细菌耐药现状和耐药机制分析

CFra Baidu bibliotekftaz Clav 8
Cefp/ Sulbact 16 67 64 71 80 63 81 64 96 87 86 59 95 94 62 92 75 80 100 100 63 100 67 60 60 25 67 100 100 0 100 100 100 71
MK826 (MK) 4
Cefot axime 8 15 50 59 31 35 35 41 70 57 73 55 95 17 0 75 67 50 78 88 38 100 67 20 20 0 33 100 100 0 0 0 100 40
Genta micin 4 60 37 71 63 44 17 41 83 70 45 55 75 17 8 100 67 50 78 0 38 83 100 40 40 0 67 50 100 0 100 0 100 54
Ami kacin 16 81 88 84 73 74 23 68 91 87 86 64 100 28 15 100 82 70 89 0 63 100 100 80 80 75 67 100 100 0 100 0 100 78
Tested on AB BioDisk E-Test MICs
Iso lates 412 408 364 316 150 81 44 23 23 22 22 20 18 13 12 12 10 9 8 8 6 6 5 5 4 3 2 2 1 1 1 1 1 2052
Pat ients 403 399 358 311 148 81 44 22 23 22 22 20 18 13 12 12 10 9 8 8 6 6 5 5 4 3 1 2 1 1 1 1 1 --
Cipro floxacin 1 57 25 63 67 59 43 48 70 65 36 68 65 17 31 100 67 50 67 38 25 83 100 60 40 0 67 100 100 0 0 0 0 52
100 100
100
2002年全国17家医院革兰阴性菌敏感性
Percentage Susceptibility: Pool Of China Gram-Negative isolates , N = 2013 Pts = 1749
Pip/ tazobact 16* 81 84 78 70 59 69 59 91 78 95 64 100 89 69 100 75 100 89 100 38 100 83 60 80 75 67 100 100 0 100 0 100 77
Ticar/ Clav 16* 49 29 55 66 32 72 27 65 70 64 45 100 61 31 67 67 60 78 0 25 100 67 40 0 25 67 50 100 0 100 100 100 49
细菌耐药现状和耐药机制分析
倪语星
一、流行病学
2002年全国17家医院主要革兰阴性菌分布
POOL OF china, Gram-Negative isolates , N = 2013, Patients = 1749
Percentage susceptibility (NCCLS Breakpoints)
Imi penem 4 62 100 99 94 96 2 98 100 87 95 100 100 83 8 100 100 90 100 0 88 100 100 100 60 100 100 100 100 100 100 0 100 85
Cefta zidime 8 75 55 58 65 43 78 43 70 74 68 59 100 61 38 92 75 80 78 100 38 83 83 40 60 50 100 0 100 100 100 0 100 100 63
Species bpt,mg/l-> Pseudomonas aeruginosa Escherichia coli Klebsiella pneumoniae Acinetobacter baumanii Enterobacter cloacae Xanthomonas maltophilia Citrobacter freundii Klebsiella spp. Acinetobacter spp. Morganella morganii Enterobacter aerogenes Proteus mirabilis Alcaligines spp. Flavobacterium spp. Serratia spp. Serratia marcescens Pseudomonas spp. Klebsiella oxytoca Pseudomonas cepacia Enterobacter spp. Proteus vulgaris Citrobacter spp. Acinetobacter calcoaceticus Aeromonas spp. Unknown species Achromobacter spp. KLEBSIELLA PNEUMONINE ATCC 70 Salmonella spp. Citrobacter diversus Escherichia spp. COMAMONAS ACIDOVORANS Chryseomonas spp. Proteus spp. ALL
Ceftr iaxone 8 35 52 61 28 34 16 41 74 61 91 55 95 17 0 83 67 60 78 100 50 100 67 20 20 0 33 100 100 0 0 0 100 44
Cefi pime 8 72 71 79 71 70 63 70 100 87 95 68 100 33 38 100 67 90 100 100 63 100 83 40 60 25 67 100 100 0 100 0 100 73
100
85
80
77 71 63 73