese mother had been diagnosed with leukemia a few weeks after giving birth,【C2】______tumors were discovered in her daughter's cheek and lung when she was 11 months old. Genetic analysis showed that the baby's cancer cells had the same mutation as the cancer cells of the mother. But the cancer cells contained no DNA whatsoever from the father,【C3】______would be expected if she had inherited the cancer from conception. That suggests the cancer cells made it into the unborn child's body across the placental barrier. The Guardian claimed this to be the first【C4】______case of cells crossing the placental barrier. But this is not the case — microchimerism,【C5】______cells are exchanged between a mother and her unborn child, is thought to be quite common, with some cells thought to pass from fetus to mother in about 50 to 75 per cent of cases and to go the other way about half【C6】______. As the BBC pointed out, the greater【C7】______in cancer transmission from mother to fetus had been how cancer cells that have slipped through the placental barrier could survive in the fetus without being killed by its immune system. The answer, in this case at least, lies in a second mutation of the cancer cells, which led to the【C8】______of the specific features that would have allowed the fetal immune system to detect the cells as foreign. As a result, no attack against the invaders was launched. 【C9】______, according to the researchers there is little reason for concern of "cancer danger". Only 17 probable cases have been reported worldwide and the combined【C10】______of cancer cells both passing the placental barrier and having the right mutation to evade the baby's immune system is extremely low.（分数：20.00）(1).【C1】（分数：2.00）A.suggestsB.suggestingC.having suggestedD.suggested(2).【C2】（分数：2.00）A.sinceB.althoughC.whereasD.when(3).【C3】（分数：2.00）A.whatB.whomD.as(4).【C4】（分数：2.00）A.predictedB.notoriousC.provenD.detailed(5).【C5】（分数：2.00）A.whereB.whenC.ifD.whatever(6).【C6】（分数：2.00）A.as manyB.as muchC.as wellD.as often(7).【C7】（分数：2.00）A.threatB.puzzleC.obstacleD.dilemma(8).【C8】（分数：2.00）A.detectionB.deletionC.amplificationD.addition(9).【C9】（分数：2.00）A.ThereforeB.FurthermoreC.NeverthelessD.Conclusively(10).【C10】（分数：2.00）A.likelihoodB.functionC.influenceD.flexibility六、PartⅣ Reading Comprehension(总题数：6，分数：60.00)The American Society of Clinical Oncology wrapped its annual conference this week, going through the usual motions of presenting a lot of drugs that offer some added quality or extension of life to those suffering from a variety of as-yet incurable diseases. But buried deep in an AP story are a couple of promising headlines that seems worthy of more thorough review, including one treatment study where 100 percent of patients saw their cancer diminish by half. First of all, it seems pharmaceutical companies are moving away from the more cost-effective one-size-fits-all approach to drug development and embracing the long tail of cancer treatments, engineering drugs that only work for a small percentage of patients but work very effectively within that group. Pfizer announced that one such drug it's pushing into late-stage testing is target for 4% of lung cancer