A Simple Baryon Triality Model for Neutrino Masses

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运用图尔敏模型的英语作文

运用图尔敏模型的英语作文

运用图尔敏模型的英语作文The Toulmin Model: A Versatile Approach to Effective ArgumentationThe Toulmin Model, developed by British philosopher Stephen Toulmin, is a widely recognized framework for constructing and analyzing arguments. This model provides a structured approach to developing and presenting persuasive arguments, making it a valuable tool for writers, students, and professionals across various fields.At its core, the Toulmin Model consists of six key elements: claim, data, warrant, backing, qualifier, and rebuttal. The claim is the central assertion or conclusion that the argument aims to support. The data is the evidence or facts that are used to support the claim. The warrant is the logical reasoning that connects the data to the claim, explaining why the data is relevant and sufficient. The backing provides additional support or justification for the warrant, strengthening the overall argument. The qualifier acknowledges the limitations or exceptions to the claim, while the rebuttal anticipates and addresses potential counterarguments.By incorporating these elements, the Toulmin Model encourageswriters to carefully consider the structure and logic of their arguments, ensuring that they are well-reasoned, comprehensive, and persuasive.One of the key advantages of the Toulmin Model is its versatility. It can be applied to a wide range of argumentative contexts, from academic essays and research papers to business proposals and public speeches. Regardless of the specific topic or setting, the Toulmin Model provides a consistent framework for organizing and presenting arguments in a clear and effective manner.In the academic context, the Toulmin Model is particularly useful for crafting persuasive research papers and essays. By following this model, students can develop a strong, well-supported thesis statement, and then use the remaining elements to build a comprehensive and logical argument. This approach not only helps students to organize their thoughts and ideas but also ensures that their writing is coherent, compelling, and responsive to potential counterarguments.Moreover, the Toulmin Model can be applied to various disciplines, from the humanities and social sciences to the natural and applied sciences. For instance, in a scientific research paper, the claim might be a hypothesis or a proposed solution to a problem, the data could be the experimental results or observations, and the warrant mightbe the underlying scientific principles or theories that explain the relationship between the data and the claim.In the business world, the Toulmin Model can be a valuable tool for crafting effective presentations, proposals, and negotiations. By clearly articulating the claim, supporting it with relevant data and warrants, and anticipating potential objections or concerns, business professionals can enhance the persuasiveness and credibility of their arguments.Beyond the academic and professional realms, the Toulmin Model can also be applied to everyday argumentative situations, such as discussions with friends, family, or colleagues. By understanding and applying the principles of the Toulmin Model, individuals can improve their ability to communicate their ideas effectively, engage in constructive dialogue, and reach mutually satisfactory resolutions.In conclusion, the Toulmin Model is a powerful and versatile framework for developing and presenting persuasive arguments. By incorporating the key elements of claim, data, warrant, backing, qualifier, and rebuttal, writers, speakers, and thinkers can craft arguments that are well-reasoned, comprehensive, and responsive to diverse perspectives. Whether in academic, professional, or personal contexts, the Toulmin Model offers a structured approach toeffective argumentation, empowering individuals to communicate their ideas with clarity, coherence, and conviction.。

了不起的大脑器官 英文作文

了不起的大脑器官 英文作文

了不起的大脑器官英文作文The Remarkable Organ of the BrainThe human brain is an extraordinary and complex organ that has long captivated the curiosity and fascination of scientists, philosophers, and thinkers throughout history. As the central control center of the body, the brain is responsible for a myriad of functions, from regulating our basic bodily processes to enabling our higher cognitive abilities and shaping our unique personalities.At its core, the brain is a remarkable biological machine, composed of billions of interconnected neurons that work together in intricate ways to process information, store memories, and generate the thoughts, emotions, and behaviors that define the human experience. The brain's remarkable plasticity and adaptability allow it to constantly evolve and change in response to our lived experiences, a phenomenon known as neuroplasticity.One of the most remarkable aspects of the brain is its unparalleled complexity. Weighing in at just three pounds on average, the human brain contains an estimated 86 billion neurons, each of which can form thousands of connections with other neurons. This vast,interconnected network of cells gives rise to the brain's extraordinary computational power, enabling it to perform a dizzying array of tasks with seemingly effortless ease.The brain's primary regions, including the cerebrum, cerebellum, and brainstem, each play a crucial role in our overall functioning. The cerebrum, for instance, is responsible for higher-order cognitive functions, such as language, reasoning, and decision-making, while the cerebellum is primarily involved in coordinating movement and maintaining balance. The brainstem, on the other hand, regulates essential involuntary functions like breathing, heart rate, and sleep-wake cycles.Moreover, the brain's remarkable plasticity allows it to adapt and change in response to our experiences and environment. Throughout our lives, the brain is constantly rewiring its neural connections, a process known as neuroplasticity, which enables us to learn new skills, form new memories, and even recover from brain injuries or neurological disorders.One of the most fascinating aspects of the brain's plasticity is its ability to compensate for damage or dysfunction in certain regions. When one part of the brain is impaired, such as in the case of a stroke or traumatic brain injury, other areas of the brain can often take on new roles and responsibilities, allowing the individual toregain lost functions or develop new coping strategies.This remarkable adaptive capacity is also evident in the brain's remarkable resilience, as it is able to withstand a significant amount of damage and still maintain its core functions. The brain's intricate system of blood vessels, for instance, provides a redundant supply of oxygen and nutrients, ensuring that even if one area is deprived, the brain can still continue to function.Furthermore, the brain's remarkable complexity is mirrored in its incredible energy efficiency. Despite its relatively small size, the brain consumes a disproportionately large amount of the body's energy resources, accounting for approximately 20% of the body's total energy expenditure. This efficiency is largely due to the brain's highly specialized neural networks, which are able to communicate and process information with remarkable speed and precision.In recent years, advances in neuroimaging techniques, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), have provided unprecedented insights into the brain's inner workings, revealing the intricate patterns of neural activity that underlie our thoughts, emotions, and behaviors. These technologies have also helped researchers better understand the brain's role in various neurological and psychiatric disorders, paving the way for more targeted and effective treatments.Despite our growing understanding of the brain, however, many of its most fundamental mysteries remain elusive. How does the brain generate consciousness? How do we form memories and retrieve them? What is the neural basis of our emotions and personality? These questions and many others continue to captivate the curiosity of scientists and thinkers around the world, driving ongoing research and exploration into this remarkable organ.As we continue to unravel the secrets of the brain, it is clear that this remarkable organ is not only the foundation of our cognitive and emotional experiences, but also a testament to the incredible complexity and adaptability of the natural world. By continuing to study and understand the brain, we may unlock new insights that could greatly improve our lives and the lives of those affected by neurological and psychiatric disorders. The brain, truly, is an extraordinary and remarkable organ that deserves our ongoing fascination and scientific pursuit.。

Neuroplasticity Changing the Brain

Neuroplasticity Changing the Brain

Neuroplasticity Changing the BrainNeuroplasticity, the ability of the brain to change and reorganize itself, is a fascinating and complex phenomenon that has captured the interest of scientists, researchers, and the general public alike. This incredible capacity of the brain to adapt and rewire itself in response to new experiences, learning, and injury has profound implications for our understanding of human cognition, behavior, and potential for recovery from neurological disorders. In this response, we will explore the concept of neuroplasticity from multiple perspectives, including its scientific basis, its implications for learning and rehabilitation, and the ethical considerations surrounding its potential applications.From a scientific standpoint, neuroplasticity is a fundamental property of the brain that underlies our ability to learn, adapt, and recover from injury. The brain is composed of billions of neurons that communicate with each other through complex networks of connections called synapses. These connections are not fixed, but rather are constantly changing in response to our experiences and activities. When we learn a new skill or acquire new knowledge, the connections between neurons are strengthened, leading to the formation of new neural pathways. Conversely, when a part of the brain is damaged, the surrounding neurons can reorganize themselves to compensate for the lost function, a process known as functional reorganization. This remarkable ability of the brain to adapt and rewire itself is the basis of neuroplasticity, and it has far-reaching implications for our understanding of human cognition and behavior.One of the most exciting implications of neuroplasticity is its potential for enhancing learning and rehabilitation. By understanding the mechanisms underlying neuroplasticity, researchers and educators can develop new strategies to optimize learning and memory, and to facilitate recovery from neurological disorders. For example, studies have shown that engaging in challenging and novel activities can promote the growth of new neurons and the formation of new synaptic connections, a process known as neurogenesis. This suggests that engaging in lifelong learning and intellectual stimulation can help to maintain and enhance cognitive function as we age. Furthermore, understanding the principles of neuroplasticity has led to the development of new rehabilitation techniques for individualsrecovering from stroke, traumatic brain injury, and other neurological conditions. For instance, constraint-induced movement therapy, which involves intensive practice of the affected limb while restraining the unaffected limb, has been shown to promote functional reorganization of the brain and improve motor function in stroke survivors. These findings highlight the potential of neuroplasticity to revolutionize our approach to education and rehabilitation, and to improve the quality of life for individuals with neurological impairments.While the potential of neuroplasticity to enhance learning and rehabilitation is certainly exciting, it also raises important ethical considerations. For example, the concept of neuroplasticity challenges traditional notions of fixed intelligence and innate talent, suggesting that our cognitive abilities are not predetermined, but rather can be shaped and improved through effort and experience. This has profound implications for education, as it suggests that all individuals have the potential to learn and excel, given the right opportunities and support. However, it also raises questions about the role of genetics and environmental factors in shaping cognitive abilities, and the potential for neuroplasticity to exacerbate existing inequalities in education and opportunity. Furthermore, the use of neuroplasticity-based interventions in rehabilitation raises ethical questions about the allocation of resources and the potential for unintended consequences. For example, if neuroplasticity-based therapies become widely available, will they be equally accessible to all individuals, or will they only be accessible to those who can afford them? These ethical considerations highlight the need for careful reflection and consideration of the societal implications of neuroplasticity research and its applications.In conclusion, neuroplasticity is a remarkable and complex phenomenon that has profound implications for our understanding of the brain, learning, and rehabilitation. From a scientific standpoint, neuroplasticity is a fundamental property of the brain that underlies our ability to learn, adapt, and recover from injury. Its potential to enhance learning and rehabilitation is exciting, but it also raises important ethical considerations about the role of genetics, environmental factors, and access to resources. As we continue to unravel the mysteries of neuroplasticity, it is essential that we approach this research with a thoughtfuland ethical mindset, considering the potential benefits and risks of its applications for individuals and society as a whole.。

2006考研模拟英语

2006考研模拟英语

SectionⅠUse of EnglishDirections:Read the following text.Choose the best word(s)for each numbered blank and mark A,B,C or D on ANSWER SHEET 1.(10 points)In the past few decades,remarkable findings have been made in ethology,the study of animal social behavior. Earlier scientists had 1 that nonhuman social life was almost totally instinctive or fixed by genetics. Much more careful observation has shown that 2 variation occurs among the social ties of most species,showing that learning is a part of social life. That is,the 3 are not solely fixed by the genes.4,the learning that occurs is often at an early age in a process that is called imprinting. Imprinting is clearly 5 instinctive,but it is not quite like the learning of humans;it is something in between the two. An illustration best 6 the nature of imprinting. Once,biologists thought that ducklings followed the mother duck because of instincts. Now we know that,shortly 7 they hatch,ducklings fix 8 any object about the size of a duck and will hen ceforth follow it. So ducklings may follow a basketball or a briefcase if these are 9 for the mother duck at the time when imprinting occurs. Thus,social ties can be considerably 10,even ones that have a considerable base 11 by genetics.Even among the social insects something like imprinting 12 influence social behavior. For example,biologists once thought bees communicated with others purely 13 instinct. But,in examining a“dance”that bees do to indicate the distance and direction of a pollen source,observers found that bees raised in isolation could not communicate effectively. At a higher level,the genetic base seems to be much more for an all purpose learning rather than the more specific responses of imprinting. Chimpanzees,for instance,generally 14 very good mother but Jane Goodall reports that some chimps carry the infant upside down or 15 fail to nurture the young. She believes that these females were the youngest or the 16 child of a mother. In such circumstances,they did not have the opportunity to observe how their own mother 17 for her young. Certainly adolescent chimps who are still with their mothers when other young are born take much interest in the rearing of their young brother or sister. They have an excellent opportunity to learn,and the social ties that are created between mother and young 18 Goodall to describe the social unit as a family. The mother offspring tie is beyond 19;there is some evidence to 20 that ties also continue between siblings of the same sex,that is“brother brother”and“sister sister”。

