益智亲水凝胶骨架片的制备
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关键词：亲水凝胶骨架片；羟丙甲基纤维素；粉末直接压片；三七总皂苷；栀子苷 基金资助：“重大新药创制”科技重大专项（N o.2009Z X09502-008，N o.2009Z X09308-003），国家自然科 学基金面上项目（N o.81073057），北京中医药大学自主选题（N o.J Y B Z Z-X S036），北京中医药大学创新团队发 展计划（No.2011-CXTD-13）
Preparation of Yizhi hydrogel matrix tablets
WU Hui-chao1, LU Yang1, DU Shou-ying1, ZHAI Yong-song2, CAI Cheng-bo1, ZHAO Jing-yi1
( 1School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China; 2Capital Medical University, Beijing 100069, China )
中华中医药杂志(原中国医药学报)2012年8月第27卷第8期 CJTCMP , August 2012, Vol . 27, No. 8
• 2069 •
DING Jian-zhong,ZHANG Liu-tong,GONG Quan,et al. Experimental study on the mechanism of warm-dryness in causing diseases.Journal of TCM,2007,48(11):1024-1026,1032 [2] 徐叔云,卞如濂,陈修,等.药理学实验方法.3版.北京:人民卫生 出版社,2002:1360 XU Shu-yun,BIAN Ru-lian,CHEN Xiu,et al.Experimental Method of Pharmacology,3th Edition.Beijing:People,s Medical Publishing House,2002:1360 [3] 钟相根,李宇航,祝小惠.慢性阻塞性肺疾病气道黏液高分泌机 制及中医药干预作用.中华中医药杂志,2011,26(8):1686-1688
（收稿日期：2011年10月8日）
益智亲水凝胶骨架片的制备
·论著·
武慧超1，陆洋1，杜守颖1，翟永松2，蔡程博1，赵静宜1
（1北京中医药大学中药学院，北京 100102；2首都医科大学，北京 100069）
摘要：目的：制备益智亲水凝胶骨架片。方法：以羟丙甲基纤维素为骨架材料制备亲水凝胶骨架片，以栀 子苷、人参皂苷R g1、人参皂苷R b1和三七皂苷R1为评价指标，考察各因素对益智亲水凝胶骨架片体外释放的影 响，优化处方和工艺。结果：辅料用量为20%且H P M C K15M:H P M C K4M为1:13时，以粉末直接压片法制备的益智亲水 凝胶骨架片在12h内持续释药，达到缓释效果，且释药曲线平稳，3批验证f2因子均大于50。结论：以羟丙甲基纤 维素为骨架材料，粉末直接压片可制得缓释效果理想的益智亲水凝胶骨架片。
Abstract: Objective: To prepare Yizhi hydrogel matrix tablets. Methods: Using ose
(HPMC) as the main carrier, gardenin, Panax Notoginseng Saponins R1, ginsenoside Rg1, and ginsenoside Rb1 were used to investigate the influence of factors in vitro releasing, to optimize formulations and preparation. Results: As 20% of the amount of materials and HPMCK15M: HPMCK4M=1:13 were used, Yizhi hydrophilic matrix prepared by direct powder compression can sustained release in 12h, displaying constant release effect, and the release curve smooth, three batches of authentication f2 factors were greater than 50. Conclusion: HPMC as matrix material, powder pellets can be obtained the desired effect of sustainedrelease Yizhi hydrophilic matrix. Yizhi hydrophilic matrix prepared by using HPMC as matrix material and using direct powder compression as preparation method displayed constant release profile.
ZHONG Xiang-gen,LI Yu-hang,ZHU Xiao-hui.Mechanism of airway mucus hypersecretion in COPD and intervention by TCM. China Joural of TCM and Pharmacy,2011,26(8):1686-1688 [4] 李建生,余学庆.病证结合模式下疗效评价指标体系建立的 思考.中华中医药杂志,2011,26(8):1666-1670 LI Jian-sheng,YU Xue-qing.Thinking on development of curative evaluation index system based on mode combination of disease and TCM syndrome.China Jioural of TCM and Pharmacy,2011, 26(8):1666-1670
Preparation of Yizhi hydrogel matrix tablets
WU Hui-chao1, LU Yang1, DU Shou-ying1, ZHAI Yong-song2, CAI Cheng-bo1, ZHAO Jing-yi1
( 1School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China; 2Capital Medical University, Beijing 100069, China )
中华中医药杂志(原中国医药学报)2012年8月第27卷第8期 CJTCMP , August 2012, Vol . 27, No. 8
• 2069 •
DING Jian-zhong,ZHANG Liu-tong,GONG Quan,et al. Experimental study on the mechanism of warm-dryness in causing diseases.Journal of TCM,2007,48(11):1024-1026,1032 [2] 徐叔云,卞如濂,陈修,等.药理学实验方法.3版.北京:人民卫生 出版社,2002:1360 XU Shu-yun,BIAN Ru-lian,CHEN Xiu,et al.Experimental Method of Pharmacology,3th Edition.Beijing:People,s Medical Publishing House,2002:1360 [3] 钟相根,李宇航,祝小惠.慢性阻塞性肺疾病气道黏液高分泌机 制及中医药干预作用.中华中医药杂志,2011,26(8):1686-1688
（收稿日期：2011年10月8日）
益智亲水凝胶骨架片的制备
·论著·
武慧超1，陆洋1，杜守颖1，翟永松2，蔡程博1，赵静宜1
（1北京中医药大学中药学院，北京 100102；2首都医科大学，北京 100069）
摘要：目的：制备益智亲水凝胶骨架片。方法：以羟丙甲基纤维素为骨架材料制备亲水凝胶骨架片，以栀 子苷、人参皂苷R g1、人参皂苷R b1和三七皂苷R1为评价指标，考察各因素对益智亲水凝胶骨架片体外释放的影 响，优化处方和工艺。结果：辅料用量为20%且H P M C K15M:H P M C K4M为1:13时，以粉末直接压片法制备的益智亲水 凝胶骨架片在12h内持续释药，达到缓释效果，且释药曲线平稳，3批验证f2因子均大于50。结论：以羟丙甲基纤 维素为骨架材料，粉末直接压片可制得缓释效果理想的益智亲水凝胶骨架片。
Abstract: Objective: To prepare Yizhi hydrogel matrix tablets. Methods: Using ose
(HPMC) as the main carrier, gardenin, Panax Notoginseng Saponins R1, ginsenoside Rg1, and ginsenoside Rb1 were used to investigate the influence of factors in vitro releasing, to optimize formulations and preparation. Results: As 20% of the amount of materials and HPMCK15M: HPMCK4M=1:13 were used, Yizhi hydrophilic matrix prepared by direct powder compression can sustained release in 12h, displaying constant release effect, and the release curve smooth, three batches of authentication f2 factors were greater than 50. Conclusion: HPMC as matrix material, powder pellets can be obtained the desired effect of sustainedrelease Yizhi hydrophilic matrix. Yizhi hydrophilic matrix prepared by using HPMC as matrix material and using direct powder compression as preparation method displayed constant release profile.
ZHONG Xiang-gen,LI Yu-hang,ZHU Xiao-hui.Mechanism of airway mucus hypersecretion in COPD and intervention by TCM. China Joural of TCM and Pharmacy,2011,26(8):1686-1688 [4] 李建生,余学庆.病证结合模式下疗效评价指标体系建立的 思考.中华中医药杂志,2011,26(8):1666-1670 LI Jian-sheng,YU Xue-qing.Thinking on development of curative evaluation index system based on mode combination of disease and TCM syndrome.China Jioural of TCM and Pharmacy,2011, 26(8):1666-1670