patients. But more than 90% of that tiny cohort responded to the drug in initial tests, and nine out often is getting pretty close to the ideal ten out of ten. By gearing drugs toward more boutique treatments rather than broad umbrella pharmaceuticals that try to fit for everyone it seems cancer researchers are making some headway. But how can we close the gap on that remaining ten percent? Ask Takeda Pharmaceutical and Celgene, two drug makers who put aside competitive interests to test a novel combination of their treatments. In atest of 66 patients with the blood disease multiple myeloma, a full 100 percent of the subjects saw their cancer reduced by half. Needless to say, a 100 percent response to a cancer drug (or in this case a drug cocktail) is more or less unheard of. Moreover, this combination never would've been tried if two competing companies hadn't sat down and put their heads together. Are there more potentially effective drug combos out there separated by walls of competitive interest and proprietary information? Who's to say, but it seems like with the vast amount of money and research being pumped into cancer drug development, the odds are pretty good. And if researchers can start pushing more of their response numbers toward 100 percent, we can more easily start talking about oncology's favorite four-letter word: cure.（分数：10.00）(1).Which of the following can be the best title for the passage?（分数：2.00）petition and CooperationB.Two Competing Pharmaceutical CompaniesC.The Promising Future of PharmaceuticalsD.Encouraging News: a 100% Response to a Cancer Drug(2).In cancer drug development, according to the passage, the pharmaceuticals now______.（分数：2.00）A.are adopting the cost-effective one-size-fits-all approachB.are moving towards individualized and targeted treatmentsC.are investing the lion's shares of their moneyD.care only about their profits(3).From the encouraging advance by the two companies, we can infer that______.（分数：2.00）A.the development can be ascribed to their joint efforts and collaborationB.it was their competition that resulted in the accomplishmentC.other pharmaceuticals will join them in the researchD.the future cancer treatment can be nothing but cocktail therapy(4).From the last paragraph it can be inferred that the answer to the question______.（分数：2.00）A.is nowhere to be foundB.can drive one crazyC.can be multipleD.is conditional(5).The tone of the author of this passage seems to be______.（分数：2.00）A.neutralB.criticalC.negativeD.optimisticLiver disease is the 12th -leading cause of death in the U. S. , chiefly because once it's determined that a patient needs a new liver it's very difficult to get one. Even in case where a suitable donor match is found, there's no guarantee a transplant will be successful. But researchers at Massachusetts General Hospital have taken a huge step toward building functioning livers in the lab, successfully transplanting culture-grown livers into rats. The livers aren't grown from scratch, but rather within the infrastructure of a donor liver. The liver cells in the donor organ are washed out with a detergent that gently strips away the liver cells, leaving behind a