Chapter 4 Replication-1病毒的复制

INTRODUC -TION TO VIROLOGY
T4侵入以后的事件
Chapter 4: Replication
• 病毒大分子的生物合成包括核酸复制与病毒蛋 白质合成两部分
Slide 18/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
T4基因组
Chapter 4: Replication
不同类型病毒的转录
Slide 30/27
INTRODUC -TION TO VIROLOGY
Class I: Double-stranded DNA
Chapter 4: Replication
Slide 31/27
INTRODUC Herpesvirus Gene -TION TO VIROLOGY
INTRODUC -TION TO VIROLOGY
Chapter 4 Replication
Chapter 4: Replication
The Replication Cycle
Slide 1/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
Influenza Virus Attachment Protein
• layers of waxes & pectin and each cell is surrounded by a thick wall of cellulose overlying the cytoplasmic membrane. No plant virus is known to use a specific cellular receptor of the type that animal & bacterial viruses use for attachment. Plant viruses rely on a breach of the integrity of a cell wall to directly introduce a virus particle into a cell. This is achieved either by the vector associated with transmission of the virus or simply by mechanical damage to cells. After replication in an initial cell, the lack of receptors poses special problems for plant viruses in recruiting new cells to the infection.
Slide 13/27
INTRODUC -TION TO VIROLOGY
副粘病毒包膜糖蛋白
Chapter 4: Replication
Slide 14/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
流 感 病 毒 包 膜 蛋 白
Slide 15/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
T7 复 制
Slide 26/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
T7 复 制
Slide 27/27
INTRODUC -TION TO VIROLOGY
Slide 23/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
ФX174复制
Slide 24/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
ФX174滚环复制
A蛋白
Slide 25/27
Chapter 4: Replication
Tφ
T7 噬 菌 体 的 基 因 组
Slide 28/27
INTRODUC RNA -TION TO 噬菌体 VIROLOGY
Chapter 4: Replication
MS2
翻 译
复 制
Slide 29/27
INTRODUC -TION TO VIROLOGY
Schematic representation of some virus receptors - arrows indicate virus attachment site:
Chapter 4: Replication
Slide 4/27
INTRODUC -TION TO VIROLOGY
Chapteplication
Expression
Slide 32/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
Herpesvirus Gene Expression
Slide 33/27
INTRODUC -TION TO VIROLOGY
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
Translocation
3) Translocation of the entire virus particle across the cytoplasmic membrane of the cell. • This process is relatively rare among viruses & is poorly understood.
intracellular vacuoles is probably the most common mechanism of virus entry into cells. • Fusion does not require any specific virus proteins (other than those already utilized for receptor binding) but relies on the normal formation & internalization of coated pits at the cell membrane. • Receptor-mediated endocytosis is an efficient process for taking up & concentrating extracellular macromolecules.
Expression of Adenovirus E1A
Chapter 4: Replication
Slide 36/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
Adenovirus E1A
Slide 37/27
INTRODUC -TION TO VIROLOGY
tL tR1
Slide 21/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
Gene Expression in λ
Slide 22/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
λ滚环复制
Slide 19/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
Genetic Map of
λ
Slide 20/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
A Simplified Genetic Map of λ
Slide 2/27
INTRODUC -TION TO VIROLOGY
Poliovirus Receptor Binding
Chapter 4: Replication
Slide 3/27
INTRODUC Virus Receptors -TION TO Many examples of virus receptors are now VIROLOGY known.
Chapter 4: Replication
腺 病 毒 复 制
Slide 34/27
INTRODUC Adenovirus Gene -TION TO VIROLOGY
Chapter 4: Replication
Expression
Slide 35/27
INTRODUC -TION TO VIROLOGY
进 入 动 物 细 胞
Slide 10/27
INTRODUC -TION TO VIROLOGY
Chapter 4: Replication
Slide 11/27
Endocytosis
INTRODUC Endocytosis -TION TO VIROLOGY of the virus into 2) Endocytosis
dPft/dt=K·ft· ， P B
Slide 7/27
INTRODUC Plant Viruses • -TION TO face special problems initiating an infection. Plant viruses Plant Viruses • The outer surfaces of plants are composed of protective VIROLOGY