孙自敏脐血造血干细胞移植上海脐血库
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China has almost 74,000 cord blood units frozen in 8 public cord blood banks for screening and use.
2015-11-29
上海脐血会 上海
7 http://www.bmdw.org/index.php?id=statistics_cordb7loo7d
MD Anderson Cancer Center;Case Western Reserve University; Stanford University
N=133
TRM 2015-11-29
OS
TRM
上海脐血会 上海 Haematologica. 2015 Oct;100(10):1361-70
14
2015-11-29
上海脐血会 上海
Better allele-level matching improves transplant-related mortality after double cord blood transplantation
MD Anderson Cancer Center;Case Western Reserve University; Stanford University
Before frozen Tubular recovery
The tubular recovery rate (%)
6/6Biblioteka Baidu
>2.5 >2.0 >1.2
>1.0 ≥80－85
3.0*
5/6
>3.5 >3.0 ≥1.5
>1.2 ≥80－85
4.0*
4/6
>4.0 >3.5 >1.8
>1.7 ≥80－85
5
5 55
220102510-581--45219/-1165-0/-225/9188
H造e血fe1i干上9th细海AP胞脐B移血MT植会C会o上n议gr海es苏s 州
6
6 66
BMDW：There are 600,000 cord blood units stored in public banks worldwide.
2
2021051-51-18--2299
造血干上细海胞脐H移血ef植会ei 会上议海苏州
33
220102510-581--5219-15--259
H造e血fei干上细海胞脐移血植会会上议海苏州
4
44
220102510-581--45219/-1165-0/-225/9188
H造e血fe1i干上9th细海AP胞脐B移血MT植会C会o上n议gr海es苏s 州
非血缘脐血移植中脐血的选择 及公共脐血库的建设
2015-11-29
孙自敏 安徽省立医院 安徽医科大学附属省立医院
上海脐血会 上海
提纲
UCBT治疗恶性血液病的现状 ； UCBT中脐血的选择； sUCBT治疗恶性血液病单中心结果； 公共脐血库提供的脐血临床移植情况。
2015-11-29
上海脐血会 上海
Mismatch at 1 or 2 alleles are well tolerated，mismatch at 5 alleles should
>3.5 >3.0 >2.0
>1.8
5.0*
* Europe Eurocord ；Choose high CFU or CFU - GM umbilical cord blood after
confirmation of TNC and CD34 cells.
2015-11-29
上海脐血会 上海
The problems to be aware of for cord blood selection
2015-11-29
tran上s海pla脐n血tat会ion上g海roup
HSCT in China
（2015年上半年68家移植中心共2288例）
2015-11-29
上海脐血会 上海
提纲
UCBT治疗恶性血液病的现状 ； UCBT中脐血的选择； sUCBT治疗恶性血液病单中心结果； 公共脐血库提供的脐血临床移植情况。
HLA、TNC、CD34+ and CFU； The status of NIMA in cord blood selection; The role of HLA-Cw mismatched in CBT; The influence of recipient HLA antibody; One-unit vs. two-unit Cord Blood;
AutoHSCT
HSCT in China
UPBST 20%
UCBT
14%
2%
36%
Sibling 28%
haplo-identical
64 hospitals N= 4418 /year（2014）
8 20T1h5e-8C-2h9inese Medical Association SocieHteyfeoi f Hematology, Hematopoietic stem cell8
N=133
TRM 2015-11-29
OS
PFS
上海脐血会 上海 Haematologica. 2015 Oct;100(10):1361-70
Better allele-level matching improves transplant-related mortality after double cord blood transplantation
2015-11-29
上海脐血会 上海
2
The choose of cord blood in China's UCBT cooperative group
HLA match
（donor-recipient）
TNC(107/Kg)
Before frozen
Tubular recovery
CD34(105/Kg)
The donor-recipient HLA matched in CB selection
