52-弥散峰度成像评估鼻咽癌放疗后颞叶灰白质微观结构变化的研究_潘海宾

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中国医学计算机成像杂志，2017，23：124-130作者单位：1 上海市第六人民医院南院放射科 2上海市第六人民医院放射科

通信地址：上海市奉贤区南桥新城南奉公路6600号 ， 上海市 201400 .通信作者：李跃华（电子邮箱：liyuehua312@ ） 李晓兵（电子邮箱：ctisus@ ）

基金项目：国家自然基金 NO. 81471656；上海市自然基金NO.14ZR1432100； 上海市人才发展基金：NO.201555

Chin Comput Med Imag ，2017，23：124-130

1Department of Radiology ，Shanghai Sixth Hospital South Branch ，Shanghai Jiaotong University

2Department of Radiology ，Shanghai Sixth Hospital ，Shanghai Jiaotong University

Address: Fengxian District, Shanghai Nanfeng Road on the 6600th Rd ，Shanghai 201400, P .R.C.

Address Correspondence to LI Yue-hua （E-mail:liyuehua312@ ）; LI Xiao-bing(E-mail:ctisus@ ）

弥散峰度成像评估鼻咽癌放疗后潘海宾1 李跃华2 杨亚旭1 李晓兵1 王 丹2

【摘要】目的：探讨弥散峰度成像（DKI）在检测鼻咽癌放疗后颞叶灰质与白质微观结构变化中的诊断价值。方法：本研究共纳入60例鼻咽癌患者和20例健康志愿者。根据放疗完成至DKI 检查时间间隔将60例鼻咽癌患者分为三组，每组20人：A 组（1周）、B 组（6个月）和C 组（12个月），所有鼻咽癌患者和对照组志愿者常规磁共振检查均未发现明显异常。由2名放射科专家在协商一致情况下手动勾画颞叶灰质和白质感兴趣区，计算感兴趣区MD、MK 和FA 值，并进行统计学分析。结果：与正常对照组相比，放疗结束后1周颞叶灰质与白质的MK 值增加，放疗结束后6个月和12个月时MK 值降低。放疗结束后1周MD 值高于正常对照组，但放疗后6个月和12个月时MD 值接近正常。结论：DKI 能够动态监测鼻咽癌放疗后不同时期颞叶灰白质微观结构变化，定量测量MD 和MK 有助于早期发现常规磁共振无法显示的隐匿性损伤，为临床早期诊断和早期干预提供更客观的影像学证据。

【关键词】鼻咽癌；弥散峰度成像；放射治疗；颞叶损伤

中图分类号：R445.2 文献标志码：A 文章编号：1006-5741（2017）-01-0124-07

颞叶灰白质微观结构变化的研究

【Abstract 】 Purpose: This study aimed to evaluate the potential value of diffusion kurtosis imaging (DKI) in the diagnosis of radiation-induced changes in the grey and white matter of temporal lobe after radiation therapy in patients with nasopharyngeal carcinoma (NPC). Methods: Sixty patients with NPC and 20 normal control individuals were enrolled. Patients with NPC were divided into 3 groups according to the duration between the time of radiotherapy and DKI scanning: group A (1 week, n=20), group B (6 months, n=20), group C (12 months, n=20). Two neuroradiologists drew the region of interest (ROIs) manually in the temporal lobe white matter and grey matter on the DKI images. Mean diffusion (MD), mean kurtosis (MK) and fractional anisotropy (FA) of the ROIs were measured. Results: Compared to that of the normal control group, MK values in grey and white matter were significantly higher at 1 week after radiotherapy and significantly lower at 6 months and 1 year after radiotherapy in patients with NPC, whereas the MD values in grey and white matter were significantly lower at 1 week after radiotherapy and returned to normal at 6 months and 1 year after radiotherapy. Conclusions: DKI can

Study of Microstructure Changes in the Grey and White Matter of T emporal Lobe after Radiotherapy

PAN Hai-bin 1,LI Yao-hua 2,YANG Ya-xu 1,LI Xiao-bing 1,WANG Dan 2

in Patients with Nasopharyngeal Carcinoma by Diffusion Kurtosis Imaging