病毒性细菌性皮肤病 Viral Dermatoses

Classification of Viral dermatoses
• Herpesvirus group
– Herpes simplesx
– Varicella ( Chickenpox )
– Herpes Zoster
– Roseala Infantum ( Sixth disease)
– Kaposi’s sarcoma
stress, menstruation
Epidemiology
• 85% of adults worldwide are seropositire for HSV-1.
Seroprevalence for HSV-2 is lower, appear at the age of onset of sexual activity.
Viral Dermatoses
Department of Dermatology
Xiao Sheng-Xiang
General Description
• Definition
Viral dermatoses are the cutaneous diseases resulting from viral infections.
USA: ~23% of adults are infected with HSV-2
Developing countries: 60~95% of infection rates of HSV-2 • Incubative or subclinical infection: 90% of all infected
Classification of Viral dermatoses
• Poxvirus group
Molluscum contagiosum, milker’s nodules
• Papovavirus group
Warts(common warts, Flat warts,
plantar warts, genital warts)
• Detection of virus antigen of the lesion
Materials:vesicular fluid ,cell百度文库 from the base of skin lesion
Methods: direct fluorescent antibody test immunoperoxidase tchniques
Virus
– Two antigenic types: HSV-1, HSV-2 HSV-1: lesions on the lips, face HSV-2: genital herpes
Lesions anywhere may be caused by either
antigenic type. – Transmission: Intimate contact ( direct inoculation through traumatized skin )
• Picornavirus group (enteroviruses)
Hand-fooot –mouth disease (coxackie virus)
• Retroviruses
AIDS
Herpes Simplex
Etiology
• Herpes Simplex Virus ( HSV ): DNA
• Common site for lesions: face, lips, mouth,
neck, anogenital area
• Heal within 1-2 weeks
Diagnosis
• Clinical Diagnosis • Laboratory Test
Tzanck smear: take a smear of cells from the base of the skin lesion spread the cells on a glass slide stain with wright or Giemsa Stain look for multinucleated giant cells Non specific: HSV VZV Accuracy rate: 60~90% False positive rate: 3~12%
– Primary infection and recurrent infection Primary infection: first infection After primary infection neuronal cells in ganglion virus migrates to the latent infection replicate
• Virus culture
Emphasis
• Serologic tests (detection of anti-HSV antibody of the blood) are generally not used in determining whether a skin lesion is due to HSV infection.
Clinial manifestation
• Features of the lesion: multiple small
papules, vesicles, clusted together.
Mature lesion: grouped vesicles and / or pustules on an erythematous edematous base
Classification of Viral dermatoses
• Parvovirus
Erythema infectiosum( fifth disease)
(B19 virus)
• Paramyxovirus group
Measles, rubella
Classification of Viral dermatoses
latent virus to reactivate by triggering factors
virus particles move on the nerve in the epithelial cells recurrent infection
– Triggering factors: fever, trauma, emotional