HY-15580_Dolastatin 10_MCE
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
Data Sheet
BIOLOGICAL ACTIVITY:
Dolastatin 10 is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia , that inhibits tubulin polymerization.
IC50 & Target: Tubulin [1]
In Vitro: Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia . These in vitro data are quite
comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI 50 values of 10-5–10-6 μg/mL (10-2–10-3 nM) against a similar minipanel of human cell lines [2]. The antibody–drug conjugate (ADC) comprises the anti–CD30 monoclonal antibody cAC10
conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10[3].
References:
[1]. Pitot HC, et al. Phase I trial of dolastatin–10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res. 1999 Mar;5(3):525–31.
[2]. Pettit GR, et al. Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications ofdolastatin 10. J Nat Prod. 2011 May 27;74(5):962–8.
[3]. Brentuximab vedotin. Drugs R D. 2011;11(1):85–95.
Product Name:Dolastatin 10Cat. No.:HY-15580CAS No.:
110417-88-4Molecular Formula:C 42H 68N 6O 6S Molecular Weight:785.09
Target:Microtubule/Tubulin; Microtubule/Tubulin; ADC Cytotoxin Pathway:Cell Cycle/DNA Damage; Cytoskeleton; Antibody–drug Conjugate/ADC Related Solubility:
10 mM in DMSO
Caution: Product has not been fully validated for medical applications. For research use only.
Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@
Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA
Certificate of Analysis
PHYSICAL AND CHEMICAL PROPERTIES
Molecular Formula:C 42H 68N 6O 6S Molecular Weight:785.09Storage:
Powder -20°C 3 years 4°C 2 years In solvent
-80°C 6 months -20°C
1 month
Chemical Structure:
ANALYTICAL DATA
Appearance:
White to off-white (Solid)1
H NMR Spectrum:
Consistent with structure LCMS:Consistent with structure Purity (LCMS):99.83%
Conclusion:
The product has been tested and complies with the given specifications.
Product Name:Dolastatin 10Cat. No.:HY-15580CAS No.:110417-88-4Batch No.:10576
Chemical Name:
L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
Caution: Product has not been fully validated for medical applications. For research use only.
Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@
Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA