口服结肠定位给药系统_周宇

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Jpn K okai Tokk yo K oho,JP09255561(1997)

(1998-07-20收稿)

口服结肠定位给药系统

周　宇综述　蒋雪涛*审校

(解放军第82医院　淮阴　223001)

摘要　本文综述了口服结肠定位给药系统的制备方法和辅料,包括时间依赖性结肠释药系统;可被结肠酶或细菌降解的结肠释药系统;pH依赖性结肠释药系统;压力控制结肠释药系统。并对其优缺点作了评价。

关键词　结肠定位释药;时间依赖;生物降解;p H依赖;压力控制

随着生物工程技术的发展,蛋白质类和肽类药物增多。这些药物在胃和小肠部位易被消化酶和胃肠道pH等因素破坏,因而稳定性差,吸收利用度亦差。结肠没有消化酶(蛋白酶),是蛋白质和肽类药物比较好的吸收部位,同时结肠输送缓慢,缺少运动刺激性,这就造成了一个有利于稳定和增强吸收的局部环境。如果口服这类药物后,使其在结肠部位释放,就可避免被

　*第二军医大学药学院　上海　200433

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国外医学药学分册　1999年8月　第26卷第4期DOI:10.13220/ k i.ji p r.1999.04.010