Piericidin A_线粒体复合体I抑制剂_2738-64-9_Apexbio
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ApexBio Technology
Piericidin A is a mitochondrial complex I inhibitor. Complex I, also known as NADH:ubiquinone oxidoreductase, catalyzes the transfer of electrons from NADH to ubiquinone as part of the respiratory chain resulting in ATP generation.
Soluble in DMSO
Store at -20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
In vitro: Previous study found that piericidin A could inhibit the electron transport system at two sites. Piericidin A specifically reacted at very low concentrations at a site near the reduced NADH dehydrogenase. At high concentrations, piericidin A inhibited the succinic dehydrogenase system, and the inhibition could be partially reversed by coenzyme Q. Moreover, it was found that both the succinate and NADH oxidase system were inhibited at high levels of piericidin A [1]. In vivo: Animal study was performed to evaluate the effect of piericidin A and antagonistic effect of vitamin K3 on respiration, blood pressure and heart rate in rats. Results showed that 0.167 mg/kg of piericidin A increased the respiratory rate and the lowered blood pressure rapidly. Furthermore, vitamin K3 (10-40 mg/kg) could restore the responses to piericidin A in rats [2]. Clinical trial: Up to now, piericidin A is still in the preclinical development stage.
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Metabolism
信号通路:
Dehydrogenase
产品描述:
特别声明
产品仅用于研究，
不针对患者销售，望谅解。
每个产品具体的储存和使用信息显示在产品说明书中。ApexBio 产品在推荐的条件下是稳定 的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的，运输温度不同于长 期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后，按照 产品说明书上的要求进行储存。
参考文献: [1] Jeng M, Hall C, Crane FL, Takahashi N, Tamura S, Folkers K. Inhibition of mitochondrial electron transport by piericidin A and related compounds. Biochemistry. 1968 Apr;7(4):1311-22. [2] Mitsui T et al. Studies on piericidin antagonistic effect of vitamin K3 on the respiratory chain of insects and mammals in the presence of piericidin A. Agricultural and Biological Chemistry Vol. 34 (1970) No. 7 P 1101-1109
产品说明书
化学性质
产品名: Piericidin A 修订日期: 6/30/2016
ຫໍສະໝຸດ Baidu
产品名: Cas No.: 分子量: 分子式: 别名:
化学名:
SMILES:
溶解性: 储存条件: 一般建议:
运输条件:
Piericidin A
2738-64-9
415.6
C25H37NO4
AR 054|Shaoguanmycin B|SN 198E
2-[(2E,5E,7E,11E)-10R-hydroxy-3,7,9R,11-tetramethyl-2,5,7,11-tridec atetraen-1-yl]-5,6-dimethoxy-3-methyl-4-pyridinol
COC1=C(O)C(C)=C(C/C=C(C)/C/C=C/C(C)=C/[C@H]([C@@H](O)/C(C) =C/C)C)N=C1OC
Piericidin A is a mitochondrial complex I inhibitor. Complex I, also known as NADH:ubiquinone oxidoreductase, catalyzes the transfer of electrons from NADH to ubiquinone as part of the respiratory chain resulting in ATP generation.
Soluble in DMSO
Store at -20°C
For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
In vitro: Previous study found that piericidin A could inhibit the electron transport system at two sites. Piericidin A specifically reacted at very low concentrations at a site near the reduced NADH dehydrogenase. At high concentrations, piericidin A inhibited the succinic dehydrogenase system, and the inhibition could be partially reversed by coenzyme Q. Moreover, it was found that both the succinate and NADH oxidase system were inhibited at high levels of piericidin A [1]. In vivo: Animal study was performed to evaluate the effect of piericidin A and antagonistic effect of vitamin K3 on respiration, blood pressure and heart rate in rats. Results showed that 0.167 mg/kg of piericidin A increased the respiratory rate and the lowered blood pressure rapidly. Furthermore, vitamin K3 (10-40 mg/kg) could restore the responses to piericidin A in rats [2]. Clinical trial: Up to now, piericidin A is still in the preclinical development stage.
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
Metabolism
信号通路:
Dehydrogenase
产品描述:
特别声明
产品仅用于研究，
不针对患者销售，望谅解。
每个产品具体的储存和使用信息显示在产品说明书中。ApexBio 产品在推荐的条件下是稳定 的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的，运输温度不同于长 期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后，按照 产品说明书上的要求进行储存。
参考文献: [1] Jeng M, Hall C, Crane FL, Takahashi N, Tamura S, Folkers K. Inhibition of mitochondrial electron transport by piericidin A and related compounds. Biochemistry. 1968 Apr;7(4):1311-22. [2] Mitsui T et al. Studies on piericidin antagonistic effect of vitamin K3 on the respiratory chain of insects and mammals in the presence of piericidin A. Agricultural and Biological Chemistry Vol. 34 (1970) No. 7 P 1101-1109
产品说明书
化学性质
产品名: Piericidin A 修订日期: 6/30/2016
ຫໍສະໝຸດ Baidu
产品名: Cas No.: 分子量: 分子式: 别名:
化学名:
SMILES:
溶解性: 储存条件: 一般建议:
运输条件:
Piericidin A
2738-64-9
415.6
C25H37NO4
AR 054|Shaoguanmycin B|SN 198E
2-[(2E,5E,7E,11E)-10R-hydroxy-3,7,9R,11-tetramethyl-2,5,7,11-tridec atetraen-1-yl]-5,6-dimethoxy-3-methyl-4-pyridinol
COC1=C(O)C(C)=C(C/C=C(C)/C/C=C/C(C)=C/[C@H]([C@@H](O)/C(C) =C/C)C)N=C1OC