A paraxial schematic eye model for the growing C57BL6 mouse

A paraxial schematic eye model for the growing C57BL6 mouse

A paraxial schematic eye model for the growing C57BL/6mouseChristine Schmucker,Frank Schaeffel*Section of Neurobiology of the Eye,University Eye Hospital,Calwerstr.7/1,72076Tuebingen,GermanyReceived 19November 2003;received in revised form 12March 2004AbstractPurpose .The mouse eye has potential to become an important model for studies on the genetic control of eye growth and myopia.However,no data are published on the development of its optical properties.We developed a paraxial schematic model of the growing eye for the most common laboratory mouse strain,the C57BL/6mouse,for the age range between 22and 100days.Methods .Refractive development was followed with eccentric infrared photorefraction and corneal curvature with infrared photokeratometry.To measure ocular dimensions,freshly excised eyes were immediately frozen after enucleation to minimize distortions.Eyes were cut with a cryostat down to the bisecting horizontal plane,until the optic nerve head became visible.The standard deviations were ±10l m for repeated measurements in highly magnified videographs,taken in several section planes close to the equator in the same eyes.To evaluate inter-eye and inter-individual variability,a total of 20mice (34eyes)were studied,with 3–4eyes for each of the 9sampling ages.Schematic eye models were developed using paraxial ray tracing software (OSLO,LT Lambda Research Corporation,and a self-written program).Results .The measured refractive errors were initially +4.0±0.6D at approximately 30days,and levelled offwith +7.0±2.5D at about 70days.Corneal radius of curvature did not change with age (1.414±0.019mm).Both axial lens diameter and axial eye length grew linearly (regression equations:lens,1619l m +5.5l m/day,R ¼0:916;axial length,2899l m +4.4l m/day,R ¼0:936).The lens grew so fast that vitreous chamber depth declined with age (regression equation:896l m )3.2l m/day,R ¼0:685).The radii of curvature of the anterior lens surface increased during development (from 0.982mm at day 22to 1.208mm at day 100),whereas the radii of the posterior lens surface remained constant ()1.081±0.054mm).The calculated homogeneous lens index increased linearly with age (from 1.568to 1.605).The small eye artifact,calculated from the dioptric difference of the positions of the vitreo-retinal interface and the photoreceptor plane,increased from +35.2to +39.1D,which was much higher than the hyperopia measured with photorefraction.Retinal image magnification increased from 31to 34l m/deg,and the f /number remained 61at all ages,suggesting a bright retinal image.A calculated axial eye elongation of 5.4–6.5l m was sufficient to make the schematic eye 1D more myopic.Conclusions .The most striking features of the mouse eye were that linear growth was slow but extended far beyond sexual maturity,that the corneal curvature did not increase,and that the prominent lens growth caused a developmental decline of the vitreous chamber depth.Ó2004Elsevier Ltd.All rights reserved.1.IntroductionMyopia is one of the most common ocular disorders in humans.Its incidence is approximately 25%of most Western populations and reaches more than 80%in Asian school children (Rajan et al.,1998).Even though there is considerable experimental (i.e.Gwiazda et al.,2003)and epidemiological evidence (i.e.Saw,2003)fromhuman studies that environmental factors play a role,a number of studies demonstrate a strong genetic influ-ence.School-age children with two myopic parents are far more likely to be myopic (62%)than children with one or no myopic parent (19%and 24%,respectively)(i.e.Thorn,Grice,Held,&Gwiazda,1998).Analyses of extended multi-generation families provide also con-vincing evidence of inheritance (i.e.Pacella et al.,1999).Although low degrees of myopia are generally innocuous,higher degrees of myopia may lead to per-manent visual impairment and blindness since high myopia is associated with a higher risk of additional ocular disorders such as glaucoma (Wu,Nemesure,*Corresponding author.Tel.:+49-7071-2980739;fax:+49-7071-295196.E-mail address:frank.schaeffel@uni-tuebingen.de (F.Schaeffel).URL:http://www.uak.medizin.uni-tuebingen.de/frank/.0042-6989/$-see front matter Ó2004Elsevier Ltd.All rights reserved.doi:10.1016/j.visres.2004.03.011Vision Research 44(2004)1857–1867/locate/visres&Leske,1999)cataract(Wu et al.,1999),retinal degen-eration,peripheral retinal changes and retinal detach-ments(Krumpaszky,Haas,Klauss,&Selbmann,1997).While the influence of environmental factors can be readily studied in both animals and humans,the map-ping of loci that include genes for the control of eye growth and myopia is more challenging(Schaeffel,Si-mon,Feldkaemper,Ohngemach,&Williams,2003). Zhou and Williams(1999a)used quantitative trait loci (QTL)analysis in mice and Young et al.(1998)used transmission disequilibrium tests(TDT)in humans. Even though several animal models(mainly chick,tree shrew,marmoset and macaque)have been established, their limitations are that information on the genome, transcriptome,and proteome may be incomplete.This is different for the mouse which represents the most widely used mammalian model for human diseases.Its genome has been largely sequenced(Mouse Genome Sequencing Consortium,2002),and many knockout models are available.Furthermore,the mouse is readily available, grows rapidly,and can be easily bred,although the highly inbred laboratory strains preclude selective breeding i.e.for high susceptibility to myopia.The mouse eye growth responds with deprivation myopia when it is covered with diffusers(Schaeffel&Burkhardt, 2002)or lid sutured(Tejedor&de la Villa,2003),al-though the responses are less reliable than in other animal models of myopia(Schaeffel,Burkhardt,How-land,&Williams,2004).Due to the lack of appropriate technologies to measure ocular dimensions,axial length data are either missing(Schaeffel&Burkhardt,2002)or have limited reliability because the histological tech-niques used for the measurement are not sensitive en-ough(Tejedor&de la Villa,2003).Also,the axial length changes calculated from schematic eye models of the adult mouse(Remtulla&Hallett,1985)were smaller than the measured changes by an order of magnitude (Tejedor&de la Villa,2003)or even more(Beuerman, Barathi,Weon,&Tan,2003).A schematic eye model for the growing eye of the most common laboratory mouse strain(C57BL/6)would provide baseline data against which data from experimentally myopic animals could be compared.Therefore,in this paper,a paraxial schematic eye model was developed for the age range between22and100days,using in vivo infrared pho-toretinoscopy and photokeratometry,and frozen sec-tions of excised eyes.2.Material and methods2.1.AnimalsBlack C57BL/6wildtype mice were obtained from Charles River,Sulzfeld,Germany,and bred in the ani-mal facilities of the Institute.A maximum of six to eight animals were housed in standard mouse cages under 12h light/dark cycle.Illuminance on the cagefloor was about500lux.The treatment of the mice was approved by the University commission for animal welfare(ref-erence AK3/02)and was in accordance with the ARVO resolution for care and use of laboratory animals.2.2.Infrared photoretinoscopyRefractive state and pupil size of the mice were re-corded by eccentric infrared photoretinoscopy(the Power Refractor)as described by Schaeffel et al.(2004). In brief,the slopes of the brightness distributions in the pupil were automatically determined in the digital video images with25Hz sampling rate using an image pro-cessing computer program written by Schaeffel.The brightness slopes were converted into refractive errors, using a factor that was determined in prior calibrations with trial lenses(Schaeffel et al.,2004).Infrared light had the advantage that the animals were not aware of the measurements,and that the pupil size remained large.A previous study(Schaeffel et al.,2004)showed that mice could be refracted with a standard deviation from several repeated measurements of±2.5 D.To measure refractions,the mice were not anesthetized and only slightly restrained by grabbing their tails.No cycloplegia was necessary since the room was kept dark. Pupil sizes were approximately2mm under these con-ditions but dropped to less than1mm when the room light was turned on(Pennesi,Lyubarsky,&Pugh,1998).2.3.Infrared photokeratometryCorneal radius of curvature was measured in vivo by infrared photokeratometry in11mice at the age of35, 58and75days.Mice were anesthetized with an intra-peritoneal injection of0.1–0.2ml of a mixture of1.2ml 10%ketamine hydrochloride,0.8ml2%xylazine hydrochloride and8.0ml sterile saline.After carefully positioning the eye,eight infrared light-emitting diodes (LEDs)arranged in a circle of a diameter of298mm created8Purkinje images on the cornea(Fig.1).The positions of these reflexes were recorded by an infrared light sensitive video camera equipped with a210mm lens and several extension rings,resulting in a highly magnified video image(about80pixel/mm).Calculation of corneal radius of curvature from the positions of the infrared light reflexes on the cornea was done following prior calibration and linear extrapolation from mea-surements on two ball bearings with known radii(3.15 and5.50mm).The standard deviation from repeated measurements of the radii of curvature in the ball bearings was±0.02mm.In addition to the in vivo measurements,corneal radii of curvature were also determined in frozen sections.Both measurements did not differ by more than0.08mm,even though these1858 C.Schmucker,F.Schaeffel/Vision Research44(2004)1857–1867differences reached significance with the large number of samples (in vivo keratometry:1.493±0.080mm;frozen sections:1.414±0.019mm;p <0:001).2.4.Frozen sectionsFreshly excised globes were placed on the cooled metal platform of the cryostat with defined orientation and immediately embedded in freezing medium (Tis-sueTec e )at )20°C.Once completely frozen after about 20min,the globes were sectioned parallel to the hori-zontal plane until the maximal equatorial diameter was reached and the optic nerve head became visible.Sub-sequently,three videographs with high magnification (about 150pixel/mm achieved with a 135mm lens with several extension rings)were taken of the frozen block at three different planes with 36l m distance in depth.After digitalization of the video frames,ocular dimen-sions and radii of curvature of the optical surfaces were determined,using Adobe Photoshop e .Radii of curva-ture of cornea,lens and retina were calculated from the equation r ¼y 2=ð2Âs Þþs =2with r ¼radius of curva-ture,s ¼sagitta of the chord,y ¼any chord (Fincham &Freeman,1974).In each videograph,three measure-ments were taken at different distances from the optical axis.No corrections were made for volume artifacts which were previously shown to be very small (Chaudhuri,Hallett,&Parker,1983).Furthermore,both Charman and Tucker (1973)and Sivak (1974)observed no sig-nificant changes in the dimensions of the anterior chamber or crystalline lens following freezing eyes in the cryostat.The data on ocular dimensions were plotted versus age and linear regressions were fit to analyze changes over time.Significant changes over time were recognized by significant correlation coefficients.Since no correla-tion was found between the axial lengths of both eyes in animals of the same age group (Schaeffel et al.,2004),eyes were treated as independent samples even if they originated from the same animal.2.5.Paraxial ray tracing and schematic eyesSchematic eyes were developed using both the ‘‘OSLO’’paraxial ray tracing program (LT Lambda Research Corporation)and a ray tracing program written by Schaeffel and Howland (1988).The programs were tested against each other and were found to pro-duce identical results.Radii of curvatures and positions were taken from the frozen sections.Refractive indices of the optical media in the mouse were taken from the literature for a wavelength of 655nm (cornea 1.4015,aqueous 1.3336and vitreous 1.3329,Remtulla &Hal-lett,1985).The refractive index of the retina of 1.351was taken from a study on the rat eye (Hughes,1979).The equivalent homogeneous refractive index of the lens was calculated by matching the refractive state of the model eye to the refractions measured with infrared photoretinoscopy.A limitation was then that nothing could be said about off-axis imagery,since this depends heavily on the nature of the refractive index gradient in the lens.As in other studies,the calculated equivalent homogeneous refractive index of the lens of the sche-matic eye was higher than what is possible for biological materials (<1.55,Hughes,1979).In the present study the position of the retinal pig-ment epithelium was assumed to be coincident with the photoreceptor plane,as it could be easily identified in the frozen block.The theoretically expected small eye artifact was calculated from the dioptric differences be-tween the photoreceptor plane and the retino–vitreal interface (Glickstein &Millodot,1970).The paraxial eye model also permitted us to calculate the developmental changes in image brightness and image magnification.3.Results3.1.Development of refractive state and pupil size The refractive development of the mice,as measured with infrared photoretinoscopy,is shown in Fig.2A.The least hyperopic refractions were measured at day 32(mean refraction ±SD:+4.1±0.6D).Hyperopia in-creased and reached a peak at around day 55(+9.8±2.7D).From day 70,the measured refractions became stable and levelled offat +7.0±2.5D.Developmental changes in pupil size are shown in Fig.2B.PupilFig.1.Screen dump of the C++program that located the first Pur-kinje images created by a circular arrangement of eight infrared LEDs on the corneal surface in a highly magnified video image of the mouse eye in vivo.The radius of curvature was automatically determined by the program,based on a prior calibration with ball bearings of known radius.Ten measurements acquired in 0.4s had a standard deviation of the radii of curvature of about 15l m.C.Schmucker,F.Schaeffel /Vision Research 44(2004)1857–18671859diameter increased from about 1.78mm at day 25to 2.08mm at day 100.The appearance of the photoretinoscopic reflexes in the pupils suggested considerable amounts of aberra-tions in the eyes since ring-shaped areas of higher brightness were visible (Fig.3)which are not detectable in eyes with high optical quality like those of humans or birds.However,since such brightness distributions were already observed by Remtulla and Hallett (1985)and were present in most of the mice in our study,it is un-likely that the underlying ocular aberrations were ran-dom.Rather,the presence of the ring-shaped areas with higher brightness may indicate that the lenses were multifocal,similar to what has been described for fish eyes by Kroger et al.(1999).3.2.Growth of the ocular dimensionsExamples of frozen sections of two mouse eyes are shown for the ages of 23days and 85days in Fig.4A and B,respectively.Note that the lens increased con-siderably in size,resulting in a decline of the vitreous chamber depth.Growth curves of corneal thickness,anterior chamber depth,axial lens thickness,vitreous chamber depth,retinal thickness and axial length are shown in Fig.5.The growth of the different components could be de-scribed by linear regressions.Exponential or logarithmic functions did not increase the quality of the fits.Accordingly,there was no indication of a reduction or saturation of the eye growth rates over the first 100days which is surprising,given that mice are mature at the age of about 50days.This observation is in line with Zhou and Williams (1999b)who state that ‘‘eye growth con-tinues long after sexual maturity is reached at 40–60days of age’’.Axial length (the sum of cornealthickness,Fig.2.(A)Average development of refractive state (mean ±SD)in three C57BL/6mice measured by infrared photoretinoscopy.No cor-rection was made for a small eye artifact (see Section 4).Note that with this technique,the mice reach a final refraction (+7.0±2.5D)after 70days of age.(B)Growth of the pupils of the mice over the first 100days.Error bars denote standarddeviations.Fig.3.Brightness distributions observed in the pupils of mice during infrared photoretinoscopy.Left colum:Appearance of the pupils in 6animals under cycloplegia (pupil sizes about 2mm).Right:Appearance of a pupil without cycloplegia,refracted at about 2lux ambient illumination (pupil size about 1mm).The ring-shaped areas of different brightness in some eyes may reflect the presence of multifocal lenses as observed by Kroger,Campbell,Fernald,and Wagner (1999)in fish eyes.1860 C.Schmucker,F.Schaeffel /Vision Research 44(2004)1857–1867anterior chamber depth,lens thickness,vitreous cham-ber depth and retinal thickness)increased from 3.00mm at day 22to 3.34mm at day 100(Fig.5F).Also the lens grew continuously in both axial andhorizontalFig.4.Frozen sections of mouse eyes at two different ages.Radii of curvature (labelled above the optical axis)and positions (labelled below the optical axis)of the optical surfaces were measured in these videographs and used to construct the schematiceyes.Fig.5.Development of the ocular dimensions of the mouse eye between day 22and 100.Axial length (F)is the sum of corneal thickness (A)+anterior chamber depth (B)+lens thickness (C)+vitreous chamber depth (D)+retinal thickness (E).Data are based on frozen sections from 34eyes (n ¼3or more eyes for each data point).Error bars denote standard deviations.C.Schmucker,F.Schaeffel /Vision Research 44(2004)1857–18671861dimensions (axial lens growth is plotted as ‘‘lens thick-ness’’),at a constant rate of 5.5l m/day.Since axial length grew only by 4.4l m/day,the vitreous chamber depth declined with age.Fig.5E shows that retinal thickness (as measured near the optic nerve head)grew from 0.176mm at day 22to 0.223mm at day 100,that is equivalent to a growth rate of 0.6l m/day.Retinal thickness was comparable in human and mice which is in line with a notion of Glickstein and Millodot (1970)that retinal thickness is similar among different species of mammals,no matter of the absolute eye size.The growth of the radii of curvature of the optical surfaces in the eye is shown in Fig. 6.Neither the anterior nor the posterior radius of corneal curvature changed significantly with age (Fig.6A and B).The averaged radii from all measurements of the anterior surface were 1.414±0.019mm,and for the posterior surface 1.415±0.044mm.Photokeratometry in vivo gave a slightly flatter anterior surface of the cornea of 1.493±0.080mm.The difference was significant due to the large number of samples (df ¼66,T ¼5:6,p <0:001,unpaired t -test).The larger standard devia-tion in the in vivo measurements reflects the difficulties in aligning the pupil axis of the mouse eye.It was noted that,if a Purkinje reflex was positioned close to the pupillary margin (due to inherent difficulties in centering),a flatter cornea was measured.This obser-vation is in agreement with findings by Remtulla and Hallett (1985)and suggests an aspherical shape of the cornea and it could also explain that the averaged radii of curvature measured with photokeratometry were larger than with frozen sections.However,both tech-niques had in common that no changes were detected with age.Different from the cornea,the radii of cur-vature of the anterior lens surface increased with age from 0.982mm at day 22to 1.208mm at day 100(Fig.6C).The posterior lens showed no significant change in shape if linear regression analysis was used (Fig.6D).The radius of curvature of the anterior and posterior retinal surface did also not change significantly with age (Fig.6E and F)with an average radius of curva-ture of the vitreo-retinal interface of )1.522±0.033mm and of the retinal pigment epithelium of )1.607±0.030mm.Fig.6.Development of the radii of curvature of the anterior and posterior surface of the cornea (A,B),lens (C,D)and retina (E,F),as determined in frozen sections.Error bars denote standard deviations.1862 C.Schmucker,F.Schaeffel /Vision Research 44(2004)1857–18673.3.Schematic eye modellingUsing the regression analyses shown in Figs.5and 6,and the measured refractions shown in Fig.2A,a schematic eye for the age range from 22to 100days was developed.The dynamic eye model allowed us to con-struct schematic eyes for all ages between these age limits.The first finding was that equivalent lens index was remarkably high and also had to increase linearly with age from 1.568to 1.605to reproduce the measured refractions (Fig.7A).The small eye artifact was calculated as the dioptric difference between the vitreo-retinal interface and the retinal pigment epithelium.It ranged from +35.2to +39.1D over the age range considered (Fig.7B).It was also calculated how much the eye had to elongate to become one diopter more myopic (Fig.7C).An elon-gation of 5.4l m was necessary in a 22-day-old mouse and 6.5l m was required for the refractive change in a 100-day-old mouse.3.4.Image magnification and f /numberAs in other studies (Hughes,1977),the posterior nodal distance (PND)and hence image magnification were highly correlated with axial length (Fig.8A).The ratio of PND to axial length provides a further variable that can determine image size at a given eye size (Ott &Schaeffel,1995).In the schematic eye of the mouse,this ratio changed only little with age (Fig.8B;from 0.603to about 0.581).Therefore,the developmental increase in retinal image magnification of about 10%,from 31l m/deg in young mice to 34l m/deg in adult mice (Fig.8C)results largely fromscaling.Fig.7.(A)The refractive index of the growing lens was adjusted so that the schematic eye matched the refractive state measured by infrared photoretinoscopy.(B)The magnitude of the small eye artifact (Glickstein &Millodot,1970)was calculated from the focal length and retinal thickness.(C)Axial elongation necessary to make the model eyes 1D more myopic,as a function ofage.Fig.8.(A)Posterior nodal distance (PND)was highly correlated with axial length.(B)The ratio of PND to axial length decreased with age and was slightly smaller than in most vertebrates (on average:0.6,Hughes,1977).(C)Retinal image magnification as a function of age.(D)The f /number declined during development resulting in a 10%brighter image at day 100than at day 22.In this case,a logarithmic fit provided the best description of the data.C.Schmucker,F.Schaeffel /Vision Research 44(2004)1857–18671863The size of the entrance pupil,as measured in vivo, was1.75mm at day22resulting in a f/number of1.033 (Fig.8D).The f/number declined slightly with age, resulting in a10%brighter image at day100than at day 22.This change is less than in the chick(50versus1day of age:+49%,Schaeffel,Howland,&Farkas,1986), toad(adult toad versus tadpole:+350%,Mathis, Schaeffel,&Howland,1988)or barn owl(60versus10 days:+30%,Schaeffel&Wagner,1996).However,with a f/number61.0,the retinal image in the mouse eye is probably among the brightest of all vertebrates.4.Discussion4.1.Developmental stagesThis study provides new data on refractive develop-ment and growth patterns in the mouse eye.In general, mice are weaned at three weeks of age(Sundberg,Smith, &John,2002).They do not open their eyelids before12–14days postnatal(Sundberg et al.,2002)and the age of sexual maturity reached between40and60days(Zhou &Williams,1999b).Decline in fecundity takes place between six and eight months of age and progressive changes of ageing develop from12months to the time of natural death at approximately99weeks(Sundberg et al.,2002).4.2.Refractive state and small eye artifactRefractive state seems to reach a constant value of approximately+7.0±2.5D at the age of70days which could indicate that a stable refraction is reached only after sexual maturity.As in many other studies(i.e. Norton,Wu,&Siegwart,2003),an unknown factor is the contribution of the small eye artifact.The true re-fraction of the mouse is likely to be more myopic than reported here.However,comparison of refractive state using both retinoscopy and visually evoked potentials in various animals(rat,Mutti,Ver Hoeve,Zadnik,& Murphy,1997;pigeon,Millodot&Blough,1971; ground squirrel,Gur&Sivak,1979)suggests that the retinoscopic reflex may not simply arise from the vi-treal–retinal interface because the small eye artifact should then be much larger and the animals,in fact, quite myopic.A new study(Norton et al.,2003)suggests that tree shrews which are measured with streak reti-noscopy at+7.0D and with an autorefractor(using infrared light)at about+4.0D,are in fact about emmetropic when measured with visual evoked poten-tials.Thus,it is likely that the small amount of hyper-opia measured with infrared photoretinoscopy in the mouse is also only a minor‘‘small eye artifact’’.The reflecting layer(s)must be closer to the photoreceptor layer than assumed in the original paper on the small eye artifact(Glickstein&Millodot,1970).The refractive errors measured by infrared photo-retinoscopy in the present study were less hyperopic than those reported by other authors in previous studies, in which white light streak retinoscopy was used.Teje-dor and de la Villa(2003)found an apparent hyperopia of approximately+13.5D in30-day-old mice and Beuerman et al.(2003)found a refractive error of more than+15.0D in adult Balb/CJ mice.A possible reason for this discrepancy is chromatic aberration which ren-ders an eye more hyperopic in the red end of the spec-trum.We have tested this hypothesis by replacing the infrared LEDs of the retinoscopy with yellow LEDs (peak emission at550nm).Cyclopleged mice were still not significantly more hyperopic.The average slope of the brightness profile in the pupil was0.71±0.24(five measurements in one untreated animal),which converts into a refractive error of about+8.0D.It is therefore also possible that the differences to previous studies can be attributed to the inherent difficulty to perform streak retinoscopy in an eye with a very small pupil.The mouse has a highly sensitive pupil response to light(Pennesi et al.,1998).Reliable measurements without cycloplegia at pupil sizes of1mm or even less appear demanding.4.3.Growth rateA striking feature of the mouse eye is its slow but long-lasting and linear growth rate between day22and 100.During this time,the lens grew at a rate of5.5l m/ day and the globe at a rate of4.4l m/day.Zhou and Williams(1999b)examined eye weights in507mice from 50different strains and also found that growth contin-ued long after sexual maturity.In their study,the eye weight data could be bestfit by linear regression when they were plotted versus the logarithm of age.There are also data on prenatal eye growth in the CD-1mouse(E8 to E19),measured by ultrasound biomicroscopy(Foster, Zhang,Duckett,Cucevic,&Pavlin,2003).Already be-fore birth,the globe and the lens appear to grow linearly at a rate of122and68l m/day,respectively.At birth, the axial length should then be about1.32mm,about 40%of the value at100days.When the mice are weaned (around day22),the globe has already reached about 90%of its size at100days,and95%when sexual maturity is reached.The growth pattern in the mouse eye is similar to other species where also a period of rapid axial growth during early infancy(in mice:form birth to approximately day22),is followed by a period of slower growth when the animals become juvenile (rhesus monkey,Bradley,Fernandes,Lynn,Tigges,& Boothe,1999;marmoset,Graham&Judge,1999;tree shrew,Norton&McBrien,1992;chick,Irving,Sivak, Curry,&Callender,1996).Also the human eye shows a biphasic growth curve(Gordon&Donzis,1985;Larsen,1864 C.Schmucker,F.Schaeffel/Vision Research44(2004)1857–1867。

