肿瘤血管生成拟态研究新进展

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(编校:谈静)

肿瘤血管生成拟态研究新进展

刘见荣，侯风刚

Research advance of the mechanism of tumor vasculogenic mimicry

Liu Jianrong，Hou Fenggang

Department of Oncology，Traditional Chinese Medical Hospital of Shanghai Municipal Affilialed to Shanghai University of Tradtional Chi-nese Medicine，Shanghai200071，China．

【Abstract】Vasculogenic mimicry(VM)is a brand－new tumor blood essels mode which is independent of angiogen-

esis．More and more research found that the formation of VM have a close relation with the plasticity of tumor cells

themselves and tumor stem cells．In addition，the tumor microenvironment such as the extracellular matrix remodeling

and hypoxia also play an important role in the forming process of vasculogenic mimicry．In recent years，the related re-

search about mechanism to tumor vasculogenic mimicry has made a lot of progress．This provides new ideas and direc-

tion for seeking the key role of VM inhibition targets，screening effective drug．This article gave an outline of VM and

summarize the formation mechanism of vasculogenic mimicry and the research status about the oncotherapy．

【Key words】vasculogenic mimicry;tumor;forming mechanism;treatment

Modern Oncology2013，21(04):0898－0902

【指示性摘要】血管生成拟态是独立于血管生成的一种全新肿瘤血管模式。越来越多的研究发现血管生成拟

态的形成机制和肿瘤细胞自身的可塑性及肿瘤干细胞关系密切，另外，肿瘤微环境如细胞外基质重塑、缺氧

等在血管生成拟态形成过程中也有很重要的作用。近年来，血管生成拟态形成机制的相关研究已经取得了

很大进展，为寻找抑制VM的关键作用靶点、筛选有效的治疗药物提供了新的思路和方向。本文就血管拟态

的发现、形成机制及其在肿瘤治疗中的研究现状等方面做一综述。

【关键词】血管生成拟态；肿瘤；形成机制；治疗

【中图分类号】R730【文献标识码】A DOI：10．3969/j．issn．1672－4992．2013．04．78

【文章编号】1672－4992－（2013）04－0898－05

【收稿日期】2012－12－06

【基金项目】国家自然基金资助项目（编号：81173221）

【作者单位】上海中医药大学附属上海市中医医院肿瘤科，上海200071

【作者简介】刘见荣（1986－），女，河南郑州人，硕士研究生，主要从事大肠癌中医临床与实验研究。E－mail：liujianrong－zz@163．com

【通讯作者】侯风刚（1972－），男，河北衡水人，副主任医师，硕士研究生导师，博士，主要从事中西医结合消化道肿瘤临床和实验研究。