炎症肠病的诊断及治疗PPT课件

Professor of Medicine. Dr. Sands is an expert in
the management of inflammatory bowel diseases
(IBD) and has earned an international reputation
froerfrhaicstocrayrediosfeapsaeti.ents首w批ith报co道mplIenxfalned ximab治疗UC有效的医
炎症性肠病
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IBD研究的历史沿革
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溃疡性结肠炎的沿革
✓Arestaeus(A.D.300)和Soranus(A.D.117) “非传 染性腹泻”
✓1859 年由英国伦敦Guy 医院的Samuel Wilks 医 生使用首次溃疡性结肠炎（ulcerative colitis）
之病名，认为是一种有别于细菌性痢疾的独立性
✓日本现有IBD10万人，其中UC8万，CD2万
✓我国UC与CD的患病率分别: 11.6/10万和1.4/10万
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Crohn's disease
✓850 AD. Written documentation of England‘s King Alfred : an illness causing pain,
disease for which he is
iknno1w9n3,0 CDrro.hnC'rsohdnispeuabslei.shed a paper in c“ol末la端bo回ra肠ti炎on：w一it种h 新th的e 临ot床he疾rs病i存nc在lu形di式ng Dr.
Paul Klemperer on a medical condition they
infliximab as a long-term treatment for--fistulizing CD.
7
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cobblestone
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中华医学会消化病学分会共识
中华医学会5次制定我国IBD的诊治规范建议：
✓同年，伦敦皇家医学会报道了从伦敦各家医院收集 的300 例以上的UC病例，并开展了相关的病因讨论。
以后，UC开始在欧美各国，尤其是白种人中陆续被
报道……
✓欧洲和北美的UC发病率为10-20/105、患病率达 100～200／105，而克罗恩病（CD）的发病率为5～
10／105、患病率为50～100/105
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Crohn's disease
克罗恩医生(June 13, 1884 in
New York – July 29, 1983 in
Connecticut) was an American
gastroenterologist and one of
the first to describe the
疾病，并称之为“单纯性特发性结肠炎”
✓美国外科军医在南北战争的医史记录中亦有采用 “UC” 病名，描述并了本病的病理组织学微观变
化
✓Allchinz在1885年，以及Hale和White在1888年逐 步将UC的临床病理特征进行了比较详细的描述
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溃疡性结肠炎的沿革
✓1909 年Hawkin 进一步报道了这种结肠炎病例，并 指出其慢性复发性的特点
among the first to report the efficacy of infliximab-a drug used to treat
autoimmune diseases-in UC, … principal investigator for the landmark ACCENT
II study, an international project that demonstrated the MeofufnitcaSciynoafi tHhoesp.i.tal
discomfort and much embarrassment (diarrhea)
whenever he ate.
✓In 1612 an autopsy was performed on a young buol一cye类wrah新ot'e的sd疾ainn病dte表wsht现oimn为ehs：adw腹ecr部oem绞pnlo痛atie、nde发dto热prb和ieo体r 重to下 hi降s；de但at不h是of阑p尾ai炎n and abdominal cramping
call “Terminal Ileitis: A new clinical
entity” later to be called Crohns Disease. Mount Sinai Hospital
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Crohn's disease
IBD转化医学专家
Bruce Sands, MD, MS is the Dr. Burrill B. Crohn
most Unit
raescew组netlll织yassAeCrAvsCesdoEcNaisaTttehIePIrhoofsespstistouardl'oysf的AMcetd主iincgi要nCeh研iaetf究Hoafr者vtahred
Medical School.
A longtime advocate for the continued translational research in CD aFra Baidu bibliotekd UC,
生 He joined Mount Sinai in 2010 as Chief of the Henry D. Janowitz Division of
GI. … was Medical Co-Director of the Crohn's & Colitis Center at MGH in
Boston, where he Gastrointestinal
only when eating.
✓1920 and 1930 an increasing number of
patients: abdominal cramping, diarrhea,
fever and weight loss that turned out not to
be appendicitis.