Sheehan's syndrome 席汉氏综合征 PPT课件
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E2（雌 激素） P（孕激 素）
Symptoms
Anatomy of the Pituitary Gland
Hypothalamus
下丘脑
Anterior part
垂体前叶(腺垂体)
Posterior part
垂体后叶
Physiology of the Anterior Pituitary Gland
ห้องสมุดไป่ตู้
Secrete hormones that control other endocrine glands.
Anterior Pituitary(腺垂体)
Prolactin
PRL (催乳素)
Growth hormone
GH (生长激素)
Gonadotropin
Gn (促性腺激素)
Luteinizing hormone
LH (黄体生成素)
Follicle stimulating hormone FSH (促卵泡素)
Mechanism
The blood supply of pituitary is from portal system(门脉系统).
Pituitary enlarges during pregnancy. The size is doubles-triples(2-3倍) at the time of delivery.
and gonad.
Causes
1. Pituitary ischemia and necrosis.
Sheehan’s syndrome
2. Pituitary tumor.
Most common in adult. 3. Hypothalamus lesions: tumor, inflammation.
Thyroid stimulating hormone
TSH (促甲状腺素)
Adrenal cortex stimulating
ACTH(促肾上腺皮质激素)
hormone
( adrenocotropic hormone)
Physiology of the Pituitary Gland
Hypothalamus 下丘脑
Clinical features
Typical progression of hormone loss: Gn, PRL, GH TSH ACTH
Symptoms of Hormone Deficiency
Deficient Hormone
PRL FSH LH
GH
Target glands hormones
Definition Mechanism Clinical features Exams and Tests Diagnosis Treatment
Definition
A rare condition that occurs in women who suffer a severe uterine(子宫) hemorrhage（出血） during childbirth. The resulting blood loss may damage the pituitary gland and result in hypopituitarism.
Easy to be damaged when lack of blood
Mechanism
Severe bleeding during childbirth Lack of blood in portal system Pituitary infarction
Impaired function of Anterior Pituitary
TRH CRH
GnRH
Anterior pituitary
腺垂体
TSH
ACTH
Gn
Negative feedback
Thyroid Adrenal cortex Gonad
(甲状腺T3,T4) (肾上腺皮质cortisol) (性腺)
Definition
Hypopituitarism:
The productions of one or more anterior pituitary hormones are decreased. Due to the various reasons. Impaired function of thyroid, adrenal cortex
Causes
4. Surgery, radiotherapy and trauma（创伤） 5. Infection: viral, bacterial, TB. 6. long-term glucocorticoid（糖皮质激素）
therapy:
Suppress the secretion of CRH and ACTH. Stop using suddenly leads to iatrogenic hypopituitarism(医
Clinical features
Anterior Pituitary
GH Gn TSH ACTH
Gonad
Thyroid
Adrenal cortex
Clinical features
Anterior pituitary destroyed 50% clinical features 75% obvious clinical features 95% severe hypopituitarism
源性腺垂体功能减退症).
Causes
7. Developmental and genetic abnormalities. 8. Others: autoimmune disease, empty sella syndrome
（空泡蝶鞍综合征）.
Sheehan’s syndrome
本课重点
Outlet
Keywords: Severe bleeding during childbirth
Mechanism
The blood supply(血液供应) of pituitary is from portal system(门脉系统). 垂体门脉系统由两组毛细血管网和连接
它们的垂体微静脉组成。
Portal system of pituitary
Symptoms
Anatomy of the Pituitary Gland
Hypothalamus
下丘脑
Anterior part
垂体前叶(腺垂体)
Posterior part
垂体后叶
Physiology of the Anterior Pituitary Gland
ห้องสมุดไป่ตู้
Secrete hormones that control other endocrine glands.
Anterior Pituitary(腺垂体)
Prolactin
PRL (催乳素)
Growth hormone
GH (生长激素)
Gonadotropin
Gn (促性腺激素)
Luteinizing hormone
LH (黄体生成素)
Follicle stimulating hormone FSH (促卵泡素)
Mechanism
The blood supply of pituitary is from portal system(门脉系统).
Pituitary enlarges during pregnancy. The size is doubles-triples(2-3倍) at the time of delivery.
and gonad.
Causes
1. Pituitary ischemia and necrosis.
Sheehan’s syndrome
2. Pituitary tumor.
Most common in adult. 3. Hypothalamus lesions: tumor, inflammation.
Thyroid stimulating hormone
TSH (促甲状腺素)
Adrenal cortex stimulating
ACTH(促肾上腺皮质激素)
hormone
( adrenocotropic hormone)
Physiology of the Pituitary Gland
Hypothalamus 下丘脑
Clinical features
Typical progression of hormone loss: Gn, PRL, GH TSH ACTH
Symptoms of Hormone Deficiency
Deficient Hormone
PRL FSH LH
GH
Target glands hormones
Definition Mechanism Clinical features Exams and Tests Diagnosis Treatment
Definition
A rare condition that occurs in women who suffer a severe uterine(子宫) hemorrhage（出血） during childbirth. The resulting blood loss may damage the pituitary gland and result in hypopituitarism.
Easy to be damaged when lack of blood
Mechanism
Severe bleeding during childbirth Lack of blood in portal system Pituitary infarction
Impaired function of Anterior Pituitary
TRH CRH
GnRH
Anterior pituitary
腺垂体
TSH
ACTH
Gn
Negative feedback
Thyroid Adrenal cortex Gonad
(甲状腺T3,T4) (肾上腺皮质cortisol) (性腺)
Definition
Hypopituitarism:
The productions of one or more anterior pituitary hormones are decreased. Due to the various reasons. Impaired function of thyroid, adrenal cortex
Causes
4. Surgery, radiotherapy and trauma（创伤） 5. Infection: viral, bacterial, TB. 6. long-term glucocorticoid（糖皮质激素）
therapy:
Suppress the secretion of CRH and ACTH. Stop using suddenly leads to iatrogenic hypopituitarism(医
Clinical features
Anterior Pituitary
GH Gn TSH ACTH
Gonad
Thyroid
Adrenal cortex
Clinical features
Anterior pituitary destroyed 50% clinical features 75% obvious clinical features 95% severe hypopituitarism
源性腺垂体功能减退症).
Causes
7. Developmental and genetic abnormalities. 8. Others: autoimmune disease, empty sella syndrome
（空泡蝶鞍综合征）.
Sheehan’s syndrome
本课重点
Outlet
Keywords: Severe bleeding during childbirth
Mechanism
The blood supply(血液供应) of pituitary is from portal system(门脉系统). 垂体门脉系统由两组毛细血管网和连接
它们的垂体微静脉组成。
Portal system of pituitary