IBS抗生素治疗的争议(英文PPT)Probiotics and IBS
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Rettger – 1930’s – early clinical application of Lactobacillus
Parker – 1974 – 1st to use the term probiotics Fuller – 1989 – defined probiotics
Probiotics
Tropபைடு நூலகம்ic effect on intestinal epithelium Maintains the enterohepatic circulation of bile acids Involved in metabolic processes (i.e., fermentation) in
Prebiotics, Probiotics, & Antibiotics: Controversies in the Treatment of IBS
Brian E. Lacy, Ph.D., M.D. Associate Professor of Medicine
Dartmouth Medical School Director, GI Motility Laboratory Dartmouth-Hitchcock Medical Center
Lactobacilli – anerobic, gram (+) rods
casei plantarum acidophilus reuteri
Bifidobacteria – anerobic, gram (+) rods VSL #3 (8 separate organisms: 3 Bifidobacteria, 1
the colon
Intestinal Microflora: Location & Prevalence
Rare in the esophagus Uncommon in the stomach
Goals
Define commonly used terms Review the microecology of the intestinal tract Discuss the mechanism of action of probiotics Review the available literature on probiotics and
Probiotics
Non-pathogenic live microbial food supplements
Organisms that, when administered in adequate amounts, exert a positive influence on the health of the host animal
Intestinal Microecology
GI Secretions
Intestinal Microflora
Gut Wall
Foods that enter the GI Tract
Intestinal Flora: A symbiotic relationship with the host
IBS Assess the role of antibiotics in the treatment of
IBS
Prebiotics
Fructooligosaccharide (aka oligofructose) Isomaltooligosaccharide Xylooligosaccharide Inulin Fiber Oligomate Palatinose Pyrodextrin Raftiline
Metchnikoff – 1907 – ingesting yogurt with Lactobacilli reduces toxic bacteria of the gut and prolongs life
Kipeloff – 1926 – stressed importance of Lactobacillus acidophilus for good health
Live organisms that benefit the host animal by improving intestinal microbial balance
Usually administered in yogurt or capsules
A Brief History of Probiotics
Human GI tract contains 10x more bacteria (1014) than eukaryotic cells in the body
Protects the host
Stimulates immune function Produces antimicrobial substances
Disclosure
Investigator Initiated Research Support: AstraZeneca, GlaxoSmithKline, Medtronics, Novartis, Prometheus
Speaker’s Bureau: Novartis, Takeda
Streptococcus, 4 Lactobacilli) Enterococcus Streptococcus salivarius Saccharomyces
How is normal mucosal immune function maintained?
GI secretions (saliva, acid, bile) Mucus Normal peristalsis (presence of MMC) Barrier function (tight junctions) Intestinal proteolysis Intestinal immune cells IgA production and secretion
Parker – 1974 – 1st to use the term probiotics Fuller – 1989 – defined probiotics
Probiotics
Tropபைடு நூலகம்ic effect on intestinal epithelium Maintains the enterohepatic circulation of bile acids Involved in metabolic processes (i.e., fermentation) in
Prebiotics, Probiotics, & Antibiotics: Controversies in the Treatment of IBS
Brian E. Lacy, Ph.D., M.D. Associate Professor of Medicine
Dartmouth Medical School Director, GI Motility Laboratory Dartmouth-Hitchcock Medical Center
Lactobacilli – anerobic, gram (+) rods
casei plantarum acidophilus reuteri
Bifidobacteria – anerobic, gram (+) rods VSL #3 (8 separate organisms: 3 Bifidobacteria, 1
the colon
Intestinal Microflora: Location & Prevalence
Rare in the esophagus Uncommon in the stomach
Goals
Define commonly used terms Review the microecology of the intestinal tract Discuss the mechanism of action of probiotics Review the available literature on probiotics and
Probiotics
Non-pathogenic live microbial food supplements
Organisms that, when administered in adequate amounts, exert a positive influence on the health of the host animal
Intestinal Microecology
GI Secretions
Intestinal Microflora
Gut Wall
Foods that enter the GI Tract
Intestinal Flora: A symbiotic relationship with the host
IBS Assess the role of antibiotics in the treatment of
IBS
Prebiotics
Fructooligosaccharide (aka oligofructose) Isomaltooligosaccharide Xylooligosaccharide Inulin Fiber Oligomate Palatinose Pyrodextrin Raftiline
Metchnikoff – 1907 – ingesting yogurt with Lactobacilli reduces toxic bacteria of the gut and prolongs life
Kipeloff – 1926 – stressed importance of Lactobacillus acidophilus for good health
Live organisms that benefit the host animal by improving intestinal microbial balance
Usually administered in yogurt or capsules
A Brief History of Probiotics
Human GI tract contains 10x more bacteria (1014) than eukaryotic cells in the body
Protects the host
Stimulates immune function Produces antimicrobial substances
Disclosure
Investigator Initiated Research Support: AstraZeneca, GlaxoSmithKline, Medtronics, Novartis, Prometheus
Speaker’s Bureau: Novartis, Takeda
Streptococcus, 4 Lactobacilli) Enterococcus Streptococcus salivarius Saccharomyces
How is normal mucosal immune function maintained?
GI secretions (saliva, acid, bile) Mucus Normal peristalsis (presence of MMC) Barrier function (tight junctions) Intestinal proteolysis Intestinal immune cells IgA production and secretion