蛋白酶切位点
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E.C.3.4.14.1
Xaa-Yaa-|-Zaa,if Xaa≠ArgorLys,or
Yaa ≠Pro,orZaa≠Pro
Dipeptidyl-peptidase IV
E.C.3.4.14.5
Preferentially Xaa-Pro-|-Zaa,(but also Xaa-Ala-|-Yaa)withYaa ≠Pro or Hyp
Arg-|-Xaa, Lys-|-Xaa,
Pancreatic elastase (胰弹性蛋白酶)
E.C.3.4.21.36
Ala-|-Xaa,andalsoGly-|-Xaa,
Val-|-Xaa, Ser-|-Xaa,
Thrombin(凝血酶)
E.C.3.4.21.5
Arg-|-Gly,
Plasmin(胞质素，胞浆素)
Aminopeptidase M or N,or alanyl aminopeptidase,or membrane alanineaminopeptidase
E.C.3.4.11.2
Preferentially Ala-|-Xaa,and Tyr-|-Xaa,if Yaa-Pro-|-Xaa in termwith Yaa=Ala,Val,Leu,Ile,Phe,Tyr or Trp,then the dipeptide Yaa-Pro could be released
≠AlaorVal
Neprilysin(脑啡肽酶),or enkephalinase(脑啡肽酶),or neutralendopeptidase
E.C.3.4.24.11
Xaa-|-Tyr,Xaa-|-Phe, Xaa-|-Trp,and
Xaa-|-Leu,
Thimet oligopeptidase(甲拌磷寡肽 酶),or endo-oligopeptidase A,or endopeptidase(肽链内切 酶)24.15,or pz-peptidease(肠促胰 酶素)
Lys-|-Xaa
Calpain(钙激活中性蛋白酶)-1,or μ-calpain
E.C.3.4.22.52
Met-|-Xaa,Tyr-|-Xaa and
Arg-|-Xaa(with LeuorVal 朊酶，胃蛋白酶)
E.C.3.4.23.1
Preferentially Phe-|-Xaa, Tyr-|-Xaa,
E.C.3.4.21.7
Lys-|-Xaa,>Arg-|-Xaa
Prolyl oligopeptidase,or prolylendopeptidase
E.C.3.4.21.26
Plasma kallikrein (血浆激肽释放酶)
E.C.3.4.21.34
Arg-|-Xaa, Lys-|-Xaa,including
And also Leu-|-Xaa,and Trp-|-Xaa, ideally with Xaa= Phe,Trp,orTyr
Cathepsin(组织蛋白酶)D
E.C.3.4.23.5
Preferentially Phe-|-Xaa, Tyr-|-Xaa,
And also Leu-|-Xaa,ideally with Xaa
Enzymes
E.C. Number
Cleavage sites
α-chymotrypsin(胰凝乳蛋白酶，糜
蛋白酶)
E.C.3.4.21.1
Tyr-|-Xaa,Trp-|-Xaa, Phe-|-Xaa, and
alsoLeu-|-Xaa,Met-|-Xaa,
Trypsin (胰朊酶，胰蛋白酶)
E.C.3.4.21.4
Aminopeptidase B
E.C.3.4.11.6
Arg-|-Xaa, Lys-|-Xaa,
AminopeptidaseA,or angiotensinase,or glutamyl-aminopeptidase
E.C.3.4.11.7
Glu-|-Xaa>>Asp-|-Xaa,
Dipeptidyl-peptidaseI,or cathepsin(组织蛋白酶)C or J
Asp or Glu
Carboxypeptidase A
E.C.3.4.17.1
Xaa-|-Yaaif Yaa ≠Asp,Glu,Arg,Lys or Pro
Carboxypeptidase B,or protaminase
E.C.3.4.17.2
Xaa-|-ArgandXaa-|-Lys
Carboxypeptidase N,or Lysine(arginine), Carboxypeptidase(羧基肽酶),or kininase I(激肽酶)
Prolyl tripeptyl-peptidase
E.C.3.4.14.12
Xaa-Yaa-Pro-|-Zaa,if Zaa≠Pro
Peptidyl-depeptidaseA, or angiotensin-converting enzyme
E.C.3.4.15.1
Xaa-|-Yaa-Zaa,if Yaa≠Pro or Zaa≠
E.C.3.4.24.15
Xaa-|-Arg, Xaa-|-Ser,Xaa-|-Ile,
Xaa-|-Ala, Xaa-|-Gly,
Leucyl-aminopeptidase
E.C.3.4.11.1
Preferentially Leu-|-Xaa,but not
Arg-|-Xaa,andLys-|-Xaa,
Arg-|-Ser,Lys-|-Arg,
Leukocyteelastase(白细胞弹性蛋白酶),orneutrophilelastase(中性白细胞弹性蛋白酶),orlysosomalelastase(溶酶体弹性蛋白酶)
E.C.3.4.21.37
Val-|-Xaa, Ala-|-Xaa,
Cathepsin B (组织蛋白酶)
E.C.3.4.22.1
Arg-Arg-|-Xaa,and also Leu-|-Xaa,
Ala-|-Xaa, Phe-|-Xaa, Trp-|-Xaa,
Clostripain(梭菌蛋白酶),or endoproteinase Arg-C
E.C.3.4.22.8
