肝纤维化新型分子标志物的研究进展
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
肝纤维化新型分子标志物的研究进展
Hong Wei;Han Tao;Shi Zhemin;Zhang Kun
【期刊名称】《中华肝脏病杂志》
【年(卷)，期】2019(027)006
【摘要】肝纤维化是慢性肝病的共同病理学过程，其导致的肝硬化、肝衰竭甚至肝癌的病死人数在世界范围内逐年増长•目前评估肝纤维化的检测方法主要包括肝组织学检查、影像学和血清学标志物,但是在临床应用上均有诸多局限性.近年有关非编码RNA和外泌体等与肝纤维化发生发展的研究日益増多，且被认为是具有潜在临床应用前景的新型分子标志物•现结合相关进展进行初步评估,以期为肝纤维化的早期诊断和治疗提供参考.%Liver fibrosis is a common pathological process of chronic liver disease z and the number of deaths from liver cirrhosisjiver failure and liver cancer is in creasing year-byyear worldwide.Presently z the detection methods to evaluate hepatic fibrosis mainly include hepatic histological examinationjmaging and serum markers z but all these have many limitations in clinical aspects.Recently z the「e have been more and more studies related to the development of non-coding RNA,exosomes and liver fibrosis that are considered as a new type of biomolecular markers with potential clinical application.Herein z we did a preliminary assessment in conjunction with relevant advances to provide a ref ere nee for the early diag nosis and treatment of liver fibrosis.
【总页数】4页(411-414)