Dynamic Causal Modelling (DCM) for fMRI动态因果模型(DCM)的功能磁共振成像

Dynamic Causal Modelling (DCM) for fMRI动态因果模型(DCM)的功能磁共振成像
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上半年《英语知识与教学能力》(高中)试题(附答案) (2)

上半年《英语知识与教学能力》(高中)试题(附答案) (2)

上半年《英语知识与教学能力》(高中)试题(附答案).第 1 题 (单项选择题)(每题 2.00 分) > 未分类 >Which of the following is the feature shared by the Englishphonemes/m/and/p/?{A}. Voiced.{B}. Voiceless.{C}. Bilabial.{D}. Dental.正确答案:C,第 2 题 (单项选择题)(每题 2.00 分) > 未分类 >Which of the following is true of English sound system?{A}. Aspiration is a distinctive feature.{B}. Voicing is a distinctive phonetic feature.{C}. Nasalization of vowels gives rise to another vowel.{D}. Length of vowels differentiates one vowel from the other. 正确答案:B,第 3 题 (单项选择题)(每题 2.00 分) > 未分类 >Though the government encourages foreign investment,__________ investors arereluctant to commit fimds in the current climate situation in the country.{A}. potential{B}. affluent{C}. optimistic{D}. solid正确答案:A,第 4 题 (单项选择题)(每题 2.00 分) > 未分类 >The man __________ the dark glasses fled away from the spot veryrapidly.{A}. in{B}. at{C}. of{D}. by正确答案:A,第 5 题 (单项选择题)(每题 2.00 分) > 未分类 >The morpheme \"-ceive\" in the word \"conceive\" isa__________.{A}. stem{B}. root{C}. allomorph{D}. suffix正确答案:B,第 6 题 (单项选择题)(每题 2.00 分) > 未分类 >There is no need__________ to teach children how to behave. {A}. however{B}. whatsoever{C}. forever{D}. whenever正确答案:B,第 7 题 (单项选择题)(每题 2.00 分) > 未分类 >__________advance seems to be following advance on almost a monthly basis.{A}. So rapid is the rate of progress that{B}. Rapid as the rate of progress is that{C}. So rapid is the rate of progress as{D}. Rapid as the rate of progress as正确答案:A,第 8 题 (单项选择题)(每题 2.00 分) > 未分类 >Tom, see that your sister gets safely back, __________?{A}. can you{B}. won't we{C}. won' t you{D}. should we正确答案:C,第 9 题 (单项选择题)(每题 2.00 分) > 未分类 >What rhetoric device is used in the sentence \"This is a successfulfailure\"?{A}. Simile{B}. Metonymy{C}. Metaphor{D}. Oxymoron正确答案:D,第 10 题 (单项选择题)(每题 2.00 分) > 未分类 >The expression\"As far as I know ...\" suggests that peopleusually observe the Maxim of __________ in their daily conversations.{A}. Quantity{B}. Quality{C}. Relevance{D}. Manner正确答案:B,第 11 题 (单项选择题)(每题 2.00 分) > 未分类 >When the teacher attempts to elicit more information from the students bysaying \"And...?\",\"Good. Anything else?\", etc, he/she isplaying the role of a __________.{A}. prompter{B}. participant{C}. manager{D}. consultant正确答案:A,第 12 题 (单项选择题)(每题 2.00 分) > 未分类 >For more advanced learners, group work may be more appropriate thanpair work for tasks that are__________.{A}. linguistically simple{B}. structurally controlled{C}. cognitively challenging{D}. thematically non-demanding正确答案:C,第 13 题 (单项选择题)(每题 2.00 分) > 未分类 >When you focus on \"utterance function\" and \"expectedresponse\" by using examples like\"Here you are\",\"Thanks\", you are probably teaching language at the __________.{A}. lexical level{B}. sentence level{C}. grammatical level{D}. discourse level正确答案:D,第 14 题 (单项选择题)(每题 2.00 分) > 未分类 >Which of the following tasks fails to encourage active language use?{A}. Reciting a text.{B}. Bargaining in a shop.{C}. Writing an application letter.{D}. Reading to get a message.正确答案:A,第 15 题 (单项选择题)(每题 2.00 分) > 未分类 >A teacher may encourage students to__________ when they come acrossnew words in fast reading.{A}. take notes{B}. ask for help{C}. guess meaning from context{D}. look up the words in a dictionary正确答案:C,第 16 题 (单项选择题)(每题 2.00 分) > 未分类 >Which of the following statements about task design is incorrect?{A}. Activities must have clear and attainable objectives.{B}. Activities should be confined to the classroom context.{C}. Activities must be relevant to students' life experiences.{D}. Activities should help develop students' language ability. 正确答案:B,第 17 题 (单项选择题)(每题 2.00 分) > 未分类 >If someone says \"I know the word\", he should not only understandits meaning but also be able to pronounce, spell, and __________ it.{A}. explain{B}. recognize{C}. memorize{D}. use正确答案:D,第 18 题 (单项选择题)(每题 2.00 分) > 未分类 >Teachers could encourage students to use__________ to gather and organizetheir ideas for writing.{A}. eliciting{B}. mind mapping{C}. explaining{D}. brainstorming正确答案:B,第 19 题 (单项选择题)(每题 2.00 分) > 未分类 >When students are asked to go to the local museum, libraries, etc. tofind out information about endangered animals and work out a plan for anexhibition, they are doing a(n) __________.{A}. survey{B}. experiment{C}. project{D}. presentation正确答案:C,第 20 题 (单项选择题)(每题 2.00 分) > 未分类 >Which of the following tasks fails to develop students′ skill ofrecognizing discourse patterns?{A}. Analyzing the structure of difficult sentences.{B}. Checking the logic of the author's arguments.{C}. Getting the scrambled sentences into a paragraph.{D}. Marking out common openers to stories and jokes.正确答案:A,第 21 题 (单项选择题)(每题 2.00 分) > 未分类 >请阅读Passage l,完成小题。

