谷氨酸受体的稳态调节详解

D-APV
GYKI
1、KAR activity is upregulated by homeostatic mechanism CNQX2、Stg induce KAR activity share the same mechanism with
TTX-induced homeostatic plasticity
1、Whether the presence or absence of Gluk2 affect
the number of KAR? 2、What will hapeen if the NMDAR was not blocked? 3、Homeostatic mechanism? Decay kinetic? 4、Is there any same mechanism in other synaptic?
Thanks
1、There is X-EPSP in the synaptic despite NMDAR/AMPAR-EPSP
2、The X-EPSC is sufficient for spike generation
EPSC
100 sin3g、le- X maybe KAR
4、Stg mice shwaesepns o synaptic develpoment changes
MF-CA3
Step 6 So it is the channel property?
Piezo-electric device Outside-out patches
Gluk5 modulate both the agonist affinity and the decay kinetics of KAR
Step 2
Is the X KAR?
1、X is KAR 2、Gluk2 play a important role in the survival of Stg mouse
Step 3 When will KAR activity be upregulated? Compensatory or Homeostatic regulation?
Step 4 What mediate the KAR activity?
Increased expression of Gluk5 is the mechanism
Step 4
What will happen if there is no Gluk5?
1、The Gluk5 KAR subnit is required for upregulated KAR activity 2、Gluk5 play a important role in the survival of Stg mouse
Step 5 How Gluk5 affect the KARactivity? KARchannel properties or the number?
MF-GC
The number and localization of the KAR complex isnot affected by the presence or absence of Gluk5
Homeostatic Control of Synaptic Transmission by Distinct Glutamate Receptors
Structure of Glutamate synaptic
Structure of Kainate receptຫໍສະໝຸດ Baidur
Step 1 KAR Activity Is Upregulated in the Absence of AMPAR Activity