biological scaffold of proteins and extracellular architecture that is very hard to duplicate synthetically. With all of that complicated infrastructure already in place, the researchers then seeded the scaffold (支架) with liver cells isolated from healthy livers, as well as some special endothelial cells to line the bold vessels. Once repopulated with healthy cells, these livers lived in culture for 10 days. The team also transplanted some two-day-old recellularized livers back into rats, where they continued to thrive for eight hours while connected into the rats' vascular systems. However, the current method isn't perfect and cannot seem to repopulate the blood vessels quite densely enough and the transplanted livers can't keep functioning for more than about 24 hours (hence the eight-hour maximum for the rat transplant). But the initial successes are promising, and the team thinks they can overcome the blood vessel problem and get fully functioning livers into rats within two years. It still might be a decade before the tech hits the clinic, but if nothing goes horribly wrong — and especially if stem-cell research establishes a reliable way to create healthy liver cells from the very patients who need transplants — lab-generated livers that are perfect matches for their recipients could become a reality.（分数：10.00）(1).It can be inferred from the passage that the animal model was mainly intended to______.（分数：2.00）A.investigate the possibility of growing blood vessels in the labB.explore the unknown functions of the human liverC.reduce the incidence of liver disease in the U. S.D.address the source of liver transplants(2).What does the author mean when he says that the livers aren't grown from scratch?（分数：2.00）A.The making of a biological scaffold of proteins and extracellular architecture.B.A huge step toward building functioning livers in the lab.C.The building of the infrastructure of a donor liver.D.Growing liver cells in the donor organ.(3).The biological scaffold was not put into the culture in the lab until______.（分数：2.00）A.duplicated syntheticallyB.isolated from the healthy liverC.repopulated with the healthy cellsD.the addition of some man-made blood vessels(4).What seems to be the problem in the planted liver?（分数：2.00）A.The rats as wrong recipients.B.The time point of the transplantation.C.The short period of the recellularization.D.The insufficient repopulation of the blood vessels.(5).The research team holds high hopes of______.（分数：2.00）A.creating lab-generated livers for patients within two yearsB.the timetable for generating human livers in the labC.stem-cell research as the future of medicineD.building a fully functioning liver into ratsPatients whose eyes have suffered heat or chemical burns typically experience severe damage to the cornea—the thin, transparent front of the eye that refracts light and contributes most of the eye's focusing ability. In a long-term study, Italian researchers use stem cells taken from the limbus, the border between the cornea and the white of the eye, to cultivate a graft of healthy cells in a lab to help restore vision in eyes. During the 10-years study, the researchers implanted the healthy