血液透析膜的制备

Hemodialysis Membrane Prepared from Cellulose/N Methylmorpholine-

N-oxide Solution. I. Effect of Membrane

Preparation Conditions on Its Permeation Characteristics

由纤维素或者N-甲基吗啉-N-氧化物溶液制备血液透析膜。一、膜的渗透特性制备条件的影响

YOSHIHIKO ABE,1AKIRA MOCHIZUKI2

1 Research & Development Center, Terumo Corporation, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa

259-0151, Japan

2 Kofu East Factory, Terumo Corporation, 1727-1 Tsuijiarai, Showa-cho, Nakakoma-gun, Yamanashi 409-3853, Japan

Received 21 May 2001; Accepted 15 August 2001

Published online 20 March 2002 in Wiley InterScience

ABSTRACT: Flat hemodialysis membranes were prepared from cellulose / N-methylmorpholine- N-oxide (NMMO) solutions (dope) with different cellulose concentrations (6–8

wt %) by using a phase-inversion method. The coagulant used was NMMO aqueous

solution, of which the NMMO concentration and its temperature were varied in the

range of 0 to 50 wt % and 5 to 60°C, respectively. The effects of these preparation

conditions on the permeation characteristics, the ultrafiltration rate (UFR) of pure

water, and sieving coefficient (SC) of dextran, were investigated. The decrease in

cellulose concentration of the dope and the increases in both temperature and NMMO concentration of the coagulant gave a membrane with high UFR. Concerning the SC,

the increase of the cellulose concentration and the decreases in both temperature and

NMMO concentration gave a good result. Consequently, the membrane having the

preferable UFR and SC as a hemodialysis membrane was obtained when the 8 wt %

cellulose dope was coagulated in water at 5°C. © 2002 Wiley Periodicals, Inc. J Appl Polym

Sci 84: 2302–2307, 2002

Key words: cellulose; hemodialysis membrane; N-methylmorpholine-N-oxide; ultrafiltration rate; sieving performance

摘要：平整的血液透析膜由纤维素或者N-甲基吗啉-N-氧化物（NMMO法）溶液（涂料）与不同浓度的纤维素（6-8wt％）使用相转移法来制备。用到的凝结剂是 NMMO的水

溶液，其中的NMMO浓度和温度是各有不同，范围分别为0到50 wt％和5至60 ° C。研究了渗透性能,纯水的超滤率（UFR）和葡聚糖的筛分系数（SC）这些准备工作条件的影响。涂布的纤维素含量的下降和对N-甲基吗啉-N-氧化物浓度和温度都上升的凝固剂浓度的增加做成了高超滤率的膜。关于筛分系数，纤维素浓度增加和对温度和N-甲基吗啉-N-氧化物浓度都下降的凝固剂浓度的降低做出了一个很好的结果。因此，具有适合的筛分系数和超滤率参数该膜作为血液透析膜时可在5℃水中8％的纤维素涂料凝结而成。©2002Wiley Periodicals, Inc. J Appl Polym Sci 84: 2302–2307, 2002

关键词：纤维素; 血液透析膜; N -甲基- N -氧化吗啉; 超滤率; 筛分性能INTRODUCTION

Today, various polymeric materials are widely applied to the preparation of hemodialysis membranes, such as regenerated cellulose, cellulose acetate, polysulfone, polyacrylonitrile, nylon, polymethylmethacrylate, and ethylene–vinyl alcohol copolymer, among which the most popular material is regenerated cellulose. The regenerated cellulose membrane, made by the cuprammonium