谷氨酸受体iGluR_抑制剂_激动剂

iGluR

Ionotropic glutamate receptors

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel

that is activated by the neurotransmitter glutamate. iGluR are integral

membrane proteins compose of four large subunits that form a

central ion channel pore. Sequence similarity among all known

glutamate receptor subunits, including the AMPA, kainate, NMDA,

and δ receptors.

AMPA receptors are the main charge carriers during basal

transmission, permitting influx of sodium ions to depolarise the

postsynaptic membrane. NMDA receptors are blocked by magnesium

ions and therefore only permit ion flux following prior depolarisation.

This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR Inhibitors & Modulators

(S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.(S)-(-)-5-Fluorowillardiine Hcl is a potent and specific AMPAR agonist (S)-Willardiine is a potent agonist of AMPA/kainate receptors with24-Hydroxycholesterol is a natural sterol, which serves as a positive

,

N-Methyl-d-Aspartate (NMDA) receptorsR

modulator7-Chlorokynurenic acid is a selective antagonist at the glycine

complex

into

reuptake of glutamate

7-Chlorokynurenic acid sodium salt is a selective antagonist at the

N-methyl-D-aspartate receptor

reuptake of glutamate antagonist and an

Cat. No.: HY-16713Cat. No.: HY-16713A Cat. No.: HY-12499Cat. No.: HY-N2370 Cat. No.: HY-B2121Cat. No.: HY-100811 Cat. No.: HY-100811A Cat. No.: HY-15073

CFM-2 is a selective non-competitive AMPAR antagonist.

CIQ is a subunit-selective potentiator of NMDA receptors containing CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor.

receptor antagonist.

ion-channel antagonist receptor/ion channel site to produce a Coluracetam(MKC-231) is a new choline uptake enhancer

CX546 is a selective positive AMPAR modulator; the prototypical

Cat. No.: HY-102053

Cat. No.: HY-12503

Cat. No.: HY-18699

Cat. No.: HY-12508

Cat. No.: HY-15066

Cat. No.: HY-101809

Cat. No.: HY-17553

Cat. No.: HY-12505

Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to . Dynorphin A (1-10) of 42.0 μM.

Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptor positive Felbamate (FBM) is a potent nonsedative anticonvulsant whose Felbamate hydrate (FBM) is a potent nonsedative anticonvulsant Flupirtine(D 9998) is a selective neuronal potassium channel opener Flupirtine Maleate(D 9998) is a selective neuronal potassium channel

opener that also has NMDA receptor antagonist properties

Cat. No.: HY-P1594

Cat. No.: HY-12881

Cat. No.: HY-10937

Cat. No.: HY-B0184

Cat. No.: HY-B0184A

Cat. No.: HY-17001A

Cat. No.: HY-17001

Cat. No.: HY-100785