stem cells into the damaged cornea in 113 eyes of 112 patients. The treatment was fully successful in more than 75 percent of the patients, and partially successful in 13 percent. Moreover, the restored vision remained stable over 10 years. Success was defined as an absence of all symptoms and permanent restoration of the cornea. Treatment outcome was initially assessed at one year, with up to 10 years of follow-up evaluations. The procedure was even successful in several patients whose burn injuries had occurred years earlier and who had already undergone surgery. Current treatment for burned eyes involves taking stem cells from a patient's healthy eye, or from the eyes of another person, and transferring them to the burned eye. The new procedure, however, stimulates the limbal stem cells from the patient's own eye to reproduce in a lab culture. Several types of treatments using stem cells have proven successful in restoring vision, but the long-term effectiveness shown here is significant. The treatment is only for blindness caused by damage to the cornea; it is not effective for repairing damaged retinas or optic nerves. Chemical eye burns often occur in the workplace, but can also happen due to mishaps involving household cleaning products and automobile batteries. The results of the study, based at Italy's University of Modena and Reggio Emilia, were published in the June 23 online issue of the New England Journal of Medicine.（分数：10.00）(1).What is the main idea of this passage?（分数：2.00）A.Stem cells can help restore vision in the eyes blinded by burns.B.The vision in the eyes blinded by burns for 10 years can be restored.C.The restored vision of the burned eyes treated with stem cells can last for 10 years.D.The burned eyes can only be treated with stem cells from other healthy persons.(2).The Italian technique reported in this passage______.（分数：2.00）A.can repair damaged retinasB.is able to treat damaged optic nervesC.is especially effective for burn injuries in the eyes already treated surgicallyD.shows a long-term effectiveness for blindness in vision caused by damage to cornea(3).Which of the following is NOT mentioned about eye burns?（分数：2.00）A.The places in which people work.B.The accidents that involve using household cleaning products.C.The mishaps that involve vehicles batteries.D.The disasters caused by battery explosion at home.(4).What is one of the requirements for the current approach?（分数：2.00）A.The stem cells taken from a healthy eye.B.The patient physically healthy.C.The damaged eye with partial vision.D.The blindness due to damaged optic nerves.(5).Which of the following words can best describe the author's attitude towards the new method?（分数：2.00）A.Sarcastic.B.Indifferent.C.Critical.D.Positive.Here is a shaming statistic: divide the US by race, sex and county of residence, and differences in average life expectancy across the various groups can exceed 30 years. The most disadvantaged look like denizens of a poor African country: a boy born on a Native American reservation in Jackson County, South Dakota, for example, will be lucky to reach his 60th birthday. A typical child in Senegal can expect to live longer