缺血对神经血管单元的损伤与临床意义-万琪教授

脑血管内皮细胞的保护 减轻BBB的渗出或破坏 减轻脑水肿，降低颅内压 保护脑细胞，降低代谢率
血ቤተ መጻሕፍቲ ባይዱ的保护
神经的保护
谢谢！
缺血对神经血管单元的损伤与临床意义-万琪教授
The Neurovascular Unit.
A conceptual framework, the neurovascular unit comprises neurons, the microvessels that supply them, and their supporting cells. Cerebral microvessels consist of the endothelium (which forms the blood–brain barrier), the basal lamina matrix, and the end-feet of astrocytes. Microglial cells and pericytes may also participate in the unit. Communication has been shown to occur between neurons and microvessels through astrocytes.
C、白细胞黏附受体表达 介导白细胞黏附与移行
B、局灶性脑缺血后 内皮细胞通透性增加
Advances in the Vascular Pathophysiology of Ischemic Stroke Gregory J. Thrombosis Research 98 (2000) V73–V81
神经血管单元损伤时防治的可能策略
-------2003
The ultrastructure of cerebral capillaries observed with electron microscopy.
脑缺血再灌注对血脑屏障结构和功能的影响
A、正常脑微血管
D、基底膜断裂 BBB完整性破坏