侵袭性B细胞淋巴瘤相关进展

MYC is an Universal amplifier of Gene Expression
MYC amplifier the preexiting gene expression program of cells.
MYC in Germinal Centre Formation and Maintenance
IHC Double Hit
MYC Genetic Vs Protein Double Hit
Do they have the same significance?
B-cell Lymphoma, Unclassified, Intermediate Between BL And DLBCL
Large cell with Terminal B-cell differentation
MYC Rearrangement In DLBCL
Double Hit (MYC and BCL2)
Double Hit (MYC and BCL6)
MYC Protein Overexpression Is More Frequent Than Genetic Alteration In DLBCL
MYC 驱动侵袭性B细胞淋巴 瘤相关进展
广东省人民医院肿瘤内四科（淋巴瘤专科） 陈菲莉
MYC was initially identified as the target oncogene dysregulated by the t(8;14)(q24;q32) translocation in Burkitt lymphoma (BL) and had been studied for more than 30 years
Hale Waihona Puke Baidu
MYC Gene, Protein and Activation
Translocation and amplification
Mutations
Transcriptional regulation
MYC as a Transcriptional Factor
MYC Mediated Apoptosis
Plasmablastic Lymphoma
MYC Alteration In PBL
Molecular Pathogenesis in PBL
ALK+ Large B Cell Lymphoma
Molecular Pathogenesis
Summary
• MYC is activated in aggressive lymphomas derived from both germinal center and terminally differentiated B-cells. • MYC is activated by genetic alteration and transcriptional mechanisms. • MYC genetic and protein alterations are frequently associated with activations of other oncogenes conferring a worse prognosis • Genetic and IHC double hits are associated with poor prognosis but may not have the same clinical significance • Screening with IHC followed by FISH analysis may be a strategy to facillitate identification of patients with a very aggressive disease.
Aggressive Lymphoma With MYC Genetic And Protein Alternations
Burkitt Lymphoma
Somatic mutations in BL
Molecular Pathogenesis in BL
MYC Alteration in DLBCL