分子诊断学EnglishPPT课件

The Molecular Biology Timeline
1865 1866 1949 1953 1970 1977 1985 2001
Gregor Mendel, Law of Heredity Johann Miescher, Purification of DNA Sickle Cell Anemia Mutation Watson and Crick, Structure of DNA Recombinant DNA Technology DNA sequencing In Vitro Amplification of DNA (PCR) The Human Genome Project
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1. Molecular Diagnostics: Emergence
The information revolution in molecular biology is permeating every aspect of medical practice
The rate of disease gene discovery is increasing exponentially, which facilitates the understanding diseases at molecular level
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1. Molecular Diagnostics
Molecular diagnostics combines laboratory medicine with the knowledge and technology of molecular genetics and has been enormously revolutionized over the last decades, benefiting from the discoveries in the field of molecular biology.
分子生物学进展
MD., Ph.D. ,
2009
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Introduction to Molecular Diagnostics
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Presentation Outline
Concept of Molecular Diagnostics History of Molecular Diagnostics Impact on Human Diseases Basis for Molecular Assay Management of the course
To face the new century, the medical practitioner not only understand molecular biology, but must also embrace the use of this rapidly expanding body of information in his medical practice, whether practicing family medicine, oncology, obstetrics and gynecology, pathology, or any other medical specialty.
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2. History of Molecular Diagnostics
Sickle cell anemia
➢Sickle cell anemia is a genetic disease which is caused by a single nucleotide change in the 6th aa of the -chain of hemoglobin.
Molecular understanding of disease is translated into diagnostic testing, therapeutics, and eventually preventive therapies
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1. Molecular Diagnostics: Significance
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1. Molecular Diagnostics: Goal
To introduce essential concepts in molecular diagnostics that impact on the identification of novel markers of human diseases
4Βιβλιοθήκη Baidu
1. Molecular Diagnostics
The use of molecular biology techniques to expand scientific knowledge of the natural history of diseases, identify people who are at risk for acquiring specific diseases, and diagnose human diseases at the nucleic acid level.
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1. Molecular Diagnosis
Molecular diagnosis of human disorders is referred to as the detection of the various pathogenic mutations in DNA and /or RNA samples in order to facilitate detection, diagnosis, subclassification, prognosis, and monitoring response to therapy.
To develop and apply useful molecular assays to monitor disease, determine appropriate treatment strategies, and predict disease outcomes.
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2. History of Molecular Diagnostics