苯扎氯铵

苯扎氯铵

běnzhālǜǎn

Benzalkonium Chloride

本品为氯化二甲基苄基烃铵的混合物。按无水物计算，含烃铵盐（C22H40CIN）应为

95.0％～105.0％。

This product is the mixture of dimethyl benzyl ammonium chloride. Calculation by anhydrous, the C22H40CIN content shall be 95.0％～105.0％.

【性状】本品为白色蜡状固体或黄色胶状体；水溶液显中性或弱碱性反应，振摇时产生多量泡沫。

本品在水或乙醇中极易溶解，在乙醚中微溶。

Shape and properties:

This product is a white waxy solid or yellow jelly; water solution is neutral or weak alkaline reaction, when shaking, a lot of foam will produce.

This product is easy to dissolve in water or ethanol, slightly soluble in ether.

【鉴别】(1) 取本品约0.2g，加硫酸1ml 使溶解，加硝酸钠0.1g，置水浴上加热 5 分钟，放冷，加水10ml与锌粉0.5g，置水浴上温热5 分钟，取上清液2ml，加5％亚硝酸钠溶液1ml ，置冰水中冷却，再加碱性β－萘酚试液3ml ，即显猩红色。

(2)取本品，加水制成每1ml中含0.5mg的溶液，照分光光度法（附录ⅣA）测定，在

257nm，262nm及269nm 的波长处有最大吸收。

(3)(3) 取本品1 ％水溶液10ml，加稀硝酸0.5ml ，即发生白色沉淀，滤过，沉淀能在

乙醇中溶解，滤液显氯化物的鉴别反应（附录Ⅲ）。

Identification:

(1)Taking this product about 0.2g, with 1ml of sulfuric acid dissolving, adding sodium nitrate 0.1g, heating on the water bath for 5 minutes, adding 10ml and zinc powder 0.5g, water bath for 5 minutes, take the supernatant 2ml, adding 5% sodium nitrite solution 1ml, cooling in water, add alkaline naphthol solution 3ml, then scarlet will show.

(2)Take this product, add water to make a solution containing 0.5mg per 1ml, according to the spectrophotometric method (Appendix IV A), at 257nm, 262nm and 269nm at the wavelength of maximum absorption.

(3)Take this product 1% aqueous solution 10ml, add dilute nitric acid 0.5ml, that is, white precipitate, filtration, precipitation can be dissolved in ethanol, the reaction of chloride in the filtrate (Appendix III).

【检查】

酸碱度：取本品0.5g，加水50ml使溶解，加溴甲酚紫溶液（取溴甲酚紫50mg，加0.1mol/L 氢氧化钠溶液0.92ml与乙醇20ml使溶解，加水稀释至100ml）0.1ml，若溶液显黄色，用氢氧化钠滴定液（0.1mol/L）滴定；若溶液显蓝紫色，用盐酸滴定液（0.1mol/L）滴定，消耗的滴定液均不得过0.1ml。

溶液的澄清度与颜色：取本品1.0g，加新沸放冷的水100ml使溶解，溶液应澄清无色；

如显浑浊，与1号浊度标准液（附录Ⅸ B）比较，不得更浓；如显色，与黄色2号标准比色液（附录Ⅸ A第一法）比较，不得更深。

水不溶物：取本品1.0g，加水10ml溶解后，不得显浑浊，不得有不溶物。

氨化合物：取本品0.1g，加水5ml溶解后，加氢氧化钠试液3ml，加热煮沸，不得发生氨臭。

水分：取本品，照水分测定法（附录Ⅷ M第一法A）测定，含水分不得过10.0%。

炽灼残渣：取本品1.0g，依法检查（附录Ⅷ N），遗留残渣不得过0.1%。

Check:

PH: take this product 0.5g, 50ml water to dissolve, with bromocresol purple solution (take bromocresol purple 50mg, plus 0.1mol/L 0.92ml 20ml sodium hydroxide solution and ethanol dissolved, diluted with water to 100ml 0.1ml), if the solution is yellow, with sodium hydroxide titration solution (0.1mol/L) titration; if the solution is blue purple, with hydrochloric acid titration solution (0.1mol/L) titration, titration solution consumption shall be exceeding 0.1ml.

Clarity and color of solution: take this product 1.0g, add new boiled water 100ml to dissolve, the solution should be clear and colorless; significant turbidity, and 1 turbidity standard solution (Appendix B), must not be thicker; such as color, and Yellow No. 2 standard colorimetric solution (appendix the first method is A), shall not be deeper.

Water insoluble: take this product 1.0g, add water 10ml dissolved, shall not be muddy, no insoluble matter.

Ammonia compounds: take this product 0.1g, 5ml of water dissolved, adding sodium hydroxide solution 3ml, boiling, no ammonia smell.

Water content: take this product, according to the determination of moisture content (Appendix VIII M A) determination of water containing not more than 10%.

Residue: take this product 1.0g, according to inspection (Appendix VIII N), legacy residue shall not exceed 0.1%.

【含量测定】取本品约0.5g，精密称定，置烧杯中，用水35ml分次洗入250ml 分液漏斗中，加0.1mol/L氢氧化钠溶液10ml与氯仿25ml，精密加入新制的5 ％碘化钾溶液10ml，振摇，静置使分层，水层用氯仿提取3 次，每次10ml，弃去氯仿层，水层移入250ml 具塞锥形瓶中，用水约15ml分3 次淋洗分液漏斗，合并洗液与水液，加盐酸40ml，放冷，用碘酸钾滴定液(0.05mol/L) 滴定至淡棕色，加氯仿5ml ，继续滴定并剧烈振摇至氯仿层无色，并将滴定的结果用空白试验校正。每1ml碘酸钾滴定液(0.05mol/L) 相当于35.40mg 的C22H40CIN 。

Content determination:

Take this product about 0.5g, precision said, the beaker of water washed into 35ml 250ml separatory funnel, plus 0.1mol/L 10ml sodium hydroxide solution and chloroform 25ml, adding 5% 10ml of potassium iodide solution precision, the new system of shaking, the static water stratification, extracted 3 times with chloroform, 10ml each time, abandoned go to the chloroform layer layer into 250ml conical flask with stopper, water is about 15ml 3 times leaching separation funnel with lotion and liquid water, hydrochloric acid 40ml, put cold with potassium iodate titration solution (0.05mol/L) titration to light brown, add chloroform and 5ml, and continue the titration vigorous shaking to chloroform layer of colorless then, the titration correction by blank test results. Potassium iodate solution per 1ml (0.05mol/L) is equivalent to 35.40mg C22H40CIN.

【类别】消毒防腐药。

【贮藏】遮光，密闭保存。

【制剂】苯扎氯铵溶液

[Category] disinfectant.

[Storage] shading, airtight preservation.