运用中药周期方法治疗冲任失调型女性黄褐斑的临床研究论文外文翻译-中英文论文对照翻译

第一部位英文论文题目：运用中药周期方法治疗冲任失调型女性黄褐斑的临床研究The use of traditional Chinese medicine-cycle approach to the treatment of the clinical study of Chong and Ren disorders female melasma[Abstract] Objective To investigate the use of traditional Chinese medicine cycle therapy adjustment red any the offset type female melasma clinical efficacy. Strictly in accordance with the criteria established by Chong and Ren disorders female chloasma 60 patients were randomly divided into two groups: the treatment group 30 cases in the control group of 30 patients. cycle approach of Chinese medicine in the treatment Chong and Ren disorders type melasma treatment group taking western medicine tranexamic acid as a control group were treated for 3 months. Observation of patients before and after lesion area, skin lesions, color and changes in reproductive hormones. Results (1) After treatment efficacy total efficiency was 86.7% and 63.3%, traditional Chinese medicine group was better than the control group tranexamic acid, and the difference was statistically significance (P <0.05). (2) TCM group after treatment, estradiol (E2) and follicle-stimulating hormone (FSH) (P <0.01) lower, better than the tranexamic acid group. (3) Chinese medicine cycle approach in the treatment of improve melasma patients a variety of clinical symptoms, the treatment group than the control group chloasma size, pigment improvement the the conclusion two drugs melasma condition has improved to some extent, but the treatment group, the total efficiency is significantly better than the control group, and with lower estradiol (E2), promote the role of follicle stimulating hormone (FSH) content. traditional Chinese medicine artificial cycle approach to the treatment of chloasma better.[Keywords] Chinese medicine cycle therapy; female chloasma; clinical research; titles of papers[Abstract] Objective To observe the use of such methods as Chinese medicine cycle therapy adjustment female chloasma with disharmony of thoroughfare and conception vessels.Methods In strict accordance with the formulation of inclusion criteria choose blunt as female chloasma with disharmony of thoroughfare and conception vessels, 60 cases patients were randomly divided into two groups: treatment group, 30 cases.With Chinese medicine cycle therapy was as disharmony of thoroughfare and conception vessels chloasma as treatment group, to take tranexamic acid as control group.Two groups of treatment were for 3 months . The patients were observed before and after the treatment of lesions area, color and reproductive hormone changes.Results The two groups of total effective rate were 86.7% and 63.3%, respectively, tranexamic acid control group was higher than the ammonia, and the difference was statistically significant (P <0.05). In Chinese medicines group after treating, estradiol (E2),follicle-stimulating hormone (FSH) reduced (P <0.01), the effect is better than that of ammonia tranexamic acid group. Chinese medicine treatment can improve clinical symptoms in patients with melasma. Size, degree of improvement in pigment in melasma treatment group was better than the controlgroup.Conclusion Two groups of drugs on chloasma condition have improved, but the total effective rate in treatment group was better than control , and has reduced estradiol (E2), follicle-stimulating hormone (FSH) levels of function.That TCM artificially cycle therapy on chloasma has better curative effect.[Keywords:] TCM cycle therapy; female chloasma; clinical researchMelasma is caused by a variety of factors, limitations, and acquired skin pigmentation. Clinical manifestations of facial symmetry distribution, clear boundary brown patches. Many good hair in young women, was chronic disease Although there were no symptoms, but serious impact on patients with facial beauty, spirit and life to bring a lot of trouble and pain, and even cause physical and psychological barriers with a high incidence of the disease, and easy diagnosis of refractory.The chloasma etiology is very complex, modern medical research that the chloasma and endocrine disorders, pregnancy, oral contraceptives, uterine, ovarian disease, sunlight and other factors. Majority of scholars believe that the incidence of endocrine dysfunction in female patients with melasmahypothalamic - pituitary - ovarian axis imbalance significant relationship, so the treatment of multiple start from endocrine adjustment and the motherland medicine Melasma is an external local manifestations