脑出血微创术后自体骨髓间充质干细胞动员对神经功能恢复的影响

脑出血微创术后自体骨髓间充质干细胞动员对神经功能恢复的

影响

胡炜;杨枫;唐尤佳

【期刊名称】《中国医科大学学报》

【年(卷),期】2014(43)5

【摘要】目的：观察微创术后骨髓间充质干细胞（BMSCs）动员对脑出血术后神经功能的影响。方法将脑出血患者45例随机分为对照组（n=20，行常规立体定

向手术治疗）和治疗组（n=25，术后3~5 d时行BMSCs动员）。术前及术后1、3、6个月行NIHSS量表、FIM量表评分，术前、术后2周测定外周血CD133+、CD34+细胞数，术后1个月及6个月行肝肾功能检查。结果2组术后NIHSS、FIM分值均显著高于术前（P<0.05），治疗组术后NIHSS、FIM分值均显著高于对照组（P<0.05）。术后2周，治疗组外周血CD133+、CD34+细胞在单核细胞中的比例明显高于对照组（P<0.05）。术后1个月及6个月2组肝肾功能检查指标均正常。结论脑出血微创术后尽早进行BMSCs动员，可促进神经功能恢复，提高患者的生活能力和质量。%Objective To observe the effects of autologous bone marrow mesenchymal stem cell mobilization on neurological function recovery after cerebral hemorrhage minimally invasive surgery. Methods Totally 45 patients with cerebral hemorrhage were randomly divided into two groups:in-cluding 20 cases in control group whom received stereotactic surgery,and BMSCs mobilization was carried out 3 to 5 days postoperation in the treated group(25 cases). NIHSS scale and FIM scale were performed before the operation and 1,3,6 months post

operation. Preoperative and 2 weeks post-operative CD133+CD34+cell count was measured in peripheral blood;postoperative liver and renal function of 1,6 months were performed. Results Postoperative NIHSS,FIM scores were significantly higher than preoperative ones in two

groups(P<0.05),postoperative NIHSS scores and FIM scores in treated group were significantly higher than that of control group(P<0.05). Two weeks postoperation,the proportion of CD133+CD34+cells in mononuclear cells in peripheral blood of treated group was significantly higher than the control group(P<0.05). Postoperative liver and renal function of 1,6 months were normal. Conclusion BMSCs mobilization can be performed as early as possible after minimally invasive surgery of ce-rebral hemorrhage,which can promote the recovery of neurological function,improve the capacity and quality of life without adverse reactions.【总页数】4页(P437-440)

【作者】胡炜;杨枫;唐尤佳

【作者单位】九江市第一人民医院神经外科，江西九江 332000;九江市第一人民医院神经外科，江西九江 332000;九江市第一人民医院神经外科，江西九江332000

【正文语种】中文

【中图分类】R651.1

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