HFRS合并肾病综合征的出血热
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5>. Arthropod-borne:
rats mite, red mite, harvest mite may carry Hantan virus. Need to be confirmed
11
3. Epidemic features
1>. District localization: mainly in Asia, Europe and Africa, America In China: higher incidence
via inhale aerosol contaminated with viruscontaining excretion or secretion of rats
2>.Food-borne transmission
via oral and esophageal mucosa (eat food contaminated with virus-containing excretion or secretion of rats)
5
Human HFRS:
caused by four type of virus: hantaan virus (type I, HTNV) seoul virus(type II, SEOV) puumala virus (type III,PUUV) dobrava-belgrade virus(DEOV)
10
3>. Infection via contact
Be bitten by rats. wound is contaminated with viruscontaining excretions or secretions of rats.
4>. Vertical transmission:
mother to baby, very rare
China: Hantaan virus Seoul virus
hantaan virus and DEOV show stronger pathogenicity than type II and III virus
6
▲ Resistance of virus
Low resistance: Inactivated by acid (<pH 5.0), ethanol, ether, chloroform. heat in 56ºC for 30min or 100ºC for 1min. Be sensitive to alcohol
■ Definition
▲ Infectious diseases with natural source ▲ Pathogen: Hantan virus ▲ Characterized by fever, hemorrhage,
proteinuria, shock and acute renal failure. Five phases in the typical cases
▶ Laboratory Rats ▶ Other animals: cats dogs rabbits
Patients:unimportant
8
Apodemus agrarius 黑线姬鼠
Mus norvegicus 褐家鼠
9
2. Modes of transmission: Five
1>.Air-borne transmission
(HFRS)
2
■ Etiolowk.baidu.comy
Hantan virus
▲ Member of the family of Bunyaviridae ▲ Feature of virus
Single-strand negative RNA virus Circular or oval in shape 78~210 nm in diameter Envelope proteins:glycoprotein1(G1)
hantaan virus (type I, HTNV) (汉滩病毒) seoul virus(type II, SEOV) (汉城病毒) puumala virus (type III,PUUV) (普马拉病毒) prospect hill virus(type IV,PHV) (希望山病毒) dobrava-belgrade virus (DEOV) (多布拉伐病毒)
S---Nucleocapsid protein:
strong antigenicity and immunogenicity, and containing complement binding antigen.
4
▲ Serologic type of Hantan virus
Over twenty serologic types
ultraviolet rays
7
■ Epidemiology
1.Sources of infection
▶ Infected field rats, house rats
In our country: Apodemus agrarius (黑线姬鼠) Mus norvegicus (褐家鼠) Apodemus sylvaticus (大林姬鼠) Citellus undulatus (长尾黄鼠)
Febrile phase, Hypotensive (shock) phase, Oliguric phase, Diuretic phase, Convalescent phase
1
Epidemic Hemorrhagic Fever ( EHF) Suggested name by WHO in 1982: Hemorrhagic Fever with Renal Syndrome
glycoprotein2(G2) Viral genome—RNA: L M S gene
3
Viral proteins
L--- Polymerase M---Envelope protein G1 and G2
the membrane antigen
G2: contain neutrolization antigen (vaccine antigen)
rats mite, red mite, harvest mite may carry Hantan virus. Need to be confirmed
11
3. Epidemic features
1>. District localization: mainly in Asia, Europe and Africa, America In China: higher incidence
via inhale aerosol contaminated with viruscontaining excretion or secretion of rats
2>.Food-borne transmission
via oral and esophageal mucosa (eat food contaminated with virus-containing excretion or secretion of rats)
5
Human HFRS:
caused by four type of virus: hantaan virus (type I, HTNV) seoul virus(type II, SEOV) puumala virus (type III,PUUV) dobrava-belgrade virus(DEOV)
10
3>. Infection via contact
Be bitten by rats. wound is contaminated with viruscontaining excretions or secretions of rats.
4>. Vertical transmission:
mother to baby, very rare
China: Hantaan virus Seoul virus
hantaan virus and DEOV show stronger pathogenicity than type II and III virus
6
▲ Resistance of virus
Low resistance: Inactivated by acid (<pH 5.0), ethanol, ether, chloroform. heat in 56ºC for 30min or 100ºC for 1min. Be sensitive to alcohol
■ Definition
▲ Infectious diseases with natural source ▲ Pathogen: Hantan virus ▲ Characterized by fever, hemorrhage,
proteinuria, shock and acute renal failure. Five phases in the typical cases
▶ Laboratory Rats ▶ Other animals: cats dogs rabbits
Patients:unimportant
8
Apodemus agrarius 黑线姬鼠
Mus norvegicus 褐家鼠
9
2. Modes of transmission: Five
1>.Air-borne transmission
(HFRS)
2
■ Etiolowk.baidu.comy
Hantan virus
▲ Member of the family of Bunyaviridae ▲ Feature of virus
Single-strand negative RNA virus Circular or oval in shape 78~210 nm in diameter Envelope proteins:glycoprotein1(G1)
hantaan virus (type I, HTNV) (汉滩病毒) seoul virus(type II, SEOV) (汉城病毒) puumala virus (type III,PUUV) (普马拉病毒) prospect hill virus(type IV,PHV) (希望山病毒) dobrava-belgrade virus (DEOV) (多布拉伐病毒)
S---Nucleocapsid protein:
strong antigenicity and immunogenicity, and containing complement binding antigen.
4
▲ Serologic type of Hantan virus
Over twenty serologic types
ultraviolet rays
7
■ Epidemiology
1.Sources of infection
▶ Infected field rats, house rats
In our country: Apodemus agrarius (黑线姬鼠) Mus norvegicus (褐家鼠) Apodemus sylvaticus (大林姬鼠) Citellus undulatus (长尾黄鼠)
Febrile phase, Hypotensive (shock) phase, Oliguric phase, Diuretic phase, Convalescent phase
1
Epidemic Hemorrhagic Fever ( EHF) Suggested name by WHO in 1982: Hemorrhagic Fever with Renal Syndrome
glycoprotein2(G2) Viral genome—RNA: L M S gene
3
Viral proteins
L--- Polymerase M---Envelope protein G1 and G2
the membrane antigen
G2: contain neutrolization antigen (vaccine antigen)