than that. America is not alone in this respect. While the picture is extreme in other rich nations, health inequalities based on race, sex and class exist in most societies—and are only partly explained by access to healthcare. But fresh insights and solutions may soon be at hand. An innovative project in Chicago to unite sociology and biology is blazing the trail (开创), after discovering that social isolation and fear of crime can help to explain the alarmingly high death rate from breast cancer among the city's black women. Living in these conditions seems to make tumors more aggressive by changing gene activity, so that cancer cells can use nutrients more effectively. We are already familiar with the lethal effect of stress on people clinging to the bottom rungs of the societal ladder, thanks to pioneering studies of British civil servants conducted by Michael Marmot of University College London. What's exciting about the Chicago project is that it both probes the mechanisms involved in a specific disease and suggests precise remedies. There are drugs that may stave tumors of nutrients and community coordinators could be employed to help reduce social isolation. Encouraged by the US National Institutes of Health, similar projects are springing up to study other pockets of poor health in populations ranging from urban black men to white poor women in rural Appalachia. To realize the full potential of such projects, biologists and sociologists will have to start treating one other with a new respect and learn how to collaborate outside their comfort zones. Too many biomedical researchers still take the arrogant view that sociology is a "soft science" with little that's serious to say about health. And too many sociologists reject any biological angle—fearing that their expertise will be swept aside and that this approach will be used to bolster discredited theories of eugenics, or crude race-based medicine. It's time to drop these outdated attitudes and work together for the good of society's most deprived members. More important, it's time to use this fusion of biology and sociology to inform public policy. This endeavor has huge implications, not least in cutting the wide health gaps between blacks and whites, rich and poor.（分数：10.00）(1).As shown in the 1st paragraph, the shaming statistic reflects______.（分数：2.00）A.injustice everywhereB.racial discriminationC.a growing life spanD.health inequalities(2).Which of the following can have a negative impact on health according to the Chicago-based project?（分数：2.00）A.Where to live.B.Which race to belong to.C.How to adjust environmentally.D.What medical problem to suffer.(3).The Chicago-based project focuses its management on______.（分数：2.00）A.a particular medical problem and its related social issueB.racial discrimination and its related social problemsC.the social ladder and its related medical conditionsD.a specific disease and its medical treatment(4).Which of the following can most probably be neglected by sociologists?（分数：2.00）A.The racial perspective.B.The environmental aspect.C.The biological dimension.D.The psychological angel.(5).The author is a big fan of______.