【WO2019207595A1】制备邻氨基苯甲酰胺衍生物的改进方法【专利】

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(51)International Patent Classification:DZ,EC,EE,EG,ES,FI,GB,GD,GE,GH,GM,GT,HN,
C07D401/04(2006.01)HR,HU,ID,IL,IN,IR,IS,JO,JP,KE,KG,KH,KN,KP,
KR,KW,KZ,LA,LC,LK,LR,LS,LU,LY,MA,MD,ME, (21)International Application Number:
MG,MK,MN,MW,MX,MY,MZ,NA,NG,NI,NO,NZ,
PCT/IN2019/050321
OM,PA,PE,PG,PH,PL,PT,QA,RO,RS,RU,RW,SA, (22)International Filing Date:SC,SD,SE,SG,SK,SL,SM,ST,SV,SY,TH,TJ,TM,TN,
20April2019(20.04.2019)TR,TT,TZ,UA,UG,US,UZ,VC,VN,ZA,ZM,ZW. (25)Filing Language:English(84)Designated States(unless otherwise indicated,for every
kind o f regional protection available).ARIPO(BW,GH, (26)Publication Language:English GM,KE,LR,LS,MW,MZ,NA,RW,
SD,SL,ST,SZ,TZ, (30)Priority Data:UG,ZM,ZW),Eurasian(AM,AZ,BY,KG,KZ,RU,TJ,
20184101524123April2018(23.04.2018)IN TM),European(AL,AT,BE,BG,CH,CY,CZ,DE,DK,
EE,ES,FI,FR,GB,GR,HR,HU,IE,IS,IT,LT,LU,LV, (71)Applicant:NATCO PHARMA LIMITED[IN/IN];Nat-MC,MK,MT,NL,NO,PL,PT,RO,RS,SE,SI,SK,SM,
co House,Road No.2,Banjara Hills,Hyderabad,Telan-TR),OAPI(BF,BJ,CF,CG,Cl,CM,GA,GN,GQ,GW, gana.,Hyderabad500034(IN).KM,ML,MR,NE,SN,TD,TG).
(72)Inventors:AMARNATH,Jam pan i:Natco Pharma Lim¬
ited,Natco House,Road No.2,Banjara Hills.,Hyderabad Declarations under Rule4.17:
500034(IN).NARESH,Ghanta;Natco Pharma Limit¬—o f inventorship(Rule4.17(iv))
ed,Natco House,Road No.2,Banjara Hills.,Hyderabad Published:
500034(IN).RADHA RANI,Samatham;Natco Phar¬—with international search report
(Art.21(3)) ma Limited,Natco House,Road No.2,Banjara Hills.,Hy¬—in black and white;the international application as filed derabad500034(IN).NAGESWARA RAO,Bollepalli;contained color or greyscale and is available for download Natco Pharma Limited,Natco House,Road No.2,Ban¬from PATENTSCOPE
jara Hills.,Hyderabad500034(IN).JANAKI RAMA
RAO,Ravi;Natco Pharma Limited,Natco House,Road
No.2,Banjara Hills.,Hyderabad500034(IN).DURGA
PRASAD,Konakanchi;Natco Pharma Limited,Natco
House,Road No.2,Banjara Hills.,Hyderabad500034(IN).
PULLA REDDY,Muddasani;Natco Pharma Limited,
Natco House,RoadNo.2,Banjara Hills.,Hyderabad500034
(IN)VENKAIAH CHOWDARY,Nannapaneni;Natco
Pharma Limited,Natco House,Road No.2,Banjara Hills.,
Hyderabad500034(IN).
(81)Designated States(unless otherwise indicated,for every
kind o f national protection available):AE,AG,AL,AM,
AO,AT,AU,AZ,BA,BB,BG,BH,BN,BR,BW,BY,BZ,
CA,CH,CL,CN,CO,CR,CU,CZ,DE,DJ,DK,DM,DO,
(54)Title:AN IMPROVED PROCESS FOR THE PREPARATION OF ANTHRANIL AMIDE DERIVATIVES
(57)Abstract:The present invention relates to an improved process for the preparation of anthranilamide derivatives.More particularly, the present invention relates to an improved process for the preparation of Chlorantraniliprole-(Ia)and Cyantraniliprole-(Ib).
AN IMPROVED PROCESS FOR THE PREPARATION OF
ANTHRANILAMIDE DERIVATIVES
Field of the Invention
The present invention relates to an improved process for the preparation of anthranilamide derivatives.More particularly,the present invention relates to an improved process for preparation of Chlorantraniliprole of formula-la and Cyantraniliprole of formula-lb.
Background of the Invention
Anthranilamide derivatives are a kind of novel insecticides with high efficacy and safety.3-Bromo-/V-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-l-(3-chloro-2-pyridyl)-/7-pyrazolc-5-carboxamidc is highly effective against insects,which is commercialized by DuPont,its generic common name is Chlorantraniliprole of formula-la;3-Bromo-l-(3-chloropyridin-2-yl)-/V-(4-cyano-2-methyl-6-(mcthylcarhamoyl)phcnyl)-/7-pyrazolc-5-carboxamidc in development is highly effective against insects too,whose common name is Cyantraniliprole of formula-lb.
Chlorantraniliprole of formula-la Cyantraniliprole of formula-lb
There are a number of methods reported for preparing anthranilamide derivatives, for example:。