脊柱骨质疏松压缩性骨折的手术治疗PPT课件
合集下载
相关主题
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
Therefore, fractures related to osteoporosis most commonly occur in areas rich in cancellous bone (ie, the vertebrae and wrist), and BMD measurements have focused on these critical anatomic sites
the above definition developed in Hong Kong in 1993
Pathophysiology of OP
Bone Remodeling • Imbalance of bone remodeling, • In pathologic situations, bone mass
menopause women begin a period of accelerated bone loss, averaging from 2%-5% per year over the next ten years.
Estrogen-Related Bone Loss
although high affinity estrogen receptors have been identified on both osteoclasts and osteoblasts.
bone mass
and this gives
decreased bone mas
Bone Loss: Cancellous vs. Cortical Bone
Although cancellous bone may account for less than 25% of the total bone mass in healthy adults, its surface area far exceeds that
Bone Loss: Cancellous vs.
Cortical Bone
During the accelerated period of bone loss occurring immediately post-menopause, cancellous bone loss is increased 3-fold, while rates of cortical bone loss are slower.
bone loss is equal increased number of
to bone formation remodeling sites
and the amount of increased porosity
bone tissue present of the bone, ie the
represents normal remodeling space,
Additionally, it is thought that estrogen deficiency is more directly associated with accelerated bone loss, but not age-related bone loss.
may be sacrificed to satisfy the body's intra- and extracellular calcium needs.
The Progression of Bone Remodeling
A specific quantity of bone is resorbed from the remodeling site and then a reversal occurs and the cavity is occupied by osteoblasts which refill that cavity with bone
Mechanisms of Bone Loss
An increased number of bone remodeling units can be activated which, when combined with either of the above two processes, may result in increased bone loss.
of cortical bone.
Bone Loss: Cancellous vs. Cortical Bone
Cancellous bone is more metabolically active than cortical bone.
If bone remodeling becomes uncoupled, with osteoclastic activity exceeding osteoblastic activity, the mass and structural integrity of cancellous bone is more severely affected than cortical bone.
SURGICAL TREATMENT OF SPINE
OSTEOPOROSIS
Concept of Osteoporosis
• A systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and a susceptibility to fracture."
high turnover with either incrቤተ መጻሕፍቲ ባይዱased formation or increased resorption or both
Patterns of Age-Related Bone
Loss
Gradual bone loss begins in both men and women between the age 30 and 40, paralleling an age-related decline in muscle mass.
the above definition developed in Hong Kong in 1993
Pathophysiology of OP
Bone Remodeling • Imbalance of bone remodeling, • In pathologic situations, bone mass
menopause women begin a period of accelerated bone loss, averaging from 2%-5% per year over the next ten years.
Estrogen-Related Bone Loss
although high affinity estrogen receptors have been identified on both osteoclasts and osteoblasts.
bone mass
and this gives
decreased bone mas
Bone Loss: Cancellous vs. Cortical Bone
Although cancellous bone may account for less than 25% of the total bone mass in healthy adults, its surface area far exceeds that
Bone Loss: Cancellous vs.
Cortical Bone
During the accelerated period of bone loss occurring immediately post-menopause, cancellous bone loss is increased 3-fold, while rates of cortical bone loss are slower.
bone loss is equal increased number of
to bone formation remodeling sites
and the amount of increased porosity
bone tissue present of the bone, ie the
represents normal remodeling space,
Additionally, it is thought that estrogen deficiency is more directly associated with accelerated bone loss, but not age-related bone loss.
may be sacrificed to satisfy the body's intra- and extracellular calcium needs.
The Progression of Bone Remodeling
A specific quantity of bone is resorbed from the remodeling site and then a reversal occurs and the cavity is occupied by osteoblasts which refill that cavity with bone
Mechanisms of Bone Loss
An increased number of bone remodeling units can be activated which, when combined with either of the above two processes, may result in increased bone loss.
of cortical bone.
Bone Loss: Cancellous vs. Cortical Bone
Cancellous bone is more metabolically active than cortical bone.
If bone remodeling becomes uncoupled, with osteoclastic activity exceeding osteoblastic activity, the mass and structural integrity of cancellous bone is more severely affected than cortical bone.
SURGICAL TREATMENT OF SPINE
OSTEOPOROSIS
Concept of Osteoporosis
• A systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and a susceptibility to fracture."
high turnover with either incrቤተ መጻሕፍቲ ባይዱased formation or increased resorption or both
Patterns of Age-Related Bone
Loss
Gradual bone loss begins in both men and women between the age 30 and 40, paralleling an age-related decline in muscle mass.