补体系统之作用机制

g W

t

D O B x G G

e

M S A H A D n f

C M H H ¡A t q h B n A b M

t q A b M mg/ml¡C O30h

A9(µ)¡A A M p G F A

g f A o e f A A

m B o i n C G O A

i A H F C

B z S G

g o H G

1.¸s b B B C

2.¦b56¢30A m i H A C

3.¤i(IgA¡B IgD¡B IgE¡B IgG4)¡C

4.¦b M s A9i B

t i i z(opsonization)¡B(chemotaxis)¡B r(anaphylatoxin) B H s(immune adherence)¡B g(passive cutaneous anaphylaxis) C

5.ÅW C

G B G

b A H l s b t A H WHO(¥

)ª(¨p G B B B B B B B B)¦h H

W(¨p G(properdin) B l l(initiating factor)¡B B l(factor B)¡B D l(factor D))¡A l h b e W(¡I)¥H O C

G

01. ¥

D n O g

E y t C A

c o F,»m S,¨A H

y IgG1¡B IgG2¡B IgG3IgM i A IgG4¡B IgA¡B IgD¡B IgE h C(µ)

O C1M A C1O3

l A O A F1C1q¡A2C1r2C1s l A t l

A C1q l q40A A C1q6y

A C1Fc q(µ)¡A C1q A C1r I C1r¡A

I C1r S C1s肽 C1s¡A i i q C H

C1s¡A H i C1s I C1s¡C

G q i G

¡I(¡I C1s)

A b l s b I C1s C4C4a C4b,¤C2C2a C2b¡A b l s b C4b C2a i I C4b2a¡A D酶

i H q

I(¡I C1s)¡

C142(¡I C4b2a) I(¡I C1s)¡ C12(C2a)

A酶(¡I C4b2a)±C3a C3b¡A C3a r

A l h y

B i M

(mast cell)Äi(histamine)»肽(basic peptide)(µ)¡A C3b h i M A

I C4b2a I C4b2a3b¡A5酶 5i5¡A i

q C

i H q

I C142(¡I C4b2a)+C3 IC1423(¡I C4b2a3b )

A5酶(¡I C4b2a3b)±5C5a C5b¡A C5a r

A l h y A

B i M(mast cell)Äi(histamine)»肽(basic peptide)¡A C5b h C6A C5b67(§I C5b67)¥i

(MAC)¡A i g M q D,¨l q M

A u l h i M A M C(µ)

01. ´

l l l(·l)(¨p:¤r B h) H IgA…(µ))±l C

B l D l b l s b i C3C3a C3b A D l S B

l Bb Ba¡A A Bb C3b I C3bBb¡A I C3bBb 酶 3酶(¡I C3bBb)»C3I C3bBb3b C3a¡A C3a r ,l h y A B i M (mast cell)Äi (histamine)»肽(basic peptide)A B C3b i H I C3bBb,¶i W I C3bBb3b C5酶,±5酶(¡I C3bBb3b)±5C5a C5b¡A C5a r A l h y A B i M (mast cell)Äi (histamine)»肽(basic peptide)¡A C5b h C6C7,¦C5b67(§I C5b67)¥i (MAC)¡A i g M q D A l q M A u l h i M A M C (µ)

G

l q

C1q 400,000 Fc

C1r 180,000 C1s

C1s 86,000 ,µC4C2 C2 117,000 f r M

C3a r ,¯l h y ,¥B i M

(mast cell)Äi (histamine)»肽(basic peptide)

C3b D n ,¤M D n z

C3c 180,000 y W h g (leucocytosis) C4a r C4b 206,000 f r M

C5a r ,¯l h y ,¥B i M

(mast cell)Äi (histamine)»肽(basic peptide)

C5b 180,000 C6 110,000 C7 95,000 C8 163,000 C9

79,000

C5b ,¦i M

B l 93,000 M G W ,¬C3酶 D l 24,000 b B l ,¦C3bBb

223,000 酶

(µG ) v G

B p.139¡

C C C1933

G B p.141¡C C C1933

B p.623¡

C i C a C2003

B s p.115¡

C t MurrayP a trick C a C2000 B p.143¡C C1933

G

1. E C3M Bf b l c c C °x W

C C2001

s

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