正常妊娠与重度子痫前期孕妇血常规参数的孕期变化对比邓文秋

正常妊娠与重度子痫前期孕妇血常规参数的孕期变化对比

邓文秋

广西壮族自治区贵港市覃塘区人民医院537121

中国图书分类号

R714

文献标识码

A

文章编号1001-

4411（2013）06-0922-04；doi ：10.7620/zgfybj.j.issn.1001－4411.2013.28.09【摘要】目的：比较重度子痫前期孕妇与正常妊娠孕妇在不同孕期下血常规参数的变化并分析其临床意义。方法：选择

重度子痫前期孕妇100例为观察组，正常妊娠孕妇100例为对照组，对两组孕妇从妊娠12周起每隔4周进行血常规检查，比较两组的参数变化。结果：观察组与对照组的白细胞计数（WBC ）、中性粒细胞比例（N ）、淋巴细胞比例（L ）在不同孕周间变化不明显，差异没有统计学意义（P ＞0.05）。相同孕周下两组WBC 、N 、L 的差异没有统计学意义（P ＞0.05）。对照组的红细胞计数（RBC ）、血红蛋白浓度（Hb ）、血细胞比容（HCT ）在整个妊娠过程中表现出先降低后升高的趋势。观察组RBC 、Hb 和HCT 在不同孕周下没有表现出先降低后升高的趋势。RBC 和Hb 水平在孕16 35周高于对照组的同期水平，HCT 水平在孕20－31周高于对照组的同期水平，差异有统计学意义（P ＜0.05）。观察组与对照组血小板（PLT ）水平在整个妊娠过程中均表现出缓慢下降的趋势，平均血小板体积（MPV ）则呈现出逐步上升的趋势。观察组PLT 在孕32 39周的水平低于同期对照组的水平，MPV 在孕28 35周的水平高于同期对照组的水平，差异有统计学意义（P ＜0.05）。结论：血常规参数在不同孕周中的变化可以大致反映孕妇的血容量、血黏度以及凝血状态的变化。有望帮助临床早期筛选出重度子痫前期孕妇，及时给予针对性的干预以减轻症状、延缓病情发展。

【关键词】

重度子痫前期

血常规

孕周

红细胞

血小板

Comparison of changes of blood routine parameters during pregnancy between nor-mal pregnant women and pregnant women with severe preeclampsia

DENG Wen －Qiu .People ＇s Hospital of Qintang District ，Guigang 537121，Guangxi Zhuang Autonomous Region ，China

〔Abstract 〕

Objective ：To compare the changes of blood routine parameters in different gestational weeks between normal pregnant

women and pregnant women with severe preeclampsia ，and analyze the clinical significance.Methods ：One hundred pregnant women with severe preeclampsia were selected as observation group ，and 100normal pregnant women were selected as control group ；blood routine test was conducted every four weeks from 12gestational weeks ，and the changes of blood routine parameters in the two groups were compared.Results ：The changes of white blood cell count ，ratio of neutrophils ，and ratio of lymphocytes in different gestational weeks in observation group and control group didn＇t change significantly ，there was no statistically significant difference （P ＞0.05）.There was no statistically significant difference in white blood cell count ，ratio of neutrophils ，and ratio of lymphocytes during the same trimester of pregnancy between the two groups （P ＞0.05）.Red blood cell count ，hemoglobin concentration ，and hematocrit in control group increased at first and then fell during the whole trimester of pregnancy ，while in observation group ，the trend didn＇t appeared.Red blood cell count and hemoglobin level at 16－35gestational weeks in observation group were statistically significantly higher than those in control group during the same period ，hema-tocrit at 20－31gestational weeks in observation group was statistically significantly higher than that in control group during the same period （P ＜0.05）.The levels of platelets in observation group and control group showed slowly decreasing trend during the whole trimester of pregnancy ，while mean platelet volumes （MPV ）in the two groups showed gradually increasing trend.The level of platelets at 32－39gesta-tional weeks in observation group was statistically significantly lower than that in control group during the same period ，while MPV at 28－35gestational weeks in observation group was statistically significantly higher than that in control group during the same period （P ＜0.05）.Conclusion ：The changes of blood routine parameters in different gestational weeks can reflect the changes of blood volume ，blood viscosity ，and coagulation status in pregnant women.They are expected to help to early screen pregnant women with severe preeclampsia ，timely pro-vide corresponding intervention to alleviate symptoms and delay the progression of disease.

〔Key words 〕

Preeclampsia ；Blood routine test ；Gestational week ；Red blood cell ；Platelet

重度子痫前期是妊娠期严重的并发症之一，是孕

产妇死亡的主要原因之一〔1〕

。本研究回顾性分析在我院产前检查（产检）以及分娩的重度子痫前期患者在不同孕周下的血常规参数变化，并与正常妊娠孕妇进行对比，旨在比较在不同孕周下两组孕妇的血常规参数变化规律及特点，现报道如下。

1资料与方法1.1

研究对象

选择2009年5月至2011年12月在

我院产检以及分娩的重度子痫前期患者100例为观察

组，分娩孕周27 39周，平均（35.12ʃ3.11）周。同时选择正常分娩的产妇100例为对照组，平均分娩孕周（39.85ʃ1.05）周，对照组产妇均无妊娠期并

·229·中国妇幼保健2013年第28卷