免疫系统组织学绪论课件

1. double negBiblioteka Baidutive stage: CD4-/CD8-
2. double positive stage: CD4+/CD8+
3.mature thymocytes stage: CD4+ or CD8+
Macrophages: phagocytose and present Ags to Lc
Plasma cell: produce Abs
Mast cell: allergic reactions,produce vasoactive mediators
(penicillin shock,hives,asthma,drug eruption....)
2.lymphoid nodules: clear border, B redominant
Primary ~ Ag
Secondary ~(germinal center: Dark. Light. Cap )
PCV
Classification of Lymphoid organs
1.Central lymphoid organs produce LC Thymus: generating place for Tc Bone marrow: generating place for Bc
胚外中胚层
haematopoitic cells migrate from extraembryonic mesoderm to intraembryonic mesoderm
Lymphatic tissue structure
lymphoid nodules
difuse LT
Structure of lymphatic tissues
1.Diffuse L.T.
no clear border, no fixed shape,no definitive size T cell predominant or both T and B postcapillary venules (PCV)
high endothelium, Lc transportation
Histology of Immune System
Lc and immune accessory cells L. tissue L. organs Mononuclear phagocytic system
Morphological Components
1. lymphoid organs(LO) thymus, lymph node, spleen, tonsils
Peripheral lymphoid organs lymph node, spleen, tonsil places to proceed immune reactions
capsule
Thymus
C
parenchyma
M
lobules
septa
Thymic structure
Capsule
3. PCV 4. blood-thymus barrier Medulla :loose T cell, rich stromal cell, thymic corpuscle.
Thymocyte development
Haematopoietic stem cell Lymphoid stem cell T precursor thymocyte
Parenchyma: incomplete lobules divided by
interlobular septa
Cortex: 1. thymocyte :dense developing T cells
2. thymic stroma cells ERC(epithelial reticular cell); macrophage; DC
lymphoid organ
blood
small intestine
macrophage Rc
Lc
silver stain of reticular tissue
lymphoid tissue: RT+ abundant Lc and some macrophages, plasma cells, mast cells,dendritic cells,WBC
2. B CD19; BCRs: B1(CD5+) / B2(CD5-) 3. NK: no T/B markers, CD16/CD56
Dendritic C(DC) :
heamatopoitic origin; extensively distributed antigen-presenting(APC); help Lc differentiates
2. lymphatic tissue(LT) (out of LO) 3. immunocompetent cells (out of LO and LT)
Function : protect the body against the invading of foreign Ags,
distinguish self from nonsefl.
Origin of immunocompetent cells: Blood Ilands syncitiotrophoblast
cytotrophoblast
Day 14
extraembryonic mesodermal cells
Blood ilands
Haemangioblasts -initial cell type differentiate to (1) Angioblasts (2) Haematopoitic stem cells
reticular tissue: reticular cell +reticular fiber + ground substance(amorphous)
tissue Lc
plasma cell
blood Lc
?
macrophage mast cells
lymphocytes
1. T CD3/TCR Th CD4 Tc CD8 Tr CD25