of the disease located in the skin, including the cause of dysfunctional organs in the body, should be taken Outer disease Governance "method [1].Through the long-term treatment of melasma, combined with years of clinical experience, and in a large number of preliminary studies on the basis of that part of the female melasma is caused because of Chong and Ren disorders using Chinese medicine artificial cycle approach in the treatment of basal body temperature by Chong and Ren disorders type chloasma, effective, safe, easy to relapse, are more satisfied with this study, the use of traditional Chinese medicine artificial cycle treatment of melasma and control to do with Western medicine tranexamic acid treatment group, by observing the clinical efficacy and serum levels of sex hormones, further to understand the relationship of female chloasma Endocrine artificial cycle approach to explore traditional Chinese medicine treatment of melasma mechanism.This January to December 2009, during the Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, dermatology clinic, clinical diagnosis chloasma, TCM Chong and Ren disorders 60 patients, divided into a treatment group and a control group, and its efficacy analysis and comparison are as follows.1 Materials and Methods1.1 General Information1.1.1 Case Source60 patients were enrolled for the period January to December 2009, the Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Dermatology outpatient treatment of female patients. Chloasma all in compliance with the diagnostic criteria.1.1.2 Standards of Medical Care1.1.2.1 diagnostic criteriaReference Integrative Medicine Institute of Dermatology and Venereology Professional Committee pigment disease study group enacted in December 2003 << melasma clinical diagnosis and efficacy criteria (revised 2003 draft) >> "develop [2].Western diagnostic criteria: (1) the face clear patches of light brown to dark brown in color boundaries, usually symmetrically distributed, inflammation and scaly. (2) no obvious symptoms. Female multiple (3) occurs mainly after puberty.(4) The condition can be certain seasonal, normally the summer heavy winter light. (5) exclude pigmentation caused by other diseases (such as zygomatic brown blue nevus of Riehl melanosis and pigmented actinic lichen planus).1.1.2.2 inclusion criteria>> << Chinese new drug clinical research guidelines published by the China Medical Science and Technology Press (2002) formulated the inclusion criteria.(1) causes related to pregnancy (2) associated with irregular menstruation (menstrual late menstruation has not regularly, after a few months, amenorrhea) and (3) the full range of abnormal to check serum reproductive hormone. (4) after the first two milk for inflation, temperament irritability, restlessness (5) before the headache. (6) premenstrual insomnia (7) purple tongue dark ecchymosis (8) pulse string or astringent.Where have the above four recognizable Chong and Ren disorders type facial melasma.1.1.2.3 efficacy criteria [2]Basic cure: the naked eye, as the stain area subsided by> 90%, the color disappeared; rated basis, decreased after treatment index> = 0.8. Markedly: the naked eye, as the stain area subsided by> 60%, the color fades significantly; scoring calculation decreased after treatment index> = 0.5. improved: the naked eye, as the stain area subsided by> 30%, the color fades; rated basis, decreased after treatment index> = 0.3. invalid: <30% regression of the naked eye, as the stain area, color changes The obvious; rated basis, decreased after treatment index> = 0.1.1.2.4 Rated methods and standards(1) lesions area score: 0 for no lesions; 1 area <2cm2; area 2 ~ 4cm2; the 3 lesion area> 4cm2 (2) lesions color score: 0 for normal skin color; 1 Hazel; 2 brown; 3 dark brown (3) total score = the area score + color score (4) scoring decline in the index calculation method: the declining index = (total score before treatment - total points after treatment) / treatment before the total score.1.1.3 grouping methodPrinciple randomized control packet .60 were randomly divided into a treatment group and ammonia tranexamic acid control group. Treatment group of 30 patients, aged 28 to 51 years of age, duration of 0.25 to 21 years; 30 patients, ages 29 to 50 years of age, duration of 0.3 to 15 years.1.2 Treatment1.2.1 treatment group(1) use drugs, the treatment group (basal body temperature, periodic use of traditional Chinese medicine treatment.) ①The menstrual late follicular phase together the Artemisia annua