Cerulenin_脂肪酸合成酶(FAS)抑制剂_17397-89-6_Apexbio

Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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信号通路:
FAS
产品描述:
Cerulenin is a fatty acid synthase (FAS) inhibitor. Fatty acids are key aliphatic acids for energy production and storage, which are synthesized by a series of decarboxylative Claisen condensation reactions from acetyl-CoA and malonyl-CoA. In vitro: In a previous study, it was found that the inhibition of fatty acid synthesis at the physiologically regulated step of carboxylation of acetyl-CoA to malonyl-CoA was not cytotoxic to breast cancer cells. FAS inhibitor of cerulenin ould induce a rapid increase in intracellular malonyl-CoA to several fold, whereas 5-(tetradecyloxy)-2-furoic acid reduced intracellular malonyl-CoA by 60%. Simultaneous exposure of breast cancer cells to 5-(tetradecyloxy)-2-furoic
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acid and an FAS inhibitor of cerulenin led to significantly reduced cytotoxicity and apoptosis [1]. In vivo: To investigate the physiological effects of in-vivo inhibition of fatty acid synthesis on global lipid metabolism, a previous study administered cerulenin or C75 to mice. Profound weight loss following treatment was observed. Weight loss occurred dose-dependently and persisted for a duration. Moreoer, all treated mice recovered their lost body weight after the effect of the drug dissipated. The treatments of both cerulenin and C75 were well tolerated without obvious toxicity [2]. Clinical trial: So far, no clinical study has been conducted. 参考文献:
特别声明
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产品说明书
化学性质
产品名: Cerulenin 修订日期: 6/30/2016
产品名: Cas No.: 分子量: 分子式: 化学名: SMILES: 溶解性: 储存条件: 一般建议:
运输条件:
Cerulenin
百度文库17397-89-6 223.3
//struct//
C12H17NO3
2R,3S-epoxy-4-oxo-7,10-dodecadienamide
C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O
Soluble in DMSO
Store at -20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.