400087 HIF2 抑制剂
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400087 HIF-2α Translation Inhibitor
Hypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II
产品信息Fra Baidu bibliotek
Form Protect from Light Packaged under inert gas Purity Chemical formula CAS number Yellow solid 是的 是的 ≥95% (sum of two isomers) C 9 H 9 N 3 O 4 S2 882268-69-1
要求的价格 若价格有变动将不另行通知
A cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5 to 10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.
商店和运输信息
Storage +2°C to +8°C
Ship
Ambient Temperature Only Standard Handling
© Merck KGaA, Darmstadt, Germany, ecom(at)merck-china.com, 2012
常规问题请联系我们的客户服务人员 Merck KGaA Frankfurter Str. 250 64293 Darmstadt Germany 电话 +49 6151 72-0 传真： +49 6151 72 2000
10 七月 2012
产品编号
400087-10MG
Qty/Pk
10 mg
价格
Hypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II
产品信息Fra Baidu bibliotek
Form Protect from Light Packaged under inert gas Purity Chemical formula CAS number Yellow solid 是的 是的 ≥95% (sum of two isomers) C 9 H 9 N 3 O 4 S2 882268-69-1
要求的价格 若价格有变动将不另行通知
A cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5 to 10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.
商店和运输信息
Storage +2°C to +8°C
Ship
Ambient Temperature Only Standard Handling
© Merck KGaA, Darmstadt, Germany, ecom(at)merck-china.com, 2012
常规问题请联系我们的客户服务人员 Merck KGaA Frankfurter Str. 250 64293 Darmstadt Germany 电话 +49 6151 72-0 传真： +49 6151 72 2000
10 七月 2012
产品编号
400087-10MG
Qty/Pk
10 mg
价格