turtle Decoction Liu Wei Di Huang Tang (2) between periods (ovulation) to promote ovulation Tonga Less. ③premenstrual (luteal phase) Immortals soup together Jinkuishenqiwan, addition and subtraction ④menstrual period Taohongsiwu soup and subtraction. (2) Method of Administration: fry a liquid of 200ml, oral, twice daily, rice after the taking.1.2.2 control group(1) control group the medication use drugs: tranexamic acid tablets (trade name: properly race-sensitive; factory name: DALLCHI SANKYO PROPHARMA CO., LTD, Shizuoka Plant; specifications: 0.5g / piece) (2): 0.25 g, orally, tid.1.2.3 treatmentTreatment without other drugs during three menstrual cycles for a course of treatment, efficacy was evaluated after a course of treatment.1.2.4 Laboratory indicatorsPatients in 3 to 7 days after the menstrual blood collection are 8:00 to 9:00 fasting blood samples were two groups of patients were measured before treatment and after each reproductive hormones.1.2.5 Observation Project(1) observed before treatment, after treatment melasma area changes (2) observed before treatment, after treatment melasma color changes. (3) ratings decline in the index calculation method see above. Weekly referral records pigment changes , plus or minus prescription compare two groups. observed before and after treatment to detect changes in the levels of serum sex hormone in six (sexhormone, SH) (4) observation of the patient's self-test basal body temperature (5) observed in both groups of patients with melasma improvement of his symptoms.1.2.6 Statistical MethodsObservable data to mean + - standard deviation (x +-s), said using the t test, count data using the chi-square test. Data processing use SPSS16.0R package.2 Results2.1 melasma clinical comparison of two groupsShown in Table 1. Treatment group of 30 patients, the effective rate was 86.7% in the control group of 30 patients, an effective rate of 63.3%. Significant difference between the two groups, the treatment group than the control group (P <0.05) Table 1 groups Comparison of clinical efficacy of melasma2.2 in serum sex hormone levelsShown in Table 2 Table 2 serum sex hormone levels before and after treatment2.3 melasma improvement of his symptoms analysisAre shown in Table 3. While the control group tranexamic acid tablets chloasma of his symptoms had no significant improving effect Table 3 treatment groups the melasma of his symptoms improve2.4 Adverse reactionsNo adverse reactions of the treatment group during treatment, control group patients withdrawal recurrence after 3 months, 2 patients feel menstrual flow decreased significantly.3 Analysis and discussion3.1 melasma and sex hormones intrinsic linkModern medicine mainly due to melasma pathogenic endocrine disorders, many factors can affect the synthesis of melanin in the melanocytes, and abnormal levels of sex hormones is one of the common causes of human hormone secretory function of organs such as the pituitary, adrenal cortex, ovarian secretion of the hormone can directly act on the melanocytes. many domestic and foreign medical experts in clinical studies: melasma occur with hormone changes, such as pregnant women prone to facial pigmentation, this color stubborn melasma spot some long-term retention in the postpartum formation [3,4]. Lin Xinyu [5] report female melasma serum FSH (follicle stimulating hormone) and LH (luteinizing hormone), E2 (estradiol) levels significantly higher T (testosterone) levels significantly reduced, P (progesterone), PRL (serum prolactin) content was normal, suggesting the incidence of female chloasma and endocrine disorders, hypothalamic - pituitary - gonadal axis (HPA axis) imbalance related . Wan Miao Jian et al [6] report female patients with melasma serum E2 levels, serum FSH, LH, P, PRL and control group differences without significant resistance. the Li Jian [7] observational study found that female patients with melasma Serum FSH, LH, E2, P levels were significantly higher than that in the control group. above studies have shown that endocrine factors play an important role in the incidence of female patients with melasma.Clinical observation, we also found a part of the female patients with melasma serum E2 or FSH levels above the normal range of values, which coincide with the findings of some scholars. Seen in this light, the incidence of melasma in vivo sexhormone levels. findings of this subject shows Chinese medicine artificial cycle therapy can reduce the abnormally high levels in the serum of patients with melasma