病理学-生殖系统疾病课件

Complex hyperplasia without atypia.
Top: When hyperplastic endometria exhibit the degree of budding seen here, the term complex hyperplasia is used. Bottom: The epithelium lining these budded glands is not atypical.
• The proliferating epithelial cells are
particularly in the upper half of the field. The
polymorphic, and the nuclei seem to
polymorphic nature of the cells is evident, with a
size and shape.
“streaming” in some areas.
Hyperplasia of prostate/benign
prostatic hypertrophy
前列腺增生症/良性前列腺肥大
Clinical manifestations
• Uterine bleeding • Give rise to carcinoma of the endometrium
hyperplasia of breast,mammary dysplasia,
fibrocystic disease of breast,mastopathy (乳腺增生症)
• endometrial hyperplasia denotes a proliferating endometrium featuring glandular architectural abnormalities that result in glandular crowding and take the form of either cystic dilation of glands (simple hyperplasia) or glandular budding (complex hyperplasia) .
• Current taxonomy further stratifies hyperplastic endometria on the basis of their cytologic features into atypical endometrial hyperplasia and nonatypical endometrial hyperplasia
Complex hyperplasia with atypia.
Top: The budding required for a diagnosis of complex hyperplasia. Bottom: Cytologic atypia sufficient to warrant a diagnosis of atypical complex hyperplasia.
touch and mold in some areas. The
mixture of round and spindle-shaped nuclei. The
intercellular spaces are irregular in both latter are aligned to give an impression of
Βιβλιοθήκη Baidu
Mode chart of gland proliferation
Simple hyperplasia without atypia.
Top: Cystically dilated and minimally budded glands that are separated by wisps of compressed stroma. Bottom: The lining epithelium is proliferative and comparable to normal late proliferative endometrium. Cytologic atypia is absent.
SMA myoepithelium
Glandular epithelium
Target organ of hormone
病理特点：
乳腺间质增生，腺体增生(数量增多，囊性扩张，腺上 皮层次增多，乳头状增生)，形成包块。
病因发病机制：体内雌激素水平持续增
高，促使乳腺增生：1，青春期和更年期好发；2，动物 模型；3，用于治疗。
nodular hyperplasia of the prostate （前列腺增生症）
endometrial hyperplasia
(子宫内膜增生症）
Estrogen proliferation
Progestin secretion
An excess of estrogen relative to progestin，if sufficiently prolonged or marked
危 害：癌变
Mode chart of gland proliferation
EPITHELIAL HYPERPLASIA
• Usual ductal hyperplasia.
• Usual ductal hyperplasia.
• A duct is virtually occluded by a solid sheet of cells. Occasional irregular spaces are present,
生殖系统疾病
Diseases of Reproductive System And Breast
The disease from imbalance of endocrine
endometrial hyperplasia (子宫内膜增生症）
hyperplasia of breast（乳腺增生症）