超声造影PPT全版.ppt
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Volumetric contrast-enhanced ultrasound imaging of renal perfusion
肾灌注的容积超声造影显像
优选
1
优选
2
一 Objective
Volumetric contrast-enhanced ultrasound (VCEUS) ima ging has the potential to monitor changes in renal perfus ion following vascular injury.
这篇文章主要致力于观察超声造影显像追踪正常及受损肾脏灌 注变化的可重复性及稳定性。
优选
6
二Method
VCEUS utilizes a series of planar image acquisitions, capturing the non-linear second harmonic signal from microbubble (MB) contrast agents flowing in the vasculature. Tissue perfusion parameters (peak intensity, IPK; time-to-peak intensity, TPK; wash-in rate, WIR; area
容积超声造影通过一系列的二维图像采集，捕捉流入脉管系统
的微气泡造影剂形成的非线性二次谐波信号。在体外流速模型
及体内正常/受损肾脏的动物研究中，收集来自时间-强度曲线
的组织灌注参数（峰强度、达峰值强度时间、內洗率、曲线下
面积）。
优选
7
For the flow phantom studies, either the concentration of MB contrast agent was held constant (10 μL/L) with varying volumetric flow rates (10, 20, and 30 mL/min) or the flow rate was held constant (30 mL/min) and the contrast agent concentration was varied (5, 10, and 20 μL/L).
under curve, AUC) were derived from time-intensity curve data coll ected during in vitro flow phantom studies and in vivo animal studie s of healthy and injured kidney.
• 容积超声造影显像可以作为一种监测血管损伤后肾脏灌注变 化的潜在手段。
优选
3
Current methods for quantifying AKI are searching for bio-markers i ndicative of kidney injury such as positive fluctuations in serum crea tinine .However, serum creatinine levels lack the sensitivity and speci ficity necessary for early detection . Due to the nephrotoxic nature of both CT and MR contrast agents, other standard perfusion imaging modalities are not suitable for diagnosis and monitoring of AKI.
通过鉴别缺血组织区域，肾脏造影能够对由于肾脏并发症造成 的缺血组织的实际百分比提供更加细致的理念。
优选
5
The focus of this paper is to investigate the repeatability and robustness of VCEUS imaging for tracking perfusion changes in the healthy and injured kidney.
目前确诊AKI的方法主要通过寻找血液中肾脏损害的生物标志物 ，例如血肌酐水平升高。但是血肌酐缺乏早期诊断的敏感性及 特异性。由于CT及MR造影本身存在肾毒性，而其他标准灌注显 像模式不适合诊断及监测AKI。
百度文库优选
4
VCEUS could provide a more detailed idea of the actual percentage of ischemic tissue resulting from this renal complication by identifying regions of ischemic tissue.
在体外流速模型研究中，保证微气泡浓度稳定（10 μL/L）， 改变容积流速率（10, 20, and 30 mL/min），或者保证流速稳定 （30 mL/min），改变微气泡浓度(5, 10, and 20 μL/L)。
优选
8
Animal studies were performed using either healthy rats or those that underwent renal ischemia-reperfusion injury. A series of renal studies were performed using healthy rats (N = 4) while the angle of the transducer was varied for each VCEUS image acquisition (reference or 0°, 45°,and 90°) to assess if repeated renal perfusion measures wer e isotropic and independent of transducer position. Blood serum
肾灌注的容积超声造影显像
优选
1
优选
2
一 Objective
Volumetric contrast-enhanced ultrasound (VCEUS) ima ging has the potential to monitor changes in renal perfus ion following vascular injury.
这篇文章主要致力于观察超声造影显像追踪正常及受损肾脏灌 注变化的可重复性及稳定性。
优选
6
二Method
VCEUS utilizes a series of planar image acquisitions, capturing the non-linear second harmonic signal from microbubble (MB) contrast agents flowing in the vasculature. Tissue perfusion parameters (peak intensity, IPK; time-to-peak intensity, TPK; wash-in rate, WIR; area
容积超声造影通过一系列的二维图像采集，捕捉流入脉管系统
的微气泡造影剂形成的非线性二次谐波信号。在体外流速模型
及体内正常/受损肾脏的动物研究中，收集来自时间-强度曲线
的组织灌注参数（峰强度、达峰值强度时间、內洗率、曲线下
面积）。
优选
7
For the flow phantom studies, either the concentration of MB contrast agent was held constant (10 μL/L) with varying volumetric flow rates (10, 20, and 30 mL/min) or the flow rate was held constant (30 mL/min) and the contrast agent concentration was varied (5, 10, and 20 μL/L).
under curve, AUC) were derived from time-intensity curve data coll ected during in vitro flow phantom studies and in vivo animal studie s of healthy and injured kidney.
• 容积超声造影显像可以作为一种监测血管损伤后肾脏灌注变 化的潜在手段。
优选
3
Current methods for quantifying AKI are searching for bio-markers i ndicative of kidney injury such as positive fluctuations in serum crea tinine .However, serum creatinine levels lack the sensitivity and speci ficity necessary for early detection . Due to the nephrotoxic nature of both CT and MR contrast agents, other standard perfusion imaging modalities are not suitable for diagnosis and monitoring of AKI.
通过鉴别缺血组织区域，肾脏造影能够对由于肾脏并发症造成 的缺血组织的实际百分比提供更加细致的理念。
优选
5
The focus of this paper is to investigate the repeatability and robustness of VCEUS imaging for tracking perfusion changes in the healthy and injured kidney.
目前确诊AKI的方法主要通过寻找血液中肾脏损害的生物标志物 ，例如血肌酐水平升高。但是血肌酐缺乏早期诊断的敏感性及 特异性。由于CT及MR造影本身存在肾毒性，而其他标准灌注显 像模式不适合诊断及监测AKI。
百度文库优选
4
VCEUS could provide a more detailed idea of the actual percentage of ischemic tissue resulting from this renal complication by identifying regions of ischemic tissue.
在体外流速模型研究中，保证微气泡浓度稳定（10 μL/L）， 改变容积流速率（10, 20, and 30 mL/min），或者保证流速稳定 （30 mL/min），改变微气泡浓度(5, 10, and 20 μL/L)。
优选
8
Animal studies were performed using either healthy rats or those that underwent renal ischemia-reperfusion injury. A series of renal studies were performed using healthy rats (N = 4) while the angle of the transducer was varied for each VCEUS image acquisition (reference or 0°, 45°,and 90°) to assess if repeated renal perfusion measures wer e isotropic and independent of transducer position. Blood serum