抗生素英文课件精品—— Anti-bacteria Medicine

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Patients with pneumonia and bacteria in blood
Penicillin
Obehandlade
Dagar
“It is not difficult to make microbes resistant to penicillin… “
“The time may come when penicillin can be bought by anyone in the shops “
Biblioteka Baidu
Antibiotics and drugs targeting nucleic acid biosynthesis and functions
3. Rifampicin (from rifamycin) subunit of DNA-primed RNA polymease
Antibiotics and drugs targeting nucleic acid biosynthesis and functions
Antibiotics and drugs targeting nucleic acid biosynthesis and functions
2. Quinolones
Nalidixic acid Ofloxacin Ciprofloxacin
Bacterial topoisomerase II- Gyrase
Bacterial Resistance to Antibiotics
• Enzymes secreted (exo-enzyme) • Enzymes not secreted (endo-enzymes) • Deletion of target molecules • Change in cell permeability • Change in target molecule affinity • Speed-up of synthesis and metabolism • Others
Antibiotic prescription for non-bacterial infection
Prophylaxis application of antibiotics Local application of antibiotics Over use of wide-spectrum antibiotics Long-term use of antibiotics Antibiotic abuse in agriculture
Selection of a potential product
1、efficacy 2、metabolic characterization 3、toxicity and adverse effect 4、Potentiality of industrial production
Antibiotics: from strain isolation to clinical application
Semi-synthesis: the most popular approach of production
Marketing potentiality Life-span of marketing and its
impact
Penicillin increased the chance of survival from 10% to 90%
production
Modern Medicine Is Not Possible Without Effective Antibiotics
Hip replacement Organ transplants Cancer chemotherapy
Care of preterm babies
The survival of the fittest
! Rifampicin must be given by a “cocktail” of drugs.
Problem of antibiotics which inhibit
protein synthesis
Antibiotics: From isolation of strain to clinical application
Antibiotics and drugs targeting nucleic acid biosynthesis and functions
1. Sulphonamides & Trimethoprim (TMP) PABA false structure
Inhibition of Dihydrofolate reductase Dihydrofolate tetrahydrofolate
抗生素英文课件精品—— Anti-bacteria Medicine
Antibacteria medicine
Sulfonamide Quilonones others
Antibiotics and drugs targeting nucleic acid biosynthesis and functions
Alexander Fleming's Nobel Lecture, 1945
The Global Challenge
Antibiotics have saved millions of lives Antibiotics are rapidly losing their effect
What is Antibiotic Resistance?
Mechanism of resistance
Selection pressure ( not only in health institutions)
Genetic recombination ( especially conjugation mediated by plasmid)
Improper prescription of antibiotics