E2, FSH levels, disorders of sex hormone levels returned to normal. explains Chinese medicine artificial cycle therapy yellow brown spots is experimental evidence that it has a role in regulation of the endocrine and balance hormone levels In addition, in melasma clinical process also can be sex hormone levels as a treatment melasma reference index, has a certain significance. TCM Differential Treatment can also get rid of the patients with a variety of discomfort syndrome.Western medicine tranexamic acid tablets treatment in a relatively short period of time (about one month to one and a half) part of the improvement in the symptoms of melasma, but ineffective treatment of his symptoms and menstruation may appear, dizziness , epigastric discomfort and other side effects in some patients in the 2 to 3 months after stopping melasma recurrence. TCM group compared to reflect the advantages.3.2 Chong and Ren disorders melasmaChong and Ren disorders are female Chong and Ren two veins dysfunctional, Chong and Ren are all meridians of the two veins kidneys, Conception Vessel "yin pulse of the sea, the any main births (uterus and ovaries). Red veins twelve meridians of the sea ", with women's menstrual and gave birth to the function are closely related. Chong and Ren disorders refers to their functionality obstacles. chloasma occurs in young women, appears on the face of melasma, and often accompanied by menstrual wrong line of abdominal pain, dark purple color, and the clot Chong and Ren stasis syndrome. TCM theory holds that: red sea of blood, vaginal pulse of the main Chong and Ren the two clock master Yun twelve blood and on the note in the face. rushed to either of two veins reconcile, normal menstruation. Chong and Ren disorders by the gas block, blood loss, lack of blood above the wing in the face, skin dystrophy, look unfamiliar brown spots. shows that Chong and Ren two veins through the air against the chaos or disorder is a major cause of melasma Therefore, many scholars for this etiology, from conditioning Chong and Ren, promoting blood qi to treat melasma.Of 3.3 basal body temperature in the clinical significanceBasal body temperature (BBT) women with normal menstrual cycles a day get enough sleep 5 ~ 8h, did not get up after you wake up, not activities, the thermometer is placed in the sublingual 5min measured body temperature normal basal body temperature The first day of menstrual cramps below 36.5 ℃, maintained for 14 to 15 days, ovulation body temperature decrease of 0.2 ° C to 0.3 ° C after ovulation pyrogenic effect of progesterone, basal body temperature, increased by 0.3 ° C to 0.5 ° C 36.5 ℃for 14 to 15 days, if not pregnancy, menstrual cramps, basal body temperature dropped to 36.5 ℃temperature tracings of the cycle in the connected grid graph paper, there will be regular biphasic curve, namely the low phase of ovulation, the Takaso after ovulation. indirectly reflect the mature female ovarian endocrine function, ovarian secretion of sex hormones under the influence of cyclical fluctuations.Growth and decline of yin and yang physiological and pathological changes of the menstrual cycle, can be reflected by the basal body temperature in the outer basal body temperature changes with the change of the female body yin and yang qi, especially kidney and the menstrual cycle - menstruation - Chong and Ren - uterus axis transformation and blood activity is closely related to [8]. basal body temperature of mature women affected by ovarian secretion of sex hormones impact of cyclical fluctuations, so that it can indirectly reflect the female ovarian function, at the same time, the basal body temperature changes can also menstrual cycle the growth and decline of yin and yang change revealed biphasic BBT variation is indeed the Yin and Yang dialectical theory is well represented on the outside. bipolar help to identify the various stages of the menstrual cycle. precisely by means of basal body temperature dual Phase of patient visits in which phase of the menstrual cycle to determine to guide therapy.BBT addition able to determine the different stages of the menstrual, also can be used as syndrome differentiation in the objective efficacy endpoint for clinical practice, the use of traditional Chinese medicine artificial cycle therapy, conform to the female yin and yang blood rise and decline of the law when the trial medication in different menstrual cycle stage, according to BBT endocrine ovulation such as traditional Chinese medicine, traditional Chinese