20例儿童横纹肌肉瘤临床特点与治疗策略

点和治疗方法进行研究 。 结果 20 例儿童横纹肌肉瘤中 ，发病年龄 2~13 岁，平均 7.5 岁；临床分期中Ⅰ期 2 例，Ⅱ
期 8 例，Ⅲ期 5 例，Ⅳ期 5 例；其中胚胎型 11 例、腺泡型 7 例、多形型 2 例。 原发灶部位在躯干者 3 例、四肢者 8 例，
头颈部者 4 例，泌尿生殖系统者 5 例。首发表现因原发部位差异而有所不同，所有患者采用两种以上方式综合治疗，
2012 年 10 月第 9 卷第 30 期
· 临床研究 ·
20 例儿童横纹肌肉瘤临床特点与治疗策略分析
池欣欣 辽宁省妇婴医院儿内科，辽宁沈阳 110007
[摘要] 目的 对 20 例儿童横纹肌肉瘤临床特点与治疗策略进行分析。 方法 回顾分析我院 2008 年 2 月~2010 年 2月
收治的 20 例儿童横纹肌肉瘤的临床资料，均由病理组织学确诊为儿童横纹肌肉瘤，对所有病例的病理类型、症状特
[关键词] 儿童横纹肌肉瘤；临床特点；治疗策略
[中图分类号] R730.54
[文献标识码] A
[文章编号] 1673-7210（2012）10（cBaidu Nhomakorabea-0047-03
Clinical analysis of clinical features and treatment strategies of 20 cases of children rhabdomyosarcoma
CHI Xinxin Department of Pediatrics, Women and Children Hospital of Liaoning Province, Shenyang 110007, China [Abstract] Objective To analyze the clinical features and treatment strategies of 20 cases of children rhabdomyosarcoma. Methods Clinical data of 20 children with children rhabdomyosarcoma from February 2008 to February 2010 in our hos pital were retrospectively analyzed, 20 cases of children rhabdomyosarcoma were diagnosed by histopathology. The patho logical type, the characteristics of symptoms and treatment study of all patients were studied. Results Among 20 cases of patients with children rhabdomyosarcoma, age from 2-13 years, the average of 7.5 years. Clinical stage: 2 cases were in stage Ⅰ, 8 cases were stage Ⅱ, 5 cases were in stage Ⅲ, 5 cases were stage Ⅳ; embryonal of 11 cases, 7 cases of alveolar, pleomorphic type of 2 cases. The primary tumor of 3 cases were sited in the trunk, 8 cases in the limbs, and 4 cases in head and neck, 5 cases in thegenitourinary system. The first manifestation of the tumor was different because of the differ ent primary sites. All patients were carried two or more ways of comprehensive treatments. After treatment, the evaluation of the efficacy: CR 9 cases, PR 5 cases, SD 4 cases and PD 2 cases. All patients were followed up for 2 years to 4 years. The results suggested 1-year survival rate was 90.0%, and 2-year survival rate was 75.0%, 3-year survival rate was 65.0%. Conclusion Children rhabdomyosarcoma is an extremely malignant soft tissue tumor. To achieve early diagnosis, we should choose the scientific comprehensive treatment including surgery and radiotherapy and chemotherapy. Combined treatments can avoid multiple metastases of advanced cancer, thereby increase the probability of cure of children with tumors. [Key words] Children rhabdomyosarcoma; Clinical features; Treatment strategies
治疗后的疗效评价为：CR 9 例，PR 5 例，SD 4 例，PD 2 例。 对所有患者连续随访 2~4 年，1 年生存率为 90.0%，2 年生
存率为 75.0%，3 年生存率为 65.0%。 结论 儿童横纹肌肉瘤是极度恶性软组织肿瘤，要做到早诊断，科学地选择手
术与放化疗结合的综合治疗方式，避免拖延造成肿瘤晚期的多发转移，从而提高患儿肿瘤的治愈可能性。