A blinded placebo-controlled randomized trial on the use

A blinded placebo-controlled randomized trial on the use

THERAPY ARTICLESA blinded placebo-controlled randomized trial on the use of astaxanthin as an adjunct to splinting in the treatment of carpal tunnel syndromeJoy C.MacDermid &Joshua I.Vincent &Bing S.Gan &Ruby GrewalPublished online:30December 2011#American Association for Hand Surgery 2011AbstractBackground Nutritional supplementation is a potential ad-junct in the conservative management of carpal tunnel syn-drome (CTS).This study investigated whether astaxanthin (a beta-carotenoid)increased the effectiveness of splinting in managing CTS.Methods This is a triple-blinded randomized controlled trial where 63patients with electrodiagnostically confirmed CTS were randomly allocated into either the experimental group (n 032)(astaxanthin –4-mg capsules+splinting)or the con-trol group (n 031)(placebo+splinting).Medications were taken for 9weeks followed by a 3-week washout.The primary outcome measure was the Symptom Severity Scale (SSS).Secondary outcome measures in the study included physical impairments,disability,and health status measures.Electrodiagnostic testing was performed before entry into the study and again at 12weeks.All other outcomes were measured at baseline,6,and 12weeks.Results There was a reduction in symptoms as measured by the SSS over the course of treatment in both groups (p 00.002),but no differences between the groups (p 00.18).The Disability of Arm,Shoulder and Hand questionnaire and the Short Form 36-item Health Survey showed no effects over time or between treatment groups.The baseline difference between the groups in the level of total cholesterol and low-density lipoproteins remained constant over the course of the study.Impairment measures demonstrated no significant changes in grip,dexterity,or sensation.Conclusion At present,the role for astaxanthin as an adjunct in conservative management of CTS has not been established.Keywords Carpal tunnel syndrome .Astaxanthin .SSS .DASH .SF-36IntroductionCarpal tunnel syndrome (CTS)is the most common com-pression neuropathy with an incidence in the population estimated at 52/100,000person-years for men and 149/J.C.MacDermidSchool of Rehabilitation Science,McMaster University,Hamilton,ON,CanadaJ.C.MacDermid (*)Clinical Research,Hand and Upper Limb Center,St.Joseph ’s Health Center,268Grosvenor Street,London,ON N6A 4L6,Canada e-mail:jmacderm@uwo.caJ.I.VincentHealth and Rehabilitation Sciences,University of Western Ontario,London,ON,CanadaB.S.GanDepartment of Surgery,University of Western Ontario,London,ON,CanadaB.S.GanHULC Cell and Molecular Biology Laboratory,268Grosvenor Street,London,ON,CanadaB.S.GanHand and Upper Limb Center,St.Joseph ’s Health Center,London,ON,CanadaR.GrewalHand and Upper Limb Center,St.Joseph ’s Health Center,Division of Orthopedics,University of Western Ontario,268Grosvenor Street,London,ON,CanadaHAND (2012)7:1–9DOI 10.1007/s11552-011-9381-1100,000person-years for women[42].Non-operative man-agement is the first line of treatment and generally includes wrist splinting of the affected extremity[13,48].Other conservative therapies that have been evaluated include non-steroidal anti-inflammatory drugs,injection of medica-tions,rehabilitation modalities(therapeutic ultra-sound, stretching,and strengthening),and pyridoxine[38,41,49]. Specific factors are known to affect treatment outcome with upper extremity pathology.Patients on workers compensa-tion are known to have a greater pain and disability with CTS.Severity of nerve compression is also known to affect the likelihood of success with conservative management [26,31,39].Astaxanthin is a lipid-soluble carotenoid found in micro-algae,yeast,salmon,trout,krill,shrimp,crayfish,and crus-taceans.Astaxanthin,unlike some carotenoids,is not converted to vitamin A(retinol)in the human body.It has lower toxicity than vitamin A and may have a different antioxidant activity than other carotenoids.The US Food and Drug Administration has approved astaxanthin as a food coloring(or color additive)for specific uses in animal and fish foods.A patent awarded by the US Patents Department to Lorenz et al.in2001[30]claimed astaxanthin as a method of retarding and ameliorating CTS.Astaxanthin, whose scientific name is ketocarotenoid astaxanthin,3,30-dihydroxy-b,b-carotene-4,40-dione,belongs to the family of xanthophylls,which are the oxygenated derivatives of ca-rotenoid.Astaxanthin is ubiquitous in nature,especially in the marine environment[29].It provides the red color of salmon meat and cooked shellfish and contributes to the pinkish-red color of their flesh[25].Astaxanthin(and other carotenoids produced by Haematococcus algae)has a long history in the food chain and human diet because they occur naturally in foods commonly consumed by humans.Previous studies have suggested that the bioactivities of carotenoids might be due to their prior conversion to vita-min A and focused on b-carotene.Subsequent studies showed that some carotenoids without pro-vitamin A activ-ity were as active and at times more active than b-carotene [48].Astaxanthin is one such carotenoid that does not pos-sess a pro-vitamin A activity and has been reported to have potent bio-activities such as antioxidative,anticancer,anti-diabetic,and anti-inflammatory activities,gastric,hepatic, neuro,cardiovascular,ocular,and skin-protective effects, and other activities,[50]which are distinctly different and, at least in some cases,more potent than that of other car-otenoids[48].Studies have confirmed that up to6mg of astaxanthin per day from a Haematococcus pluvialis algal extract can be safely consumed by healthy adults[17].Absorption is aided by including the dosage in a fat-rich meal.A dosage of4mg of astaxanthin per day from Haematococcus algae is a relatively low amount that would normally be consumed in the human diet from salmonids or shrimp and will not cause any adverse effects in humans.Splinting has been accepted as a relatively risk-free meth-od of treating CTS conservatively.It has demonstrated ef-fectiveness,although the rate of success and the severity of the CTS amenable to splinting are debatable[38].Astaxan-thin has been claimed to have effect on CTS[30,34]as it acts as an anti-inflammatory agent because of its inhibitory effects on the production of nitric oxide[51].Therefore,a potential role for astaxanthin would be as an adjunct to increase the effectiveness of splinting in a conservative approach to CTS.The purpose of this study is to evaluate the effectiveness of the food additive astaxanthin as an adjunct in the man-agement of CTS.Materials and MethodsSubjectsAll patients presenting with symptoms of primary CTS were evaluated by surgeons at the Hand and Upper Limb Center,London,Ontario,Canada.The diagnosis of carpal tunnel syndrome was made first by the refer-ring family physician and secondarily by experienced hand surgeon at the Hand Center,and all were verified by electrophysiology.Referral electrophysiology was performed by different physical medicine specialists depending on the referring family physician.Follow-up electrophysiology was performed in a single laboratory. All were hand surgeons,and physical medicine special-ists were academically appointed at the same university and follow the criteria stated by Remphel et al.[40]for clinical and electrophysiological diagnosis of CTS which includes a recommendation for using the most current version of the American Association of Electro-diagnostic Medicine criteria for diagnosis of CTS. Patients were recruited into the study by their hand surgeon and referred to the Clinical Outcomes Lab for independent blinded assessment of study outcomes.The patients signed an informed consent form before they could participate in the study.Patients were included in the study if they satisfied the following inclusion and exclusion criteria:Inclusion Criteria1.CTS clinically diagnosed by hand surgeons andsupported by electrophysiological abnormalitypetent to comply with treatment and completestudy evaluations3.Aged18–65yearsExclusion Criteria1.Concurrent hand pathology including recent trauma,i.e.,fracture,amputation,tumor,or nerve compres-sion such as thoracic outlet syndrome[23];2.Pregnancy;3.Wrist arthritis,rheumatoid arthritis,diabetes mellitus,orthyroid disease;4.Urgent or severe CTS requiring early operativeintervention;5.Inability to complete study forms/assessments;and6.Neurological disorders.Outcomes and MeasuresThe primary outcome of this study was the severity of symptoms of CTS measured by the Symptom Severity Scale (SSS)[28]designed specifically for CTS outcome evalua-tion.The primary outcome was measured at baseline,6and 12weeks.The SSS has11questions covering six different symptom areas.Each question has five responses ranging from1point(mildest)to5points(most severe).Previous research on a group of38patients with CTS has shown the SSS to be a highly reliable and responsive tool in capturing the symptom severity[28].A reliability of0.91has been documented for the SSS[28].At the conclusion of the study, patients also answered a global rating of change to say whether they had no improvement,mild moderate improve-ment in symptoms,or complete resolution.Secondary outcomes in our study included physical impairments,disability,and health status measures.Second-ary outcomes were measured at baseline,6,and12weeks according to standardized methods described below,with the exception of electrophysiology which was performed only at baseline and12weeks.1.Motor nerve function:Motor nerve functional impair-ment was assessed by measuring pinch(tripod)and grip strength using the NK computerized hand evaluation system.The inter-instrument reliability of the NK pinch gauge was high(ICC>0.90)[31].The pinch strength scores obtained with NK pinch gauge and two other pinch gauges were consistent and can be compared with normative data obtained with the other pinch gauges[31].The inter-rater reliability for NK pinch gaugewas also very high(ICC>0.87)[32].2.Dexterity:Dexterity was measured using the NKHand Dexterity Board(NKHDT).This provided an objective assessment of the patient’s ability to ma-nipulate three subgroups of objects(small,medium, and large).NKHDT has demonstrated good concur-rent validity(r00.47–0.87)with Jebson’s Hand Function Test[33]and has a good test–retestreliability0.48–0.85[43].Its responsiveness has also been found to be satisfactory[1].3.Vibration sensory threshold:A vibrometer with asoftware-controlled protocol was used to determine vi-bration sensory threshold.Vibrometer measurements have been found to be consistent with electrodiagnostic findings of CTS[16].Vibrometry at50Hz has demon-strated reliability(reliability coefficient00.86)[19]. 4.Upper extremity disability:It was measured usingthe Disability of Arm,Shoulder and Hand(DASH) Questionnaire[6,20].It is a30-item self-report measure that evaluates impairments,activity limita-tions,as well as participation restrictions due to disorders of the upper limb[44,45].The total DASH score is calculated from the raw scores obtained and can range from0(no disability)to 100(severe disability).The DASH has been vali-dated for use in carpal tunnel syndrome[15,27].5.Health status:Physical health status was measured usingthe physical component summary score of the Short Form36-item Health Survey(SF-36).This is a36-item questionnaire,yielding an eight-scale profile of scores,as well a physical component summary score and a mental component summary score[46,47].The SF-36is a generic health status measure that has been used in multiple musculoskeletal disorders[2,5,8,14, 24],including carpal tunnel syndrome[3,4,9].6.Touch perception sensory threshold:Touch thresholdwas measured using the NK pressure specified sensory device.It has demonstrated high test–retest reliability of r00.95[12].7.Electrophysiology:Parameters including the distallatencies,conduction velocities,and amplitudes of the motor and sensory potentials were measured.At base-line,these were taken from the records provided by the referring family physician/physical medicine specialist;follow-up EMG was performed in a single lab accord-ing to a standardized protocol.In both cases,laborato-ries comply with the recommended guidelines proposed by the American Association of Electrodiagnostic Medicine as outlined by the consensus criteria for diagnosis of carpal tunnel[40].Buch and Foucher[11] and others[18,40]have described nerve conduction studies to be an indispensable part of the pre-operative evaluation of CTS.These tests have been reported to have very high sensitivity and specificity of85%and87%,respectively[18].8.Lipid profile:A high level of low-density lipoproteins(LDL)has been described as a risk factor for idiopathic CTS[7,36].Blood levels of LDL,high-density lipoproteins(HDL),triglycerides,and total cholesterol were measured in blinded samples by an independent laboratory.ProcedureSixty-three patients with electrodiagnostically confirmed CTS were recruited into the study over a1-year interval (see Table2).Astaxanthin capsules and identical placebos were provided to patients according to a computer-generated randomized permutated block design.Allocation was blinded to surgeons,assessors,and clinic staff.The charac-teristics of the recruited patients are described in Table1. The recruited patients were randomly allocated into either the experimental group(n032)or the control group(n031).EvaluationAll patients were evaluated by their surgeon for entry into the study,and the all study assessments were administered by a blinded research assistant.All patients had standardized tests performed upon entry into study and at6and12weeks following ponents of these evaluations were: 1.Baseline medical evaluation including history andclinical examination by experienced hand surgeon;2.Electrophysiology to establish severity of CTS;3.Screening blood work including CBC,electrolytes,BUN,creatine,ESR,CRP,LFT,and lipid profile.4.Radiography was performed as part of the clinical evalu-ation if indicated by history or physical examination,e.g., diagnosis of malalignment with a previous wrist fracture/ wrist arthrosis.Results were used to exclude ineligible patients,but not recorded as a study outcome.5.Impairment and disability outcome measures InterventionsAll patients had been referred by a primary practitioner and received management prior to being seen by a hand surgeon. The exact nature of this varied according to primary care physician.Patient agreed to participate in a trial of splinting with random allocation to the adjunctive treatment.Patients were randomized to receive either placebo or astaxanthin which were coded to maintain triple blinding (physician,research assistant,and patient).The astaxanthin group received4-mg capsules of astaxanthin;the placebo group a visually identical capsule.All patients were asked to take the tablets after evening meals.The medications were taken for a9-week period followed by a3-week wash-out period.Phone checks were performed at3-week intervals by the study assistant to check that patients were taking their medication,had enough medication,and had experienced no adverse reactions or unusual symptoms.Patients were asked to return medication bottles,and pill counts were performed to further monitor pliance was also evaluated by questionnaire at each re-evaluation.The wrist was splinted in a position of neutral wrist flexion,i.e.,0°at night,with supplemental splinting during the day for activities that placed the wrist in a position of risk.Patients were instructed not to request a change in treatment during the course of the study and to inform the research assistant if a change became necessary. Statistical AnalysisData was entered and verified by cross-checking the data-base with original records,performed by a second blinded research assistant.All statistical analysis was performed using SPSS statistical software(α00.05).Analysis of vari-ance(generalized linear models with repeated measures on the time factor)was used to detect treatment differences over time and between the two treatment groups for the primary outcome measure(SSS)and all secondary out-comes.Number needed to treat(NNT)is the number of patients who need to be treated in order to achieve one successful additional improvement in symptoms(aboveTable1Patient characteristics (n063)NS not significant,SD standard deviationa Statistically significant differenceAstaxanthin(n032)Placebo(n031)P valueAge mean(SD)49[7]range31–6449[9]range29–74NS Sex30%male;70%female25%male;75%female NS Writing hand92%right94%right NS Affected hand Left11%;right35%;both54%Left17%;right33%;both50%NS Previous episode of splinting86%70%0.03a Concomitant arthritis44%28%NS Concomitant diabetes6%8%NS Concomitant thyroid disease14%6%NS Females postmenopausal52%36%NS Never smoked42%44%NS Changes job due to CTS11%6%NS Workers compensation for CTS25%25%NScontrol)and is the inverse of the absolute risk reduction.The absolute risk reduction is the difference in rate of patients achieving a positive improvement in symptoms in the control group versus the treatment group.ResultsPrimary OutcomePatients were similar on most descriptive factors with the exception of the fact that more people in the astaxanthin group had a previous episode of splinting for CTS(see Table1)and they had higher baseline cholesterol levels. There was a significant improvement in symptom severity over time in both treatment groups(p00.002)(see Table2). There was no significant difference in the functional scores over time.There was no significant difference between the groups for either symptoms or functional status.More patients responded to global rating that they had a moderate or better improvement with astaxanthin as compared with placebo(13vs.8),although this was not significantly dif-ferent(p00.18).This translated into a NNT of7(i.e.,seven patients would be needed to be treated with astaxanthin before one patient would gain benefit not achieved through the standard treatment).However,the extent of reduction in symptoms was relatively small;the severity of symptoms at the end of the study was still clinically significant.To explore the potential impact of clinical covariates, ANCOVA was performed with presence of hand arthritis (e.g.,mild CMC was not an exclusion),previous episode of splinting,or baseline cholesterol as a covariates.These variables were not significant covariates neither did it alter the significance of the primary outcome.Secondary OutcomesImpairments in secondary outcomes including the DASH, SF-36,and cholesterol(Table3);hand impairment measures (dexterity,grip strength,and sensory threshold;Table4)and electrodiagnostic findings(Table5)were not significantly different between treatment groups.The majority of these measures also did not show a significant improvement over time with the exception of vibration thresholds which improved over time in both treatment arms and motor amplitude which improved in the placebo arm.Mental health status approximated the US population norm of50 whereas physical health status was significantly lower than the population mean(see Table4).We did a follow-up survey of all patients who had exceeded the normal range for blood levels,in case the family physician had changed medications as a result of these findings.None of the patients reported medication changes,even when specifi-cally questioned about cholesterol-lowering medications.Side EffectsA few“side-effects”were reported by patients.Our ethics board did not require formal reporting of minor symptomatic complaints such as stomach upset and diarrhea.These were reported with equal frequency between the group getting active astaxanthin and the placebo.No moderate or severe adverse events were reported in either treatment arm. DiscussionThis study did not demonstrate a significant adjunctive effect of astaxanthin when added to a splinting programTable2Primary outcomes of treatmentPrimary outcomen063Baseline score6-week score12-week score P value for time effect P value for Rx effect Mean SD Mean SD Mean SDCTS Symptom Severity Scale/55Astaxanthin359321131100.002a NS00.18Placebo318309289CTS Functional Scale/40Astaxanthin207207198NS00.25NS00.40Placebo186177177ANCOV A controlling for arthritis:time effect remained significant(p00.008);other effects were not significant:arthritis effect00.21,group effect00.12;time×arthritis or group,both0NSANCOV A controlling for differences in baseline cholesterol resulted in differences occurring over time being NS(reduced power),however,there was no significant effect of total baseline cholesterol(p00.15)or treatment(p00.29)a Statistically significant differencefor conservative management of patients with prolonged symptoms of CTS.This is in contradiction to the reports of Lorenz et al.[30]claiming the ameliorating effects of astaxanthin on CTS.The results of this study augment and confirm the findings of Nir et al.[37].In their study,they followed 20subjects,randomly allocated to either to the astax-anthin group or the placebo group,for8weeks.They reported a trend of decreased pain rate and duration;but their results did not reach statistical significance.They concluded that there is insufficient evidence to recom-mend for or against the use of astaxanthin for CTS and recommended a further large-scale study.Our study in contrast included63subjects,and we analyzed multiple outcomes and still found non-significant between-group differences.We observed small differences over time to suggest that there was an improvement in symptoms in patient’s splinted with or without active astaxanthin. Since this analysis is dependent on repeated measures of individuals over time,it had higher power for detect-ing differences than did the between-group comparisons. Our study was powered to detect a20%improvement. Both treatment arms experienced less than10%im-provement overall and thus did not reach a level con-sidered clinically significant.If small differences of10%were considered clinically significant,then sample size would need to be substantially larger.Since we recruited patients with persistent symptoms, many of whom had a previous episode of conservative management,we might view this as a resistant popula-tion.In light of this,these results should not be con-sidered generalizable to a first attempt at conservative management.In Canada,patients are often managed at the primary care level for substantial amounts of time as hand surgeons have a waitlist.It is known that patients with more prolonged or severe carpal tunnel are less likely to respond to traditional conservative management[10,35].A number of these groups may have failed a second attempt at conservative management which may explain the relatively low overall response across different outcome measures.We selected a resistant population,with the view that,if astaxanthin was beneficial in a more difficult population,then it would be an important clinical contribution.However,this effectiveness was not demonstrated.A global rating of moderate improve-ment was more commonly reported in the astaxanthin group (13/32versus8/31)and was associated with a number needed to treat of7which might be considered a reasonable treatment threshold.Therefore,we cannot preclude the possibility that astaxanthin has a role if clear indications for patients whoTable3Secondary outcomes of treatment—disability,health status measures,and lipid profile NS not significant,SD standard deviation,Rx effect treatment effect,DASH the Disability of Arm,Shoulder and Hand ques-tionnaire,SF-36Short Form36-item Health Survey Secondary outcomes(disability,health status measures,and lipid profile)n063Baseline score6-week score12-week score P value fortime effectP value forgroup effect Mean SD Mean SD Mean SDDASH/100Astaxanthin372038253724NS00.70NS00.16 Placebo311730192922SF-36-Physical Component Summary Score(US norm050)Astaxanthin371036123612NS00.09NS00.09 Placebo408399428SF-36-Mental Component Summary Score(US norm050)Astaxanthin501350135013NS00.87NS00.55 Placebo481249114712Total cholesterol(mg/dL)Astaxanthin 5.80.7 5.90.80 5.60.8NS00.800.006 Placebo 5.00.9 5.00.80 5.20.8Triglycerides(mg/dL)Astaxanthin 1.90.8 2.10.8 1.9 1.1NS00.63NS00.50 Placebo 2.5 2.2 1.8 1.1 2.5 2.0HDL cholesterol(mg/dL)Astaxanthin 1.20.3 1.20.3 1.20.3NS00.18NS00.77 Placebo 1.20.4 1.20.4 1.20.5LDL cholesterol(mg/dL)Astaxanthin 3.70.5 3.70.7 3.60.6NS00.980.0005 Placebo 2.90.7 3.00.9 3.00.7could potentially benefit could be defined.Any future study that wishes to do so should focus on patients earlier in their natural history or progression of carpal tunnel syndrome and who have not had a previous trial of conservative manage-ment.Since our study had relatively small numbers in subgroups,it was not possible for us to investigate whether specific subgroups were more likely to respond.Patients were interviewed every3weeks with careful attention to the occurrence of self-reported side effects. It is interesting to note that patients in both groups felt that they experienced medication-related side effects. However,the nature and frequency of these were similar between the placebo and astaxanthin groups.As these primarily related to digestive problems or exacerbation of current problems(such as acne),it is highly likely these reported side-effects reflected the current health status of the patients rather than medication-induced changes.The fact that the placebo group reported side effects illustrates how patients can interpret routine symptoms as attributable to an inert medication.A similar attribution occurs in recall bias.This illustrates the importance of prospective,blinded placebo-controlled trials to provide unbiased assessment of treat-ment effects and side effects/complications.Systematic reviews have confirmed that conservative management is effective[21,35]and that surgery has a larger overall benefit[22,41],in particular,for those who fail conservative management.Our findings of a small improvement over time in a group with chronic carpal tunnel syndrome are in agreement with these evidence syntheses.This study has not identified astaxanthin to be an effective adjunct to standard conservative management.Table4Secondary outcomes of treatment—impairment measuresNS not significant,SD standard deviation,Rx effect treatment effect,NK PSSD NK pressure specified sensory devicea Statistically significant difference Secondary outcomes(impairment measures)n063Baseline score6-week score12-week score P value fortime effectP value forRx effect Mean SD Mean SD Mean SDNK dexterity test–small objects—affected(time in seconds)Astaxanthin502049164722NS00.09NS00.95 Placebo501449164817NK dexterity test–medium objects—affected(time in seconds)Astaxanthin3173283317NS00.87NS00.93 Placebo348338328NK dexterity test–large objects—affected(time in seconds)Astaxanthin4514491751230.08NS00.90 Placebo471349135012Grip strength affected hand(kg)Astaxanthin24925102610NS00.17NS00.60 Placebo26928112610Vibration threshold affected(m/s2)Astaxanthin2317161316140.005a NS00.40 Placebo273222181917NK PSSD affected hand(g/mm2)Astaxanthin 5.75 5.6118.917NS00.47NS00.48 Placebo7.110 4.023 3.32Table5Electrodiagnostic studiesNS not significant,SD standard deviation,A astaxanthin group, P placebo groupa Statistically significant difference Variable for median nerve Group Baseline12weeks P valuefor timeP valuefor groupMean SD Mean SDMotor amplitude in millivolts(mV)A9.549.530.02a NS00.20P8.038.63Sensory Amplitude in microvolt(μV)A19.5822.57NS00.34NS00.93P19.51321.715Sensory latency in milliseconds(ms)A 3.50.7 3.50.62NS00.43NS00.95P 3.60.7 3.30.53。

