--医学PPT课件器官循环
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③ Myocardium regional metabolic product is the main factor which causes coronary dilation and the function of adenosine is the most important. H+,CO2, ethylidene lactic acid 、BK、PGE also can dilate coronary. 心肌局部代谢产物是导致冠脉扩张的主要因素， 其PG中E等腺亦苷可作舒用张最冠为脉重。要。H+、CO2、 乳酸、BK、
⒉ The diastolic and systolic state of blood vessel in this organ 该器官阻力血管的舒缩状态
I. Coronary Circulation 冠脉循环 II. Pulmonary Circulation 肺循环 III. Cerebral Circulation 脑循环
(1) Regulation of metaboilic level of myocardium to coronary flow 心肌代谢水平对冠脉血流量的调节
Metaboilic level of myocardium is an important factor . 心肌本身的代谢水平是最重要因素。
等容收缩期↓↓→快速射血期↑→ 减慢射血期↓→ 舒张期↑（等容舒张期↑↑）
Level of arterial diastolic pressure and size of diastolic phase are important factors of determining coronary flow . 动脉舒张压高低和舒张期长短是决定冠脉血流量 的重要因素。
SECTION 5 ORGAN CIRCULATION
第五节 器官循环
The blood flow of organ denpends on 器官的血流量取决于：
⒈ The difference between aortic pressure and central venous pressure 主动脉压与中心静脉压之差
② Myocardial capillary distribution is extremely abundance . 心肌的毛细血管网分布极为丰富 。
③ Collateral coincidence between coronary is less . 冠脉动脉之间的侧支吻合少 。
2. Physiological characteristic of coronary circulation 冠脉循环的生理特点
① The energy for myocardial contraction nearly all comes from aerobic metabolism. 心肌收缩的能量几乎完全来自有氧代谢。
② Consumed oxygen of myocardium is large, oxygen intake much, oxygen uptake potency low. So the demand of myocardium to oxygen increase mainly depends on coronary distension. 心肌耗氧量大，摄氧多，摄氧潜力低。故心肌对 氧需求增加主要依赖冠脉扩张。
(2) Neural regulation 神经调节
① The pathway is short and blood flow is fast 途径短，血流快
② Blood pressure is high 血压较高
③ Blood flow is big and it is 4%～5% of cardiac output
血流量大,心输出量的4%～5%
Contraction and relaxation impact on right ventricle
is not so obvious as to left ventricle. 收缩及舒张对右心室的影响不及对左心室明显。
3. Regulation of coronary blood flow.
I . Coronary Circulation 冠脉循环
供血区域
左冠状动脉
左心室前部 和左侧部
右冠状动脉
左心室后部 和右心室
回流途径
冠状窦→
右心房
心前静脉→
右心房
1. Anatomic consideration 解剖特点
① The boles and branches of left and right coronary artery often penetrate myocardium in direction perpendicular to cardiac surface. 左右冠状动脉主干分支垂直于心脏表面的方向 穿入心肌 。
冠脉血流量的调节
Normal value: 60-80ml/100g.min. 静息血流量为60～80ml/100g.min Exercise 300-400ml/100g.min 运动时血流量为300～400ml/100g.min O2 consumption 7-9ml/100g.min. O2 extraction 65-70% 氧耗量为7～9ml/100g.min，占氧输出量的65～70%。
④ Arteriovenous oxygen difference is great during silence period
平静d flow fluctuates with cardiac cycle
血流量随心动周期波动
Isovolumic contraction phase ↓↓→ rapid ejection phase ↑→reduced ejection phase ↓→ diastolic phase (isovolumic relaxation phase)
⒉ The diastolic and systolic state of blood vessel in this organ 该器官阻力血管的舒缩状态
I. Coronary Circulation 冠脉循环 II. Pulmonary Circulation 肺循环 III. Cerebral Circulation 脑循环
(1) Regulation of metaboilic level of myocardium to coronary flow 心肌代谢水平对冠脉血流量的调节
Metaboilic level of myocardium is an important factor . 心肌本身的代谢水平是最重要因素。
等容收缩期↓↓→快速射血期↑→ 减慢射血期↓→ 舒张期↑（等容舒张期↑↑）
Level of arterial diastolic pressure and size of diastolic phase are important factors of determining coronary flow . 动脉舒张压高低和舒张期长短是决定冠脉血流量 的重要因素。
SECTION 5 ORGAN CIRCULATION
第五节 器官循环
The blood flow of organ denpends on 器官的血流量取决于：
⒈ The difference between aortic pressure and central venous pressure 主动脉压与中心静脉压之差
② Myocardial capillary distribution is extremely abundance . 心肌的毛细血管网分布极为丰富 。
③ Collateral coincidence between coronary is less . 冠脉动脉之间的侧支吻合少 。
2. Physiological characteristic of coronary circulation 冠脉循环的生理特点
① The energy for myocardial contraction nearly all comes from aerobic metabolism. 心肌收缩的能量几乎完全来自有氧代谢。
② Consumed oxygen of myocardium is large, oxygen intake much, oxygen uptake potency low. So the demand of myocardium to oxygen increase mainly depends on coronary distension. 心肌耗氧量大，摄氧多，摄氧潜力低。故心肌对 氧需求增加主要依赖冠脉扩张。
(2) Neural regulation 神经调节
① The pathway is short and blood flow is fast 途径短，血流快
② Blood pressure is high 血压较高
③ Blood flow is big and it is 4%～5% of cardiac output
血流量大,心输出量的4%～5%
Contraction and relaxation impact on right ventricle
is not so obvious as to left ventricle. 收缩及舒张对右心室的影响不及对左心室明显。
3. Regulation of coronary blood flow.
I . Coronary Circulation 冠脉循环
供血区域
左冠状动脉
左心室前部 和左侧部
右冠状动脉
左心室后部 和右心室
回流途径
冠状窦→
右心房
心前静脉→
右心房
1. Anatomic consideration 解剖特点
① The boles and branches of left and right coronary artery often penetrate myocardium in direction perpendicular to cardiac surface. 左右冠状动脉主干分支垂直于心脏表面的方向 穿入心肌 。
冠脉血流量的调节
Normal value: 60-80ml/100g.min. 静息血流量为60～80ml/100g.min Exercise 300-400ml/100g.min 运动时血流量为300～400ml/100g.min O2 consumption 7-9ml/100g.min. O2 extraction 65-70% 氧耗量为7～9ml/100g.min，占氧输出量的65～70%。
④ Arteriovenous oxygen difference is great during silence period
平静d flow fluctuates with cardiac cycle
血流量随心动周期波动
Isovolumic contraction phase ↓↓→ rapid ejection phase ↑→reduced ejection phase ↓→ diastolic phase (isovolumic relaxation phase)