755nm翠绿宝石皮秒激光治疗太田痣-中英文

Treatment of Nevus of Ota With a Picosecond 755-nm Alexandrite Laser

755nm翠绿宝石皮秒激光治疗太田痣

Nevus of Ota, also known as nevus fusco-caeruleus ophthalmo-maxillaris, is a benign dermal melanocytic condition mostly seen as blue–gray patches on the faces of more darkly pigmented individuals, especially Asians, but it has been observed in all races.1

太田痣，也被称为眼上腭部褐青色痣，是一种存在于真皮层的良性色素斑块，多发于有色人种，在面部呈现蓝灰色斑块，特别多发于亚洲人种，但可发生于所有肤色人种。

Lesions of nevus of Ota have historically been a difficult problem to treat, but lasers have shown positive results. Through selective photothermolysis, the advent of Q-switched (QS) lasers with pulse durations as short as 10 nanoseconds (ns) allowed precise targeting of the melanosomes with reduced collateral damage.2,3 The 10-ns pulse duration of the QS lasers is much shorter than the 50- to 250-ns thermal relaxation times of the 500- to 1,000-nm diameter dermal melanosomes.4 However, many patients plateau

before their desired end point, and that end point requires a large number of treatments.4

太田痣一直以来被认为是很难治愈的疾病，但是激光治疗却显示除了积极的结果。通过选择性光热作用，脉宽可达10ns的Q开关激光的出现，可以更加精确的锁定黑色素细胞，降低对周围组织的损伤。10ns脉宽的Q开关激光相比于500-1000nm直径的黑色素细胞50-250ns的热弛豫时间来说更短，然而许多病人在达到他们期望的结果前就到了停滞期，然后如果想达到他们期待的结果则需要更多次的治疗。

Picosecond lasers were first shown to be effective in tattoo removal by Ross and colleagues5 in the 1990s.A commercially available and FDA-approved 755-nm alexandrite (Cynosure, Westford, MA) version became available in 2012 for treatment of tattoos but has not been reported for use with Nevus of Ota.

20世纪90年代Ross和同事们最早发现皮秒激光对祛除纹身有效，2012年赛诺秀开始销售经FDA认证的

755nm翠绿宝石激光，用于去除文身，但当时报告并没有说可以用于治疗太田痣。

Objective 目的

Because both tattoos and nevus of Ota share a pigmented chromophore in the dermis, the authors hypothesized that a picosecond 755-nm alexandrite laser might show improvement in nevus of Ota lesions that had plateaued or were otherwise minimally responsive to QS laser treatment, just as it had with recalcitrant tattoos.

由于纹身和太田痣都是存在于真皮层的色素团，像治疗顽固的纹身一样，作者假设755nm翠绿宝石皮秒激光可以改善经过Q开关治疗且已达停滞期的这些太田痣患者，或者对Q开关激光治疗不起作用的这些患者。The authors now report results of the novel use of a picosecond 755-nm alexandrite laser in 3 patients with nevus of Ota lesions recalcitrant to QS laser or no longer responding to treatment.

作者找到3位太田痣患者，这3位患者已经对Q开关激光治疗方法不再有效果，对他们进行755nm翠绿宝石皮秒激光进行治疗。

Materials and Methods 材料和方法

Over 12 months, 3 patients (2 female and 1 male; age,24, 32, 34 years) were selected from a university’s academic practice. All patients were of skin Type IV and had nevus of Ota lesions that had 4 to 10 or more previous QS laser treatments but did not respond or were no longer responding to such treatments.