重庆市巴蜀中学2023-2024学年高二上学期期中英语试卷

重庆市巴蜀中学2023-2024学年高二上学期期中英语试卷

高2025届高二(上) 半期考试英语试卷(命题人: 徐薇、孙小涵审题人: 杨静)注意事项:1. 答题前, 考生务必将自己的姓名、准考证号、班级、学校在答题卡上填写清楚。

2. 每小题选出答案后, 用2B铅笔把答题卡上对应题目的答案标号涂黑, 如需改动, 用橡皮擦干净后, 再选涂其他答案标号。

在试卷上作答无效。

3. 考试结束后, 请将答题卡交回, 试卷自行保存。

满分150分, 考试用时120分钟。

第I卷(选择题)第一部分听力(共两节, 满分20分)第一节(共5小题: 每小题1分, 满分5分)听下面5段对话。

每段对话后有一个小题, 从题中所给的A、B、C三个选项中选出最佳选项。

听完每段对话后, 你都有10秒钟的时间来回答有关小题和阅读下一小题。

每段对话仅读一遍。

1. What’s wrong with the woman’s foot?A. It’s broken.B. It has a skin disease.C. It got burned by hot oil.2. What was Sparky probably doing?A. Trying on a hat.B. Destroying a hat or a tie.C. Chewing on one of his toys.3. Where does the woman want to go?A. To the office.B. To the library.C. To the dining hall.4. Why did the woman start her business?A. To learn about dogs.B. To help her neighbors.C. To finish a research project for school.5. Where might the speakers be?A. On a bridge.B. At a movie theater.C. In a car.第二节(共15小题: 每小题1分, 满分15分)听下面5 段对话或独白。

Novel type of phase transition in a system of self-driven particles

Novel type of phase transition in a system of self-driven particles
Abstract
A simple model with a novel type of dynamics is introduced in order to investigate the emergence of self-ordered motion in systems of particles with biologically motivated interaction. In our model particles are driven with a constant absolute velocity and at each time step assume the average direction of motion of the particles in their neighborhood with some random perturbation (η) added. We present numerical evidence that this model results in a kinetic phase transition from no tran |va| = 0) to finite net transport through spontaneous symmetry breaking of the rotational symmetry. The transition is continuous since |va| is found to scale as (ηc − η)β with β ≃ 0.45.
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One of the most interesting aspects of many particle systems is that they exhibit a complex cooperative behavior during phase transition [1]. This remarkable feature of equilibrium systems has been studied in great detail for the last couple of decades leading to a deeper understanding of processes which may take place in an assembly

一种新的部分神经进化网络的股票预测(英文)

一种新的部分神经进化网络的股票预测(英文)

