国外大学细胞生物学课件-英文1bioy

2
Why should we study cell biology?
• Provides insight into the mechanism of how cells work • We have to understand the details of a single cell in order to understand a complex, multi-cellular organism. • Fascinating Essential for the understanding of human diseases and their treatments.
9
Comparing the size of biological objects
Electron microscope
ቤተ መጻሕፍቲ ባይዱ
Light microscope
10
W2011 D103 Cell Biology - lecture 1 © Suetterlin and MacGregor - all rights reserved.
W2011 D103 Cell Biology - lecture 1 © Suetterlin and MacGregor - all rights reserved.
7
Limitation of microscopy
Rule of thumb for the resolving power of a microcsope: 1/2 wavelength Light microscope: Visible light serves as the source of illumination (wavelength of 700 to 400 nm) Light microscopy can resolve details that are at least 200 nm apart
1
VERTEBRATES ORGANS TISSUES CELLS Cells are the smallest subunit of every organism
W2011 D103 Cell Biology - lecture 1 © Suetterlin and MacGregor - all rights reserved.
Lecture 1 Introduction to Cell Biology
1. Why do we study cell biology? 2. What can we see by microscopy? 3. What are model organisms?
W2011 D103 Cell Biology - lecture 1 © Suetterlin and MacGregor - all rights reserved.
Cell Biology: Reveals size, shape and location of cellular components Provides insight into mechanism behind a process Biochemistry: Reveals molecular structure and chemistry of purified cell constituents Genetics: Reveals roles of healthy genes and the consequences of damaged genes
How can we see smaller structures???
W2011 D103 Cell Biology - lecture 1 © Suetterlin and MacGregor - all rights reserved.
8
Electron microscopy can resolve structures as small as 0.2 nm.
Developmental Biology: Reveals changes in cells as they specialize
W2011 D103 Cell Biology - lecture 1 © Suetterlin and MacGregor - all rights reserved.
W2011 D103 Cell Biology - lecture 1 © Suetterlin and MacGregor - all rights reserved.
3
“The key to every biological problem must be sought in the cell, for every organism is, or at sometime has been, a cell.”
Why? Electrons, which have a much shorter wavelength, serve as light source.
W2011 D103 Cell Biology - lecture 1 © Suetterlin and MacGregor - all rights reserved.
5
Comparing the size of biological objects
W2011 D103 Cell Biology - lecture 1 © Suetterlin and MacGregor - all rights reserved.
6
What can we see by light microscopy?
Edmund Beecher (EB) Wilson Cell Biologist, 1925
W2011 D103 Cell Biology - lecture 1 © Suetterlin and MacGregor - all rights reserved.
4
Approaches to understanding biology