高级别胶质瘤电场治疗研究进展

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(收稿日期:2018-0717修回日期=2018-04-09)

高级别胶质瘤电场治疗研究进展

谭春燕综述，任庆兰%审校

(重庆医科大学附属第一医院肿瘤科，重庆400000)

[关键词]高级别胶质瘤；肿瘤治疗电场；有丝分裂；替莫唑胺；综述

DOI：10.3969/j.issn.1009-5519.2019.09.029中图法分类号:R73

文章编号:1009-5519(2019)09-1377-04文献标识码:A

胶质瘤是起源于神经胶质细胞的肿瘤，也是最常见的颅内肿瘤$目前世界卫生组织(WHO)将胶质瘤分为I〜

*级$I、#级为低级别胶质瘤，&、*级为高级别胶质瘤J1]$高级别胶质瘤的年发病率是(3〜5)/10万，其中男性较好发$高级别胶质瘤可能发生在各个年龄段，但发病率最高的是50〜60岁J4'$胶质母细胞瘤(GBM)占原发性脑恶性肿瘤的46%[5],且存在高发病率、术后高复发率、高病死率及低治愈率等特点$胶质瘤传统的治疗方式为手术、化疗、放疗等，尽管有积极的多模态治疗，但GBM患者的预后仍较差$从既往的资料看，GBM患者的2年生存率为27%,而只有10%的患者存活时间超过5年$对于初始治疗后进展的患者，目前的治疗方式有限，在过去10年中进行系统性治疗的临床试验未能改善GBM患者的预后$人们翘首期待新的治疗方式$近年来，一项名为肿瘤治疗电场(TTFields)的新型治疗

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