一种新的部分神经进化网络的股票预测(英文)一种新的部分神经进化网络的股票预测自从股票市场的出现以来,人们一直在寻求能够提前预测股票走势的方法。

许多投资者和研究人员尝试使用各种技术分析工具和模型来预测股票未来的走势,但是股票市场的复杂性和难以预测性使得这变得困难重重。

因此,寻找一种能够准确预测股票走势的方法一直是金融界的热点问题。

近年来,人工智能技术在金融领域的应用日益增多。

其中,神经网络是一种被广泛使用的工具,它可以自动学习和识别模式,并根据所学的模式进行预测。

然而,传统神经网络在预测股票市场方面存在诸多问题,例如过拟合和难以处理大量数据等。

为了克服这些问题,本文提出了一种新的部分神经进化网络(Partial Neural Evolving Network, PNEN)模型来预测股票走势。

PNEN模型将神经网络和进化算法相结合,通过优化和训练来实现更准确的预测结果。

PNEN模型的核心思想是将神经网络的隐藏层拆分为多个小模块,每个小模块只负责处理一部分输入数据。

通过这种方式,模型可以更好地适应不同的市场情况和模式。

同时,采用进化算法来优化模型的参数,可以进一步提高模型的预测性能。

具体而言,PNEN模型包括以下几个步骤:1. 数据准备:从股票市场获取历史交易数据,并对数据进行预处理和归一化处理,以便更好地输入到模型中。

2. 构建模型结构:将神经网络的隐藏层拆分为多个小模块,通过进化算法来确定每个小模块的结构和参数。

进化算法通过优化模型的准确性和稳定性,以获得更好的预测结果。

3. 训练模型:使用历史数据集对模型进行训练,并通过反向传播算法来更新模型的权重和偏置。

同时,通过与进化算法的交互,不断调整模型结构和参数。

4. 预测结果:使用训练好的模型对未来的股票走势进行预测。

通过模型对市场的分析和判断,可以为投资者提供决策参考。

为了验证PNEN模型的效果,我们在实际的股票市场数据上进行了实验。

结果表明,与传统神经网络模型相比,PNEN 模型在预测股票走势方面具有更好的准确性和稳定性。

关于《中国民航大学学报》改用彩色印刷的通告

关于《中国民航大学学报》改用彩色印刷的通告

第39卷第1期韩鹏,赵嶷飞,刘宏:无人机地面撞击风险评估体系构建及趋势展望-47 -national Conference on Unmanned Aircraft Systems (ICUAS), June 9­12, 2015, Denver, CO, USA . IEEE, 2015: 1301-1309.[7] AWAD A I. An analysis of the risk from UAS missions in the nationalairspace[D]. Washington: University of Washington, 2013.[N] BARR L C, NEWMAN R, ANCEL E, et al. Preliminary risk assessmentfor small unmanned aircraft systems[C]//17th AIAA Aviation Technolo ­gy, Integration, and Operations Conference, June5-9, 2017, Denver,Colorado . Reston, Virginia: AIAA, 2017.[9] FORD A, MCENTEE K. Assessment of the risk to ground populationdue to an unmanned aircraft in-flight failure[C]//10th AIAA AviationTechnology, Integration, and Operations Conference, September 13- 15,2010, Fort Worth, Texas . Reston, Virginia: AIAA, 2010.[10] LUM C, WAGGONER B. A risk based paradigm and model for un ­manned aerial systems in the national airspace[M]. Missouri: Aerospace,2011.[11] WEIBEL R E, HANSMAN R J. Safety considerations for operation ofunmanned aerial vehicles in the national airspace system[R]. Cam ­bridge: MIT International Center for Air Transportation, 2005.[12] WOLF S E. Modeling small unmanned aerial system mishaps using lo ­gistic regression and artificial neural networks[R]. Dayton: Air Force In ­stitute of Technology, 2012.[13] ANCEL E, CAPRISTAN F M, FOSTER J V, et al. Real-time risk as ­sessment framework for unmanned aircraft system (UAS) traffic manage - ment(UTM)[C]//17th AIAA Aviation Technology, Integration, and Ope ­rations Conference, June 5-9, 2017, Denver, Colorado . Reston, Virginia:AIAA, 2017.[14] COUR -HARBO A L .Ground impact probability distribution for smallunmanned aircraft in ballistic descent[C]//2020 International Confer ­ence on Unmanned Aircraft Systems(ICUAS), September 1-4, 2020,Athens, Greece . IEEE, 2020: 1442-1451.[15] HAARTSEN Y, AALMOES R, CHEUNG Y S. Simulation of unmannedaerial vehicles in the determination of accident locations[C]//2016 IEEE International Conference on Unmanned Aircraft Systems, Arlington VA,June 7-10, 2016: 993-1002.[16] KING D W, BERTAPELLE A, MOSES C. UAV failure rate criteria forequivalent level of safety [C]//International Helicopter Safety Sympo ­sium, Montreal, Quebec, September 26-29, 2005: 1-11.[17] MELNYK R V, SCHRAGE D P, VOLOVOI V, et al. A third-party ca ­sualty risk model for UAS operations[J]. Reliability Engineering and System Safety, 2014, 124: 105-116.[18] STEVENSON J D, YOUNG S, ROLLAND L. Estimated levels of safetyfor small unmanned aerial vehicles and risk mitigation strategies [J]. Journal of Unmanned Vehicle Systems, 2015, 3(4): 205-221.[19] WU P, CLOTHIER R A. The development of ground impact models forthe analysis of the risks associated with unmanned aircraft operationsover inhabited areas[C]//11th Probabilistic Safety Assessment and Mana ­gement Conference, Helsinki, Finland, June 25-29, 2012: 1-14.[20] ANDREW D, KNOTT M, BURKE D. Population density modeling tool[R]. Maryland: Department of the Navy, Naval Air Warfare Center Air ­craft Division, 2012.[21] BURKE D A, HALL C E, COOK S P. System-level airworthiness tool[J]. Journal of Aircraft, 2011,48(3): 777-785.[22] DALAMAGKIDIS K, VALAVANIS K P, PIEGL L A. On integrating un ­manned aircraft systems into the national airspace system: issues, chal ­lenges, operational restrictions, certification, and recommendations [M]. Berlin: Springer Science and Business Media, 2011.[23] GUGLIERI G, QUAGLIOTTI F, RISTORTO G. Operational issues andassessment of risk for light UAVs[J]. Journal of Unmanned Vehicle Sys ­tems, 2014, 2(4): 119-129.[24] WAGGONER B. Developing a risk assessment tool for unmanned air 一craft system operations[D]. Washington: University of Washington, 2010.[25] BALL J A, KNOTT M, BURKE D. Crash lethality model[R]. Maryland:Naval Air Warfare Centre Aircraft Division, 2012.[26] LARSON E, HABER J M. Final quantitative risk analysis for genericlifting entry vehicle landing at edwards air force base[R]. California: AirForce Flight Test Center, 2001.[27] 韩 鹏,赵嶷飞•基于飞行环境建模的UAV 地面撞击风险研究[J].中国安全科学学报,2020, 30(1): 142-147.(责任编辑:刘佩佩)关于《中国民航大学学报》改用彩色印刷的通告为更好地呈现论文图片信息,《中国民航大学学报》于2021年第1期开始采用彩色印刷。

英语三级笔译综合能力2004年试卷、答案及解析

英语三级笔译综合能力2004年试卷、答案及解析

英语三级笔译综合能力2004年试卷Section 1 Vocabulary and Grammar (25 points)This section consists of three parts. Bead the directions for each part before answering the questions. The time for this section is 25 minutes.Part 1 Vocabulary SelectionIn this party there are 20 incomplete sentences. Below each sentence, there are four choices respectively marked by letters A, B, C and D. Choose the word or phrase which best completes each sentence. There is only ONE right answer. Then blacken the corresponding letter with a single bar across the square brackets on your Machine-scoring ANSWER SHEET.1. Grover Cleveland was the first president ______ in the White House.A. got marriedB. to get marriedC. has got marriedD. was married2. If cauliflowers are not _____ from extreme temperatures, the heads get discolored.A. protectedB. shelterC. shadeD. saved3. The gas ______ from the tank is dangerous.A. given offB. giving outC. giving awayD. given up4. When it started to snow, we turned round and _____ the hotel.A. got byB. searched forC. made forD. cleared up5. Since writing home to their parents for money, they had lived _____ hope.A. inB. forC. onD. through6. Rice is the ______ food of most Southeast Asians.A. commonB. generalC. stapleD. popular7. William Byrd was the owner of the largest library in colonial ______.A. periodB. timeC. timesD. periods8. Exobiology is the study of life ______ other planets.A. inB. atC. onD. to9. The Declaration of Independence, _______ the Constitution of the United States,was drawn up with the help of Benjamin Franklin.A. andB. alsoC. as well asD. so too10. It was from the Lowell Laboratory that the ninth ______, Pluto, was sighted in1930.A. planetB. constellationC. stardomD. satellite11 .The rodent, _______ the mouse, rat, guinea pig, and porcupine, are mammals withincisor-like teeth in both jaws.A. made upB. includingC. consistingD. constitute12. ______ into oceans and rivers is a serious form of pollution.A. Pouring sewageB. Emptying litterC. Throwing garbageD. Dumping sewage13. Products which are made from dirts and are _____ high temperatures are knownas ceramics.A. tempered inB. subjected toC. exposed toD. baked in14. A pigment called melanin protects the _____ layers of skin from sun rays.A. underB. belowC. underlyingD. underneath15. Oranges are a ______ source of vitamin C.A. wellB. betterC. goodD. very16. Even after having their grandchildren live with them for ten years, the couple feltthat ______ children these days was the most difficult of all family matters.A. risingB. raisingC. caringD. taking care17. The most important ______ of the farmers in Iraq is dates, of which Iraq is theworld's leading exporter.A. economic cropB. cash cropC. money cropD. staple18. More has been learned about the Moon than any other of the Earth's neighbors inspace because of the Apollo program, which enabled men to walk on the Moon and bring back hundreds of pounds of _____.A. rocksB. rockC. stoneD. stones19. _____ the variety that the average family has in beef, fish, poultry, and vegetarianrecipes, they find most meals unexciting.A. InspiteB. InspiteC. Despite ofD. Despite20. The speaker _____ have criticized the paraprofessionals, knowing full well thatthey were seated in the audience.A. should not toB. must notC. ought not toD. may notPart 2 Vocabulary ReplacementThis part consists of 15 sentences in which one word or phrase is underlined. Below each sentence, there are four choices respectively marked by letters A, By C and D. Choose the word or phrase that can replace the underlined part without causing any grammatical error or changing the basic meaning of the sentence. There is only ONE right answer. Blacken the corresponding letter with a single bar across the square brackets on your Machine-scoring ANSWER SHEET.21. Iceland has the oldest parliament, which goes as far back to 930 A. D. whenAlthing, the legislative organization, was established.A. officeB. adobeC. assemblyD. building22. The only problem with the debate last week was that the beginning sounded morelike a personal attack than a dispassionate, intellectual arguing.A. discussionB. argumentC. talkD. speech23. Susan Jones was at the bus stop well on time to take the 7:01 bus, but she had tomiss her breakfast to do it.A. catch up withB. catchC. run up toD. be catching24. Since her father could not drive her to the airport, she requested her uncle to driveher instead.A. takeB. bringC. dispatchD. deliver25. A famous collection of Persian, Indian, and Arabian folktales, the Arabian Nightswas supposedly told by the legendary queen Scheherazade to her husband every night for 1,001 days.A. imaginaryB. imageryC. fabledD. legend26. What may be the oldest fossil footprint yet found was discovered in June 1968 byWilliam J. Meister, a non-professional fossil collector.A. a part-timeB. a spare-timeC. an untrainedD. an amateur27. Most of us think of sharks as dangerous, owing to lack of information rather thanfear.A. due toB. becauseC. asD. for28. Double Eagle D, the first trans-Atlantic balloon, was greeted by avid crowds inFrance.A. eagerB. surgingC. appreciativeD. vigorous29. The discovery of the connection between aspirin and Reyessyndrome, a rare anddeadly ailment, is a recent example of the caution with which drugs must be used, even for medical purposes.A. diseaseB. sickC. illD. illness30. My parents moved out of their old home sometime last year after they hadcelebrated their 50th year there.A. anniversaryB. years oldC. ageD. wedding31. The library she worked in lent books, magazines, audio-cassettes and maps to itscustomers, who could keep them for four weeks.A. borrowersB. lendersC. patronsD. clients32. A common question that people ask a story writer is whether or not he hasexperienced what he has written about.A. fictionB. scienceC. imaginaryD. literary33. At the World literacy Center, an organization that works to help people read, thehelpers work hard, enabling them to successfully reach their goals.A. assistantsB. volunteersC. part-timersD. amateurs34. The officers made it clear that they were letting her go only because that she wasold and not because she was above suspicion.A. for reasonB. due toC. because ofD. on the grounds35. The book, which is a useful guide for today's young people, deals with manyquestions and problems that face them at school and at home as well as in society.A. are facedB. confrontC. in oppositionD. meetPart 3 Error CorrectionThis part consists of 75 sentences in which there is an underlined part that indicates a grammatical error. Below each sentence, there are four choices respectively marked by letters A, B, C and D. Choose the word or phrase that can replace the underlined part so that the error is corrected. There is only ONE right answer. Blacken the corresponding letter with a single bar across the square brackets on your Machine-scoring ANSWERSHEET.36. All don't have a free ticket must pay the admission fee.A. Everyone who doesn't have a free ticketB. No one who doesn't have a free ticketC. No one who has free ticketsD. Anyone who has free tickets37. When I last saw them, the police had chased the robbers down Columbus Street.A. were chasingB. was chasingC. chasedD. were on a chase38. Erosion that is a slow process, but it constantly changes the features on the surfaceof the earth.A. which isB. althoughC. beingD. is39. When an organism is completely encapsulated and preserved, it becomes a fossil,therefore turning into evidence of things that once lived.A. therebyB. as a result ofC. soD. in the end40. The pictures of the Loch Ness Monster show a remarkable resemblance to aplesiosaur, a large water reptile of the Mesozoic era presuming extinct for more than 70 million years.A. supposedB. presumablyC. presumptuousD. is presumed41. In our own galaxy, the Milky Way, there are perhaps 200 billion stars, a small partof them probably have planets on which life is feasible.A. a small fraction in whichB. a small fraction of whichC. a small fraction whichD. which a fraction of42. "But you'll be able to come, won’t you?" "Yes, I think such."A. thatB. itC. soD. this43. The professor is quite difficult pleased.A. to pleaseB. to be pleasedC. for pleasingD. pleasing44. Because everyone knows, facts speak louder than words.A. SinceB. ThatC. ItD. As45. The trapeze artist who ran away with the clown broke up the lion tamer's heart.A. broke awayB. broke downC. brokeD. broken down46. His heavy drinking and fond of gambling makes him a poor role model.A. and fact that he gamblesB. and that he gamblesC. and he gambles whichD. and gambling47. Depression that inflicts people who believe their lives lack content when the rushof the busy week stops referred to by a prominent psychiatrist as Sunday Neurosis.A. has been referred to by a prominent psychiatristB. has been referred to as by a prominent psychiatristC. a prominent psychiatrist has referred to itD. it has been referred to by a prominent psychiatrist48. Just as there are occupations that require college degrees also there areoccupations for which technical training is necessary.A. so to there areB. so too there areC. so there areD. so too are there49. Most of the older civilizations which flourished during the fifth century B. C. aredied out.A. they have died outB. has died outC. have died outD. they had died out50. The student asked her professor if he would have gone on the spaceship he didknow earlier.A. if he knewB. if he knowsC. he had knownD. had he known Section 2 Reading Comprehension (55 points)In this section you will find after each of the passages a number of questions or unfin-ished statements about the passage, each with four (A, B, C and D) choices to com-plete the statement. You must choose the one which you think fits best. Then blacken the corresponding letter with a single bar across the square brackets on your Machine-scoring ANSWER SHEET.Passage OneQuestions 51 - 56 are based on die following passage.Awarded the Nobel Prize for physics in 1918, German physicist Max Planck is best remembered as the originator of the quantum theory. His work helped usher in a new era in theoretical physics and revolutionized the scientific community’s understanding of atomic and subatomic processes.Planck introduced an idea that led to the quantum theory, which became the foundation of twentieth century physics. In December 1900, Planck worked out an equation that described the distribution of radiation accurately over the range of low to high frequencies. He had developed a theory which depended on a model of matter that seemed very strange at the time. The model required the emission of electromagnetic radiation in small chunks or particles. These particles were later called quantums. The energy associated with each quantum is measured by multiplying the frequency of the radiation, v, by a universal constant, h. Thus, energy, or E, equals hv. The constant, h, is known as Planck's constant. It is now recognized as one of the fundamental constants of the world.Planck announced his findings in 1900, but it was years before the full consequences of his revolutionary quantum theory were recognized. Throughout his life, Planck made significant contributions to optics, thermodynamics and statistical mechanics, physical chemistry, among other fields.51. In which of the following fields did Max Planck NOT make a significantcontribution?A. Optics.B. Thermodynamics.C. Statistical mechanics.D. Biology.52. The word "revolutionary" as used in Line 15 means_.A. radicalB. extremistC. momentousD. militaristic53. It can be inferred from the passage that Planck’s work led to the development of________.A. The rocketB. The atomic bombC. The internal combustion engineD. The computer54. The particles of electromagnetic radiation given off by matter are known as ____.A. quantumsB. atomsC. electronsD. valences55. The implication in this passage is that ______.A. only a German physicist could discover such a theoryB. quantum theory, which led to the development of twentieth century physics, isbasically a mathematical formulaC. Planck's constant was not discernible before 1900D. radiation was hard to study56. ―An idea‖ as used in line 5, refers to _____.A. a model of matterB. emission of electromagnetic radiationC. quantumsD. the equation that described the distribution of radiation accurately over the range of low to high frequenciesPassage TwoQuestions 57 ~ 62 are based on the following passage.There has been much speculation about the origin of baseball. In 1907 a special commission decided that the modern game was invented by Abner Doubleday in 1839. One hundred years later the National Baseball Museum was opened to honor Doubleday. Historians, however, disagree about the origin of baseball. Some say that baseball comes from bat-and-ball games of ancient times. It is a matter of record that in the 1700s English boys played a game they called ―baseball‖. Americans have played a kind of baseball since about 1800. At first the American game had different rules and different names in various parts of the country —―town ball‖, ―rounders‖, or ―one old cat‖. Youngsters today still play some of these simplified forms of the game.Baseball did not receive a standard set of rules until 1845, when Alexander Cartwright organized the Knickerbocker Baseball Club of New York City. The rules Cartwright set up for his nine-player team were widely adopted by other clubs and formed the basis of modern baseball. The game was played on a "diamond" infield with the bases 90 feet apart. The first team to score 21 runs was declared the winner. By 1858 the National Association of Baseball Players was formed with 25 amateur teams. The Cincinnati Red Stockings began to pay players in 1869.57. Which of the following is true about the origins of baseball?A. Historians agree that baseball was invented by Abner Doubleday.B. Baseball, as played in the early 19th century, differed very little from today'sgame.C. As early as the 1700s, English boys played a game called "baseball".D. The first standard set of baseball rules was established at the turn of the century.58. What was the first professional baseball team called?A. New York Knickerbockers.B. Milwaukee Braves.C. Cincinnati Red Stockings.D. Brooklyn Dodgers.59. Who first gave baseball a standard set of rules?A. Abner Doubleday.B. Alexander Cartwright.C. Albert Spalding.D. Babe Ruth.60. Which of the followings was not a predecessor of baseball?A. Rounders.B. Town ball.C. Cricket.D. One old cat.61. The tone of the passage is ______.A. persuasiveB. informativeC. biasedD. argumentative62. The passage implies that until 1869, baseball was played for all of the followingreasons except _______.A. exerciseB. leisureC. profitD. socializingPassage ThreeQuestions 63-68 are based on the following passage.The blue of the sea is caused by the scattering of sunlight by tiny particles suspended in the water. Blue light, being of short wavelength, is scattered more efficiently than light of longer wavelengths. Although waters of the open ocean are commonly some shade of blue, green water is commonly seen near coasts, especially in tropical or subtropical regions. This is caused by yellow pigments being mixed with blue water. Phytoplankton are one source of the yellow pigment. Other microscopic plants may color the water brown or brownish-red. Near the shore, silt or sediment in suspension can give water a brownish hue. Outflow of large rivers can often be observed many miles offshore by the coloration of suspended soil particles.Marine phytoplankton (Greek for "plant wanderers") are microscopic single-celled plants that include diatoms, dinoflagellates, coccolithophorids, green algae, and blue-green algae, among others. The growth of these organisms, which photogynthesize light, depends on a delicate balance of nutrient enrichment via vertical mixing, which is often limited by the availability of nitrogen and light. Diatoms are one-celled plants with patterned glass coverings. Each glass, or silicon dioxide box, is ornamented with species-specific designs, pits, and perforations making them popular with microscopists and, more recently, electron scanning microscopists.63. Green water near coastlines is almost always caused by _____.A. sand colorB. red pigments in coastal watersC. blue pigmentD. reflected light and yellow pigment from plant life64. Phytoplankton are the source of which color pigment?A. Red.B. Green.C. Yellow.D. Blue.65. What can give waters a brownish hue near the shore?A. Sediment.B. Phytoplankton.C. Blue pigment.D. Diatoms.66. Which of the following is NOT a type of phytoplankton?A. Green algae.B. Diatoms.C. Blue-green algae.D. Amoeba.67. The growth of phytoplankton is often limited by the availability of _____.A. oxygenB. hydrogenC. nitrogenD. carbon dioxide68. The main idea of this passage is that _____.A. light causes sea colorB. sea coloration is varied because of a combination of length of light waves andmicroscopic plant life and siltC. microscopic plant life causes sea colorD. water composition causes sea colorPassage FourQuestions 69 - 75 are based on the following passage.The United States government publishes guidelines for appropriate nutrient intakes. These are known as the Recommended Dietary Allowances (RDAs) and are updated regularly based on new research in nutrition. RDAs are suggested amounts of calories, protein, and some minerals and vitamins for an adequate diet. For other dietary substances, specific goals must await further research. However, for the U.S. population as a whole, increasing starch and fiber in one's diet and reducing calories (primarily from fats, sugar, and alcohol) is sensible. These suggestions are especially appropriate for people who have other factors for chronic diseases due to family history of obesity, premature heart disease, diabetes, high blood pressure, and high blood cholesterol, or for those who use tobacco.Snacks can furnish about one-fourth of the calorie requirements among teenagers. Those snacks should also provide much of the day's allowances for protein, minerals, and vitamins. Sandwiches, fruit, and milk make good snacks for active teenagers. Food from the food pyramid may be part of any meal. A grilled cheese sandwich or a bowl of whole-grain cereal is just as nutritious in the morning as it is at noon. In addition, a good breakfast consists of any foods that supply about one-fourth of the necessary nutrients for the day.69. The passage directly states that most of the U. S. population should increase theirintake of ______.A. proteinB. fatsC. starch and fiberD. sandwiches70. A good breakfast should supply about what percentage of the necessary nutrientsfor the day?A. One-half.B. One-third.C. One-fourth.D. Less than one-fourth.71. The passage implies which of the following?A. The rime of day when food is consumed affects its nutritive value.B. Different foods can be combined to increase total nutrition value.C. It can be detrimental to your health to eat breakfast foods later in the day.D. When food is eaten has no bearing on its nutritive effects.72. Why are RDAs regularly updated?A. New discoveries in the science of nutrition are constantly being made.B. Americans' diets are constantly changing.C. As people age, their nutritional needs change.D. Very little is currently known about nutrition.73. In this passage RDAs refers to___.A. types of vitaminsB. types of proteinC. types of mineralsD. amounts of energy, protein, vitamins, and minerals74. One implication in this passage is that _____.A. all RDAs have been establishedB. not all RDAs have been established yetC. it's not important to know RDAsD. RDAs are necessary only for sick people75. The reduction of calories in the diet is particularly good for people who sufferfrom ________.A. obesityB. premature heart disease and diabetesC. high blood pressure and cholesterol levelsD. all of the abovePassage FiveQuestions 76 - 81 are based on the following passage.The most popular organic gem is the pearl. A pearl is the response of a marine mollusk to the presence of an irritating impurity accidentally introduced into its body;a cultured pearl is the result of the intentional insertion of a mother-of-pearl bead into a live mollusk. Whether introduced accidentally or intentionally, the pearl-making process is the same: the mollusk coats the irritant with a substance called nacre. Nacre is composed chiefly of calcium carbonate. Because very few natural pearls are now on the market, most pearls used in fine jewelry are cultured. These include "Biwa" pearls and most other freshwater pearls. Cultured pearls are not easily distinguished from natural pearls except by an expert.76. Which of the following people could tell the difference between a cultured pearland an organic pearl?A. Scuba diver.B. Fisherman.C. Jeweler.D. Clerk.77. What is the chief component of nacre?A. Sand.B. Bead.C. Calcium carbonate.D. Biwa.78. The difference between a pearl and a cultured pearl is the nature of the ____.A. colorB. introduction of the irritating impurityC. coating materialD. irritating impurity79. Nacre is a substance that is ______.A. mechanically manufacturedB. the result of laboratory testingC. organically secreted by the molluskD. present in the chemical composition of freshwater pounds80. The main idea of this passage is that ______.A. most marketable pearls are cultured because nature does not produce enough ofits own to satisfy the marketB. cultured pearls are of a higher quality than natural pearlsC. there are two major methods of pearl-makingD. a natural ―drought‖ of pearl production is taking place81. Cultured pearl is formed by ____.A. insertion of a pearl into a live molluskB. an oyster into which a piece of grit has been placedC. putting in a live molluskD. placing a bead into culturePassage SixQuestions 82-87 are based on the following passage.Stress is with us all the time. It comes from mental or emotional activity as well as physical activity. It is unique and personal to each of us. So personal, in fact, that what may be relaxing to one person may be stressful to another. For example, if you're a busy executive who likes to keep occupied all of the time, "taking it easy" at the beach on a beautiful day may be extremely frustrating, nonproductive, and upsetting. You may be emotionally distressed from "doing nothing." Too much emotional stress can cause physical illnesses such as high blood pressure, ulcers, or even heart disease. Physical stress from work or exercise is not likely to cause such ailments. The truth is that physical exercise can help you to relax and to better handle your mental or emotional stress.82. Which of the following people would find ―taking it easy‖ stressful?A. Construction workers.B. Business executives.C. Farm workers.D. Truck drivers.83. Which of the following would be a determinant as to what people find stressful?A. Personality.B. Education.C. Marital status.D. Shoe size.84. This article, published by the Department of Health and Human Services,probably came from the ______.A. Federal Bureau of InvestigationB. Alcohol, Drug Abuse, and Mental Health AdministrationC. Education AdministrationD. Communicable Diseases Administration85. A source of stress NOT specifically mentioned in this passage is _____.A. educational activityB. physical activityC. mental activityD. emotional activity86. Physical problems caused by emotional stress can appear as all of the followingEXCEPT _____.A. ulcersB. pregnancyC. heart diseaseD. high blood pressure87. One method mentioned to help handle stress is ____.A. physical exerciseB. tranquilizersC. drugsD. taking it easy Passage SevenQuestions 88 ~ 92 are based on the following passage.With the sudden onset of severe psychotic symptoms, the individual is said to be experiencing acute schizophrenia (精神分裂症) - "Psychotic" means out of touch with reality, or unable to separate real from unreal experiences. Some people have only one such psychotic episode. Others have many episodes during a lifetime but lead relatively normal lives during interim periods. The individual with chronic (continuous or recurring) schizophrenia often does not fully recover normal functioning and typically requires long-term treatment, generally including medication, to control the symptoms. These symptoms may include hallucinations (幻觉), incoherence, delusions, lack of judgment, deterioration of the abilities to reason and feel emotion, and a lack of interaction between the patient and his environment. The hallucinations may be a visual, auditory, or tactile. Some chronic schizophrenic patients may never be able to function without assistance of one sort or another.88. Which of the following is not a symptom of schizophrenia?A. Hallucinations.B. Delusions.C. Incoherence.D. Vertigo.89. It can be inferred from the passage that a person experiencing acute schizophreniamost likely ______.A. cannot live without medicationB. cannot go on livingC. can hold a full-time jobD. cannot distinguish real from unreal90. According to this passage, thinking that one can fly might be an example of ____.A. medicine overdoseB. being out of touch with realityC. recovering normal functioningD. symptom control91. The passage suggests that the beginning of severe psychotic symptoms of acuteschizophrenia may be any of the following EXCEPT_____.A. debilitatingB. sudden occurrenceC. occurring after a long period of normalcyD. drug-induced92. The passage implies that normal life may be possible for the chronicschizophrenic with the help of ______.A. medicinesB. neurotic episodesC. psychotic episodesD. time Passage EightQuestions 93 ~ 100 are based on the following passage.Aspirin is one of the safest and most effective drugs invented by man. The most popular medicine in the world today, it is an effective pain reliever. Its bad effects are relatively mild. It is also cheap.For millions of people suffering from arthritis, it is the only thing that works. Aspirin, in short, is truly the 20th-century wonder drug. It is also the second largest suicide drug and is the leading cause of poisoning among children. It has side effects that, although relatively mild, are largely unrecognized among users.Although aspirin was first sold by a German company in 1899, it has been around much longer than that. Hippocrates, in ancient Greece, understood the medical value of tree barks and leaves which today are known to contain a chemical found in aspirin. During the 19th century, there was a great deal of experimentation in Europe with this。

