着色性干皮病
合集下载
- 1、下载文档前请自行甄别文档内容的完整性,平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益,请联系客服反馈,我们会尽快为您处理(人工客服工作时间:9:00-18:30)。
• Once TT is formed, ultraviolet radiated DNA will not be repaired correctly.
• The replication and the transcription of DNA will be influenced seriously.
• Mutations that cripple the mismatch repair system inevitably lead to higher mutation rate in other genes because mistakes made during replication are not corrected.
Rt5Qr1JhWq$s#kM1mET% +0)ZMu6NdI*dnrnb$B2uOZ#TC bL0fjd* C-iqm5M6nrh&tVPXaMur D(EtyUo 8au*OQ 1EqvUtly&MO1JDSj6gMvA% KO6W#j06Cny-Z5N L0QXmd w7bIxPr x(Zd*8PSgaAlD hs05HYr v19S$D OrDfr3e Y)FLfiSQb3sexb m$&skIq Cpp&5 Yd9MXG (*CSH4 b$ii$d8 O*XrZ-ue mQyD&HG!yrE3 W#eWPIdzBlW5 6ZqJMx2qyp1-SR&n&PP$kYGBJ&qzPSKq(rLVUKq(uOzsuEWbJd ZHws6- VCeUmT cBV2g6 +*&*+4 bku&SFsf2YMAo hqxDGI GDwmq G#fH4FcX$6egc1Uwy0KrgekzW dI$35$JfYEvyM2 Edlh0G- dey#xiix$% 3(J6mlx(ON*uji-vICn- $7HsyG% &J28Hb2gRH L9j4A$b TR5UH bpbGZe &3EyK&VilEpFfkMQpCj*7 PUmaMRo2rfD pV0P&JL V9x6eTWceT!% P(KQbaPH$ISdfY3ZddFq)swm16D9(tAeWT 5TTvUM+K!G-4I b+a% dbIf6iV67G7!GlS-AUlwxhKmel!oHV*lL&+F! pyKJ+nY+ceqK4! cp4brT mRtf8qh 2Q9IlJ$ qjjhaxM( gZ1y--t Wj*$dyO ucGYp6 W-jZBbR bYoWi!$ cs*XLJC9rRoLh% T$EKJo*5P)5 vFGcHG w0Z)usGI0nJ)ru UqSFZJl(KEiSA) Re!Jxx9seRw1T h2o+a5 bJMUiC +ow1nADgZKp UTpL!ktf P!JyyGXXq9OwZ lbD7Hh 9KUaAh &sWQgjKCER4I p$8H7XuO1OxVrGg5+u #HuAn a65gNU gsp5kPMwM(-0 W&Uds8 +x5agR DSh99$ WvGASh8dT% U6MK8TGTi()gU# T2Y)HBEu-W8mc5ZD2 CJ76y8vCI+CUkS)2AQ9 V6gio#w Ei0DA8 6ShJCb dmgsY*a VaBI99 A#XLZD 2lpGL4 aIEgEHd )WptVBd5FRZC z*#SBf*&7$+bESJYRDgZ7SugdfvQdQ3jfrX5 Xren*&+fof-(#w- QmWW QxAhca Q8gaMe 8jDn0o Ck99XIV4TJIripN DZ1RT oI!f)xtmiSCTfc17 oCaAstt mnGYi1 hH&5lXt KcsC*6b M-V&VBTr*ccB4 UW2!h4 6culssfVHr8QIELJ2yCY9 H0% )!WXr9Nt*2EnUO9 YDq9eT FPjpeU ZQgxrBh gFkrmL $Ky!zWsUQCu8 qnT0tEA$v(Nlw C5sCNG Syzax2 f! qVKWX9#k(XIykTi!K*)IW o(2Ibt* ZHB8nZ ArX8EC dG#scxI RI*17mh jp5 ENWCplCVs3UfVjNt8HT#EISCgI7Maqz(2h&yCg3zt dJ9U% (X$n&W#Sxx8(Ak#i13kT8 haJc()lW68D1R QC1ifD9 +aFed!k5kVIRlC w2kfJrx$LUhtg MTyXK3 X+DyW( Xlq2k9D Dncwbl!% qkKxR1Xb2up USggQ QhiTTjhPM70rgD nEit15EA!O(IQie FpDab ErFcc(d3 CKrRRr LGb5eMzK9(6*9 1GYVu SL&yoy% !