medicine to increase the luteal phase, traditional Chinese medicine to promote endometrial exfoliative improving and treating melasma treatment effect in addition to conscious patients with melasma symptoms improve or eliminate, menstrualcycle, menstrual flow is adjusted properly, the associated symptoms may disappear, more patients monthly test basal body temperature changes before and after treatment the objective confirmed, play a multiplier effect.3.4 TCM artificial cycle therapyModern medicine, the use of estrogen and progesterone regulation disorder menstrual cycle or periodic supplemental estrogen and progesterone formation of the menstrual cycle, known as artificial cycle therapy [9]. Clinical therapy of traditional Chinese medicine artificial cycle, combined with the menstrual cycle in accordance with the basic theory of TCM gynecology the menstrual late, after the interval, transformed by the early period of yin and yang, growth and decline of rhythm, periodic medication treatment.Which is characterized by ovarian cyclical changes in the menstrual cycle, the diagnosis and treatment combined with periodic TCM drugs to herbal medicine artificial cycle therapy is the 1963 Jiangxi character silicon Professor founded cycle therapy for the treatment of ovulatory dysfunction and menstrual disorders, In Chinese medicine Kidneys Reproductive, reproductive and kidney - menstruation - Chong any - between the uterus balance, based on the theory of traditional Chinese medicine, to absorb the cyclical changes of modern medicine ovarian and uterine function and founded cycle sexual medication therapy, which were equivalent to the follicular phase, ovulation, luteal phase, menstruation election party agents to adjust the blood and viscera of yin and yang to normal levels in the different stages of the menstrual cycle, the choice of the rule of law and Recipe different adjustment Chong and Ren homeostasis, to restore kidney - menstruation - Chong and Ren - the function of the uterus, the red veins Chongsheng Conception Vessel patency, both with each other AIDS help.Occur due to melasma and are closely related to the female reproductive system, based on basal body temperature in the clinical use of traditional Chinese medicine artificial cycle approach to the treatment of female Chong and Ren disorders type chloasma, the effect is obvious side effects, difficult to rebound and recurrence. Lot of discomfort and associated symptoms compared to alleviate or disappear at the same time, after all, a fundamental law. menstrual flow reduction in side effects and some patients of the comparison group, after stoppingchloasma easy to relapse, and accompanying his symptoms not improve with them on full reflects the traditional Chinese medicine artificial cycle therapy treatment melasma advantage.3.5 a problemResearchers manpower, time constraints, the number of cases of samples collected is small, that may affect the results. Shorter study period, failed to carry out the follow-up, can not reflect the traditional Chinese medicine artificial cycle therapy for the long-term effect of the disease on this topic continues in progress.[References]Feng Anji. Chloasma etiology and pathogenesis of First Military Medical University, 2000,20 (2) :183-184.2 China Association of Integrative Medicine Dermatology and Venereology Committee of pigment disease study group. Melasma clinical diagnosis and treatment standards (revised version of 2003). Chinese Journal of Dermatology, 2004,37 (7): 440.3 Costin GE, Birl EA SA.What is the mechanism for melasma that so commonly accompanies human pregnancy.IUBMB Life, 2006,58 (1) :55-57.4 Moin A, Jabery Z, Fallah N.Prevalence and awareness of melasma during pregnancy.Int J Dermatol, 2006,45 (3) :285-288.5 Lin Xinyu, Zhou Guangping, Lee Lee. Female patients with melasma sex hormone level detection of Dermatology, 1997,26 (5) :285-287.60000 Miao Jian, Zhao the Cai Ruikang. Melasma serum sex hormone levels. Dermatology, 1997,30 (6) :403-404.7 Li Jian, Wang Xinyan female patients with melasma serum hormone level detection and Efficacy. Clinical skin magazine, 2004,33 (12) :738-739.8 Xu Xiaojuan, Deng Linwen, PEI red pigeon on basal body temperature "yin andyang of growth and decline of" in cycle therapy of traditional Chinese medicine. Hubei Journal of Traditional Chinese Medicine, 2008,30 (3): 46.9 Wang Aiqin Journal of Chinese Integrative Gynecology Beijing: Beijing Publishing House, 1996:14.第二部分中文论文运用中药周期方法治疗冲任失调型女性黄褐斑的临床研究【摘要】目的观察运用中药周期疗法调节冲任失调型女性黄褐斑的临床疗效。