6条目孤独感量表(ULS-6)是测量中国成年人群孤独感的有效工具

6条目孤独感量表(ULS-6)是测量中国成年人群孤独感的有效工具

孤独感是当个体缺乏社会支持或者社会互动不足时产生的消极主观体验[1],这种消极体验已越来越成为全球备受关注的公共卫生问题,多项研究表明,持续的孤独感会影响个体的身心健康,长期有孤独感经历和体验的人会产生更多的焦虑、抑郁症状和睡眠问题,甚至会有更大的自杀和早期死亡风险[2-5]。

目前有关研究大多集中在老年人群体上,这是因为孤独感是老年人明确的严重疾病和死亡的危险因素[6]。

但老年人并不是唯一面临孤独感风险的人群,孤独感普遍存在于各个年龄阶段的人群中。

如今青年人的孤独感正在逐渐升高,孤独感的高峰值也被证实存在于大约30岁和60岁年龄阶层的人群中[7]。

且自疫情发生以来,由于隔离政策的实行,许多人的生活和工作方式被迫发生了改变,社交距离的拉长进一步导致了孤独感流行率的增高,孤独感的发生更为普遍[8-11],所以在关注老年人群体孤独感的同时,其它成年人群的孤独感也亟需引起重视。

洛杉矶加州大学孤独感量表(ULS )[12]是目前最常用的测量成年人群孤独感的量表[13,14],为减轻被试的答题负担及探究量表在不同人群中的适用情况,ULS 被修订为多个简式版本,如Hughes 等[15]修订的3条目简式版本、Russell 等[16]修订的4条目简式版本、Hays 等[17]修订的8条目简式孤独感量表(ULS-8)。

其中ULS-8在国内Reliability and validity of the 6-item UCLA Loneliness Scale (ULS-6)for application in adultsXIAO Rong 1,2,DU Jingwen 11Department of Psychology,School of Public Health,Southern Medical University,Guangzhou 510515,China;2Department of Psychiatry,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China摘要:目的修订6条目孤独感量表(ULS-6)并在成年人群中使用,评价其测量学性能和适用性。

肌肉神经系统英语作文

肌肉神经系统英语作文

肌肉神经系统英语作文The Muscular and Nervous SystemsThe human body is a complex and intricate system, composed of various interconnected components that work together to maintain our overall health and well-being. Two of the most critical systems within the body are the muscular system and the nervous system. These two systems play a vital role in our ability to move, feel, and interact with the world around us.The muscular system is composed of hundreds of individual muscles, ranging from the small muscles in the hands and feet to the large, powerful muscles of the legs and torso. Each muscle is made up of specialized cells called muscle fibers, which are capable of contracting and relaxing in response to signals from the nervous system. When these muscle fibers contract, they pull on the bones and joints, allowing us to move and perform a wide range of physical activities.The nervous system, on the other hand, is responsible for coordinating and controlling the various functions of the body. It is divided into two main parts: the central nervous system (CNS), whichincludes the brain and spinal cord, and the peripheral nervous system (PNS), which includes the nerves that extend throughout the body. The nervous system receives and processes information from the senses, and then sends signals to the muscles, telling them when to contract or relax.The relationship between the muscular and nervous systems is a complex and interdependent one. The nervous system is responsible for initiating and controlling the movements of the muscles, while the muscles in turn provide feedback to the nervous system about the position and movement of the body. This constant communication between the two systems allows us to perform a wide range of physical activities, from simple movements like walking or reaching for an object, to more complex tasks like playing a sport or playing a musical instrument.One of the key functions of the muscular and nervous systems is the coordination of movement. When we want to move a part of our body, the nervous system sends a signal to the appropriate muscle or group of muscles, telling them to contract. This contraction then causes the muscle to pull on the bone or joint, resulting in the desired movement. The nervous system also plays a crucial role in the fine-tuning of these movements, allowing us to make small, precise adjustments as needed.In addition to movement, the muscular and nervous systems also play a role in our ability to sense and perceive the world around us. The nervous system is responsible for processing sensory information, such as touch, temperature, and pain, and sending this information to the brain for interpretation. The muscles, in turn, provide feedback to the nervous system about the position and movement of the body, allowing us to maintain balance and coordination.Another important aspect of the muscular and nervous systems is their role in maintaining overall health and well-being. Regular physical activity, which involves the coordinated movement of the muscles, has been shown to have numerous benefits for both physical and mental health. Exercise can help to improve cardiovascular health, increase muscle strength and endurance, and reduce the risk of chronic diseases such as diabetes and heart disease.The nervous system also plays a crucial role in our overall health and well-being. The brain, which is the central hub of the nervous system, is responsible for regulating a wide range of bodily functions, including sleep, mood, and cognitive function. When the nervous system is functioning properly, we are able to think clearly, feel emotionally balanced, and maintain a healthy sleep-wake cycle. However, when the nervous system is disrupted or damaged, it canlead to a variety of health problems, such as chronic pain, anxiety, and depression.In conclusion, the muscular and nervous systems are two of the most important and complex systems in the human body. They work together to allow us to move, sense, and perceive the world around us, and they play a crucial role in maintaining our overall health and well-being. By understanding the intricate workings of these systems, we can better appreciate the remarkable capabilities of the human body and take steps to keep these systems functioning at their best.。