（分数：2.00）A.the combination of a traditional and new way of thinking in promoting healthB.the integration of biologists and sociologists to reduce health inequalitiesC.the mutual understanding and respect between racesD.public education and health promotionAmerican researchers are working on three antibodies that many mark a new step on the path toward an HIV vaccine, according to a report published online Thursday, July 8, 2010, in the journal Science. One of the antibodies suppresses 91 percent of HIV strains, more than any AIDS antibody ever discovered, according to a report on the findings published in the Wall Street Journal. The antibodies were discovered in the cells of a 60-year-old African-American gay man whose body produced them naturally. One antibody in particular is substantially different from its precursors, the Science study says. The antibodies could be tried as a treatment for people already infected with HIV, the WSJ reports. At the very least, they might boost the efficacy of current antiretroviral drugs. It is welcome news for the 33 million people the United Nations estimated were living with AIDS at the end of 2008. The WSJ outlines the painstaking method the team used to find the antibody amid the cells of the African-American man, known as Donor 45. First they designed a probe that looks just like a spot on a particular molecule on the cells that HIV infects. They used the probe to attract only the antibodies that efficiently attack that spot. They screened 25 million of Donor 45's cell to find just 12 cells that produced the antibodies. Scientists have already discovered plenty of antibodies that either don't work at all or only work on a couple of HIV strains. Last year marked the first time that researchers found "broadly neutralizing antibodies, " which knock out many HIV strains. But none of those antibodies neutralized more than about 40 percent of them, the WSJ says. The newest antibody, at 91 percent neutralization, is a marked improvement. Still, more work needs to be done to ensure the antibodies would activate the immune system to produce natural defenses against AIDS, the study authors say. They suggest three test methods that blend the three new antibodies together in raw form to prevent transmission of the virus, such as from mother to child; in a microbicide gel that women or gay men could use before sex to prevent infection; or as a treatment for HIV/AIDS, combined with antiretroviral drug. If the scientists can find the right way to stimulate production of the antibodies, they think most people could produce then, the WSJ says.（分数：10.00）(1).We can learn from the beginning of the passage that______.（分数：2.00）A.a newly discovered antibody defeats 91 % of the HIV strainsB.a new antiretroviral drug has just come on the marketC.American researchers have developed a new vaccine for HIVD.the African-American gay man was cured of his HIV infection(2).What is the implication of the antibodies discovered in the cells of the African-American gay man?（分数：2.00）A.They can cure the 33 million AIDS patients in the world.B.They may strengthen the effects of the existing antiretroviral drugs.C.They will kill all the HIV viruses.D.They will help make a quick diagnosis of an HIV infection.(3).The newest antibody found in Donor 45 reflects a dramatic advance in terms of______.（分数：2.00）A.pathologyB.pharmacologyC.HIV neutralizationD.HIV epidemiology(4).According to the study authors, the three test methods are intended to______.（分数：2.00）。