Arg-|-Xaa including Arg-|-Pro,but not
Xaa-Yaa-|-Zaa,if Xaa≠ArgorLys,or
Yaa ≠Pro,orZaa≠Pro
Dipeptidyl-peptidase IV
E.C.3.4.14.5
Preferentially Xaa-Pro-|-Zaa,(but also Xaa-Ala-|-Yaa)withYaa ≠Pro or Hyp
Arg-|-Xaa, Lys-|-Xaa,
Pancreatic elastase (胰弹性蛋白酶)
E.C.3.4.21.36
Ala-|-Xaa,andalsoGly-|-Xaa,
Val-|-Xaa, Ser-|-Xaa,
Thrombin(凝血酶)
E.C.3.4.21.5
Arg-|-Gly,
Plasmin(胞质素，胞浆素)
Aminopeptidase M or N,or alanyl aminopeptidase,or membrane alanineaminopeptidase
E.C.3.4.11.2
Preferentially Ala-|-Xaa,and Tyr-|-Xaa,if Yaa-Pro-|-Xaa in termwith Yaa=Ala,Val,Leu,Ile,Phe,Tyr or Trp,then the dipeptide Yaa-Pro could be released
≠AlaorVal
Neprilysin(脑啡肽酶),or enkephalinase(脑啡肽酶),or neutralendopeptidase
E.C.3.4.24.11
Xaa-|-Tyr,Xaa-|-Phe, Xaa-|-Trp,and
Xaa-|-Leu,
Thimet oligopeptidase(甲拌磷寡肽 酶),or endo-oligopeptidase A,or endopeptidase(肽链内切 酶)24.15,or pz-peptidease(肠促胰 酶素)
Lys-|-Xaa
Calpain(钙激活中性蛋白酶)-1,or μ-calpain
E.C.3.4.22.52
Met-|-Xaa,Tyr-|-Xaa and
Arg-|-Xaa(with LeuorVal 朊酶，胃蛋白酶)
E.C.3.4.23.1
Preferentially Phe-|-Xaa, Tyr-|-Xaa,
E.C.3.4.21.7
Lys-|-Xaa,>Arg-|-Xaa
Prolyl oligopeptidase,or prolylendopeptidase
E.C.3.4.21.26
Plasma kallikrein (血浆激肽释放酶)
E.C.3.4.21.34
Arg-|-Xaa, Lys-|-Xaa,including
And also Leu-|-Xaa,and Trp-|-Xaa, ideally with Xaa= Phe,Trp,orTyr
Cathepsin(组织蛋白酶)D
E.C.3.4.23.5
Preferentially Phe-|-Xaa, Tyr-|-Xaa,
And also Leu-|-Xaa,ideally with Xaa
Enzymes
E.C. Number
Cleavage sites
α-chymotrypsin(胰凝乳蛋白酶，糜
蛋白酶)
E.C.3.4.21.1
Tyr-|-Xaa,Trp-|-Xaa, Phe-|-Xaa, and
alsoLeu-|-Xaa,Met-|-Xaa,
Trypsin (胰朊酶，胰蛋白酶)
E.C.3.4.21.4
Aminopeptidase B
E.C.3.4.11.6
Arg-|-Xaa, Lys-|-Xaa,
AminopeptidaseA,or angiotensinase,or glutamyl-aminopeptidase
E.C.3.4.11.7
Glu-|-Xaa>>Asp-|-Xaa,
Dipeptidyl-peptidaseI,or cathepsin(组织蛋白酶)C or J
Asp or Glu
Carboxypeptidase A
E.C.3.4.17.1
Xaa-|-Yaaif Yaa ≠Asp,Glu,Arg,Lys or Pro
Carboxypeptidase B,or protaminase
E.C.3.4.17.2
Xaa-|-ArgandXaa-|-Lys
Carboxypeptidase N,or Lysine(arginine), Carboxypeptidase(羧基肽酶),or kininase I(激肽酶)
Prolyl tripeptyl-peptidase
E.C.3.4.14.12
Xaa-Yaa-Pro-|-Zaa,if Zaa≠Pro
Peptidyl-depeptidaseA, or angiotensin-converting enzyme
E.C.3.4.15.1
Xaa-|-Yaa-Zaa,if Yaa≠Pro or Zaa≠
E.C.3.4.24.15
Xaa-|-Arg, Xaa-|-Ser,Xaa-|-Ile,
Xaa-|-Ala, Xaa-|-Gly,
Leucyl-aminopeptidase
E.C.3.4.11.1
Preferentially Leu-|-Xaa,but not
Arg-|-Xaa,andLys-|-Xaa,
Arg-|-Ser,Lys-|-Arg,
Leukocyteelastase(白细胞弹性蛋白酶),orneutrophilelastase(中性白细胞弹性蛋白酶),orlysosomalelastase(溶酶体弹性蛋白酶)
E.C.3.4.21.37
Val-|-Xaa, Ala-|-Xaa,
Cathepsin B (组织蛋白酶)
E.C.3.4.22.1
Arg-Arg-|-Xaa,and also Leu-|-Xaa,
Ala-|-Xaa, Phe-|-Xaa, Trp-|-Xaa,
Clostripain(梭菌蛋白酶),or endoproteinase Arg-C
E.C.3.4.22.8
Arg-|-Xaa including Arg-|-Pro,but not