1568 hematological malignancies patients receiving sUCBT were examined for the effect of allele-level matching at HLA-A、B、C、DRB1 on the outcome of transplantation；
2015-11-29
上海脐血会 上海
7 http://www.bmdw.org/index.php?id=statistics_cordb7loo7d
MD Anderson Cancer Center;Case Western Reserve University; Stanford University
N=133
TRM 2015-11-29
OS
TRM
上海脐血会 上海 Haematologica. 2015 Oct;100(10):1361-70
14
2015-11-29
上海脐血会 上海
Better allele-level matching improves transplant-related mortality after double cord blood transplantation
MD Anderson Cancer Center;Case Western Reserve University; Stanford University
Before frozen Tubular recovery
The tubular recovery rate (%)
6/6Biblioteka Baidu
>2.5 >2.0 >1.2
>1.0 ≥80－85
3.0*
5/6
>3.5 >3.0 ≥1.5
>1.2 ≥80－85
4.0*
4/6
>4.0 >3.5 >1.8
>1.7 ≥80－85
5
5 55
220102510-581--45219/-1165-0/-225/9188
H造e血fe1i干上9th细海AP胞脐B移血MT植会C会o上n议gr海es苏s 州
6
6 66
BMDW：There are 600,000 cord blood units stored in public banks worldwide.
2
2021051-51-18--2299
造血干上细海胞脐H移血ef植会ei 会上议海苏州
33
220102510-581--5219-15--259
H造e血fei干上细海胞脐移血植会会上议海苏州
4
44
220102510-581--45219/-1165-0/-225/9188
H造e血fe1i干上9th细海AP胞脐B移血MT植会C会o上n议gr海es苏s 州
非血缘脐血移植中脐血的选择 及公共脐血库的建设
2015-11-29
孙自敏 安徽省立医院 安徽医科大学附属省立医院
上海脐血会 上海
提纲
UCBT治疗恶性血液病的现状 ； UCBT中脐血的选择； sUCBT治疗恶性血液病单中心结果； 公共脐血库提供的脐血临床移植情况。
2015-11-29
上海脐血会 上海
Mismatch at 1 or 2 alleles are well tolerated，mismatch at 5 alleles should
>3.5 >3.0 >2.0
>1.8
5.0*
* Europe Eurocord ；Choose high CFU or CFU - GM umbilical cord blood after
confirmation of TNC and CD34 cells.
2015-11-29
上海脐血会 上海
The problems to be aware of for cord blood selection
2015-11-29
tran上s海pla脐n血tat会ion上g海roup
HSCT in China
（2015年上半年68家移植中心共2288例）
2015-11-29
上海脐血会 上海
提纲
UCBT治疗恶性血液病的现状 ； UCBT中脐血的选择； sUCBT治疗恶性血液病单中心结果； 公共脐血库提供的脐血临床移植情况。
HLA、TNC、CD34+ and CFU； The status of NIMA in cord blood selection; The role of HLA-Cw mismatched in CBT; The influence of recipient HLA antibody; One-unit vs. two-unit Cord Blood;
AutoHSCT
HSCT in China
UPBST 20%
UCBT
14%
2%
36%
Sibling 28%
haplo-identical
64 hospitals N= 4418 /year（2014）
8 20T1h5e-8C-2h9inese Medical Association SocieHteyfeoi f Hematology, Hematopoietic stem cell8
N=133
TRM 2015-11-29
OS
PFS
上海脐血会 上海 Haematologica. 2015 Oct;100(10):1361-70
Better allele-level matching improves transplant-related mortality after double cord blood transplantation
2015-11-29
上海脐血会 上海
2
The choose of cord blood in China's UCBT cooperative group
HLA match
（donor-recipient）
TNC(107/Kg)
Before frozen
Tubular recovery
CD34(105/Kg)
The donor-recipient HLA matched in CB selection
1568 hematological malignancies patients receiving sUCBT were examined for the effect of allele-level matching at HLA-A、B、C、DRB1 on the outcome of transplantation；