首都医科大学神经病学2016年考博真题试卷
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首都医科大学
2016年攻读博士学位研究生入学考试试题
考试科目：神经病学
注意：所有答案一律写在答题纸上，写在试题纸上或其他地方一律不给分。
一、名词解释
1.Meige征
2.路易体痴呆
3.来米特征
4.克雅病
二、选择题
关于AD、三叉神经痛、PD、重症肌无力、Lamerton病
三、简答题
1.脑干反射的类型。
2.TIA原因和机制
3.核间性眼肌麻痹。
4.去大脑强直和去皮质强直的临床意义、病损部位。
5.癫痫的治疗原则。
6.截瘫后尿潴留的原因。
7.黄斑回避的定义和通路、
四、论述题
1.血管性痴呆的分类和定义。
2.脑动脉盗血综合征的常见类型。
3.PD病例分析（诊断、鉴别诊断、治疗原则）
医学类考博试题集
2004年中山医博士肿瘤学部分试题1-7题选答4条。
每条10分1.简述肿瘤外科在肿瘤综合治疗中的作用。
2.术前放疗的原则3.根治性化疗的理论基础和原则4.肿瘤免疫治疗有哪些方法？5.蒽环类最常见的副作用有哪些？如何防治？6.肿瘤细胞信号传导有哪些基本组成要素？7.8-25选3，各20分。
1.肺癌转移的各站淋巴结2.化疗药物有哪些不良反应？举例说明。
3.颈清术有哪些并发症？处理原则？4.基因突变的形式和检测方法?5.AFP对肝癌诊断和治疗的意义天津医科大学2003年眼科学（博士）一、名词解释（每题2分，共20分）1、眼表2、圆锥角膜3、规则散光4、对比敏感度5、基底细胞癌6、AMD7、ROP8、Exotropia9、Epicanthus10、Fungal keratitis二、简答题（每题5分，共40分）1、简述青光眼临床分类2、简述干眼症临床表现3、简述Fuchs综合征临床特点4、简述调节性内斜视的临床分类5、简述真菌性角膜炎的临床表现6、简述低视力概念及国际诊断标准7、简述视网膜色素变性临床表现及遗传方式8、简述增殖性糖尿病视网膜病变（PDR）的临床表现三.问答题（共40分）1.介绍房水成分，作用及循环径路（10分）2.说明弱视的临床分类，主要发病机制，治疗时机和方法（15分）3.试述眼科影像诊断技术的进展（15分）协和医科大学2004年分子生物学（博士）1.名解:同工酶染色体染色质核基质转化密码子的偏嗜性基因簇2.简答为什么核酸和蛋白都是有方向的?信号转导的cAMP通路什么是内切酶的星号活性3.判断对错,说明理由关于乳糖操纵子的4.论述给定一个cDNA序列,如何表达,纯化到蛋白质5.填空协和生化的老主任是谁(这道题好变态)谁用什么实验证明了核酸是遗传物质可以磷酸化的氨基酸是哪三个带苯环的氨基酸是哪三个DNA在多少nm有最大的光吸收,为什么?协和医科大学2004年博士研究生入学考试妇产科学试卷一、名词解释先期化疗HELLPsyndromeLEEPUSIFETALDEATHTTTS四、简答题1、异位妊娠的保守治疗指征2、“吊床”学说3、交界性肿瘤的特点4、？五、论述题1、宫腔镜治疗的并发征及其处理2、宫颈癌的手术方式及其指征3、子宫内膜异位症的治疗新进展及其前景协和医科大学2004年硕士入学考试生物化学试题一,名词解释(大约有67个,是关于代谢与分子部分的，只记得三个)1.PCR2.KLENOW片段3.转化二,填空(有关代谢的)1.胆固醇：合成部位、直接前体2.糖酵解:关于整个过程消耗几个A TP,生成几个A TP，NADH，是人就会答3.糖酵解中有多少酶(只记得这些)三,选择10道题,是关于代谢的,能量代谢占大部分,如CO阻止了哪一部分的电子传递，某某化合物含不含高能磷酸键，某某反应步骤放不放ATP之类，很简单。
打印版考博眼科专业试题8套
1复旦医学院2002年博士入学考试眼科试题名词解释1. Plateau iris2. Pseudohypopyon3. Arteriovenous fistula4. Macular sparing5. Terson`s sydrome6. Band keratopathy7. Axenfeld-Rieger sydrome8. ICR问答题1. 视网膜神经节细胞损伤的发生机制及保护研究进展2. 眼科干细胞的研究进展及其在临床应用3. 试述随年龄增加的晶状体发生的改变4. 葡萄膜损伤后的临床及病理生理改变2山医大眼科2004试题眼科专业一、名词解释（1-4题每题3分，5.6题每题4分，共20分）1. 视神经管2. 对比敏感度3. 泪液膜4. 低视力5. Weiss环6. 房角后退二、问答题（每题15分，共60分）1. 人工角膜手术的适应症及并发症，你所认为的理想的人工角膜是怎样的？2. 青光眼的视神经保护药物3. 视神经病变的鉴别诊断4. 双眼单视形成的条件及功能分级三、论述题（20分）角膜内皮细胞移植术的新近展3天津医科大学2002年博士入学考试眼科试题一.名词解释（每题2分，共20分）1.盲2.偏盲3.老视4.双行睫5.玻璃体液化6.ICGA7.Ocular hypertension8.Angular blepharitis9.Gonioscope10.Retinal pigment epithelium (RPE)]二.简答题（每题5分，共40分）1.简述青光眼的分类2.简述眼表的范围3.说明复视与混淆视的区别4.简述甲状腺相关眼病的病理改变5.真菌性角膜炎的临床表现及常见致病菌属6.简述化学眼外伤的急救原则及措施7.Eales`病的主要临床表现及病理改变8.简述Behcet`s病的病因及临床表现三.问答题（共40分）1.“白瞳症”的鉴别诊断（10分）2.青光眼滤过性手术后的常见并发症，判断及处理（10分）3.试述青光眼诊断技术和治疗新进展（20分）4首都医科大学2004年博士入学考试眼科试题１、名词解释视网膜前膜迷离瘤牵牛花综合症leber氏病眼球痨波前相差ICEBerlin水肿２、简答题泪膜的组成及功能真菌性角膜炎的感染菌属及临床表现外伤性青光眼性低眼压第机制视觉的种类及简查３、问答题青光眼的分类、详细列举继发青光眼的类型和现代青光眼的治疗Coats病的机制、临床表现糖尿病视网膜病变的分期及治疗5复旦医学院2002年博士入学考试眼科试题名词解释1. Plateau iris2. Pseudohypopyon3. Arteriovenous fistula4. Macular sparing5. Terson`s sydrome6. Band keratopathy7. Axenfeld-Rieger sydrome8. ICR问答题1. 视网膜神经节细胞损伤的发生机制及保护研究进展2. 眼科干细胞的研究进展及其在临床应用3. 试述随年龄增加的晶状体发生的改变4. 葡萄膜损伤后的临床及病理生理改变6北京大学（一附属）2002年博士入学考试眼科试题一. 名词解释（20分）1. 视角2. 水眼3. 配偶肌4. 后胚胎环5. 黑朦猫眼6. 血影细胞性青光眼7. Duane`s综合征8. 带状角膜变性9. Marfan`s 综合征10. Vogt-Koyanagi-Harada syndrome二. 填空（20分）1. 黄斑樱桃红点见于----，----，---。
