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通过鉴别缺血组织区域，肾脏造影能够对由于肾脏并发症造成 的缺血组织的实际百分比提供更加细致的理念。
The focus of this paper is to investigate the repeatability and robustness of VCEUS imaging for tracking perfusion changes in the healthy and injured kidney.
under curve, AUC) were derived from time-intensity curve data collected during in vitro flow phantom studies and in v容的iv积微o 超气an声泡im造造al影影st通剂ud过形ie一成s o系的f h列非e的线alt二性hy维二a图次nd像谐in采波ju集信re，号d k捕。id捉在ne流体y.入外脉流管速系模统型
及体内正常/受损肾脏的动物研究中，收集来自时间-强度曲线 的组织灌注参数（峰强度、达峰值强度时间、內洗率、曲线下 面积）。
For the flow phantom studies, either the concentration of
MB
contrast agent was held constant (10 μL/L) with
这篇文章主要致力于观察超声造影显像追踪正常及受损肾脏灌 注变化的可重复性及稳定性。
VCEUS utilizes a series of planar image acquisitions, capturing the non-linear second harmonic signal from microbubble (MB) contrast agents flowing in the vasculature. Tissue perfusion parameters (peak intensity, IPK; time-to-peak intensity, TPK; wash-in rate, WIR; area
，例如血肌酐水平升高。但是血肌酐缺乏早期诊断的敏感性及 特异性。由于CT及MR造影本身存在肾毒性，而其他标准灌注显 像模式不适合诊断及监测AKI。
VCEUS could provide a more detailed idea of the actual percentage of ischemic tissue resulting from this renal complication by identifying regions of ischemic tissue.
to assess if repeated renal perfusion measures were isotropic
and independent of transducer position. Blood serum
b动iom物a研rk究er应s a用nd健i康mm小u鼠no及h遭ist受ol缺og血y w再e灌re注u的sed小t鼠o c来o完nfi成rm。a用cu正te k常idn小e鼠y i完nj成ur一y. 系列肾脏研究，每次超声造影图像采集的传感器
在μ体L/外L)流. 速模型研究中，保证微气泡浓度稳定（10 μL/L），
改变容积流速率（10, 20, and 30 mL/min），或者保证流速稳定
（30 mL/min），改变微气泡浓度(5, 10, and 20 μL/L)。
Animal studies were performed using either healthy rats or
肾灌注的容积超声造影显像
Volumetric contrast-enhanced ultrasound (VCEUS) imaging has the potential to monitor changes in renal perfusion following vascular injury.
detection . Due to the nephrotoxic nature of both CT and MR
contrast agents, other standard perfusion imaging modalities a目re前n确ot诊suAitKaIb的le方fo法r d主ia要gn通o过sis寻an找d血m液on中it肾ori脏ng损o害f A的K生I.物标志物
those that underwent renal ischemia-reperfusion injury. A
series of renal studies were performed using healthy rats (N =
4) while the angle of the transducer was varied for each VCEUS image acquisition (reference or 0°, 45°,and 90°)
• 容积超声造影显像可以作为一种监测血管损伤后肾脏灌注变 化的潜在手段。
Current methods for quantifying AKI are searchi来自百度文库g for bio-
markers indicative of kidney injury such as positive
fluctuations in serum creatinine .However, serum creatinine levels lack the sensitivity and specificity necessary for early
varying volumetric flow rates (10, 20, and 30 mL/min) or
the flow rate was held constant (30 mL/min) and the
contrast agent concentration was varied (5, 10, and 20
The focus of this paper is to investigate the repeatability and robustness of VCEUS imaging for tracking perfusion changes in the healthy and injured kidney.
under curve, AUC) were derived from time-intensity curve data collected during in vitro flow phantom studies and in v容的iv积微o 超气an声泡im造造al影影st通剂ud过形ie一成s o系的f h列非e的线alt二性hy维二a图次nd像谐in采波ju集信re，号d k捕。id捉在ne流体y.入外脉流管速系模统型
及体内正常/受损肾脏的动物研究中，收集来自时间-强度曲线 的组织灌注参数（峰强度、达峰值强度时间、內洗率、曲线下 面积）。
For the flow phantom studies, either the concentration of
MB
contrast agent was held constant (10 μL/L) with
这篇文章主要致力于观察超声造影显像追踪正常及受损肾脏灌 注变化的可重复性及稳定性。
VCEUS utilizes a series of planar image acquisitions, capturing the non-linear second harmonic signal from microbubble (MB) contrast agents flowing in the vasculature. Tissue perfusion parameters (peak intensity, IPK; time-to-peak intensity, TPK; wash-in rate, WIR; area
，例如血肌酐水平升高。但是血肌酐缺乏早期诊断的敏感性及 特异性。由于CT及MR造影本身存在肾毒性，而其他标准灌注显 像模式不适合诊断及监测AKI。
VCEUS could provide a more detailed idea of the actual percentage of ischemic tissue resulting from this renal complication by identifying regions of ischemic tissue.
to assess if repeated renal perfusion measures were isotropic
and independent of transducer position. Blood serum
b动iom物a研rk究er应s a用nd健i康mm小u鼠no及h遭ist受ol缺og血y w再e灌re注u的sed小t鼠o c来o完nfi成rm。a用cu正te k常idn小e鼠y i完nj成ur一y. 系列肾脏研究，每次超声造影图像采集的传感器
在μ体L/外L)流. 速模型研究中，保证微气泡浓度稳定（10 μL/L），
改变容积流速率（10, 20, and 30 mL/min），或者保证流速稳定
（30 mL/min），改变微气泡浓度(5, 10, and 20 μL/L)。
Animal studies were performed using either healthy rats or
肾灌注的容积超声造影显像
Volumetric contrast-enhanced ultrasound (VCEUS) imaging has the potential to monitor changes in renal perfusion following vascular injury.
detection . Due to the nephrotoxic nature of both CT and MR
contrast agents, other standard perfusion imaging modalities a目re前n确ot诊suAitKaIb的le方fo法r d主ia要gn通o过sis寻an找d血m液on中it肾ori脏ng损o害f A的K生I.物标志物
those that underwent renal ischemia-reperfusion injury. A
series of renal studies were performed using healthy rats (N =
4) while the angle of the transducer was varied for each VCEUS image acquisition (reference or 0°, 45°,and 90°)
• 容积超声造影显像可以作为一种监测血管损伤后肾脏灌注变 化的潜在手段。
Current methods for quantifying AKI are searchi来自百度文库g for bio-
markers indicative of kidney injury such as positive
fluctuations in serum creatinine .However, serum creatinine levels lack the sensitivity and specificity necessary for early
varying volumetric flow rates (10, 20, and 30 mL/min) or
the flow rate was held constant (30 mL/min) and the
contrast agent concentration was varied (5, 10, and 20