瑞氏综合征
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Can potentially affects all organs of the body , can result in cerebral edema and the accumulation of fat in the liver and other organs.
第1页/共45页
His来自百度文库ory
When admitted, all but two of the 21 children were in a coma or stupor, although their illness had started out a few days or weeks earlier with only common childhood upper respiratory symptoms
Some children had even appeared to be recovering before the more serious phase of the illness began, with fever, relentless vomiting, convulsions, wild delirium, screaming, intense irritability, and violent movements.
In 1963, North Carolina doctor George Johnson reported an epidemic of 16 fatal cases of an encephalitis-like illness during an influenza B outbreak.
Reye syndrome , named after Australian pathologist R. Douglas Reye, who first reported it as a distinct syndrome in 1963.
第3页/共45页
George Johnson, Reye-Johnson
syndrome
In 1963,an epidemic of 16 fatal cases of an encephalitis-like disease occurring within a four-month period during an outbreak of influenza B in a small North Carolina community.
of the viscera of unknown cause
Each year between March 1951 and March 1962, the Royal Alexandra Hospital for Children in New South Wales, Australia, admitted one or two children in such a critical state that most of them could not be saved, despite the most advanced medical care.
The syndrome had been reported as early as 1929 but now was identified and characterized as a distinct entity.
第2页/共45页
Douglas Reye, fatty degeneration
Although children in this group were older than those studied by Reye, and their preceding illness was flu, it was subsequently theorized from Johnson's description of the symptoms and postmortem findings that several of the children who died may have also had the syndrome described by Reye.
They also noted that it followed chicken pox, with children aged 5 to 15 most often affected. Less often it was associated with other viruses and acute respiratory and diarrheal illnesses.
Seventeen of the children died within an average of 27 hours after admission.
At autopsy, all were found to have brain swelling, a slightly enlarged, firm and uniformly bright yellow liver, and a change in the appearance of the kidneys
Reye syndrome
a condition in which there is brain damage (encephalopathy) and liver damage of an unknown cause.
It is associated with the use of aspirin to treat chicken pox or influenza in children.
After the Reye-Johnson reports were published, numerous reports came in from the United States and other parts of the world showing
During the 1960s and 70s, scientists observed that the syndrome occurred in association with outbreaks of the flu, especially influenza B.
第1页/共45页
His来自百度文库ory
When admitted, all but two of the 21 children were in a coma or stupor, although their illness had started out a few days or weeks earlier with only common childhood upper respiratory symptoms
Some children had even appeared to be recovering before the more serious phase of the illness began, with fever, relentless vomiting, convulsions, wild delirium, screaming, intense irritability, and violent movements.
In 1963, North Carolina doctor George Johnson reported an epidemic of 16 fatal cases of an encephalitis-like illness during an influenza B outbreak.
Reye syndrome , named after Australian pathologist R. Douglas Reye, who first reported it as a distinct syndrome in 1963.
第3页/共45页
George Johnson, Reye-Johnson
syndrome
In 1963,an epidemic of 16 fatal cases of an encephalitis-like disease occurring within a four-month period during an outbreak of influenza B in a small North Carolina community.
of the viscera of unknown cause
Each year between March 1951 and March 1962, the Royal Alexandra Hospital for Children in New South Wales, Australia, admitted one or two children in such a critical state that most of them could not be saved, despite the most advanced medical care.
The syndrome had been reported as early as 1929 but now was identified and characterized as a distinct entity.
第2页/共45页
Douglas Reye, fatty degeneration
Although children in this group were older than those studied by Reye, and their preceding illness was flu, it was subsequently theorized from Johnson's description of the symptoms and postmortem findings that several of the children who died may have also had the syndrome described by Reye.
They also noted that it followed chicken pox, with children aged 5 to 15 most often affected. Less often it was associated with other viruses and acute respiratory and diarrheal illnesses.
Seventeen of the children died within an average of 27 hours after admission.
At autopsy, all were found to have brain swelling, a slightly enlarged, firm and uniformly bright yellow liver, and a change in the appearance of the kidneys
Reye syndrome
a condition in which there is brain damage (encephalopathy) and liver damage of an unknown cause.
It is associated with the use of aspirin to treat chicken pox or influenza in children.
After the Reye-Johnson reports were published, numerous reports came in from the United States and other parts of the world showing
During the 1960s and 70s, scientists observed that the syndrome occurred in association with outbreaks of the flu, especially influenza B.