2015医学考博试题
2015医学考博试题2015年中山大学肿瘤防治中心分子医学专业考博试题生物化学（一）六选五1.米氏方程式公式是什么？Km，Vmax的意义。
三种可逆性抑制剂存在情况下，Km，Vmax的变化。
2.如何进行克隆的构建以及质粒的扩增与抽提？3.衰老的细胞分子机制（至少五点并作解释）。
4.分子量20KD，PI=5.5的核蛋白的抽提。
5.蛋白质的翻译后修饰及生理作用，写出修饰的氨基酸。
6.可以进行分子标记三种酶，并比较底物和作用方式。
细胞生物学六选五1.应用抗原抗体反应的分子生物学技术（至少五种）2.比较细胞自噬，细胞凋亡，细胞坏死3.细胞骨架的组成及如何调控胞质分裂和核分裂4.细胞周期各时期的物质合成5.膜泡运输的方式及调控2015中山医肿瘤学考博真题必答题（15*4）1. 良恶性肿瘤的区别2. 肿瘤三级预防的定义和方法3. 简述第二信使4. P53基因异常表达的形式选答题（6选2 20*2）5. 肿瘤化疗用药的原则6. NHL和HL的区别（病理类型上，治疗方案上）7. 食管癌手术的注意事项8. 乳腺癌放疗原则9. 对不起忘啦10. 肿瘤干细胞的定义和特征11. 实验设计题，给出肿瘤转移可能相关基因，设计实验进行功能验证12. 细胞周期各期特点和关键check-point2015年浙大考博专业基础课--病理与病理生理学真题（回忆版）病理学部分一、名词解释（3*8）：表观遗传学，细胞信号传导，DNA甲基化，凋亡，基因芯片，转录因子，异型性，癌前病变二、简答题（六选三，3*12）：1.简述病毒与肿瘤的关系。
2.请简述肿瘤的分子分型。
3.目前结直肠癌发生的分子机制有几种，请你谈谈你的评价。
4.消化道常见的溃疡性病变有哪些（至少4种）及其病理学特点及鉴别要点。
5.肿瘤上皮间质转化（EMT）的概念，它与肿瘤存在哪些联系，谈谈你所了解的机制。
6.免疫组织化学技术的概念及其应用范围。
病理生理学部分（四选二，2*20）1.抑癌基因失活的机制有哪些？请举例说明其在肿瘤发生发展中的作用。
首都医科大学神经病学2015年考博真题试卷
3.简述腔隙性脑梗死的分类及临床表现。
4.手足徐动症。
5.溶栓适应症。
6.癫痫药物治疗的一般原则。
7.髓内、髓外硬膜内及硬膜外病变的鉴别。
四、论述题：15分*3
1.血管源性认知障碍的定义及诊断。
2.神经变性病？
3.临床常见神经系统副肿瘤综合征的分类及临床表现。
首都医科大学
医学考博真题试卷
攻读博士学位研究生入学考试试卷
2015年首都医科大学宣武医院神经病学考博真题
一、名词解释：2分*5Fra bibliotek1.丘脑综合征
2.Fisher综合征
3.延髓内侧综合征
4.核间性眼肌麻痹
5.基底动脉尖综合征
二、选择题：1分*10
考的比较偏，有些书上找不到
三、简答题：5分*7
1.核间性眼肌麻痹。
眼科博士入学考试题目
07眼科5×6一名词解释1 干眼综合症2 沙眼3 角膜缘移植术4 眼用内镜5 年龄相关性白内障6 视网膜色素变性二问答4×81 眼球的起源和发育过程2 原发性开角型青光眼的诊断和治疗3 眼科滴眼剂必须具备的基本特性4 紫外线对眼的损伤三简答1 老年性黄斑变性的临床治疗现状及其进展2 oct的眼科应用优势及其存在的问题08眼科一名词解释1stardardt病2latanoprost（xalatan）眼液其主要成分为前列腺素F2受体相关的衍生物，主要通过作用于睫状肌和葡萄膜巩膜通道的基质金属蛋白酶，增加细胞外基质的降解，造成肌间隙增宽，从而增加房水经葡萄膜巩膜通道外流而降低眼压，其房水的排出不受巩膜静脉压的影响。
该类药物降低眼压幅度大，点药次数少，安全性高。
不良反应包括点药后短暂性烧灼感、刺痛、痒感和结膜充血；长期点眼可造成虹膜色素增加、睫毛增长、眼周围皮肤色素增加。
3sjogren综合症是一种累及全身多系统的疾病，又称为干燥综合症、分泌抑制综合症，该综合症包括干眼、口干、结缔组织损害(关节炎)，三个症状中两个存在即可诊断。
绝经期妇女多发。
泪腺有淋巴细胞和浆细胞浸润，造成泪腺增生，结构功能破坏。
4前房角5蚕蚀性角膜溃疡是一种自发性、慢性、边缘性、进行性、疼痛性角膜溃疡，病因不明，可能与自身免疫功能异常有关。
组织学上，蚕食性角膜溃疡周围角膜组织内含有大量浆细胞、淋巴细胞等炎症细胞。
血清免疫复合物水平高。
研究提示，蚕食性角膜溃疡可能是体液免疫及细胞免疫均参与的自身免疫性疾病。
6眼用内镜7基因治疗将正常基因植入靶细胞代替遗传缺陷的基因或关闭、抑制异常表达的基因，以达到预防和治疗疾病的目的的一种临床治疗技术。
常用的策略有以下几种：基因修复、基因代替、基因抑制或失活、基因增强。
二问答1 简述红绿色弱的形成2 简述基因治疗中的载体3 简述眼后节OCT的原理及其应用4 简述与眼有关的三叉神经及其功能三简答1 从房角平衡的角度阐述眼压升高和控制眼压升高的基本机制及其研究发展趋势2 病毒性、细菌性、过敏性结膜炎在病理、体征、症状、治疗的区别分泌物：细菌性常出现脓性分泌物、过敏性出现黏性分泌物、病毒性出现水样或浆液状分泌物3 OCT在眼科的应用优势及其存在的问题。
完整word版首医考博试题
完整word版首医考博试题Word版首医考博试题一、单选题1. 下列哪项为氨基酸中的无极性疏水氨基酸？A. 谷氨酸B. 赖氨酸C. 苏氨酸D. 番氨酸2. 以下哪个器官是人体最大的内分泌腺？A. 甲状腺B. 肾上腺C. 胰腺D. 垂体3. 下列哪种物质可以通过胎盘屏障进入胎儿循环系统？A. 红细胞B. 白细胞C. 蛋白质D. 脂肪酸4. 高浓度的胆汁会导致下列哪种胆结石最易形成？A. 胆盐结石B. 胆固醇结石C. 黑色素结石D. 铁结石5. 下列哪种白细胞在炎症反应中首先出现？A. 嗜好性粒细胞B. 巨噬细胞C. 嗜酸性粒细胞D. 中性粒细胞二、多选题1. 下列哪些物质能穿过血脑屏障？A. 葡萄糖B. 氯化钠C. 氨基酸D. 氯化铵2. 下列哪些形成过程中与凝血无关？A. 纵隔静脉血栓形成B. 动脉粥样硬化斑块形成C. 静脉曲张形成D. 血小板聚集形成血栓3. 以下哪些细胞可以分泌胃酸？A. 表皮细胞B. 刺激细胞C. 壁细胞D. G细胞4. 下列哪些是调节体温的主要因素？A. 室内温度B. 外界温度C. 代谢热D. 神经调节5. 以下哪些物质由肾脏排泄？A. 毒物B. 代谢产物C. 水分D. 药物三、判断题1. 生活垃圾属于医疗废物。
（）2. 人体的胆固醇主要通过肝脏代谢清除。
（）3. 淋巴系统的主要功能是输送乳汁。
（）4. 低钠血症可导致细胞溶解。
（）5. 静脉曲张是静脉瓣功能障碍导致的。
（）四、简答题1. 请解释生物体的稳态。
生物体的稳态是指在变化的外界条件下，通过内部调节机制使得生物体的内部环境保持相对稳定的状态。
这种稳态使得生物体能够适应外界环境的变化，并保持其正常生理功能的进行。
2. 请解释血液凝固过程中的内外路线。
血液凝固过程中的内外路线是指在不同的刺激下，血液凝结的两条途径。
内路线是由血液内部因子直接参与的凝血过程，外路线是由血管损伤刺激引起的凝血过程。
3. 请解释代谢性酸中毒和呼吸性酸中毒的区别。