宫颈癌三维后装治疗与传统二维后装治疗剂量学参数的对比研究

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Clinical Journal of Chinese Medicine 2018 V ol.(10) No.22 -128-

宫颈癌三维后装治疗与传统二维后装治疗剂量学参数的对比研究

A comparative study on dose parameters of treating cervical cancer by three-dimensional afterloading therapy and traditional two-dimensional afterloading therapy

韩秀丽

(山东省单县中医院,山东菏泽,274300)

中图分类号:R271.1文献标识码:A文章编号:1674-7860(2018)22-0128-

【摘要】目的:探讨宫颈癌三维后装治疗与传统二维后装治疗剂量学参数的对比。方法:随机抽取2015年3月-2017年3月40例行宫颈癌放疗治疗患者,使用后装治疗计划系统进行计划设计,观察患者在三维后装治疗下与传统二维后装治疗下的靶区覆盖指数、危及器官体积指数与靶区适形指数。结果:两组患者的靶区覆盖指数无显著变化,且三维后装治疗与传统二维后装治疗的2次计划与1次计划的靶区剂量与危及器官剂量无显著变化,不具有统计学意义(P>0.05);三维后装的靶区适形指数明显优于二维后装,二维后装的膀胱、直肠体积指数明显高于三维后装,二者差异具有统计学意义(P<0.05)。结论:运用三维后装治疗宫颈癌能够对患者的膀胱与直肠形成更好的保护,但二者在靶区剂量与对危及器官的保护方面不存在显著变化。

【关键词】三维后装治疗;二维后装治疗;宫颈癌;剂量学参数

【Abstract】Objective: To compare the dose parameters between three-dimensional afterloading therapy and traditional two-dimensional afterloading therapy on treating cervical cancer. Methods: 40 cases were randomly selected and given afterloading therapy plan system. The target coverage index, the organ volume index and the target-conformal index between three-dimensional afterloading therapy and traditional two-dimensional afterloading therapy were observed. Results: There was no significant change of the target coverage index, the target dose and the dose of the risk organs between the two times plan in groups (P>0.05). The target-conformal index of three-dimensional afterloading therapy was significantly better than the traditional two-dimensional afterloading therapy. The rectal volume index of traditional two-dimensional afterloading therapy was significantly higher than the three-dimensional afterloading therapy; and the difference was statistically significant (P<0.05). Conclusion: The three-dimensional afterloading in treating cervical cancer can form a better protection for bladder and rectum. There was no significant difference of target dose and the protection of the organs in groups.

【Keywords】Three-dimensional afterloading therapy; Traditional two-dimensional afterloading therapy; Cervical cancer; Dose parameters

doi:10.3969/j.issn.1674-7860.2018.22.059

将体外照射与腔内照射联合使用可有效提升宫颈癌的照射剂量,同时能在较大程度上避免其周围组织受到损伤,有效治疗宫颈癌,尤其是使用后装治疗,更将获得良好的效果。伴随着医疗技术的不断进步,目前临床中多使用CT、MRI等技术进行扫描成像,并将其引入到腔内后装治疗中[1]。本文将重点探讨宫颈癌三维后装治疗与传统二维后装治疗剂量学参数的对比。

1资料与方法

1.1 一般资料

随机抽取2015年3月-2017年3月40例行宫颈癌放疗治疗患者,年龄为45~67岁,平均年龄为(52.1±5.3)岁,所有患者均为鳞状细胞癌类型,其中共有27例患者处于IIB 期,13例患者处于IIIB期。

1.2 方法

使用三维适形强调放疗对所有的患者进行体外照射,每次1.8Gy,进行6周照射,共28次,总剂量为50.4Gy;在体外照射4周并转入后装治疗前使用MRI对患者的喷枪进行扫描并获得相应的扫描图像。在患者的宫腔与阴道内放置CT下专用施源器,以此对患者的靶区参数进行检测。对患者进行CT扫描,图像层厚设定为3mm,随后将扫描成像置入三维后装系统中,对肿瘤靶区、直肠、膀胱进行勾画,以使医生能够看见整个病灶区。在阴道穹窿上、旁开2cm作为A点,利用二维计划进行剂量测量。医生在三维后装治疗系统下分

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