高中英语精华双语文章实验中的“小白鼠”素材

高中英语精华双语文章实验中的“小白鼠”素材

高中精华双语文章:实验中的“小白鼠”医学研究以及各种药物的研发,都要在动物身上进行大量的实验才能用于人身上。

为此,国际反动物痉实验协会提出了反对意见。

无论在何处,有可能的话,基于伦理和科学的原因,我们不应使用动物做实验,但完全停止在动物身上实验还有很长的路要走。

The Little White Mice in Experiments实验中的“小白鼠”Professor Colin Blakemore works at Oxford University Medical School doing research into eye problems and believes that animal research has given humans many benefits: 科林·布莱克默教授在牛津大学医学院工作,从事眼睛疾病的研究。

他相信对动物的研究已使人类获益匪浅。

The use of animals has been central to the development of anaesthetics, vaccines and treatments for diabetes, cancer, developmental disorders…most of the major medical advances have been based on a background of animal research and development. 使用动物对于麻醉学和疫苗的发展,对糖尿病、癌症和紊乱的治疗等极其重要。

多数重要的医学都是以动物研究和开发的背景为基础的。

There are those who think the tests are simply unnecessary. The International Association Against Painful Experiments on Animals is an organization that promotes the use of alternative methods of research which do not make animals suffer. Their spokesman Colin Smith says: Animal research is irrelevant to our health and it can often produce misleading results. People and animals are different in their reactions to drugs and in the way their bodies work. We only have to look at some of the medical mistakes to see this is so.有些人认为这些实验毫无必要。

1999年6月全国大学英语六级考试(CET-6)真题及答案解析

1999年6月全国大学英语六级考试(CET-6)真题及答案解析

1999年6月大学英语六级(CET-6)真题Part I Listening Comprehension (20 minutes)Section ADirections:In this section, you will hear 10 short conversations. At the end of each conversation, a question will be asked about what was said. Both the conversation and the question will be spoken only once. After each question there will be a pause. During the pause, you must read the four choices marked A), B), C) and D), and decide which is the best answer. Then mark the corresponding letter on the Answer Sheet with a single line through the centre.Example:You will hear:You will read: A) 2 hours.B) 3 hours.C) 4 hours.D) 5 hours.From the conversation we know that the two are talking about some work they will start at 9 o’clock in the morning and have to finish at 2 in the afternoon. Therefore, D) “5 hours” is the correct answer. You should choose [D] on the Answer Sheet and mark it with a single linethrough the center.Sample Answer [A] [B] [C] [D]1.A) The man attended the concert, but didn’t like it.B) The man was sorry to miss the football game.C) The man is more interested in football than in classical music.D) The man was sorry that he didn’t attend the concert.(C)2.A) Singing loudly.B) Listening to music.C) Studying.D) Talking on the phone.(B)3.A) She can’t receive any calls.B) She can’t make any calls.C) She can do nothing with the phone.D) She can’t repair the phone.(A)4.A) Tom is very responsible.B) Tom’s words aren’t reliable.C) What Tom said is true.D) Tom is not humorous at all.(B)5.A) How to use a camera.B) How to use a washer.C) How to use a keyboard.D) How to use a tape recorder.(A)6.A) They should put the meeting to an end.B) They should hold another meeting to discuss the matter.C) She would like to discuss another item.D) She wants to discuss the issue again later.(D)7.A) He believes the Browns have done a sensible thing.B) He doesn’t think the Browns should move to another place.C) He doesn’t think the Browns’ investment is a wise move.D) He believes it is better for the Browns to invest later.(C)8.A) He may convert it and use it as a restaurant.B) He may pull it down and build a new restaurant.C) He may rent it out for use as a restaurant.D) He may sell it to the owner of a restaurant.(A)9.A) She doesn’t like the way the professor lectures.B) She’s having a hard time following the professor’s lectures.C) She is not interested in course.D) She’s having difficulty with the heavy reading assignments.(D)10.A) He never keeps his promises.B) He is crazy about parties.C) He has changed his mind.D) He is not sociable.(C)Section B Compound Dictation注意: 听力理解的B节(Section B)为复合式听写(CompoundDictation),题目在卷二上。

动力学 英文卷子

动力学 英文卷子

动力学英文卷子Chapter 1: Introduction to System Dynamics1.The five disciplines1) Systems thinking 2) Personal mastery 3) Mental models4) Building shared vision 5) Team learning2.The definition of Mental ModelsMental models are the images (attitudes and assumptions) we carry in our minds about ourselves, other people, institutions, and every aspect of the world which guide our interpretations and behavior.3.Butterfly EffectThe butterfly effect is the sensitive dependence on initial conditions in which a small change at one place in a deterministic nonlinear system can result in large differences in a later state.Chapter2: Systems and System Thinking1.Modeling conceptsA model is an abstraction of a real object or system.2.System definitionA system is a set of two or more elements that satisfies the following three conditions:It fulfills a certain functionThe behavior of each element has an effect on the behavior of the wholeThe behavior of the elements and their effects on the whole are interdependentThe behavior of a system depends not only on the behavior of the components of a system but also on how these components interact.3.System components1)Objects 2) States 3) Events 4) Time 5) Space 6)Structure4. “Complex systems”are systems in which there are multiple interactions between many different components (or agents). A complex system is characterized by multiple agents whose interactions give rise to structural effects that aren’t apparent in the agents themselves.Chapter 4: Structure and Behavior of Dynamic Systems4.1 Fundamental modes of dynamic behaviorFundamental modes of dynamic behaviorThe most fundamental modes of behavior are exponential growth, goal seeking, and oscillation. Each of these is generated by a simple feedback structure:- Exponential growth arises from positive feedback- Goal seeking arises from negative feedback- Oscillation arises from negative feedback with time delays in the loop.Other common modes of behavior, including S-shaped growth, S-shaped growth with overshoot and oscillation, and overshoot and collapse, arise from nonlinear interactions of the fundamental feedback structures.4.1.1 Exponential GrowthExponential growth arises from positive (self-reinforcing) feedback. The larger the quantity, the greater its net increase, further augmenting the quantity and leading to ever-faster growth.Pure exponential growth has the remarkable property that the doubling time is constant: the state of the system doubles in a fixed period of time, no matter how large.When a Rate Is Not a RateIn dynamic modeling, the term "rate" generally refers to the absolute rate of change in a quantity. The term "birth rate" here refers to the number of people born per time period. Often, however, the term "rate" is used as shorthand for the fractional rate of change of a variable. For example, the birth rate is often interpreted as the number of births per year per thousand people. Similarly, we commonly speak of the unemployment rate. The word "rate" in these cases actually means "ratio": the unemployment rate is the ratio of the number of unemployed workers to the labor forceThe units of measure for rates of flow are units/time period.The units of measure for fractional rates of flow are units per unit per time period= 1/time periods.4.1.2 Goal SeekingNegative loops seek balance, equilibrium, and stasis. Negative feedback loops act to bring the state of the system in line with a goal or desired stat e.When the relationship between the size of the gap and the corrective action is linear, the rate of adjustment is exactly proportional to the size of the gap and the resulting goal-seeking behavior is exponential decay. As the gap falls, so too does the adjustment rate.Every negative loop includes a process to compare the desired and actual conditions and take corrective action.4.1.3 OscillationOscillation is the third fundamental mode of behavior observed in dynamic systems. Like goal-seeking behavior, oscillations are caused by negative feedback loops.In an oscillatory system, the state of the system constantly overshoots its goal or equilibrium state, reverses, then undershoots, and so on.The overshooting arises from the presence of significant time delays in the negative loop. The time delays cause corrective actions to continue even after the state of the system reaches its goal, forcing the system to adjust too much, and triggering a new correction in the opposite directionOscillations are among the most common modes of behavior in dynamic systems. Damped oscillations Limit cycles ChaosOscillations can arise if there is a significant delay in any part of the negative loop. Perceiving the state of the system caused by the measurement and reporting system Initiating corrective actions after the discrepancy is perceived due to the time required to reach a decision.Delays between the initiation of a corrective action and its effect on the state of the systemeg. It takes time for a company to measure and report inventory levels, time for management to meet and decide how much to produce, and more time while raw materials procurement, the labor force, and other needed resources respond to the new production schedule.。

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+0.27 ∆m2 21 = 7.9 −0.28 +1.1 −0.89
× 10−5 eV2 ,
(1) (2) (3) (4) (5)
−3 ∆m2 eV2 , 31 = 2.6 ± 0.2 (0.6) × 10
where we have employed the conventional notation for the superfields [11]. For later use, we have also included the superpotential terms involving the downlike Higgs superfield. The terms in WLi violate Rparity (a Z2 -symmetry) as well as proton hexality [12, 13] (a Z6 -symmetry), but conserve baryon triality (B3 , a Z3 -symmetry, sometimes also misleadingly called baryon parity) [14, 15, 16]. The Majorana neutrino masses are generated via tree-level mixing with the neutralinos, as well as via radiative corrections [10, 17, 18, 19, 20, 21, 22]. There is an implicit see-saw mechanism in the neutralino-neutrino sector: κ2 i /M1/2 , but with a much smaller hierarchy of mass scales. Furthermore, no new fields or mass scales are required. Within a baryon triality supergravity model the largest neutrino mass is naturally small [11]. For universal soft breaking terms, the mixing, κi , with the neutralinos is zero at the unification scale. It is subsequently generated at the order of a few MeV via renormalization group equations. It is thus proportional to the product of a (small) down-like Higgs Yukawa coupling (for example of the bottom quark or the tau lepton), a (small) baryon triality coupling and the Higgs mixing parameter µ [11, 23, 24, 25]. The lighter neutrino masses are generated via radiative corrections, and are naturally further suppressed. There are 9 + 27 + 3 = 39 lepton-number violating (complex) parameters in the superpotential WL . There are also 39 corresponding soft-supersymmetry breaking parameters, which in principle are independent, but are usually related to those of WL via universal soft-supersymmetry breaking [26]. In a top-down approach, e.g. based on the Froggatt-Nielsen mechanism [27], one can attempt to predict the order of magnitude of all superpotential parameters, i.e. WLp together with the Higgs Yukawa couplings, based on a spontaneously broken gauge symmetry, Ref. [28, 29] and references therein. See also Refs. [21, 22, 30, 31]. In this letter, we instead propose a baryon tri-
A Simple Baryon Triality Model for Neutrino Masses
Herbi K. Dreiner,∗ Jong Soo Kim ,† and Marc Thormeier ‡
Physikalisches Institut der Universit¨ at Bonn Nußallee 12, 53115 Bonn, Germany (Dated: February 2, 2008) We make a simple ansatz for the supersymmetric lepton-number violating Yukawa couplings, by relating them to the corresponding Higgs Yukawa couplings. This reduces the free B3 parameters from 36 to 6. We fit these parameters to solve the solar and atmospheric neutrino anomalies in terms of neutrino oscillations. The resulting couplings are consistent with the stringent low-energy bounds. We investigate the resulting LHC collider signals for a stau LSP scenario.
∗ E-mail: † E-mail:
dreiner@th.physik.uni-bonn.de jsk@th.physik.uni-bonn.de ‡ E-mail: thor@th.physik.uni-bonn.de
ality model of neutrino masses, based on a simple phenomenological ansatz, which relates the Higgs superpotential parameters to those that violate leptonnumber. The justification for this is that the down-like Higgs doublet superfield and the lepton-doublet superfields have identical Standard Model gauge quantum numbers. We make no assumption about the possible underlying theory at the unification scale. This ansatz dramatically reduces the number of free parameters. If experimentally confirmed it would give a clear indication on how to construct the more fundamental unified theory. In the literature there are other simple ans¨ atze [32, 33, 34], the most common and also the most similar to ours is pure bi-linear lepton-number violation, i.e. λijk = λ′ ijk = 0, and κi = 0. For this there is an extensive literature, see for example [17, 18, 21, 30, 35, 36] and references therein. We discuss how our ansatz differs from the bi-linear case in Sect. III. A special feature of baryon triality models for the neutrino masses, is that they lead to other observable effects at colliders and can thus be tested [34, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52]. In the case of pure tri-linear couplings (κi = 0), a fit to the neutrino data, Eqs. (1)-(5), leads to values in −5 the range λijk , λ′ − 10−4 [53, 54, 55, 56]. ijk ∼ 10 These couplings are very small, in particular, too small for the resonant production of supersymmetric particles [57]. However, they do lead to the decay of the lightest supersymmetric particle in the detector, possibly with a detached vertex. This model can be confirmed by measuring the branching ratios of the various lightest supersymmetric particle (LSP) decays and thereby measuring the couplings. However, several points have in my opinion been missed in the literature. In the case of a pure fit, i.e. not a model, it is possible to have larger couplings, which do not contribute to the neutrino masses, or which are not required for the fit. In this case, the LSP decay which dominates the collider signals will be completely independent of the neutrino sector. Thus pure fit models can only be tested if the neutrino mass parameters dominate the B3 sector. We consider here a complete model, where the fit to the neutrino data fixes all the B3 parameters. Second, it has hitherto been assumed, that the LSP is the lightest neutralino. We go beyond this and also consider a scalar tau LSP [11, 58]. Our analysis is structured as follows: In Sect. II, we present our model in detail. We then briefly review the neutrino masses in baryon triality models, Sect. IV. In Sect. V, we estimate the values of the free parameters which result in acceptable neutrino masses. In Sect. VI, we numerically evaluate the new parameters in our model, such that the neutrino masses and mixing angles fall in the required experimental ranges, cf Eqs. (1)-(5). In order to obtain at least two non-vanishing neutrino masses, we must violate 2
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