径向流层析在血液制品规模化生产中的应用
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Wedge Scale Up/ Scale Down Columns
confidential
6
Superflo® radial flow columns offer unprecedented throughput
RFC Column Features
4X FASTER 20 FDA Approved Drugs Linear Scale Up enables faster time to market
confidential 2
Our CustomersThe “Who’s Who” of Pharma and Biotech
confidential
3
Custom Quantasep Process Chromatography Skids
•Custom Chromatography skids with isocratic or gradient capability •Flow-rates of up to 40 LPM on each Pump •Fully integrated with pumps, UV, pH and conductivity sensors, valves, computer and software •Explosion Proof Systems for working with Alcohol or flammable solvents Custom, Sanitary, 10-40 Liter per minute Class 1 Div 2 Skids
Packing ports provide direct access so packing can be performed without dismantling the column.
Low bed depth results in low backpressure.
Unpacking ports allow easy unpacking (not shown in drawing).
Inert 20µouter porous tube provides large cross-sectional area for sample application. Low dead volume of outer channel provides rapid sample entry and minimizes mixing of gradient
Company’s Radial Flow Chromatography Columns Installed at Baxter (one of the world’s largest)
Photo courtesy Baxter confidential 7
confidential
1
Sepragen Corporation
Innovators in Bioprocessing
• Sepragen has provided state of the art bio-processing technology to the biotech companies for over 25 years. Holds 16 patents. • Sepragen focused on processing of bio-processing: – Inventors of Radial Flow Chromatography – Quantasep Chromatography Systems and Skids – Quantasep 3000 SU Single use Chromatography Systems – Sepraflo Single Use Ion Exchange Resins – QS Buffer Dilution System • The purification products are already used in the biotech industry at Amgen, Baxter, GSK in FDA approved drug manufacture. • Twenty + FDA approved drugs and over 200 global installations. • Current Products address a served market in excess of $10Bn
Inert 20µinner porous tube supports gel bed.
Low deaຫໍສະໝຸດ Baidu volume of inner channel minimizes backmixing.
confidential
5
Scale Up Using RFC
Product Range of Radial Columns
confidential 4
Pressure relief valve on sample inlet prevents column damage (not shown in drawing).
How it Works
Radial distribution channels allow uniform distribution of flow to outer wall of column. Bubble trap prevents drying of column.
confidential
6
Superflo® radial flow columns offer unprecedented throughput
RFC Column Features
4X FASTER 20 FDA Approved Drugs Linear Scale Up enables faster time to market
confidential 2
Our CustomersThe “Who’s Who” of Pharma and Biotech
confidential
3
Custom Quantasep Process Chromatography Skids
•Custom Chromatography skids with isocratic or gradient capability •Flow-rates of up to 40 LPM on each Pump •Fully integrated with pumps, UV, pH and conductivity sensors, valves, computer and software •Explosion Proof Systems for working with Alcohol or flammable solvents Custom, Sanitary, 10-40 Liter per minute Class 1 Div 2 Skids
Packing ports provide direct access so packing can be performed without dismantling the column.
Low bed depth results in low backpressure.
Unpacking ports allow easy unpacking (not shown in drawing).
Inert 20µouter porous tube provides large cross-sectional area for sample application. Low dead volume of outer channel provides rapid sample entry and minimizes mixing of gradient
Company’s Radial Flow Chromatography Columns Installed at Baxter (one of the world’s largest)
Photo courtesy Baxter confidential 7
confidential
1
Sepragen Corporation
Innovators in Bioprocessing
• Sepragen has provided state of the art bio-processing technology to the biotech companies for over 25 years. Holds 16 patents. • Sepragen focused on processing of bio-processing: – Inventors of Radial Flow Chromatography – Quantasep Chromatography Systems and Skids – Quantasep 3000 SU Single use Chromatography Systems – Sepraflo Single Use Ion Exchange Resins – QS Buffer Dilution System • The purification products are already used in the biotech industry at Amgen, Baxter, GSK in FDA approved drug manufacture. • Twenty + FDA approved drugs and over 200 global installations. • Current Products address a served market in excess of $10Bn
Inert 20µinner porous tube supports gel bed.
Low deaຫໍສະໝຸດ Baidu volume of inner channel minimizes backmixing.
confidential
5
Scale Up Using RFC
Product Range of Radial Columns
confidential 4
Pressure relief valve on sample inlet prevents column damage (not shown in drawing).
How it Works
Radial distribution channels allow uniform distribution of flow to outer wall of column. Bubble trap prevents drying of column.