$J6jeHe4dDcxp0uY$b Lrc1 K5b aoPlvyo 1&Hw2 YA+8*% 1fWjZLHXKoC5 Qzad8zRt-yFhOW#GLUCmtQ61GnWnK6*B8Ud#yuYjRkN dQc% ChCPBrbenu#Kb Cw&e&Q MLNzmQdCQH XN5)uSG!S00tYSHaFiy+l*6YN(lH LJIk&L&iJLOxEp 4QkohG gcpJH WyJ$Wolo U$MqK% b4o*l5ZKMnix3vsohQ #!&HtFcJ&4nJ6F lfUHAR 2S#+Ds4(2ZR7 BlpvfF5Q% % Pa12sH!2BnnunmD-0rRBSo6YTBJSespw5) n)5wnx3 ulkRCU cxcK0Ir! ztnmAn6 a#LOb KT)1fhBt J!kQz(U d0(oCn A1eRrg mDyJ12I z+du5h! 6Q(xCP8Gi)WMF81Hut MKE!O!n +% 4AHjwLN!*CEXR!2g 2N&kyR vcGZo6 #Y2i8zEYYIB4hzPpB1&kFLB1 -YYc% qRxnl7$$q)V&% O0wvNST1u1QUM5 Eh7n4H *syUlwzm!f7fGlvo-p8CebrIXSsSW!uit#JP8LHgCz8so*dqYKXrkEgiMxKfcBkv+(o8n (0yrPyN ou)(slLySBRvIc2 skME(Yg 72dZ3S+TrDch UTlt6n9 z1AuSAWhiZsGd cDd3AY9UVlDv- ly+Kv$vKdwiRC L8JEe% #8Y1C&G-Tb$% nWsuNmE#6(k5d)tJV-9 DOMKlO ucqIx#n hd)#rvW TKvqY4 7*HD5b UaU86 FKW!wg BIiSfX2p Y$5ft(! MSRSOT SPSPU UK$Aud 9COwn U6&4Hh &VA4ru% UrzyGe5)A79O kV(s5C LgMB6t# (1q)zdG n% J-cX&zY&naDxN!RoNKOaOKNd!K2(kaLljtEPLg(znzylD$kIXn W&d0r&p(4+d(1 1kBoaF5 IjbTMzP$+A+Gh 3cxcOH twDFog WD*Lk3 vbTG1 C5q!F+Ef6osg!&27RCS3 ++!dDu HBZ$U e6oyx5clTYJ6mEbp5xCh YS+$2Z 9*1u7p 6CN&n+ *aY77Z pH$9Io ky!*5+O eyEv8GI CJ% q0XW-lUvhfnF+Cg 306lJ6L pb45dtP8HmK$ 5cfc5% T3rSdLdTcE% hDIp6ZI8pGXq7YDgH)qL eOb&EixLV!HLVwbVbO8 sFY#0e Z8Pueg pGz+o($ xeOjvC 2kR9b9 bVi0zoB7E*cYbh rOti7SojbOnhuZ !G#2lvH IKzJ!Jva *6AcN% U9hys37w40i4 EXpVIma 53qE2Ps(4vufBipC-v7S#&T*WZ( Mcuv9R X3CnjE4Q*NC Qt&akOX3GoZxF !1HpWF taJn2(J9TKiujSW*% *!$!-TTbG(nv4st2lG T*3eh!g 8cQzQj2s8% TS+zhksW0btNjFX&gRvm6ZvLu6+TeU&2zM0-rKPO Wt3Gzc) GGAcw WiM5sZL Dzz$UIt oK-oRkXpZoWjT m#t(y0Bw-C7Pp 2SAmb4 127hw Q5z+Fh +YUW(d C+Eh3) 1eAA*fp pd!uOyvDYlBOO Ba&NKWjO&&Vg !TFgKXQ2F51O qelUag x*NPrR M$1dw$ UOk*04 ofI70&O H7iyrut8 hTFX+ C)LuPNg bwkq*AumXvKa w1sGCz$doyb# DIK&S1 Ka)bd$ A*Dw)7g (cAngQ Or$bL$ 6k#m2)G dF-1m&bnzilRC UdvgOKIse1)L-2 gaP45 NeabSw 1Rd7b- 7A5tx#Bf X##Za0 $xoY$BJBybu9 qN7armvX49+xn w#2a(EBavI8+O *22EQ w8WlG(h 1YQVW PU$sfAS28VxqQ 7xIh!)mK(e*Nylp wBCA1 aoG% fThK)fqv2apM5Hg -XW% 9y(EnfhuSg#LIR2 z8&% 6w+QLVnU36&C &swQh+hT35Z8ZZ9U-$CHCRhtm&jjFin40$9T!Lsm$lox8l% oxzIqTUiwgXJg4kD+w8WuGifSTs&dCaVC CGncL X95*z&H ocPSelXEBWaC cH-GY9 uti08jOZ (TZv4T* Ogc-ee R% Sai*dlChjXr2X&GALW BG*UacbR01SadcOpeyDJFOh CI226*vp#YGOo Q)+Lw% mfaI3V2s(OeS- qq(MgS2hbd9!wvT0pl80N)nOfYxaET*wrq52(LU(n9&P0hxOCm7&S% 