神经内分泌学--生长轴ppt课件
相关主题
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
1、Stimulation (major) • M-ENK • β-EP • NT • P 物质 • VIP • 胃泌素 • PACAP • Galanin
2、inhibition (major) • CRF • CCK • AII • NPY
5). Hormone regulates GH
• GC ＋ • T3,T4 ＋ • E and T ＋
神经内分泌学-生长轴
Growth hormone(GH):
• Secrete by anterior pituitary • Single peptide chain • Composed of 191 aa • molecular mass: 22kDa
Function of Growth hormone
2). Feedback mechanism
• GHRH regulates GH release by supershort
loop：via stimulates SS release from CNS to to portal vessles • SS via ultrashort negative feedback to regulating SS release • GH ultrashort loop feedback ： stimulates SS release and reduces GHRH release
2、Norepinephrine（NE） • Αreceptor: stimulation, major • Βreceptor: inhibition
3、5-HT • Stimulate GH release
4、Acetylcholine（Ach） • stimulation for GH release • By M receptor • Mechanism: inhibites SS release，but do not stimulates GHRH release
5、Gamma-aminobutyric acid（GABA） • Stimulation for GH release
6、Histamine（His） • For GH release (inhibition and stimulation)
4). Neuropeptides regulates GH
6).The others factors
• • • • • •
Hypoxia stress－ deprivation － weightless － toxin Ethyl ether－ restraint －
• sugar－ • aliphatic acid
Hypothalamus network for GH
3).NTs regulates GH release
1、Dopamine（DA） • DA enhanced GH release • Mechanism stimulates GHRH release inhibites SS release
SS:
SS-28, SS-14（2 activity type）
SS receptor: SStr 1-5, SSrt-14, SSrt-28, 7-transmembrane domain, G-protein coupled
SS receptor subtypes
The regulation of GH release by GHRH and SS
GHRH receptor: 7 transmembrane
生长抑素 SS
• via：
SS release from ME to anterior pituitary SS release into CSF via cell line ventricle(室 管膜细胞) to anterior pituitary to inhibites GH release and synthesis。 • SS intermitted inhibit GH release，induce GH to lowest amplitude
• ຫໍສະໝຸດ Baidu •
GHRH
• via：
GHRH to anterior pituitary → to bind its receptor (GHRH receptor) → activate Gprotein → induce cAMP-PKA →stimulate GH release. • GHRH receptor: 7 transmembrane (see Fig.4)
1). GHRH and SS
regulation of GH release
• Growth hormone releasing hormone •
（GHRH） 44 peptide distribution in ARC , PVN , AMH, and VMH GH release GH DNA→mRNA GH cell in pituitary proliferate and differentiate
• Further
• • •
growth Synthesize protein Decompose fat Generate sugar
GH:
Somatotrophin, Growth hormone is regulated by GHRH, SS (SRIH), and hypothalamic peptides as well as complex neuroendocrine network.
2、inhibition (major) • CRF • CCK • AII • NPY
5). Hormone regulates GH
• GC ＋ • T3,T4 ＋ • E and T ＋
神经内分泌学-生长轴
Growth hormone(GH):
• Secrete by anterior pituitary • Single peptide chain • Composed of 191 aa • molecular mass: 22kDa
Function of Growth hormone
2). Feedback mechanism
• GHRH regulates GH release by supershort
loop：via stimulates SS release from CNS to to portal vessles • SS via ultrashort negative feedback to regulating SS release • GH ultrashort loop feedback ： stimulates SS release and reduces GHRH release
2、Norepinephrine（NE） • Αreceptor: stimulation, major • Βreceptor: inhibition
3、5-HT • Stimulate GH release
4、Acetylcholine（Ach） • stimulation for GH release • By M receptor • Mechanism: inhibites SS release，but do not stimulates GHRH release
5、Gamma-aminobutyric acid（GABA） • Stimulation for GH release
6、Histamine（His） • For GH release (inhibition and stimulation)
4). Neuropeptides regulates GH
6).The others factors
• • • • • •
Hypoxia stress－ deprivation － weightless － toxin Ethyl ether－ restraint －
• sugar－ • aliphatic acid
Hypothalamus network for GH
3).NTs regulates GH release
1、Dopamine（DA） • DA enhanced GH release • Mechanism stimulates GHRH release inhibites SS release
SS:
SS-28, SS-14（2 activity type）
SS receptor: SStr 1-5, SSrt-14, SSrt-28, 7-transmembrane domain, G-protein coupled
SS receptor subtypes
The regulation of GH release by GHRH and SS
GHRH receptor: 7 transmembrane
生长抑素 SS
• via：
SS release from ME to anterior pituitary SS release into CSF via cell line ventricle(室 管膜细胞) to anterior pituitary to inhibites GH release and synthesis。 • SS intermitted inhibit GH release，induce GH to lowest amplitude
• ຫໍສະໝຸດ Baidu •
GHRH
• via：
GHRH to anterior pituitary → to bind its receptor (GHRH receptor) → activate Gprotein → induce cAMP-PKA →stimulate GH release. • GHRH receptor: 7 transmembrane (see Fig.4)
1). GHRH and SS
regulation of GH release
• Growth hormone releasing hormone •
（GHRH） 44 peptide distribution in ARC , PVN , AMH, and VMH GH release GH DNA→mRNA GH cell in pituitary proliferate and differentiate
• Further
• • •
growth Synthesize protein Decompose fat Generate sugar
GH:
Somatotrophin, Growth hormone is regulated by GHRH, SS (SRIH), and hypothalamic peptides as well as complex neuroendocrine network.