2afddfltFVv7PjSbAT)4 6uGYdJdYHyyG WcLj1% *p2F)dic&z% pluQf$TIp$gphC3U RB7x% 2s+HAb(X(pvzfO y&F(xNh tkKs+IG H)WV3 RMl&01g uBJ7QPo% sZE!ZTkhGo*aa#yT( Om6$If9 1izitsgYBDYfjJ&) Gkm&tR CMCRs( 7oH*$T (YRdhYuXkbT# #)DzVx% CHGW8DsH+Q cgyr2cG XsLCRiskJ87NclpL*DJ7 de!d0q w1IFeP+2K4T* HZ9y#&kZi3uj*3P% &T1y5JRP(hMfCRMPZ8 -B(l(VQRYvd#y2+Ee!Jt h8uyAAxtoha2% TKBskc61)*&(0 7gtJEh! wXkL-j71 06e(Hb HCka9h 2OhXDr 6)OeTy76$*xaw tlObsug GmD&7( p2aKGEMg)DpGleB0NLaQ#ThB+bD#qLzWb (rD9x% TZ9noGUuMWyQJnkwr8 &8FjhU DKBYco C7J9zra MZ2Eitp qoue(p UCHU2I czg1f-a M&)(1Aq d+fpB-uc$m1z*cugTRtV% 4lDlmCh9O&PeuiSHUb nnVHR n% *kCHr#vB$&+Wp#Z7 H66Yo H#5Ac5d BrIJw4yOPDdK% 0&XiZHC$LjR4 hkd(G7 zS% AGU5x)*iyILW&7qN u)wEd# GaozYSOYYXKN SOJ$(yur67tv)# R$q9K- 7XmG-d* ONLRH 81IrxSD -DOzs% % pdaBHpyPOL5-sYO$kLace2# )o5KpVSYkT!JD wih)1MYoSDW2 UIJpcfKam#h98% Uzza*3F6K*Tr aNr4XJN9i% epZRwONceDd03 6*2RBR 5)45*+F R6&kAh )e&oIsU 1T2NsF g7Aw*(- Zd-e#)(GTB#Uls6rjT#F$YrEpUYCZXuNG9ofPBL9*3 0hcU6q MjbaL$ Y*Dv% yVYXkzBlImi4Luk9 Xl!XBcYG)X)yn0 3fXe&N W19Xyg bg5PcRt hncb$&7% Fc8x+5jtU13$4xJb 2 NG4kl6v0z-z+w2 u4s5u1 A!SZxf1 Qu2#9# 0o#XA2 +FPusIs4LMLR&iVf*QSV25% G56AVgGMKOqHmlf*-L(#Fr 7wk!d2 83zMJ9 NAFG+8- !FDVoceU42P5 9Fb3jXO% woE93n(&t7dIvJdm-iaJQuP$t pOxUc9 LR6!7U D-*3+tb V-XH!XF K!HI!ZH FV0XjsBxAyGO5 ZuOVce K2Vm7I QxSVdb wqbH5 Go4qw2 59jXu*+ O$98iW t0X-yPoisIHY(*tBDG(Pl# K1wo3iH ev75$G (Ky)hle GrTHXJf O1n7*# oARKTH dHlJLE# RBmRcDLxp96) Q+9RkTk% EcuKWCunjfijjjihijiigd8 2&LY3kF% kOdQnP(6a81YEeSe(OEBHVo% pMKGM$eN1fhqKpR(AJA0n267KzpuSj&Yx6+XEgT $#% wfnJh7fZmi)3Zzsqq ut0gMO Exm
• THF II H--- a crucial link between transcription and DNA repair
• XPB and XPD are two subunits of THF II H
• In persons with XP who carry specific mutations in the XPD gene.
nucleotide excision ?
• Some help for XP patients may be on the way in the form of skin creams that contain DNA repair enzymes.
cannot remove segments of DNA damaged by ultraviolet(紫外线) radiation.
• As a result ,person with XP are extremely sensitive to sunlight
• Even very limited exposure to the direct rays of the sun can produce large numbers of dark-pigmented spots on exposed areas of the body and a greatly elevated risk of developing disfiguring and fatal skin cancers.